Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes.

abstract：:AIM:To compare KAI1 in cancer of papilla of Vater and pancreas to evaluate whether there are differences in biologic behavior which might account for prognosis.METHODS:We compared the expression in 24 papillay and 29 pancreatic cancers using Northern blot analysis, immunochemical assay and in situ hybridization, and i...

journal_title：World journal of gastroenterology

authors： Guo XZ,Friess H,Shao XD,Liu MP,Xia YT,Xu JH,Buchler MW

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects. AIM:To explore the mechanisms mediating the clinical effic...

journal_title：World journal of gastroenterology

authors： Khayyal MT,Wadie W,Abd El-Haleim EA,Ahmed KA,Kelber O,Ammar RM,Abdel-Aziz H

更新日期：2019-10-21 00:00:00

abstract：AIM:To investigate the influence of experimental obstructive jaundice and exogenous bombesin (BBS) and neurotensin (NT) administration on the expression of the tight junction (TJ)-protein claudin-4 in intestinal epithelium of rats. METHODS:Forty male Wistar rats were randomly divided into five groups: I = controls, II...

journal_title：World journal of gastroenterology

authors： Assimakopoulos SF,Vagianos CE,Charonis AS,Alexandris IH,Spiliopoulou I,Thomopoulos KC,Nikolopoulou VN,Scopa CD

更新日期：2006-06-07 00:00:00

abstract：:Successful cannulation of the common bile duct may be difficult in patients in whom the papilla is located entirely within a diverticulum. In this study, we report successful biliary cannulation in three patients following intubation of the distal tip of the duodenoscope into the duodenal diverticulum and locating the...

journal_title：World journal of gastroenterology

authors： Wang BC,Shi WB,Zhang WJ,Gu J,Tao YJ,Wang YQ,Wang XF

更新日期：2012-12-28 00:00:00

abstract：:Pancreatic cysts are identified at an increasing frequency. Although mucinous cystic neoplasms represent a pre-malignant condition, the majority of these lesions do not progress to cancer. Over the last 10 years several societies have established guidelines for the diagnosis, initial evaluation and surveillance of the...

journal_title：World journal of gastroenterology

authors： Hasan A,Visrodia K,Farrell JJ,Gonda TA

更新日期：2019-08-21 00:00:00

abstract：AIM:To investigate the effect of a fat rich diet on non-steroidal anti-inflammatory drug (NSAID)-induced mucosal damage in the murine small intestine. METHODS:C57BL6 mice were fed 4 types of diets with or without indomethacin. One group was fed standard laboratory chow. The other groups were fed a fat diet consisting ...

journal_title：World journal of gastroenterology

authors： Ueda T,Hokari R,Higashiyama M,Yasutake Y,Maruta K,Kurihara C,Tomita K,Komoto S,Okada Y,Watanabe C,Usui S,Nagao S,Miura S

更新日期：2015-01-07 00:00:00

abstract：:The impact of a chronic disease such as inflammatory bowel disease (IBD) on sexual functioning and body image can significantly impair the quality of life of patients. This review considers the sexual and fertility aspects of IBD patients and their daily management. Modern IBD healthcare management should include appr...

journal_title：World journal of gastroenterology

authors： Leenhardt R,Rivière P,Papazian P,Nion-Larmurier I,Girard G,Laharie D,Marteau P

更新日期：2019-09-28 00:00:00

abstract：:The fact that the acid-secreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using (3)H-thymidine radioautography in combination with electron microscopy, it was possible to demonstrate...

journal_title：World journal of gastroenterology

authors： Karam SM

更新日期：2010-02-07 00:00:00

abstract：:Hepatitis B virus (HBV) infection is still the most common cause of hepatocellular carcinoma and liver cirrhosis world wide. Recently, however, there has been quite dramatic improvement in the understanding of HBV associated liver disease and its treatment. It has become clear that high viral replication is a major ri...

journal_title：World journal of gastroenterology

authors： Tillmann HL

更新日期：2007-01-07 00:00:00

abstract：:Endoscopic retrograde cholangiopancreatography (ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air...

