Clinical significance of granuloma in Crohn's disease.

Abstract:

AIM:Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this study was to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or without granuloma exhibit a different clinical course. METHODS:Fifty-six patients with newly diagnosed CD were included in the study. Jejunoscopy, enteroclysis and ileo-colonoscopy were performed in all patients. At least two biopsy specimens from each examined gastrointestinal segment were examined microscopically searching granuloma. The clinical course was followed in all patients, and extraintestinal manifestations as well as details of any immunosuppressive therapy and surgical intervention were noted. RESULTS:Granuloma was found in 44.6% of the cases (25 patients). Patients with granuloma had higher activity parameters at the time of the biopsies. Extraintestinal manifestations were observed and surgical interventions were performed more often in the granuloma group. The need of immunosuppressive therapy was significantly more frequent in the patients with granuloma. Granuloma formation is more often seen in younger patients, and mainly in the severe, active penetrating disease. CONCLUSION:The significantly higher frequency of surgical interventions and immunosuppressive therapy suggests that granuloma formation is associated with a more severe disease course during the first years of CD.

journal_name

World J Gastroenterol

authors

Molnár T,Tiszlavicz L,Gyulai C,Nagy F,Lonovics J

doi

10.3748/wjg.v11.i20.3118

keywords:

subject

Has Abstract

pub_date

2005-05-28 00:00:00

pages

3118-21

issue

20

eissn

1007-9327

issn

2219-2840

journal_volume

11

pub_type

杂志文章
  • Capsule endoscopy in pediatric patients.

    abstract::Wireless capsule endoscope (WCE) for the investigation of the small bowel is an approved technique both in adults and children (more than 10 years old). The present review provides data on the indications, diagnostic yield, adverse events and limitations of the WCE technique in children and tries to predict the future...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.4152

    authors: Shamir R,Eliakim R

    更新日期:2008-07-14 00:00:00

  • Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.

    abstract:AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers. METHODS:DNA was extracted from undiluted pancreatic and biliary fluids. As a surrogate for a genome-wide hypomethylation assay, levels of long interspersed nuc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i11.1718

    authors: Kato N,Yamamoto H,Adachi Y,Ohashi H,Taniguchi H,Suzuki H,Nakazawa M,Kaneto H,Sasaki S,Imai K,Shinomura Y

    更新日期:2013-03-21 00:00:00

  • Study on hepatoprotective effect of peptide S-8300 from shark liver.

    abstract:AIM:To explore the effects of peptide S-8300 from shark liver (S-8300) on liver function as well as in regulating immune functions in experimental injury models. METHODS:Mice were administered with different doses of S-8300 for four consecutive days, followed by mice injected with tetrachloromethane (CCl(4)) on d 3. T...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i12.1809

    authors: Huang FJ,Lv ZB,Li Q,Wei LJ,Zhang L,Wu WT

    更新日期:2005-03-28 00:00:00

  • Massive presacral bleeding during rectal surgery: from anatomy to clinical practice.

    abstract:AIM:To investigate control of two different types of massive presacral bleeding according to the anatomy of the presacral venous system. METHODS:A retrospective review was performed in 1628 patients with middle or low rectal carcinoma who were treated surgically in the Department of Colorectal Surgery, Changhai Hospit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i25.4039

    authors: Lou Z,Zhang W,Meng RG,Fu CG

    更新日期:2013-07-07 00:00:00

  • Tuberculous peritonitis in children: report of nine patients and review of the literature.

    abstract:AIM:To present our experience with tuberculous peritonitis treated in our hospital from 2002-2007. METHODS:We reviewed the medical records of 9 children with tuberculous peritonitis. RESULTS:Nine patients (5 boys, 4 girls) of mean age 14.2 years were diagnosed with peritoneal tuberculosis. All patients presented with...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.7235

    authors: Dinler G,Sensoy G,Helek D,Kalayci AG

    更新日期:2008-12-21 00:00:00

  • Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer.

