A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings.

Abstract:

:Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of the diseases and time. We report a patient with hepatocellular carcinoma (HCC) who was suspected of having spinal lesions based on neurological findings, and a metastatic spinal tumor was found by imaging examination. Assuming that metastasis had occurred at the time lumbar pain developed, the patient reached the level of gait disturbance within only 4 mo, showing a rapid advancement of symptoms. If early diagnosis had been possible, treatment could be performed before acute myelopathy progressed to complete paralysis. We speculate that the terminal stage of HCC is not only liver failure associated with intrahepatic lesions but also metastasis to other regions, treatment for individual pathologies therefore, will be needed, which constitutes an important issue.

journal_name

World J Gastroenterol

authors

Tamaki K,Shimizu I,Urata M,Kohno N,Fukuno H,Ito S,Sano N

doi

10.3748/wjg.v13.i19.2758

subject

Has Abstract

pub_date

2007-05-21 00:00:00

pages

2758-60

issue

19

eissn

1007-9327

issn

2219-2840

journal_volume

13

pub_type

杂志文章,评审
  • Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis.

    abstract::This article is to offer a concise review on the use of cytoreductive surgery (CRS) plus intraperitoneal hyperthermic chemotherapy (IPHC) for the treatment of peritoneal carcinomatosis (PC). Traditionally, PC was treated with systemic chemotherapy alone with very poor response and a median survival of less than 6 mo. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.1159

    authors: Al-Shammaa HA,Li Y,Yonemura Y

    更新日期:2008-02-28 00:00:00

  • Mutation of RET proto-oncogene in Hirschsprung's disease and intestinal neuronal dysplasia.

    abstract:AIM:To investigate the genetic relationship between Hirschsprung's disease (HD) and intestinal neuronal dysplasia (IND) in Chinese population. METHODS:Peripheral blood samples were obtained from 30 HD patients, 20 IND patients, 18 HD/IND combined patients and 20 normal individuals as control. Genomic DNA was extracted...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i7.1136

    authors: Tou JF,Li MJ,Guan T,Li JC,Zhu XK,Feng ZG

    更新日期:2006-02-21 00:00:00

  • High expression level of soluble SARS spike protein mediated by adenovirus in HEK293 cells.

    abstract:AIM:To develop a highly efficacious method for preparation of soluble SARS S-protein using adenovirus vector to meet the requirement for S-protein investigation. METHODS:The human adenovirus vector was used to express the soluble S-protein (corresponding to 1 approximately 1190 amino acids) fused with Myc/His tag usin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i9.1452

    authors: Zhong F,Zhong ZY,Liang S,Li XJ

    更新日期:2006-03-07 00:00:00

  • Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer.

    abstract:BACKGROUND:Pancreatic cancer is a major cause of cancer-related death, with a 5-year overall survival rate being below 5%. The main causes of poor prognosis in pancreatic cancer include easy metastasis, high recurrence rate, and robust drug resistance. Gemcitabine is a first-line drug for patients with unresectable pan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i37.5590

    authors: Wei L,Wen JY,Chen J,Ma XK,Wu DH,Chen ZH,Huang JL

    更新日期:2019-10-07 00:00:00

  • Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer.

    abstract:AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy (NACRT) for resectability of locally advanced gastric cancer (LAGC). METHODS:Between November 2007 and January 2014, 29 patients with LAGC (clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT fo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i9.2711

    authors: Kim MS,Lim JS,Hyung WJ,Lee YC,Rha SY,Keum KC,Koom WS

    更新日期:2015-03-07 00:00:00

  • Diagnostic value of gadobenate dimeglumine-enhanced hepatocyte-phase magnetic resonance imaging in evaluating hepatic fibrosis and hepatitis.

    abstract:AIM:To evaluate the diagnostic value of gadobenate dimeglumine (Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging (MRI) in evaluating hepatic fibrosis and hepatitis. METHODS:Hepatocyte-phase images of Gd-BOPTA-enhanced MRI were retrospectively evaluated in 76 patients with chronic liver disease. These pat...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v23.i17.3133

    authors: Li XM,Chen Z,Xiao EH,Shang QL,Ma C

    更新日期:2017-05-07 00:00:00

  • Prevalence and factors associated with irritable bowel syndrome among university students in Lebanon: findings from a cross-sectional study.

    abstract:AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i12.3628

    authors: Costanian C,Tamim H,Assaad S

    更新日期:2015-03-28 00:00:00

  • Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.

    abstract:AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury. METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation. They were divided into 3 groups: Control G...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i41.15319

    authors: Nogueira MA,Coelho AM,Sampietre SN,Patzina RA,Pinheiro da Silva F,D'Albuquerque LA,Machado MC

