Determination of the upper cut-off values of serum alanine aminotransferase and aspartate aminotransferase in Chinese.

Abstract:

AIM:To determine the upper cut-off values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a Northern Chinese population. METHODS:A total of 3769 subjects in Jilin Province Northeast China were stratified to determine the potential factors affecting serum ALT and AST levels. The upper cut-off values of serum ALT and AST in these subjects were determined using receiver operating characteristic analysis and their sensitivity and specificity were evaluated. RESULTS:Stratification analysis revealed that serum ALT and AST levels were associated with gender, alcohol consumption, serum cholesterol and triglyceride levels, and body mass index. The upper cut-off values of serum ALT and AST were 22.15 U/L and 25.35 U/L for healthy men and 22.40 U/L and 24.25 U/L for healthy women, respectively. The new cut-off values had a higher sensitivity, but a slightly lower specificity than the current standards. CONCLUSION:Our results indicate that the new upper cut-off values of serum ALT and AST are markedly lower than current standards and may be valuable for the evaluation of liver function.

journal_name

World J Gastroenterol

authors

Zhang P,Wang CY,Li YX,Pan Y,Niu JQ,He SM

doi

10.3748/wjg.v21.i8.2419

subject

Has Abstract

pub_date

2015-02-28 00:00:00

pages

2419-24

issue

8

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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