    abstract:AIM:To investigate the expression and clinical relevance of inhibitor of differentiation (ID) proteins in biliary tract cancer. METHODS:ID protein expression was analyzed in 129 samples from patients with advanced biliary tract cancer (BTC) (45 extrahepatic, 50 intrahepatic, and 34 gallbladder cancers), compared to no...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i48.9334

    authors: Harder J,Müller MJ,Fuchs M,Gumpp V,Schmitt-Graeff A,Fischer R,Frank M,Opitz O,Hasskarl J

    更新日期:2013-12-28 00:00:00

  • Value of transient elastography for the prediction of variceal bleeding.

    abstract:AIM:To determine if liver stiffness (LS) measurements by means of transient elastography (TE) correlate with the presence of significant esophageal varices (EV) and if they can predict the occurrence of variceal bleeding. METHODS:We studied 1000 cases of liver cirrhosis divided into 2 groups: patients without EV or wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i17.2206

    authors: Sporea I,Raţiu I,Sirli R,Popescu A,Bota S

    更新日期:2011-05-07 00:00:00

  • Recent advances in pharmacological treatment of irritable bowel syndrome.

    abstract::Irritable bowel syndrome (IBS) is a highly prevalent functional disorder that reduces patients' quality of life. It is a chronic disorder characterized by abdominal pain or discomfort associated with disordered defecation in the absence of identifiable structural or biochemical abnormalities. IBS imposes a significant...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i27.8867

    authors: Lazaraki G,Chatzimavroudis G,Katsinelos P

    更新日期:2014-07-21 00:00:00

  • Lower folate levels in gastric cancer: is it a cause or a result?

    abstract::Folate deficiency and its association with cancer have been studied in the literature, but its clinical impact is still unknown. Folate deficiency and its result on gastric cancer is a mysterious part of oncology, with ongoing studies hopefully clarifying its impact on gastric cancer management. Lee et al studied fola...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v21.i13.4101

    authors: Alkan A,Mızrak D,Utkan G

    更新日期:2015-04-07 00:00:00

  • Use of chorioamniotic membrane instead of bogota bag in open abdomen: how i do it?

    abstract::It is one of the most important problems for general surgeons to decide which operation should be undertaken on patients with intra-abdominal infection, especially those with concomitant abdominal hypertension. Recently, closure techniques using prosthetic meshes in order to retain abdominal tension and to control sep...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.14.815

    authors: Tekin S,Tekin A,Kucukkartallar T,Cakir M,Kartal A

    更新日期:2008-02-07 00:00:00

  • Diagnostic efficacy of the Japan Narrow-band-imaging Expert Team and Pit pattern classifications for colorectal lesions: A meta-analysis.

    abstract:BACKGROUND:Pit pattern classification using magnifying chromoendoscopy is the established method for diagnosing colorectal lesions. The Japan Narrow-band-imaging (NBI) Expert Team (JNET) classification is a novel NBI magnifying endoscopic classification that focuses on the vessel, and surface patterns. AIM:To determin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i40.6279

    authors: Zhang Y,Chen HY,Zhou XL,Pan WS,Zhou XX,Pan HH

    更新日期:2020-10-28 00:00:00

  • Role of ion channels in gastrointestinal cancer.

    abstract::In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell. The functions of ion channels in the gastrointestinal (GI) tract influence a variety of cellular processes, many of which overlap with these hallmarks of cancer. In this review we fo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i38.5732

    authors: Anderson KJ,Cormier RT,Scott PM

    更新日期:2019-10-14 00:00:00

  • Upregulation of 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase by butyrate in Caco-2 cells.

    abstract:AIM:To investigate the possible involvement of 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase [1alpha-25(OH) (2) D(3)] in butyrate-induced differentiation in human intestinal cell line Caco-2 cells. METHODS:Caco-2 cells were incubated either with 3 mmol/L butyrate and 1 micromol/L 25(OH) (2) D(3) or with 1 micromol/L 1al...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i45.7136

    authors: Schröder O,Turak S,Daniel C,Gaschott T,Stein J

    更新日期:2005-12-07 00:00:00

  • Ceftriaxone-induced toxic hepatitis.

