Cancer in inflammatory bowel disease.

Abstract:

:Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Many of the molecular alterations responsible for sporadic colorectal cancer, namely chromosomal instability, microsatellite instability, and hypermethylation, also play a role in colitis-associated colon carcinogenesis. Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel. Chemoprevention includes aminosalicylates, ursodeoxycholic acid, and possibly folic acid and statins. To reduce CRC mortality in IBD, colonoscopic surveillance with random biopsies remains the major way to detect early mucosal dysplasia. When dysplasia is confirmed, proctocolectomy is considered for these patients. Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma. Ulcerative colitis patients with total proctocolectomy and ileal pouch anal-anastomosis have a rather low risk of dysplasia in the ileal pouch, but the anal transition zone should be monitored periodically. Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates. New endoscopic and molecular screening approaches may further refine our current surveillance guidelines and our understanding of the natural history of dysplasia.

journal_name

World J Gastroenterol

authors

Xie J,Itzkowitz SH

doi

10.3748/wjg.14.378

subject

Has Abstract

pub_date

2008-01-21 00:00:00

pages

378-89

issue

3

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

杂志文章,评审
  • A newly designed big cup nitinol stent for gastric outlet obstruction.

    abstract:AIM:To find out whether a newly designed big cup nitinol stent is suitable for treatment of patients with gastric outlet obstruction resulting from gastric cancer. METHODS:The new stent is composed of a proximal big cup segment (20 mm in length and 48-55 mm in diameter), a middle part (60 mm in length and 20 mm in dia...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i33.4206

    authors: Shi D,Liao SH,Geng JP

    更新日期:2010-09-07 00:00:00

  • Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines: a meta-analysis.

    abstract:AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease (IBD) by conducting a meta-analysis. METHODS:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of IBD. The search terms were: ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v19.i34.5738

    authors: Rahimi R,Nikfar S,Abdollahi M

    更新日期:2013-09-14 00:00:00

  • Evaluation of CMU-1 preservation solutions using an isolated perfused rat liver model.

    abstract:AIM:CMU-1 is a new preservation solution with a low potassium concentration as well as low viscosity that is highly effective in reducing preservation injury. The purpose of this experiment is to compare the protective effect of CMU-1 solution with that of UW during cold preservation and normothermic reperfusion. METH...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i16.2522

    authors: Cheng Y,Liu YF,Cheng DH,Li BF,Zhao N

    更新日期:2005-04-28 00:00:00

  • Full-thickness myotomy is associated with higher rate of postoperative gastroesophageal reflux disease.

    abstract:AIM:To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types of peroral endoscopic myotomy (POEM) for achalasia. METHODS:We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i42.9419

    authors: Wang XH,Tan YY,Zhu HY,Li CJ,Liu DL

    更新日期:2016-11-14 00:00:00

  • Age distribution, polyps and rectal cancer in the Egyptian population-based cancer registry.

    abstract:AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i30.3997

    authors: Veruttipong D,Soliman AS,Gilbert SF,Blachley TS,Hablas A,Ramadan M,Rozek LS,Seifeldin IA

    更新日期:2012-08-14 00:00:00

  • Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis.

    abstract:AIM:To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH). METHODS:We studied 174 consecutive unrelated homozygous for the C282Y HFE mutation of HH (C282Y+/+ HH) patients ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i22.2813

    authors: Valenti L,Maggioni P,Piperno A,Rametta R,Pelucchi S,Mariani R,Dongiovanni P,Fracanzani AL,Fargion S

    更新日期:2012-06-14 00:00:00

  • Extrahepatic collaterals and liver damage in embolotherapy for ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery.

    abstract:AIM:To evaluate the effects of extrahepatic collaterals to the liver on liver damage and patient outcome after embolotherapy for the ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery. METHODS:We reviewed 9 patients who underwent transcatheter arterial embolization (TAE) for the ruptured...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i3.408

    authors: Tajima Y,Kuroki T,Tsutsumi R,Sakamoto I,Uetani M,Kanematsu T

    更新日期:2007-01-21 00:00:00

  • Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement.

    abstract:AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infection in inflammatory bowel disease (IBD). METHODS:A cohort of 40 IBD patients (17 refractory) and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest. Vi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i6.1915

    authors: Ciccocioppo R,Racca F,Paolucci S,Campanini G,Pozzi L,Betti E,Riboni R,Vanoli A,Baldanti F,Corazza GR

    更新日期:2015-02-14 00:00:00

  • Evaluation of a novel hybrid bioartificial liver based on a multi-layer flat-plate bioreactor.

    abstract:AIM:To evaluate the efficacy and safety of a hybrid bioartificial liver (HBAL) system in the treatment of acute liver failure. METHODS:Canine models with acute liver failure were introduced with intravenous administration of D-galactosamine. The animals were divided into: the HBAL treatment group (n = 8), in which the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i28.3752

    authors: Shi XL,Zhang Y,Chu XH,Han B,Gu JY,Xiao JQ,Tan JJ,Gu ZZ,Ren HZ,Yuan XW,Ding YT

