Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients.

Abstract:

AIM:To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease (NERD) patients. METHODS:Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance - pH on rabeprazole. The symptom index (SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter. RESULTS:In 14 (40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes (46.7%) than in distal ones (5.7%) (P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes (38.5%) and distal ones (20.5%) (NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent (31.0%) than in distal reflux ones (3.3%) (P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes (29.4%) and distal ones (14.3%) (NS). CONCLUSION:The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy.

journal_name

World J Gastroenterol

authors

Nakagawa K,Koike T,Iijima K,Saito M,Kikuchi H,Hatta W,Ara N,Uno K,Asano N,Shimosegawa T

doi

10.3748/wjg.v21.i47.13352

subject

Has Abstract

pub_date

2015-12-21 00:00:00

pages

13352-9

issue

47

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

杂志文章
  • Hepatic failure caused by plasma cell infiltration in multiple myeloma.

    abstract::Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma (MM), it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with ka...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2038

    authors: Rahhal FE,Schade RR,Nayak A,Coleman TA

    更新日期:2009-04-28 00:00:00

  • Giant duodenal ulcers.

    abstract::Giant duodenal ulcers (GDUs) are a subset of duodenal ulcers that have historically resulted in greater morbidity than usual duodenal ulcers. Until recently, few cases had been successfully treated with medical therapy. However, the widespread use of endoscopy, the introduction of H-2 receptor blockers and proton pump...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.4995

    authors: Newton EB,Versland MR,Sepe TE

    更新日期:2008-08-28 00:00:00

  • Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model.

    abstract:AIM:To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS:Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanofor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i23.4200

    authors: Dianzani C,Foglietta F,Ferrara B,Rosa AC,Muntoni E,Gasco P,Della Pepa C,Canaparo R,Serpe L

    更新日期:2017-06-21 00:00:00

  • Altered profiles of nuclear matrix proteins during the differentiation of human gastric mucous adenocarcinoma MGc80-3 cells.

    abstract:AIM:To find and identify specific nuclear matrix proteins associated with proliferation and differentiation of carcinoma cells, which will be potential markers for cancer diagnosis and targets in cancer therapy. METHODS:Nuclear matrix proteins were selectively extracted from MGc80-3 cells treated with or without hexam...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i30.4628

    authors: Zhao CH,Li QF

    更新日期:2005-08-14 00:00:00

  • Atrial fibrillation and gastroesophageal reflux disease: From the cardiologist perspective.

    abstract::We have read with interest the paper by Roman C. and colleagues discussing the relationship between gastroesophageal reflux disease and atrial fibrillation. The review is presenting the available evidence for the common pathogenic mechanisms. However, from a cardiologist perspective, some available data were not highl...

    journal_title:World journal of gastroenterology

    pub_type: 评论,杂志文章

    doi:10.3748/wjg.v21.i10.3154

    authors: Floria M,Drug VL

    更新日期:2015-03-14 00:00:00

  • Relationship between entero-hepatic bile acid circulation and interdigestive migrating myoelectrical activity in rats.

    abstract:AIM:To investigate the effects of entero-hepatic bile acid circulation on the inter-digestive migrating myoelectrical complex (MMC) in rats. METHODS:Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i34.5377

    authors: Fang P,Dong L,Zhang WJ,Luo JY

    更新日期:2005-09-14 00:00:00

  • Gastrin and antral G cells in course of Helicobacter pylori eradication: six months follow up study.

    abstract:AIM:To assess long-term effects of Helicobacter pylori (H pylori) eradication on antral G cell morphology and function in patients with and without duodenal ulcer (DU). METHODS:Consecutive dyspeptic patients referred to the endoscopy entered the study. Out of 39 H pylori positive patients, 8 had DU (H pylori +DU) and ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i27.4140

    authors: Sokic-Milutinovic A,Todorovic V,Milosavljevic T,Micev M,Drndarevic N,Mitrovic O

    更新日期:2005-07-21 00:00:00

  • Single port laparoscopic right hemicolectomy with D3 dissection for advanced colon cancer.

    abstract::We report the first case of single port laparoscopic right hemicolectomy for advanced colon cancer. An abdominal 3 cm length incision was made via the umbilicus. A small wound retractor and a surgical glove were used as a single port. All soft tissue anterior to the superior mesenteric vein was completely removed and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i2.275

    authors: Choi SI,Lee KY,Park SJ,Lee SH

    更新日期:2010-01-14 00:00:00

  • Is alcoholic pancreatitis associated with enteroviral infection?

