Study on hepatoprotective effect of peptide S-8300 from shark liver.

abstract：:Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of a long half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a f...

journal_title：World journal of gastroenterology

authors： Peker E,Cagan E,Dogan M

更新日期：2009-06-07 00:00:00

abstract：AIM:Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism of a wide range of carcinogens, but deletions of the genes are commonly found in the population. The present study was undertaken to evaluate the association between GSTM1 and GSTT1 gene polymorphisms and hepatocellular ...

journal_title：World journal of gastroenterology

authors： Deng ZL,Wei YP,Ma Y

更新日期：2005-01-14 00:00:00

abstract：AIM:To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS:Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, suc...

journal_title：World journal of gastroenterology

authors： Strup-Perrot C,Vozenin-Brotons MC,Vandamme M,Linard C,Mathé D

更新日期：2005-10-28 00:00:00

abstract：AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten (PTEN) hamartoma tumor syndrome (PHTS) and to perform a systematic literature review regarding the same. METHODS:This study was approved by the appropriate institutional review board prior to ...

journal_title：World journal of gastroenterology

authors： Stanich PP,Pilarski R,Rock J,Frankel WL,El-Dika S,Meyer MM

更新日期：2014-02-21 00:00:00

abstract：AIM:To investigate the effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing radical distal gastrectomy. METHODS:Within 24 h of intensive care unit management, patients with gastric cancer were enrolled after written informed consent and randomize...

journal_title：World journal of gastroenterology

authors： Liu HC,Zhou YB,Chen D,Niu ZJ,Yu Y

更新日期：2012-06-07 00:00:00

abstract：AIM:To evaluate the application of bipolar coagulation (BIP) in hepatectomy by comparing the efficacy of BIP alone, cavitron ultrasonic surgical aspirator (CUSA) + BIP and conventional clamp crushing (CLAMP). METHODS:Based on our database of patient records, a total of 380 consecutive patients who underwent hepatectom...

journal_title：World journal of gastroenterology

authors： Guo JY,Li DW,Liao R,Huang P,Kong XB,Wang JM,Wang HL,Luo SQ,Yan X,Du CY

更新日期：2014-07-14 00:00:00

abstract：AIM:To identify factors related to serious postoperative bacterial and fungal infections in the first 3 mo after living donor liver transplantation (LDLT). METHODS:In the present study, the data of 207 patients from 2004 to 2011 were reviewed. The pre-, intra- and post-operative factors were statistically analyzed. Al...

journal_title：World journal of gastroenterology

authors： Li C,Wen TF,Mi K,Wang C,Yan LN,Li B

更新日期：2012-04-28 00:00:00

abstract：AIM:To assess the effectiveness of pancreatic stents for preventing pancreatitis in high-risk patients after endoscopic retrograde cholangiopancreatography (ERCP). METHODS:PubMed, Embase, Science Citation Index, and Cochrane Controlled Trials Register were searched to identify relevant trials published in English. Inc...

journal_title：World journal of gastroenterology

authors： Shi QQ,Ning XY,Zhan LL,Tang GD,Lv XP

更新日期：2014-06-14 00:00:00

abstract：AIM:To determine whether the expression profiles of EphB receptor and ephrin-B ligand can be used as markers for dysplastic/oncogenic transformation in gastric mucosa. METHODS:The protein expression and localization of EphB and ephrin-B in normal, ulcerated regenerating, and dysplastic gastric mucosa were examined in ...

journal_title：World journal of gastroenterology

authors： Uchiyama S,Saeki N,Ogawa K

更新日期：2015-01-14 00:00:00

abstract：AIM:To study the pattern of cancer incidence and determine the incidence rates in Eastern Libya (for the first time in a decade). METHODS:A hospital-based registry of cancer patients was formed using records from the primary oncology center in eastern Libya - focusing on those diagnosed in the year 2012. RESULTS:The ...

journal_title：World journal of gastroenterology

authors： Bodalal Z,Azzuz R,Bendardaf R

更新日期：2014-05-28 00:00:00

abstract：AIM:To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of meta-analysis. METHODS:We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our sel...