    abstract::Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of a long half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2669

    authors: Peker E,Cagan E,Dogan M

    更新日期:2009-06-07 00:00:00

  • Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents.

    abstract:AIM:To investigate the effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. METHODS:Fifteen samples of autoantibodies against beta(1)-adrenoceptor positive sera of patients with hepatitis virus myocarditis were obtained and IgGs were puri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i8.1171

    authors: Liu K,Liao YH,Wang ZH,Li SL,Wang M,Zeng LL,Tang M

    更新日期:2004-04-15 00:00:00

  • Intestinal preparation prior to capsule endoscopy administration.

    abstract::In order to have an adequate view of the whole small intestine during capsule endoscopy, the preparation recommended consists of a clear liquid diet and an overnight fast. However, visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents. To improve mucosal visualization, ...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.14.5773

    authors: Pons Beltrán V,Carretero C,Gonzalez-Suárez B,Fernandez-Urien I,Muñoz-Navas M

    更新日期:2008-10-07 00:00:00

  • Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning.

    abstract:AIM:To investigate the role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning (IPC). METHODS:A rat model of acute hepatic ischemia-reperfusion was established, 24 healthy male Wistar rats were randomly divided into sham-operated group, ische...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i13.1934

    authors: Sun K,Liu ZS,Sun Q

    更新日期:2004-07-01 00:00:00

  • Effects of ethanol on insulin-like growth factor-I system in primary cultured rat hepatocytes: implications of JNK1/2 and alcoholdehydrogenase.

    abstract:AIM:To evaluate the effects of ethanol on the insulin-like growth factor-I (IGF-I) system involved in c-Jun N-terminal kinase (JNK1/2) and alcoholdehydrogenase (ADH) activity in primary cultured rat hepatocytes. METHODS:Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of et...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.4324

    authors: Oh YI,Kim JH,Kang CW

    更新日期:2008-07-21 00:00:00

  • Experimental study on therapeutic effect of in vivo expression of Cell I-Hep II recombinant polypeptide of fibronectin on murine H22 hepatocellular carcinoma.

    abstract:AIM:To investigate the inhibitory effect of in vivo expression of expressing plasmid pCH510 of recombinant fibronectin polypeptide (CH50) on hepatocellular carcinoma and the improved therapeutic effect of pCH510 in combination with chemotherapeutic agents and Hsp70-H22 hepatocarcinoma antigen peptide on tumor. METHODS...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.1940

    authors: Zhang GM,Yang Y,Huang B,Xiao H,Li D,Feng ZH

    更新日期:2003-09-01 00:00:00

  • Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer.

    abstract:AIM:To investigate the relationship between autophagy and perineural invasion (PNI), clinical features, and prognosis in patients with pancreatic cancer. METHODS:Clinical and pathological data were retrospectively collected from 109 patients with pancreatic ductal adenocarcinoma who underwent radical resection at the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i40.7232

    authors: Yang YH,Liu JB,Gui Y,Lei LL,Zhang SJ

    更新日期:2017-10-28 00:00:00

  • Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement.

    abstract:AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infection in inflammatory bowel disease (IBD). METHODS:A cohort of 40 IBD patients (17 refractory) and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest. Vi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i6.1915

    authors: Ciccocioppo R,Racca F,Paolucci S,Campanini G,Pozzi L,Betti E,Riboni R,Vanoli A,Baldanti F,Corazza GR

    更新日期:2015-02-14 00:00:00

  • Impact of disease severity on gastric residual volume in critical patients.

