Abstract：
:Hepatitis B virus (HBV) infection is still the most common cause of hepatocellular carcinoma and liver cirrhosis world wide. Recently, however, there has been quite dramatic improvement in the understanding of HBV associated liver disease and its treatment. It has become clear that high viral replication is a major risk factor for the development of both cirrhosis and hepatocellular carcinoma. Early studies have shown lamivudine lowers the risk of HBV associated complications. There are currently three nucleos(t)ides licensed, in addition to interferon, and there are more drugs coming to the market soon. Interferon or its pegylated counterpart are still the only options for treatment with defined end points, while nucleos(t)ides therapy is used mostly for long term treatment. Combination therapies have not been shown to be superior to monotherapy in naive patients, however, the outcome depends on how the end point is defined. Interferon plus lamivudine achieves a higher viral suppression than either treatment alone, even though Hbe-seroconversion was not different after a one year treatment. HBV-genotypes emerge as relevant factors, with genotypes "A" and "B" responding relatively well to interferon, achieving up to 20% HBsAg clearance in the case of genotype "A". In addition to having a defined treatment duration, interferon has the advantage of lacking resistance selection, which is a major drawback for lamivudine and the other nucleos(t)ides. The emergence of resistance against adefovir and entecavir is somewhat slower in naive compared to lamivudine resistant patients. Adefovir has a low resistance profile with 3%, 9%, 18%, and 28% after 2, 3, 4, and 5 years, respectively, while entecavir has rarely produced resistance in naive patients for up to 3 years.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Tillmann HLdoi
10.3748/wjg.v13.i1.125subject
Has Abstractpub_date
2007-01-07 00:00:00pages
125-40issue
1eissn
1007-9327issn
2219-2840journal_volume
13pub_type
杂志文章,评审abstract：:AIM:To investigate the specific pathogenesis of O-polysaccharide (O-PS) which is on the outer membrane of lipopolysaccharides (LPS) from Shigella flexneri.METHODS:The O-PS was isolated and purified from Shigella flexneri 5 M90T by enzymatic hydrolysis and gel chromatography. Effects of O-PS were observed by in vitro e...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v5.i3.245
更新日期：1999-06-01 00:00:00
abstract：AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture risk. METHODS:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v17.i25.3035
更新日期：2011-07-07 00:00:00
abstract：AIM:To evaluate the efficacy of sequential vs hybrid therapy in patients with Helicobacter pylori (H. pylori) infection. METHODS:From March 2013 to May 2014, one hundred and seventy-five H. pylori infected patients who had not been treated for H. pylori before were randomized to receive either sequential therapy (rabe...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.3748/wjg.v21.i36.10435
更新日期：2015-09-28 00:00:00
abstract：AIM:To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS:Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as thei...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v23.i21.3805
更新日期：2017-06-07 00:00:00
abstract：AIM:To evaluate the expressions of apoptotic signal proteins FADD, TRADD, FasL, Fas, and NFkappaB in gastric carcinoma tissues and their clinical significance. METHODS:Western blot immune trace method was adopted to detect the expressions of apoptotic signal proteins FADD, TRADD, FasL, Fas, and NFkappaB in 55 tissue s...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i25.3846
更新日期：2005-07-07 00:00:00
abstract：BACKGROUND:The etiology of inflammatory bowel disease (IBD) is unknown, but it is believed to be multifactorial. The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases. AIM:To test the hygiene hypothesi...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v26.i25.3611
更新日期：2020-07-07 00:00:00
abstract：AIM:To investigate the anti-hepatofibrotic effects of Gardenia jasminoides in liver fibrosis. METHODS:Male Sprague-Dawley rats underwent common bile duct ligation (BDL) for 14 d and were treated with Gardenia jasminoides by gavage. The effects of Gardenia jasminoides on liver fibrosis and the detailed molecular mechan...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v18.i48.7158
更新日期：2012-12-28 00:00:00
abstract：AIM:To examine the expressions of matrix metalloproteinases-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in rat fibrotic liver and in normal rat hepatic stellate cells, and to investigate the changes in their expressions in response to treatment with interleukin-10 (IL-10) and platelet-derived growth...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v10.i17.2574
更新日期：2004-09-01 00:00:00
abstract：AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i39.6349
更新日期：2006-10-21 00:00:00
abstract：:This paper pays a tribute to Dr. Frank I Tovey on his 90th birthday which happens on September 1, 2011, and briefly describes the major findings in his research career and contributions as follows. The geographical prevalence of duodenal ulceration is related to staple diets. Unrefined wheat and maize, soya, certain p...
