Translational pancreatic cancer research: A comparative study on patient-derived xenograft models.

abstract：:In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC, it failed in patients with Crohn's disease (CD). This finding strongly hints at a different contribution of JAK signaling in both ...

journal_title：World journal of gastroenterology

authors： Cordes F,Foell D,Ding JN,Varga G,Bettenworth D

更新日期：2020-07-28 00:00:00

abstract：:Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome (OMIM 208085) is an autosomal recessive disorder that is caused by mutations in 2 interacting genes VPS33B and VIPAS39. Mutations in VPS33B gene account for most cases of ARC. As low or normal gamma-glutamyl transpeptidase (GGT) activity has been describ...

journal_title：World journal of gastroenterology

authors： Wang JS,Zhao J,Li LT

更新日期：2014-04-28 00:00:00

abstract：AIM:To investigate the pharmacological effects of rice flavone (5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D-glucopyranosyloxy-flavone, RF) separated from panicle-differentiating to flowing rice on rat experimental hepatic injury. METHODS:Models of rat acute hepatic injury induced by carbon tetrachloride (CCl(4)) adminis...

journal_title：World journal of gastroenterology

authors： Xu DH,Mei XT,Chen Y,Li YM,Lv JY,Xu SB

更新日期：2005-03-28 00:00:00

abstract：AIM:To characterize high mobility group box chromosomal protein 1 (HMGB1) polymorphisms in patients infected with hepatitis B virus (HBV) and determine the different patterns in patient subgroups. METHODS:A total of 1495 unrelated Han Chinese HBV carriers were recruited in this hospital-based case-control study. The H...

journal_title：World journal of gastroenterology

authors： Deng CQ,Deng GH,Wang YM

更新日期：2013-08-21 00:00:00

abstract：AIM:To investigate the utility of K-ras mutation analysis of ultrasound guided fine-needle aspirate biopsy of pancreatic masses. METHODS:Sixty-six ultrasound guided fine-needle biopsies were evaluated by cytology, histology and k-ras mutation. The mutation at codon 12 of the k-ras oncogene was detected by artificial r...

journal_title：World journal of gastroenterology

authors： Zheng M,Liu LX,Zhu AL,Qi SY,Jiang HC,Xiao ZY

更新日期：2003-01-01 00:00:00

abstract：AIM:To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (...

journal_title：World journal of gastroenterology

authors： Karaman A,Binici DN,Kabalar ME,Calikuşu Z

更新日期：2008-11-28 00:00:00

abstract：AIM:To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS:Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated...

journal_title：World journal of gastroenterology

authors： Jiang ZX,Peng WJ,Li WT,Tang F,Liu SY,Qu XD,Wang JH,Lu HF

更新日期：2008-10-14 00:00:00

abstract：AIM:To investigate the correlation between the serum soluble intercellular adhesion molecule-1 (sICAM-1) and the clinicopathologic features and to evaluate the possible prognostic significance of sICAM-1 concentration in colorectal cancer. METHODS:A total of 56 patients (mean age 57.3 years) having transitional cell c...

journal_title：World journal of gastroenterology

authors： Kang X,Wang F,Xie JD,Cao J,Xian PZ

更新日期：2005-07-21 00:00:00

abstract：AIM:To develop a novel method for the rapid and efficient extraction of exosomes secreted by tumor cells. METHODS:Unlike the traditional extraction method, the supernatants of cell cultures were concentrated, and the exosomes were isolated promptly and effectively using a novel nanomaterial called ExoQuick. Coomassie ...

journal_title：World journal of gastroenterology

authors： Zhu L,Qu XH,Sun YL,Qian YM,Zhao XH

更新日期：2014-06-07 00:00:00

abstract：AIM:To evaluate the agreement of multichannel intraluminal impedance-pH monitoring (MII-pHM) and gastroesophageal reflux scintigraphy (GES) for the diagnosis of gastroesophageal reflux disease. METHODS:Seventy-five consecutive patients with suspected gastroesophageal reflux disease (GERD) underwent 24-h combined MII-p...