    更新日期:2012-07-28 00:00:00

  • Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology.

    abstract:AIM:To evaluate ATP-binding cassette (ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer (CRC) development. METHODS:Literature search was conducted on PubMed using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflamma...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i41.11862

    authors: Andersen V,Svenningsen K,Knudsen LA,Hansen AK,Holmskov U,Stensballe A,Vogel U

    更新日期:2015-11-07 00:00:00

  • Endoscopic management of intragastric penetrated adjustable gastric band for morbid obesity.

    abstract::This report describes a case of successful endoscopic management of intragastric penetrated adjustable gastric band in a patient with morbid obesity. The favorable course of the case described here demonstrates that adjustable gastric bands in the process of migration need not be removed surgically in patients who are...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i25.4098

    authors: De Palma GD,Formato A,Pilone V,Rega M,Giuliano ME,Simeoli I,Forestieri P

    更新日期:2006-07-07 00:00:00

  • Experimental study of diode-laser induced thermocoagulation on hepatic tissue with scanner fiber tip.

    abstract:AIM:To explore a safe, efficient, and cost-effective technique for local thermo-ablation of hepatic tumors. METHODS:The livers of 16 healthy rabbits were thermocoagulated by diode-laser with a hand-made scanner fiber tip, 6 w for 10 min. At the same time, the temperature was measured at 5 and 10 mm from the laser tip....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i10.2350

    authors: Hong DF,Peng SY,Li SY,Tong LM

    更新日期:2003-10-01 00:00:00

  • Lower folate levels in gastric cancer: is it a cause or a result?

    abstract::Folate deficiency and its association with cancer have been studied in the literature, but its clinical impact is still unknown. Folate deficiency and its result on gastric cancer is a mysterious part of oncology, with ongoing studies hopefully clarifying its impact on gastric cancer management. Lee et al studied fola...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v21.i13.4101

    authors: Alkan A,Mızrak D,Utkan G

    更新日期:2015-04-07 00:00:00

  • Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm.

    abstract::Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v24.i14.1521

    authors: Losurdo G,Principi M,Iannone A,Amoruso A,Ierardi E,Di Leo A,Barone M

    更新日期:2018-04-14 00:00:00

  • Current hurdles in the management of eosinophilic oesophagitis: the next steps.

    abstract::Eosinophilic oesophagitis (EoE) is a chronic, antigen mediated disease of the disease of the oesophagus that may present in both adults and children. It is characterised by intermittent dysphagia, food bolus obstruction and weight loss. The pathogenesis is incompletely understood but is thought to culminate in poor co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i6.790

    authors: Attwood SE,Wilson MS

    更新日期:2013-02-14 00:00:00

  • Hepatocellular carcinoma review: current treatment, and evidence-based medicine.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. Multiple treatment options are available for HCC including curative resection, liver transplantation, radiofrequency ablation, trans-arterial chemoembolization, radioembolization and systemic targeted agent like sorafenib. The treatment of HCC de...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i15.4115

    authors: Raza A,Sood GK

    更新日期:2014-04-21 00:00:00

  • Transcription factor PDX-1 in human colorectal adenocarcinoma: a potential tumor marker?

    abstract:AIM:To examine the expression of pancreatic duodenal homeobox-1 (PDX-1) transcription factor in human colorectal cancer. METHODS:RT-PCR, Western blotting, and immuno-histochemistry were performed to determine the expression pattern of transcription factor PDX-1 in primary colorectal tumor, hepatic metastasis, and beni...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5823

    authors: Ballian N,Liu SH,Brunicardi FC

    更新日期:2008-10-14 00:00:00

  • Endoscopic treatment of gastroparesis.

    abstract::Gastroparesis has traditionally been a largely medically managed disease with refractory symptoms typically falling under the umbrella of the surgical domain. Surgical options include, but are not limited to, gastrostomy, jejunostomy, pyloromyotomy, or pyloroplasty, and the Food and Drug Administration approved gastri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i22.6842

    authors: McCarty TR,Rustagi T

    更新日期:2015-06-14 00:00:00

  • Non-invasive biomarkers for monitoring the fibrogenic process in liver: a short survey.

    abstract::The clinical course of chronic liver diseases is significantly dependent on the progression rate and the extent of fibrosis, i.e. the non-structured replacement of necrotic parenchyma by extracellular matrix. Fibrogenesis, i.e. the development of fibrosis can be regarded as an unlimited wound healing process, which is...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.15.2433

    authors: Gressner AM,Gao CF,Gressner OA

    更新日期:2009-05-28 00:00:00

  • Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor.

    abstract:AIM:To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit (ICU). Special focus was drawn on patients with liver cirrhosis. METHODS:The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i16.4201

    authors: Friedrich-Rust M,Wanger B,Heupel F,Filmann N,Brodt R,Kempf VA,Kessel J,Wichelhaus TA,Herrmann E,Zeuzem S,Bojunga J

    更新日期:2016-04-28 00:00:00

  • Generation of human/rat xenograft animal model for the study of human donor stem cell behaviors in vivo.

