Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors.

abstract：AIM:To explore the relationship between α-fetoprotein (AFP) and various clinicopathological variables and different staging system of hepatocellular carcinoma (HCC) thoroughly. METHODS:A retrospective cohort study of consecutive patients diagnosed with HCC between January 2008 and December 2009 in West China Hospital ...

journal_title：World journal of gastroenterology

authors： Liu C,Xiao GQ,Yan LN,Li B,Jiang L,Wen TF,Wang WT,Xu MQ,Yang JY

更新日期：2013-03-21 00:00:00

abstract：AIM:To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-kappaB expression in multiple organs of SAP rats as well as the mechanisms involved. METHODS:Ninety Sprague-Dawley (SD) rats with SAP...

journal_title：World journal of gastroenterology

authors： Zhang XP,Zhang L,Chen LJ,Cheng QH,Wang JM,Cai W,Shen HP,Cai J

更新日期：2007-01-28 00:00:00

abstract：AIM:To study the expression of a disintegrin and metalloproteinase 17 (ADAM17) mRNA in hepatocellular carcinoma (HCC) and to evaluate the relationship between ADAM17 mRNA expression and clinicopathological features of HCC. METHODS:Hepatocellular carcinomas (HCC) from 31 cases were divided into small HCC (SHCC), nodula...

journal_title：World journal of gastroenterology

authors： Ding X,Yang LY,Huang GW,Wang W,Lu WQ

更新日期：2004-09-15 00:00:00

abstract：:Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where ...

journal_title：World journal of gastroenterology

authors： Shi JH,Line PD

更新日期：2014-11-21 00:00:00

abstract：:A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors...

journal_title：World journal of gastroenterology

authors： Soga K,Konishi H,Tatsumi N,Konishi C,Nakano K,Wakabayashi N,Mitsufuji S,Kataoka K,Okanoue T,Mukaisho K,Hattori T

更新日期：2008-02-21 00:00:00

abstract：AIM:To study the effect of selenium on peripheral blood mononuclear cell (PBMC) membrane fluidity and immune function in patients with chronic hepatitis. METHODS:PBMCs were pretreated with selenium (1.156x10(-7) mol/L) for 6 h in vitro or extracted directly from patients after administration of selenium-yeast continuo...

journal_title：World journal of gastroenterology

authors： He SX,Wu B,Chang XM,Li HX,Qiao W

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Pancreatic endocrine insufficiency after acute pancreatitis (AP) has drawn increasing attention in recent years. AIM:To assess the impact of risk factors on the development of pancreatic endocrine insufficiency after AP. METHODS:This retrospective observational long-term follow-up study was conducted in a ...

journal_title：World journal of gastroenterology

authors： Yu BJ,Li NS,He WH,He C,Wan JH,Zhu Y,Lu NH

更新日期：2020-06-21 00:00:00

abstract：:A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, cSS, cN0, cH0, cP0, cM0 cStage II, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were re...

journal_title：World journal of gastroenterology

authors： Takeshita N,Fukunaga T,Kimura M,Sugamoto Y,Tasaki K,Hoshino I,Ota T,Maruyama T,Tamachi T,Hosokawa T,Asai Y,Matsubara H

更新日期：2015-11-28 00:00:00

abstract：AIM:To evaluate the effect of long-term treatment with leukocyte natural α-interferon (ln-α-IFN) plus ribavirin (RBV). METHODS:Forty-six patients with hepatitis C virus (HCV) recurrence received 3 MU three times a week of ln-α-IFN plus RBV for 1 mo; then, patients with good tolerability (n = 30) were switched to daily...

journal_title：World journal of gastroenterology

authors： Tamè M,Buonfiglioli F,Del Gaudio M,Lisotti A,Cecinato P,Colecchia A,Azzaroli F,D'Errico A,Arena R,Calvanese C,Quarneti C,Ballardini G,Pinna AD,Mazzella G

更新日期：2013-08-28 00:00:00

abstract：:Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinoge...

journal_title：World journal of gastroenterology

authors： Sipos F,Galamb O

更新日期：2012-02-21 00:00:00

abstract：AIM:To investigate the effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. METHODS:Fifteen samples of autoantibodies against beta(1)-adrenoceptor positive sera of patients with hepatitis virus myocarditis were obtained and IgGs were puri...