    abstract:AIM:To investigate whether enteroviral infection might trigger acute pancreatitis in patients made susceptible due to high alcohol consumption. METHODS:Patients with alcohol-induced acute pancreatitis were analyzed for signs of simultaneous or preceding enteroviral infection. We studied the serum samples of 40 patient...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i24.3819

    authors: Khan J,Nordback I,Seppänen H,Lappalainen-Lehto R,Järvinen S,Oikarinen S,Tauriainen S,Räty S,Hyöty H,Sand J

    更新日期:2013-06-28 00:00:00

  • Full-thickness myotomy is associated with higher rate of postoperative gastroesophageal reflux disease.

    abstract:AIM:To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types of peroral endoscopic myotomy (POEM) for achalasia. METHODS:We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i42.9419

    authors: Wang XH,Tan YY,Zhu HY,Li CJ,Liu DL

    更新日期:2016-11-14 00:00:00

  • Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver.

    abstract:AIM:To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS:Fifty-four adult male Wistar rats were randomly divided i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i47.7621

    authors: Xu CP,Ji WM,van den Brink GR,Peppelenbosch MP

    更新日期:2006-12-21 00:00:00

  • Endoscopic submucosal tunnel dissection of upper gastrointestinal submucosal tumors: A comparative study of hook knife vs hybrid knife.

    abstract:AIM:To compare the efficacy and safety of a hook knife (HO) with a hybrid knife (HK) during endoscopic submucosal tunnel dissection (ESTD) procedure. METHODS:Between August 2012 and December 2015, the ESTD procedure was performed for 83 upper GI submucosal lesions, which originated from the muscularis propria layer id...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i10.1843

    authors: Zhou JQ,Tang XW,Ren YT,Wei ZJ,Huang SL,Gao QP,Zhang XF,Yang JF,Gong W,Jiang B

    更新日期:2017-03-14 00:00:00

  • Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis.

    abstract:BACKGROUND:Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM:To evaluate the impact of small-for-size ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v25.i36.5559

    authors: Ma KW,Wong KHC,Chan ACY,Cheung TT,Dai WC,Fung JYY,She WH,Lo CM,Chok KSH

    更新日期:2019-09-28 00:00:00

  • Hepatoid adenocarcinoma of the stomach: a report of three cases.

    abstract::Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i27.4437

    authors: Ye MF,Tao F,Liu F,Sun AJ

    更新日期:2013-07-21 00:00:00

  • Hepatic resection for hepatocellular carcinoma in end-stage renal disease patients: two decades of experience at Chang Gung Memorial Hospital.

    abstract:AIM:Hepatocellular carcinoma (HCC) is a common disease in Taiwan. The prevalence of viral hepatitis infection and the subsequent development of HCC are well known to be higher in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) or peritoneal dialysis (PD) than among the general population. Howev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i14.20

    authors: Yeh CN,Lee WC,Chen MF

    更新日期:2005-04-14 00:00:00

  • Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.

    abstract:AIM:To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS:Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v16.i47.6020

    authors: Zhang GH,Mai RQ,Huang B

    更新日期:2010-12-21 00:00:00

  • Eosinophilic esophagitis: a newly established cause of dysphagia.

    abstract::Eosinophilic esophagitis has rapidly become a recognized entity causing dysphagia in young adults. This review summarizes the current knowledge of eosinophilic esophagitis including the epidemiology, clinical presentation, diagnostic criteria, pathophysiology, treatment, and prognosis. An extensive search of PubMed/Me...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i15.2328

    authors: Yan BM,Shaffer EA

    更新日期:2006-04-21 00:00:00

  • Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese.

    abstract:AIM:Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i6.797

    authors: Huang MJ,Yang SS,Lin MS,Huang CS

    更新日期:2005-02-14 00:00:00

  • Size does not determine the grade of malignancy of early invasive colorectal cancer.

    abstract:AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers (EI-CRCs), and to determine whether malignancy grade depends on size. METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2708

    authors: Matsuda T,Saito Y,Fujii T,Uraoka T,Nakajima T,Kobayashi N,Emura F,Ono A,Shimoda T,Ikematsu H,Fu KI,Sano Y,Fujimori T

    更新日期:2009-06-14 00:00:00

  • Regional variation of pediatric inflammatory bowel disease in Saudi Arabia: Results from a multicenter study.