    更新日期:2014-11-07 00:00:00

  • Wireless capsule endoscopy: perspectives beyond gastrointestinal bleeding.

    abstract::Wireless capsule endoscopy (CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal (GI) bleeding. Over subsequent years, this technology has bee...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i42.15664

    authors: Redondo-Cerezo E,Sánchez-Capilla AD,De La Torre-Rubio P,De Teresa J

    更新日期:2014-11-14 00:00:00

  • Intravenous vs intraperitoneal mesenchymal stem cells administration: what is the best route for treating experimental colitis?

    abstract:AIM:To investigate the therapeutic effects of mesenchymal stem cells (MSCs) transplanted intraperitoneally and intravenously in a murine model of colitis. METHODS:MSCs were isolated from C57BL/6 mouse adipose tissue. MSC cultures were analyzed according to morphology, cellular differentiation potential, and surface mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i48.18228

    authors: Gonçalves Fda C,Schneider N,Pinto FO,Meyer FS,Visioli F,Pfaffenseller B,Lopez PL,Passos EP,Cirne-Lima EO,Meurer L,Paz AH

    更新日期:2014-12-28 00:00:00

  • Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma.

    abstract:AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study. All patients ha...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i44.4890

    authors: Tamai T,Uto H,Takami Y,Oda K,Saishoji A,Hashiguchi M,Kumagai K,Kure T,Mawatari S,Moriuchi A,Oketani M,Ido A,Tsubouchi H

    更新日期:2011-11-28 00:00:00

  • Evidence-based medical oncology and interventional radiology paradigms for liver-dominant colorectal cancer metastases.

    abstract::Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is (limited) extrahepatic disease. Unfortunately, these pa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i11.3127

    authors: Sag AA,Selcukbiricik F,Mandel NM

    更新日期:2016-03-21 00:00:00

  • T cell immune response is correlated with fibrosis and inflammatory activity in hepatitis B cirrhotics.

    abstract:AIM:To explore the relationship among interferon-gamma (IFN-gamma) activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity. METHODS:Peripheral blood samples from a total of 43 hepatitis B cirrhotic patients (LC) and 19 healthy controls (NC) were collected to measure their serum levels of IFN-...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i19.3015

    authors: Tang JT,Fang JY,Gu WQ,Li EL

    更新日期:2006-05-21 00:00:00

  • Tumor rupture during surgery for gastrointestinal stromal tumors: pay attention!

    abstract::In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v19.i12.2009

    authors: Peparini N,Chirletti P

    更新日期:2013-03-28 00:00:00

  • Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance.

    abstract:AIM:To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. METHODS:Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immunohistochemical assay of expression of mucins and E-cadhe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.3044

    authors: Zhang HK,Zhang QM,Zhao TH,Li YY,Yi YF

    更新日期:2004-10-15 00:00:00

  • Validation of the chronic liver disease questionnaire in Serbian patients.

    abstract:AIM:To translate into Serbian and to investigate the validity of the cross-culturally adapted the chronic liver disease questionnaire (CLDQ). METHODS:The questionnaire was validated in 103 consecutive CLD patients treated between October 2009 and October 2010 at the Clinic for Gastroenterology, Clinical Centre of Serb...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i30.4950

    authors: Popovic DDj,Kovacevic NV,Kisic Tepavcevic DB,Trajkovic GZ,Alempijevic TM,Spuran MM,Krstic MN,Jesic RS,Younossi ZM,Pekmezovic TD

    更新日期:2013-08-14 00:00:00

  • Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas.

    abstract::Microsatellite instability (MSI) is a prognostic factor and a marker of deficient mismatch repair (MMR) in colorectal adenocarcinomas (CRC). However, a proper application of this marker requires understanding the following: (1) The MSI concept: The PCR approach must amplify the correct locus and accurately identify th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i37.5932

    authors: Blanes A,Diaz-Cano SJ

    更新日期:2006-10-07 00:00:00

  • Human scFv antibody fragments specific for hepatocellular carcinoma selected from a phage display library.

    abstract:AIM:To identify the scFv antibody fragments specific for hepatocellular carcinoma by biopanning from a large human naive scFv phage display library. METHODS:A large human naive scFv phage library was used to search for the specific targets by biopanning with the hepatocellular carcinoma cell line HepG2 for the positiv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i26.3985

    authors: Yu B,Ni M,Li WH,Lei P,Xing W,Xiao DW,Huang Y,Tang ZJ,Zhu HF,Shen GX

    更新日期:2005-07-14 00:00:00

  • Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma.