journal_title：World journal of gastroenterology

authors： Geng J,Zhang YW,Huang GC,Chen LB

更新日期：2008-11-21 00:00:00

abstract：AIM:To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS:Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for ...

journal_title：World journal of gastroenterology

authors： Gong SS,Fan YH,Wang SY,Han QQ,Lv B,Xu Y,Chen X,He YE

更新日期：2018-04-28 00:00:00

abstract：:Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer (GC) at an early stage. Due to the low incidence of lymph node metastasis and favorable prognosis in early GC, function-preserving surgery which improves postoperative quality of life may be possible. Pylorus-preserving gastrectomy (...

journal_title：World journal of gastroenterology

authors： Saito T,Kurokawa Y,Takiguchi S,Mori M,Doki Y

更新日期：2014-12-14 00:00:00

abstract：:Currently approved treatments for hepatitis B virus (HBV) infection include the immunomodulatory agent, IFN-alpha, and nucleos(t)ide analogues. Their efficacy is limited by their side effects, as well as the induction of viral mutations that render them less potent. It is thus necessary to develop drugs that target ad...

journal_title：World journal of gastroenterology

authors： Wu GY,Chen HS

更新日期：2007-02-14 00:00:00

abstract：:AIM:To observe the protective effect of combined i.v. administraction of Yuanhu injection (YHI) and Huoxuehuayu injection-I (HHI-I) against acute pancreatitis (AP) in rabbits.METHODS:Sever acute pancreatitis (SAP) was induced by retrograde infusion of artificial bile juice into biliary-pancreatic duct, and treated wit...

journal_title：World journal of gastroenterology

authors： Zhao LG,Wu XX,Han EK,Chen YL,Chen C,Xu DQ

更新日期：1998-06-01 00:00:00

abstract：AIM:To elucidate the efficacy and safety of a split dose of midazolam in combination with meperidine for colonoscopy. METHODS:Eighty subjects undergoing outpatient colonoscopy were randomly assigned to group A or B. Group A (n = 40) received a split dose of midazolam in combination with meperidine. Group B (n = 40) re...

journal_title：World journal of gastroenterology

authors： Lee H,Kim JH

更新日期：2009-08-14 00:00:00

abstract：AIM:To investigate the effect of activation of canonical Wnt signaling pathway on the proliferation and differentiation of hepatic oval cells in vitro. METHODS:WB-F344 cells were treated with recombinant Wnt3a (20, 40, 80, 160, 200 ng/mL) in serum-free medium for 24 h. Cell proliferation was measured by Brdu incorpora...

journal_title：World journal of gastroenterology

authors： Zhang Y,Li XM,Zhang FK,Wang BE

更新日期：2008-11-21 00:00:00

abstract：AIM:Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159) polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced a...

journal_title：World journal of gastroenterology

authors： Meiler C,Muhlbauer M,Johann M,Hartmann A,Schnabl B,Wodarz N,Schmitz G,Scholmerich J,Hellerbrand C

更新日期：2005-10-14 00:00:00

abstract：:The purpose of this article is to review the evidence regarding transmission of infection during gastrointestinal endoscopy, factors important in endoscope reprocessing and infection control, areas to focus on to improve compliance, and recent developments and advances in the field. ...

journal_title：World journal of gastroenterology

authors： Nelson DB,Muscarella LF

更新日期：2006-07-07 00:00:00

abstract：AIM:To retrospectively evaluate the prognosis of patients with hepatocellular carcinoma (HCC) with or without a history of therapy for HCC following transcatheter arterial embolization (TAE). METHODS:One hundred and twenty-one patients with HCC treated with TAE from 1992 to 2004 in our hospital were enrolled in this s...

journal_title：World journal of gastroenterology

authors： Hiraoka A,Kumagi T,Hirooka M,Uehara T,Kurose K,Iuchi H,Hiasa Y,Matsuura B,Michitaka K,Kumano S,Tanaka H,Yamashita Y,Horiike N,Mochizuki T,Onji M