journal_title：World journal of gastroenterology

authors： Liu K,Liao YH,Wang ZH,Li SL,Wang M,Zeng LL,Tang M

更新日期：2004-04-15 00:00:00

abstract：AIM:To investigate the association of seven single nucleotide polymorphisms (SNPs) of the IL23R gene with the clinical picture of ulcerative colitis (UC). METHODS:Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagn...

journal_title：World journal of gastroenterology

authors： Fischer S,Kövesdi E,Magyari L,Csöngei V,Hadzsiev K,Melegh B,Hegyi P,Sarlós P

更新日期：2017-01-21 00:00:00

abstract：:We report a case of isolated gastrointestinal metastasis from breast lobular carcinoma, which mimicked primary anal cancer. In July 2000, an 88-year-old woman presented with infiltrating lobular cancer (pT1/G2/N2). The patient received postoperative radiotherapy and hormonal therapy. Four years later, she presented wi...

journal_title：World journal of gastroenterology

authors： Puglisi M,Varaldo E,Assalino M,Ansaldo G,Torre G,Borgonovo G

更新日期：2009-03-21 00:00:00

abstract：AIM:To develop a sensitive assay for screening compounds against hepatitis C virus (HCV). METHODS:The proteolytic cleavage of NS3/4A on enhanced yellow fluorescent protein (eYFP)-mitochondrial antiviral signaling protein (MAVS) was examined by reporter enzyme secreted placental alkaline phosphatase (SEAP), which enabl...

journal_title：World journal of gastroenterology

authors： Fu QX,Wang LC,Jia SZ,Gao B,Zhou Y,Du J,Wang YL,Wang XH,Peng JC,Zhan LS

更新日期：2010-11-28 00:00:00

abstract：AIM:To assess the role of three-dimensional endoanal ultrasound (3D-EAUS) for morphological assessment of the anal sphincter of female patients with chronic proctalgia (CP). METHODS:In this unmatched case control study, 30 consecutive female patients with CP and 25 normal women (control group) were enrolled. 3D-EAUS w...

journal_title：World journal of gastroenterology

authors： Xue YH,Ding SQ,Ding YJ,Pan LQ

更新日期：2017-06-07 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhi...

journal_title：World journal of gastroenterology

authors： Verrecchia F,Mauviel A

更新日期：2007-06-14 00:00:00

abstract：AIM:Growth factors (GF) that participate in regeneration and apoptosis have an important role in chronic liver diseases. We analyzed serum GF concentration during antiviral treatment and correlated it with morphological liver failure in chronic hepatitis C. METHODS:The levels of GF were determined in sera by ELISA met...

journal_title：World journal of gastroenterology

authors： Anatol P,Robert F,Danuta P

更新日期：2005-03-28 00:00:00

abstract：AIM:To investigate H(+), K(+)-ATPase inhibition, anti-H pylori, antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS:SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g ...

journal_title：World journal of gastroenterology

authors： Srikanta B,Siddaraju M,Dharmesh S

更新日期：2007-10-21 00:00:00

abstract：:The incidence of adenocarcinoma of the esophago-gastric junction is constantly increasing. Curative treatment is no longer possible at the time of diagnosis in more than 50% of patients with esophageal carcinoma, and palliative treatment focusing on eliminating dysphagia is required. Endoscopic therapy with stent impl...

journal_title：World journal of gastroenterology

authors： Aymaz S,Dormann AJ

更新日期：2008-06-28 00:00:00

abstract：BACKGROUND:The prognosis of gastric cancer continues to remain poor, and epigenetic drugs like histone deacetylase inhibitors (HDACi) have been envisaged as potential therapeutic agents. Nevertheless, clinical trials are facing issues with toxicity and efficacy against solid tumors, which may be partly due to the lack ...

journal_title：World journal of gastroenterology

authors： Amnekar RV,Khan SA,Rashid M,Khade B,Thorat R,Gera P,Shrikhande SV,Smoot DT,Ashktorab H,Gupta S

更新日期：2020-02-14 00:00:00

abstract：AIM:To investigate the long-term prognosis in peptic ulcer patients continuing taking antithrombotics after ulcer bleeding, and to determine the risk factors that influence the prognosis. METHODS:All clinical data of peptic ulcer patients treated from January 1, 2009 to January 1, 2014 were retrospectively collected a...