    abstract:BACKGROUND:Incidence and severity variations of inflammatory bowel disease (IBD) have been reported from Western populations between continents and regions of the same countries. However, no data were available from other countries. AIM:To investigate the regional differences in the IBD profiles of pediatric patients ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v26.i4.416

    authors: El Mouzan MI,AlEdreesi MH,Hasosah MY,Al-Hussaini AA,Al Sarkhy AA,Assiri AA

    更新日期:2020-01-28 00:00:00

  • Rationale for the potential use of mesenchymal stromal cells in liver transplantation.

    abstract::Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i44.16418

    authors: Vandermeulen M,Grégoire C,Briquet A,Lechanteur C,Beguin Y,Detry O

    更新日期:2014-11-28 00:00:00

  • Angiography for diagnosis and treatment of colorectal cancer.

    abstract:AIM:To evaluate the role of preoperative angiography in the diagnosis and treatment of colorectal cancer. METHODS:The authors performed selective arterial cannulation by Seldinger's method in 47 patients to locate the primary cancer and to diagnose metastasis to the liver. Each patient was then given intra-arterial re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i2.288

    authors: Gu J,Ma ZL,Li Y,Li M,Xu GW

    更新日期:2003-02-01 00:00:00

  • Determination of the upper cut-off values of serum alanine aminotransferase and aspartate aminotransferase in Chinese.

    abstract:AIM:To determine the upper cut-off values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a Northern Chinese population. METHODS:A total of 3769 subjects in Jilin Province Northeast China were stratified to determine the potential factors affecting serum ALT and AST levels. The upper cu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i8.2419

    authors: Zhang P,Wang CY,Li YX,Pan Y,Niu JQ,He SM

    更新日期:2015-02-28 00:00:00

  • Peripheral mechanism of inhibitory effect of centrally administrated histamine on gastric acid secretion.

    abstract::AIM:To study the peripheral mechanism of the inhibitory effect of intra-third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats.METHODS:Gastric acid was continuously washed with 37&mgr; saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i3.222

    authors: Zhang ZF,Wang ZL,Lu GQ

    更新日期:1998-06-01 00:00:00

  • H pylori and host interactions that influence pathogenesis.

    abstract::H. pylori is probably the most prevalent human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H. pylori has also been implicated in gastric carcinoma and was classified as a class I carcinogen. In the last two decades, a notew...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v12.i35.5599

    authors: Beswick EJ,Suarez G,Reyes VE

    更新日期:2006-09-21 00:00:00

  • Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis.

    abstract::Although thousands of DNA damaging events occur in each cell every day, efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the chromosomes to corr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i30.9021

    authors: Santos JC,Ribeiro ML

    更新日期:2015-08-14 00:00:00

  • Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer.

    abstract:AIM:To screen a suspected Hungarian HNPCC family to find specific mutations and to evaluate their effect on the presentation of the disease. METHODS:The family was identified by applying the Amsterdam and Bethesda Criteria. Immunohistochemistry was performed, and DNA samples isolated from tumor tissue were evaluated f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i8.1192

    authors: Tanyi M,Olasz J,Lukács G,Csuka O,Tóth L,Szentirmay Z,Ress Z,Barta Z,Tanyi JL,Damjanovich L

    更新日期:2006-02-28 00:00:00

  • Late course accelerated hyperfractionated radiotherapy for clinical T1-2 esophageal carcinoma.

    abstract:AIM:This retrospective study was designed to analyze the results and the failure patterns of late course accelerated hyperfractionated radiotherapy for clinical T(1-2)N(0)M(0) esophageal carcinoma. METHODS:From Aug. 1994 to Feb. 2001, 56 patients with clinical T(1-2) esophageal carcinoma received late course accelerat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i6.1374

    authors: Zhao KL,Wang Y,Shi XH

    更新日期:2003-06-01 00:00:00

  • Requirements for transfusion and postoperative outcomes in orthotopic liver transplantation: a meta-analysis on aprotinin.

    abstract:AIM:To study the effect of aprotinin used in orthotopic liver transplantation (OLT) on the intraoperative requirement for blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality. METHODS:A systematic review of the literature in the electronic database Medline and the Clinic Tria...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.14.1425

    authors: Liu CM,Chen J,Wang XH

    更新日期:2008-03-07 00:00:00

  • Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.

    abstract::Pancreatic carcinomas with acinar differentiation are rare, accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma (PACC), pancreatoblastoma, and carcinomas of mixed differentiation. Patients with PACC have a prognosis better than pancreatic ductal adenocarcinomas but worse than...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i45.7945

    authors: Al-Hader A,Al-Rohil RN,Han H,Von Hoff D

    更新日期:2017-12-07 00:00:00