journal_title：World journal of gastroenterology

authors： Yilmaz B,Roach EC,Koklu S,Aydin O,Unlu O,Kilic YA

更新日期：2015-04-21 00:00:00

abstract：AIM:To explore whether the presence of a sliding hiatus hernia influences gastroesophageal reflux. METHODS:Endoscopy and 24 h pH monitoring were performed for 197 outpatients with gastroesophageal reflux symptoms. RESULTS:Of the 197 patients with symptoms of gastroesophageal reflux, patients with hiatus hernia accoun...

journal_title：World journal of gastroenterology

authors： Zhu HM

更新日期：1997-03-15 00:00:00

abstract：AIM:To evaluate liver stiffness measurement (LSM) using non-invasive transient elastography (Fibroscan) in comparison with liver biopsy for assessment of liver fibrosis in children with biliary atresia (BA). METHODS:Thirty-one children with BA admitted to the Department of Pediatric Surgery of Beijing Children's Hospi...

journal_title：World journal of gastroenterology

authors： Shen QL,Chen YJ,Wang ZM,Zhang TC,Pang WB,Shu J,Peng CH

更新日期：2015-06-14 00:00:00

abstract：AIM:To investigate the inhibitory effect and possible mechanism of action of schisandrin B in SC-B on gastric cancer cells in vitro. METHODS:SC-B consisted of schisandrin B, aloe-emodin, and Astragalus polysaccharides. Exponentially growing human gastric cancer SGC-7901 cells were divided into six treatment groups: (1...

journal_title：World journal of gastroenterology

authors： Liu XN,Zhang CY,Jin XD,Li YZ,Zheng XZ,Li L

更新日期：2007-12-28 00:00:00

abstract：:Castleman's disease (CD) is a rare lymphoproliferative disorder of unknown etiology. Clinically, it occurs as a localized (unicentric) disease or as a systemic (multicentric) disease. Unicentric Castleman's disease (UCD) presents as a solitary mass and primarily affects the mediastinal, retroperitoneal, and cervical l...

journal_title：World journal of gastroenterology

authors： Lee HJ,Jeon HJ,Park SG,Park CY

更新日期：2015-02-07 00:00:00

abstract：AIM:To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS:Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-naïve HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups...

journal_title：World journal of gastroenterology

authors： Akiyama T,Mizuta T,Kawazoe S,Eguchi Y,Kawaguchi Y,Takahashi H,Ozaki I,Fujimoto K

更新日期：2011-02-21 00:00:00

abstract：:This issue presents different new techniques aiming to increase our understanding of the gastrointestinal system and to improve treatment. The technologies cover selected methods to evoke and assess gut pain, new methods for imaging and physiological measurements, histochemistry, pharmacological modelling etc. There i...

journal_title：World journal of gastroenterology

authors： Drewes AM,Gregersen H

更新日期：2009-01-14 00:00:00

abstract：AIM:To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon cooperative activation. METHODS:HDC expression was examined by immunohistochemistry, reverse transcriptase p...

journal_title：World journal of gastroenterology

authors： Ku HJ,Kim HY,Kim HH,Park HJ,Cheong JH

更新日期：2014-01-07 00:00:00

abstract：AIM:To investigate the inhibitory effects of sinomenine (SIN) combined with 5-fluorouracil (5-FU) on esophageal carcinoma in vitro and in vivo. METHODS:Esophageal carcinoma (Eca-109) cells were cultured in DMEM. The single or combined growth inhibition effects of SIN and 5-FU on the Eca-109 cells were examined by meas...

journal_title：World journal of gastroenterology

authors： Wang J,Yang ZR,Dong WG,Zhang JX,Guo XF,Song J,Qiu S

更新日期：2013-12-07 00:00:00

abstract：AIM:To investigate microRNA-133a (miR-133a) expression in colorectal cancer (CRC) and its relationship with tumorigenesis and disease prognosis. METHODS:Quantitative real-time polymerase chain reaction was used to measure levels of miR-133a in tumor samples and adjacent non-cancerous tissues from 169 patients undergoi...

journal_title：World journal of gastroenterology

authors： Wang LL,Du LT,Li J,Liu YM,Qu AL,Yang YM,Zhang X,Zheng GX,Wang CX

更新日期：2014-08-28 00:00:00

abstract：:Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Many of the molecular alterations responsible for sporadic colorectal cancer, namely chromosomal instability, microsatellite instability, and hypermethylation, also play a role in colitis-associat...