journal_title：World journal of gastroenterology

authors： Wang XX,Dong B,Hong B,Gong YQ,Wang W,Wang J,Zhou ZY,Jiang WJ

更新日期：2017-01-28 00:00:00

abstract：AIM:To describe a new clinical and pathological subtype of microscopic colitis in children. METHODS:A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described. RESULTS:Multiple biopsies of colon showed large mononuclear c...

journal_title：World journal of gastroenterology

authors： Józefczuk J,Wozniewicz BM

更新日期：2008-01-14 00:00:00

abstract：:Cystic dystrophy of the duodenal wall is a rare condition characterized by the development of cysts in heterotopic pancreatic tissue localized in the duodenal wall. A 38-year-old man was admitted to the hospital for abdominal pain and vomiting after food intake. The diagnosis of acute pancreatitis was initially suspec...

journal_title：World journal of gastroenterology

authors： Jovanovic I,Knezevic S,Micev M,Krstic M

更新日期：2004-09-01 00:00:00

abstract：:Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection (OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise...

journal_title：World journal of gastroenterology

authors： Cherian PT,Mishra AK,Kumar P,Sachan VK,Bharathan A,Srikanth G,Senadhipan B,Rela MS

更新日期：2014-10-07 00:00:00

abstract：AIM:To identify the scFv antibody fragments specific for hepatocellular carcinoma by biopanning from a large human naive scFv phage display library. METHODS:A large human naive scFv phage library was used to search for the specific targets by biopanning with the hepatocellular carcinoma cell line HepG2 for the positiv...

journal_title：World journal of gastroenterology

authors： Yu B,Ni M,Li WH,Lei P,Xing W,Xiao DW,Huang Y,Tang ZJ,Zhu HF,Shen GX

更新日期：2005-07-14 00:00:00

abstract：:In colon cancer, classic disease staging remains the key prognosis and treatment determinant. Although adjuvant chemotherapy has an established role in stage III colon cancer patients, in stage II it is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic...

journal_title：World journal of gastroenterology

authors： Saridaki Z,Souglakos J,Georgoulias V

更新日期：2014-06-14 00:00:00

abstract：AIM:To examine the expression of pancreatic duodenal homeobox-1 (PDX-1) transcription factor in human colorectal cancer. METHODS:RT-PCR, Western blotting, and immuno-histochemistry were performed to determine the expression pattern of transcription factor PDX-1 in primary colorectal tumor, hepatic metastasis, and beni...

journal_title：World journal of gastroenterology

authors： Ballian N,Liu SH,Brunicardi FC

更新日期：2008-10-14 00:00:00

abstract：AIM:To investigate the relationship between the methylation status in the SLIT2 and TGFB2 promoters and colonic inflammation in inflammatory bowel disease patients. METHODS:We evaluated the methylation status of 2 genes (SLIT2 and TGFB2) in 226 biopsies taken from 62 colonoscopies of 38 patients (29 ulcerative colitis...

journal_title：World journal of gastroenterology

authors： Lobatón T,Azuara D,Rodríguez-Moranta F,Loayza C,Sanjuan X,de Oca J,Fernández-Robles A,Guardiola J,Capellá G

更新日期：2014-08-14 00:00:00

abstract：AIM:To demonstrate the non-inferiority (15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate (TDF) vs the combination of lamivudine (LAM) plus adefovir dipivoxil (ADV) in the maintenance of virologic response in patients with chronic hepatitis B (CHB) and prior failure with LAM. METHODS:This st...

journal_title：World journal of gastroenterology

authors： Rodríguez M,Pascasio JM,Fraga E,Fuentes J,Prieto M,Sánchez-Antolín G,Calleja JL,Molina E,García-Buey ML,Blanco MÁ,Salmerón J,Bonet ML,Pons JA,González JM,Casado MÁ,Jorquera F,TENOSIMP-B Research Group.

更新日期：2017-11-07 00:00:00

abstract：AIM:To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS:A prospective, non-comparative, and non-randomized trial was performed and registered on Eudra CT database (2011-002953-80) and on www.trial.gov (NCT01398098). All patients had a validated indication for colonoscopy a...

journal_title：World journal of gastroenterology

authors： Coriat R,Polin V,Oudjit A,Henri F,Dhooge M,Leblanc S,Delchambre C,Esch A,Tabouret T,Barret M,Prat F,Chaussade S

更新日期：2014-10-07 00:00:00