更新日期：2006-04-07 00:00:00

abstract：AIM:To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 (TP53 gene, p53 protein) and its role in tumor invasion and response to therapy. METHODS:We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between A...

journal_title：World journal of gastroenterology

authors： Abdel-Rahman WM,Al-Khayyal NA,Nair VA,Aravind SR,Saber-Ayad M

更新日期：2017-05-21 00:00:00

abstract：INTRODUCTION:This paper provides a review of the practice of liver transplantation with the main emphasis on UK practice and indications for transplantation. REFERRAL AND ASSESSMENT:This section reviews the process of referral and assessment of patients with liver disease with reference to UK practice. DONOR ORGANS:T...

journal_title：World journal of gastroenterology

authors： Bramhall SR,Minford E,Gunson B,Buckels JA

更新日期：2001-10-01 00:00:00

abstract：AIM:To examine the effects of combined treatment of oxaliplatin and phosphatidylinositol 3'-kinase inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) for gastric cancer. METHODS:Cell viability was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Apoptotic cells were ...

journal_title：World journal of gastroenterology

authors： Liu J,Fu XQ,Zhou W,Yu HG,Yu JP,Luo HS

更新日期：2011-01-14 00:00:00

abstract：:The KRAS oncogene is mutated in approximately 35%-45% of colorectal cancers, and KRAS mutational status testing has been highlighted in recent years. The most frequent mutations in this gene, point substitutions in codons 12 and 13, were validated as negative predictors of response to anti-epidermal growth factor rece...

journal_title：World journal of gastroenterology

authors： Tan C,Du X

更新日期：2012-10-07 00:00:00

abstract：AIM:To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC). METHODS:Liver biopsies and HCC specimens from patients were collected and histologically examined. The expression of PD-1, PD-L1, and PD-L...

journal_title：World journal of gastroenterology

authors： Wang BJ,Bao JJ,Wang JZ,Wang Y,Jiang M,Xing MY,Zhang WG,Qi JY,Roggendorf M,Lu MJ,Yang DL

更新日期：2011-07-28 00:00:00

abstract：AIM:To determine the evolution of transient elastography (TE) in patients with alcoholic liver disease according to alcohol cessation or continuation. METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and...

journal_title：World journal of gastroenterology

authors： Bardou-Jacquet E,Legros L,Soro D,Latournerie M,Guillygomarc'h A,Le Lan C,Brissot P,Guyader D,Moirand R

更新日期：2013-01-28 00:00:00

abstract：:Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of...

journal_title：World journal of gastroenterology

authors： Tamaki K,Shimizu I,Urata M,Kohno N,Fukuno H,Ito S,Sano N

更新日期：2007-05-21 00:00:00

abstract：:According to a meta-analysis, H pylori and non-steroidal anti-inflammatory drugs (NSAID) independently and significantly increase the risk of gastroduodenal ulcer and ulcer bleeding. Their coincidence is frequent, demonstration of a possible relationship and consequent attitude is of important implications. But unfort...

journal_title：World journal of gastroenterology

authors： Ji KY,Hu FL

更新日期：2006-06-28 00:00:00

abstract：AIM:To examine fibrinogen-like protein 2 (fgl2) expression during taurocholate-induced acute pancreatitis progression in rats and its correlation with pancreatic injury severity. METHODS:Forty-eight male Sprague-Dawley rats were randomly divided into the severe acute pancreatitis (SAP) group (n = 24) and the sham oper...

journal_title：World journal of gastroenterology

authors： Ye XH,Chen TZ,Huai JP,Lu GR,Zhuge XJ,Chen RP,Chen WJ,Wang C,Huang ZM

更新日期：2013-04-28 00:00:00

abstract：AIM:To investigate the effects of entero-hepatic bile acid circulation on the inter-digestive migrating myoelectrical complex (MMC) in rats. METHODS:Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of th...

journal_title：World journal of gastroenterology

authors： Fang P,Dong L,Zhang WJ,Luo JY

更新日期：2005-09-14 00:00:00