journal_title：World journal of gastroenterology

authors： Xie J,Itzkowitz SH

更新日期：2008-01-21 00:00:00

abstract：AIM:To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (HCC). METHODS:Firstly, we detected expression of lysosome-associated membrane protein 2a (Lamp-2a), which is the key protein of...

journal_title：World journal of gastroenterology

authors： Wu JH,Guo JP,Shi J,Wang H,Li LL,Guo B,Liu DX,Cao Q,Yuan ZY

更新日期：2017-04-07 00:00:00

abstract：AIM:To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis. METHODS:Serum cancer antigens (CA)199, CA242, carcinoembryonic antigen (CEA), and CA125 levels were measured in 78 patients with gallbladder cancer (GBC), 78 patients with benign gallbladder dis...

journal_title：World journal of gastroenterology

authors： Wang YF,Feng FL,Zhao XH,Ye ZX,Zeng HP,Li Z,Jiang XQ,Peng ZH

更新日期：2014-04-14 00:00:00

abstract：:The purpose of this article is to review the evidence regarding transmission of infection during gastrointestinal endoscopy, factors important in endoscope reprocessing and infection control, areas to focus on to improve compliance, and recent developments and advances in the field. ...

journal_title：World journal of gastroenterology

authors： Nelson DB,Muscarella LF

更新日期：2006-07-07 00:00:00

abstract：:Inflammatory bowel diseases (IBDs) are characterized by a chronic course with an alternation of relapses and remissions. Questions about prognosis are important for the patient who wants to know how the disease will affect his/her life and also for clinicians to make management decisions. Correct selection of the pati...

journal_title：World journal of gastroenterology

authors： Modesto I,Perricone G,Orlando A,Cottone M

更新日期：2012-08-07 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. At the molecular level, GISTs can be categorized into two groups based on the causative oncogenic mutations. Approximately 85% of GISTs are caused by gain-of-function mutations in the tyrosine kinase receptor ...

journal_title：World journal of gastroenterology

authors： Zhao Y,Feng F,Guo QH,Wang YP,Zhao R

更新日期：2020-09-14 00:00:00

abstract：AIM:To evaluate whether the cytokine responses in liver and serum differ in chronic hepatitis C patients with normal and high alanine aminotransferase (ALT) levels. METHODS:Thirty-three (16 with normal ALT level as group 1 and 17 with elevated ALT level as group 2) patients infected with genotype 1b hepatitis C virus ...

journal_title：World journal of gastroenterology

authors： Akyüz F,Polat N,Kaymakoglu S,Aksoy N,Demir K,Beşişik F,Badur S,Cakaloglu Y,Okten A

更新日期：2005-12-07 00:00:00

abstract：AIM:To examine the protective effect of green tea extract (GT) on hepatic fibrosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced rats. METHODS:HSC-T6, a rat hepatic stellate cell line, was used as an in vitro assay system. Cell proliferation, collagen content, and type 1 collagen expression were examined i...

journal_title：World journal of gastroenterology

authors： Kim HK,Yang TH,Cho HY

更新日期：2009-11-07 00:00:00

abstract：AIM:Quasispecies of hepatitis C virus (HCV) are the foundation for rapid sequence evolution of HCV to evade immune surveillance of hosts. The consensus sequence evolution of a segment of HCV NS3 region, which encompasses putative cytotoxic T cell epitopes, was evaluated. METHODS:Three male patients, infected with HCV ...

journal_title：World journal of gastroenterology

authors： Guo HZ,Yin Y,Wang WL,Zhang CS,Wang T,Wang Z,Zhang J,Cheng H,Wang HT

更新日期：2004-03-15 00:00:00

abstract：AIM:To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B (CHB). METHODS:A total of 137 consecutive patients with CHB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were...

journal_title：World journal of gastroenterology

authors： Zhang YX,Wu WJ,Zhang YZ,Feng YL,Zhou XX,Pan Q

更新日期：2008-12-14 00:00:00

abstract：:Common gastrointestinal diseases such as radiation enteritis (RE), acute pancreatitis, inflammatory bowel diseases (IBD) and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level, mostly involving the activation of many pathways of the immune response, ultimately leading to tissue inju...

journal_title：World journal of gastroenterology

authors： Camara-Lemarroy CR

更新日期：2014-04-07 00:00:00