    abstract:AIM:To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS:Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i15.2007

    authors: Hsu CW,Sun SF,Lee DL,Lin SL,Wong KF,Huang HH,Li HJ

    更新日期:2011-04-21 00:00:00

  • Prognostic factors in patients with advanced cholangiocarcinoma: role of surgery, chemotherapy and body mass index.

    abstract:AIM:To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS:A retrospective review of the medical records of 55 patients diagnosed with cholangio-carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to de...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3224

    authors: Farhat MH,Shamseddine AI,Tawil AN,Berjawi G,Sidani C,Shamseddeen W,Barada KA

    更新日期:2008-05-28 00:00:00

  • Acceptance on colorectal cancer screening upper age limit in South Korea.

    abstract:BACKGROUND:The Korea National Cancer Screening Program currently provides screening for colorectal cancer (CRC) for adults older than 50 years with no upper age limit. In general, people are likely to only pay attention to the benefits of cancer screening and to neglect its risks. Most consider the benefits of cancer s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i27.3963

    authors: Luu XQ,Lee K,Lee YY,Suh M,Kim Y,Choi KS

    更新日期:2020-07-21 00:00:00

  • Study of the influence of hiatus hernia on gastroesophageal reflux.

    abstract:AIM:To explore whether the presence of a sliding hiatus hernia influences gastroesophageal reflux. METHODS:Endoscopy and 24 h pH monitoring were performed for 197 outpatients with gastroesophageal reflux symptoms. RESULTS:Of the 197 patients with symptoms of gastroesophageal reflux, patients with hiatus hernia accoun...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v3.i1.27

    authors: Zhu HM

    更新日期:1997-03-15 00:00:00

  • Comparison of the analgesic effects between electro-acupuncture and moxibustion with visceral hypersensitivity rats in irritable bowel syndrome.

    abstract:AIM:To observe whether there are differences in the effects of electro-acupuncture (EA) and moxibustion (Mox) in rats with visceral hypersensitivity. METHODS:EA at 1 mA and 3 mA and Mox at 43 °C and 46 °C were applied to the Shangjuxu (ST37, bilateral) acupoints in model rats with visceral hypersensitivity. Responses ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i16.2928

    authors: Zhao JM,Li L,Chen L,Shi Y,Li YW,Shang HX,Wu LY,Weng ZJ,Bao CH,Wu HG

    更新日期:2017-04-28 00:00:00

  • Imaging features of intraductal papillary mucinous neoplasms of the pancreas in multi-detector row computed tomography.

    abstract:AIM:To retrospectively evaluate the imaging features of pancreatic intraductal papillary mucinous neoplasms (IPMNs) in multi-detector row computed tomography (MDCT). METHODS:A total of 20 patients with pathologically-confirmed intraductal papillary mucinous neoplasms (IPMNs) were included in this study. Axial MDCT ima...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.4037

    authors: Tan L,Zhao YE,Wang DB,Wang QB,Hu J,Chen KM,Deng XX

    更新日期:2009-08-28 00:00:00

  • Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis.

    abstract:AIM:To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS:Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 m...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i13.1622

    authors: Rodríguez C,Medici M,Mozzi F,Font de Valdez G

    更新日期:2010-04-07 00:00:00

  • Diagnosis and evaluation of gastric cancer by positron emission tomography.

    abstract::Gastric cancer is the second leading cause of cancer mortality worldwide. The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy. Effective technologies for accurate staging and quantitative evaluation are still in demand to merit reasonable treatment ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i16.4574

    authors: Wu CX,Zhu ZH

    更新日期:2014-04-28 00:00:00

  • Evidence or eminence in abdominal surgery: recent improvements in perioperative care.

    abstract::Repeated surveys from Europe, the United States, Australia, and New Zealand have shown that adherence to an evidence-based perioperative care protocol, such as Enhanced Recovery After Surgery (ERAS), has been generally low. It is of great importance to support the implementation of the ERAS protocol as it has been sho...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i44.16615

    authors: Segelman J,Nygren J

    更新日期:2014-11-28 00:00:00