    abstract::Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma (HCC). HCC develops over several decades and is associated with fibrosis. This sequence suggests that persistent viral infection ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i41.15018

    authors: Murata M,Yoshida K,Yamaguchi T,Matsuzaki K

    更新日期:2014-11-07 00:00:00

  • Tumor growth inhibition effect of hIL-6 on colon cancer cells transfected with the target gene by retroviral vector.

    abstract::AIM:To observe the tumor inhibitory effects by transfecting IL-6 cDNA into colon cancer cell line HT-29 with retroviral vector pZIP cDNA.METHODS:Human IL-6 gene was reconstructed in retrovirus vector and transfected into incasing cells PA317 by lipofectamine mediated method, the clones of the cells transferred with hI...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i1.89

    authors: Xiao B,Jing B,Zhang YL,Zhou DY,Zhang WD

    更新日期:2000-02-01 00:00:00

  • Ghrelin and gastrointestinal stromal tumors.

    abstract::Ghrelin, as a kind of multifunctional protein polypeptide, is mainly produced in the fundus of the stomach and can promote occurrence and development of many tumors, including gastrointestinal tumors, which has been proved by the relevant researches. Most gastrointestinal stromal tumors (GISTs, about 80%), as the most...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i10.1758

    authors: Zhu CZ,Liu D,Kang WM,Yu JC,Ma ZQ,Ye X,Li K

    更新日期:2017-03-14 00:00:00

  • Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients.

    abstract:AIM:To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease (NERD) patients. METHODS:Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impeda...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i47.13352

    authors: Nakagawa K,Koike T,Iijima K,Saito M,Kikuchi H,Hatta W,Ara N,Uno K,Asano N,Shimosegawa T

    更新日期:2015-12-21 00:00:00

  • Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats.

    abstract:AIM:To examine the possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats. METHODS:Female rats were fed a standard diet and received a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception. In study 1, neonatal rats...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i21.3281

    authors: Selim ME,Al-Ayadhi LY

    更新日期:2013-06-07 00:00:00

  • Safety of lamivudine treatment for chronic hepatitis B in early pregnancy.

    abstract:AIM:To evaluate the safety of lamivudine (LAM) treatment for chronic hepatitis B in early pregnancy. METHODS:A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study. All of the pregnant women volunteered to take lamivudine during pregnancy and w...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v18.i45.6645

    authors: Yi W,Liu M,Cai HD

    更新日期:2012-12-07 00:00:00

  • Effects of betaine on ethanol-stimulated secretion of IGF-I and IGFBP-1 in rat primary hepatocytes: involvement of p42/44 MAPK activation.

    abstract:AIM:To evaluate the effects of betaine on the ethanol-induced secretion of IGF-I and IGFBP-1 using radioimmunoassay and Western blotting, respectively, in primary cultured rat hepatocytes. METHODS:Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of ethanol and PD98059 proce...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i11.1718

    authors: Lee MS,Kim MS,Park SY,Kang CW

    更新日期:2006-03-21 00:00:00

  • Pediatric inflammatory bowel disease.

    abstract::Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, ra...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i20.3204

    authors: Diefenbach KA,Breuer CK

    更新日期:2006-05-28 00:00:00

  • Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies.

    abstract::Gastrointestinal cancers represent a major cause of morbidity and mortality, with incomplete response to chemotherapy in the advanced stages and poor prognosis. Angiogenesis plays a crucial part in tumor growth and metastasis, with most gastrointestinal cancers depending strictly on the development of a new and devote...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i1.21

    authors: Gheonea DI,Cârţână T,Ciurea T,Popescu C,Bădărău A,Săftoiu A

    更新日期:2011-01-07 00:00:00

  • Translational pancreatic cancer research: A comparative study on patient-derived xenograft models.

    abstract:AIM:To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS:This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i7.794

    authors: Rubio-Manzanares Dorado M,Marín Gómez LM,Aparicio Sánchez D,Pereira Arenas S,Praena-Fernández JM,Borrero Martín JJ,Farfán López F,Gómez Bravo MÁ,Muntané Relat J,Padillo Ruiz J

    更新日期:2018-02-21 00:00:00

  • Drug therapy for ulcerative colitis.

    abstract::Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Azulfidine, Asacol, Pentasa, Dipe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v10.i16.2311

    authors: Xu CT,Meng SY,Pan BR

    更新日期:2004-08-15 00:00:00

  • Angiography for diagnosis and treatment of colorectal cancer.

    abstract:AIM:To evaluate the role of preoperative angiography in the diagnosis and treatment of colorectal cancer. METHODS:The authors performed selective arterial cannulation by Seldinger's method in 47 patients to locate the primary cancer and to diagnose metastasis to the liver. Each patient was then given intra-arterial re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i2.288

    authors: Gu J,Ma ZL,Li Y,Li M,Xu GW

    更新日期:2003-02-01 00:00:00