journal_title：World journal of gastroenterology
pub_type： 社论
doi：10.3748/wjg.v17.i31.3565
更新日期：2011-08-21 00:00:00
abstract：AIM:To investigate the role of peritoneal macrophage (PM) polarization in the therapeutic effect of abdominal paracentesis drainage (APD) on severe acute pancreatitis (SAP). METHODS:SAP was induced by 5% Na-taurocholate retrograde injection in Sprague-Dawley rats. APD was performed by inserting a drainage tube with a ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v24.i45.5131
更新日期：2018-12-07 00:00:00
abstract：AIM:To assess the diagnostic value of a laparoscopic finding of a hepatic subcapsular spider-like telangiectasis (HSST) sign in biliary atresia. METHODS:A retrospective study was conducted first and then a validation set was used to investigate the value of an HSST sign in predicting biliary atresia (BA). In the retro...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v23.i39.7119
更新日期：2017-10-21 00:00:00
abstract：AIM:To identify risk factors to help predict which patients are likely to fail to appear for an endoscopic procedure. METHODS:This was a retrospective, chart review, cohort study in a Canadian, tertiary care, academic, hospital-based endoscopy clinic. Patients included were: those undergoing esophagogastroduodenoscopy...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.2882
更新日期：2009-06-21 00:00:00
abstract：AIM:To investigate whether mesenchymal stem cells (MSCs) from adipose-derived stromal cells (ADSCs) and bone marrow stromal cells (BMSCs) have similar hepatic differentiation potential. METHODS:Mouse ADSCs and BMSCs were isolated and cultured. Their morphological and phenotypic characteristics, as well as their multip...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v23.i38.6973
更新日期：2017-10-14 00:00:00
abstract：AIM:To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures. METHODS:A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation comb...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,meta分析
doi：10.3748/wjg.v24.i21.2311
更新日期：2018-06-07 00:00:00
abstract：AIM:To identify the subset of patients with stage IB gastric cancer with an unfavorable prognosis. METHODS:Overall survival (OS) rates were examined in 103 patients with stage IB (T1N1M0 and T2N0M0) gastric cancer between January 2000 and December 2011. Univariate and multivariate analyses were performed to identify r...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i21.6580
更新日期：2014-06-07 00:00:00
abstract：AIM:To analyze retrospectively the records of 294 consecutive patients operated upon for gallbladder stones, to determine the predictive factors of synchronous common bile duct (CBD) stones and validate prospectively the generated model. METHODS:The prognostic estimation of a biochemical test and ultrasonography alone...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i21.3267
更新日期：2005-06-07 00:00:00
abstract：AIM:To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS:A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levof...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i40.5118
更新日期：2010-10-28 00:00:00
abstract：AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS:The data from 41 patients with CD and 22 patients w...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.3748/wjg.v20.i11.2995
更新日期：2014-03-21 00:00:00
abstract：AIM:To explore the cooperative effects of antisense oligonucleotide (ASON) of cell adhesion molecules and cimetidine on the expression of E-selectin and ICAM-1 in endothelial cells and their adhesion to tumor cells. METHODS:After treatment of endothelial cells with ASON and/or cimetidine and induction with TNF-alpha, ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v10.i1.62
更新日期：2004-01-01 00:00:00
abstract：AIM:To evaluate the long-term outcome of standard 5-FU based adjuvant or neoadjuvant radiochemotherapy and to identify the predictive factors, especially anemia before and after radiotherapy as well as hemoglobin increase or decrease during radiotherapy. METHODS:Two hundred and eighty-six patients with Union Internati...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i12.1849
更新日期：2006-03-28 00:00:00
abstract：:Intestinal Ca(2+) absorption is a crucial physiological process for maintaining bone mineralization and Ca(2+) homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3 steps: the entrance of Ca(2+) across the brush border membranes (BBM) of enterocytes through epithelial ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v21.i23.7142
更新日期：2015-06-21 00:00:00
abstract：AIM:To investigate the protective effects of early enteral feeding (EEF) on postburn impairments of renal function and their possible mechanisms. METHODS:Wistar rats with 30 % of total body surface area (TBSA) full-thickness burn were adopted as the experimental model. The effects of EEF on the postburn changes of gas...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v9.i7.1545
更新日期：2003-07-01 00:00:00
abstract：:Some patients with ascites due to liver cirrhosis become no longer responsive to diuretics. Once other causes of ascites such as portal vein thrombosis, malignancy or infection and non-compliance with medications and low sodium diet have been excluded, the diagnosis of refractory ascites can be made based on strict cr...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.15.67
更新日期：2009-01-07 00:00:00
abstract：:Recently, the use of confocal laser endomicroscopy (CLE) in the diagnosis of chronic ulcerative colitis (CUC) was reported. In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC. The study involved a patient presenting long-standing CUC. Confocal...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v17.i5.677
更新日期：2011-02-07 00:00:00
abstract：AIM:To examine the expression of activin A, a member of the transforming growth factor (TGFbeta) superfamily, recently has been reported to be overexpressed in liver cirrhosis, in the course of carbon tetrachloride-induced rat hepatic fibrosis. METHODS:Hepatic fibrosis was induced in rats by subcutaneous injections of...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v7.i1.37
更新日期：2001-02-01 00:00:00
abstract：:In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is...
journal_title：World journal of gastroenterology
pub_type： 评论,信件
doi：10.3748/wjg.v19.i12.2009
更新日期：2013-03-28 00:00:00
abstract：AIM:To identify the scFv antibody fragments specific for hepatocellular carcinoma by biopanning from a large human naive scFv phage display library. METHODS:A large human naive scFv phage library was used to search for the specific targets by biopanning with the hepatocellular carcinoma cell line HepG2 for the positiv...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i26.3985
更新日期：2005-07-14 00:00:00
abstract：:Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have b...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v20.i29.9716
更新日期：2014-08-07 00:00:00
abstract：:E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v19.i21.3189
更新日期：2013-06-07 00:00:00
