Combined small bowel and reduced auxiliary liver transplantation: case report.

Abstract:

AIM:To present a case of combined small bowel and reduced auxiliary liver transplantation. METHODS:A 55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft. A liver was added to restore the patient's liver function and to protect the intestinal allograft from rejection. His own liver was not removed. RESULTS:Without donor pretreatment and by conventional immunosuppresive therapy following transplantation, the patient experienced had only one episode of mild intestinal rejection, which was easily reversed by treatment with Methylprednisolone. No liver rejection occurred. Unfortunately, the patient died of heart and lung failure 30d after transplantation, despite successful graft replacement. Histopathologic examination of specimens after death demonstrated normal structure in both intestinal and liver grafts. CONCLUSION:The auxiliary liver graft might play a role in preventing intestinal allograft rejection. However, the observation period in this case is short. Further study is needed to determine the risks, effect on the protecting the small-bowel from rejection, and feasibility of general application of this procedure.

journal_name

World J Gastroenterol

authors

Zhang WJ,Liu DG,Ye QF,Sha B,Zhen FJ,Guo H,Xia SS

doi

10.3748/wjg.v8.i5.956

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

956-60

issue

5

eissn

1007-9327

issn

2219-2840

journal_volume

8

pub_type

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