    abstract:AIM:To accurately and realistically elucidate human stem cell behaviors in vivo and the fundamental mechanisms controlling human stem cell fates in vivo, which is urgently required in regenerative medicine and treatments for some human diseases, a surrogate human-rat chimera model was developed. METHODS:Human-rat chim...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i19.2707

    authors: Sun Y,Xiao D,Pan XH,Zhang RS,Cui GH,Chen XG

    更新日期:2007-05-21 00:00:00

  • Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: Report of a case.

    abstract::We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by gian...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i33.5408

    authors: Okazaki H,Higuchi K,Shiba M,Nakamura S,Wada T,Yamamori K,Machida A,Kadouchi K,Tamori A,Tominaga K,Watanabe T,Fujiwara Y,Nakamura K,Arakawa T

    更新日期:2006-09-07 00:00:00

  • Construction and characterization of chimeric BHIV (BIV/HIV-1) viruses carrying the bovine immunodeficiency virus gag gene.

    abstract:AIM:To explore the possibility of the replacement of the gag gene between human immunodeficiency virus and bovine immunodeficiency virus, to achieve chimeric virions, and thereby gain a new kind of AIDS vaccine based on BHIV chimeric viruses. METHODS:A series of chimeric BHIV proviral DNAs differing in the replacement...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i17.2609

    authors: Zhu YX,Liu C,Liu XL,Qiao WT,Chen QM,Zeng Y,Geng YQ

    更新日期:2005-05-07 00:00:00

  • Metastasis of hepatocellular carcinoma to the small bowel manifested by intussusception.

    abstract::Hepatocellular carcinoma (HCC) is a highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal (GI) tract is rare, and most common site is stomach. Metastasis to the small intes...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i12.1969

    authors: Kim HS,Shin JW,Kim GY,Kim YM,Cha HJ,Jeong YK,Jeong ID,Bang SJ,Kim DH,Park NH

    更新日期:2006-03-28 00:00:00

  • Role of genetic disorders in acute recurrent pancreatitis.

    abstract::There was remarkable progress in the understanding of the role genetic risk factors in chronic pancreatitis. These factors seem to be much more important than thought in the past. The rare autosomal-dominant mutations N29I and R122H of PRSS1 (cationic trypsinogen) as well as the variant N34S of SPINK1 (pancreatic secr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.1011

    authors: Keim V

    更新日期:2008-02-21 00:00:00

  • Changes in circulating Foxp3(+) regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure.

    abstract:AIM:To longitudinally investigate cytokine gene expression and protein levels in Th17 and Treg cells, to observe T-cell phenotypes during hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACHBLF) and to analyze changes in Th17 and Treg phenotypes during disease progression. METHODS:We measured the expres...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i26.8558

    authors: Liang XS,Li CZ,Zhou Y,Yin W,Liu YY,Fan WH

    更新日期:2014-07-14 00:00:00

  • Eosinophilic esophagitis: a newly established cause of dysphagia.

    abstract::Eosinophilic esophagitis has rapidly become a recognized entity causing dysphagia in young adults. This review summarizes the current knowledge of eosinophilic esophagitis including the epidemiology, clinical presentation, diagnostic criteria, pathophysiology, treatment, and prognosis. An extensive search of PubMed/Me...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i15.2328

    authors: Yan BM,Shaffer EA

    更新日期:2006-04-21 00:00:00

  • Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo.

    abstract:AIM:To investigate the anticancer effect of a recombinant adenovirus-mediated p53 (rAd-p53) combined with 5-fluorouracil (5-FU) in human colon cancer resistant to 5-FU in vivo and the mechanism of rAd-p53 in reversal of 5-FU resistance. METHODS:Nude mice bearing human colon cancer SW480/5-FU (5-FU resistant) were rand...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i32.7342

    authors: Xie Q,Wu MY,Zhang DX,Yang YM,Wang BS,Zhang J,Xu J,Zhong WD,Hu JN

    更新日期:2016-08-28 00:00:00

  • Trocar-related abdominal wall bleeding in 200 patients after laparoscopic cholecistectomy: Personal experience.

    abstract:AIM:To determine the complications and incidence of the first and second access-related vascular injuries induced by videolaparoscopic cholecistectomy. METHODS:We retrospectively reviewed vascular injuries in 200 consecutive patients who underwent videolaparoscopic cholecistectomy from 2003 to 2005. One hundred and on...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i44.7165

    authors: Geraci G,Sciume C,Pisello F,Li Volsi F,Facella T,Modica G

    更新日期:2006-11-28 00:00:00

  • Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization.

    abstract::Angiosarcoma is a rare primary malignant neoplasm of the liver with a poor prognosis. Here, we report a case of a patient with a ruptured hepatic angiosarcoma which was treated by emergency catheter-directed embolization, followed by left-sided hemihepatectomy. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i5.804

    authors: Leowardi C,Hormann Y,Hinz U,Wente MN,Hallscheidt P,Flechtenmacher C,Buchler MW,Friess H,Schwarzbach MH

    更新日期:2006-02-07 00:00:00