journal_title：World journal of gastroenterology

authors： Uslu Kızılkan N,Bozkurt MF,Saltık Temizel IN,Demir H,Yüce A,Caner B,Özen H

更新日期：2016-11-21 00:00:00

abstract：:An estimated 300 million people worldwide suffer from chronic hepatitis C with a prevalence of 0.8%-1.0% of the general population in Canada. An increasing pool of evidence exists supporting the use of pegylated- interferon (pegIFN) and ribavirin combination therapy for hepatitis C. We report a 49-year old male of Nor...

journal_title：World journal of gastroenterology

authors： Zandieh I,Adenwalla M,Cheong-Lee C,Ma PE,Yoshida EM

更新日期：2006-08-14 00:00:00

abstract：AIM:To investigate the relationship between urinary peptide changes and Helicobacter pylori (H. pylori) infection using urinary peptidome profiling. METHODS:The study was performed in volunteers (n=137) who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatograph...

journal_title：World journal of gastroenterology

authors： Xiao D,Meng FL,He LH,Gu YX,Zhang JZ

更新日期：2011-02-07 00:00:00

abstract：AIM:To investigate the clinical utility of biological age (BA) measurement in screening colonoscopy for the detection of colorectal adenomas in the average-risk population. METHODS:A consecutive series of asymptomatic subjects aged ≥ 30 years who underwent colonoscopy in routine check-ups were enrolled. Colorectal ade...

journal_title：World journal of gastroenterology

authors： Kim SJ,Kim BJ,Kang H

更新日期：2017-10-07 00:00:00

abstract：:AIM:To infect mice with Helicobacter pylori and detect immune response against two form of H. pylori.METHODS:An isolate of H. pylori obtained from a patient with gastric cancer was used to infect mice. Fifty mice were divided into eight groups. Two groups served as negative control without any inoculation and internal...

journal_title：World journal of gastroenterology

authors： Hua JS,Bow H,Zheng PY,Yeoh GK,Ng CH,Lim GS

更新日期：1998-12-01 00:00:00

abstract：:We report a case of isolated gastrointestinal metastasis from breast lobular carcinoma, which mimicked primary anal cancer. In July 2000, an 88-year-old woman presented with infiltrating lobular cancer (pT1/G2/N2). The patient received postoperative radiotherapy and hormonal therapy. Four years later, she presented wi...

journal_title：World journal of gastroenterology

authors： Puglisi M,Varaldo E,Assalino M,Ansaldo G,Torre G,Borgonovo G

更新日期：2009-03-21 00:00:00

abstract：:We report an extremely rare case where a mesenchymal differentiation, especially embryonal sarcoma, was demonstrated in cholangiocarcinoma. At autopsy, a yellowish-white tumor (15 cm x 12 cm) was found in the right hepatic lobe, and there were several daughter nodules in both hepatic lobes. Histologically, most of the...

journal_title：World journal of gastroenterology

authors： Sumiyoshi S,Kikuyama M,Matsubayashi Y,Kageyama F,Ide Y,Kobayashi Y,Nakamura H

更新日期：2007-02-07 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhi...

journal_title：World journal of gastroenterology

authors： Verrecchia F,Mauviel A

更新日期：2007-06-14 00:00:00

abstract：AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

journal_title：World journal of gastroenterology

authors： Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

更新日期：2006-10-21 00:00:00

abstract：AIM:To present our experience with tuberculous peritonitis treated in our hospital from 2002-2007. METHODS:We reviewed the medical records of 9 children with tuberculous peritonitis. RESULTS:Nine patients (5 boys, 4 girls) of mean age 14.2 years were diagnosed with peritoneal tuberculosis. All patients presented with...

journal_title：World journal of gastroenterology

authors： Dinler G,Sensoy G,Helek D,Kalayci AG

更新日期：2008-12-21 00:00:00

abstract：:The Prague C and M Criteria have been developed for the objective endoscopic diagnosis of Barrett's esophagus (BE). BE arises between the squamocolumnar junction and the gastroesophageal junction at the proximal margin of the gastric folds. In this study, we reported that 43.0% of the subjects examined were diagnosed ...

journal_title：World journal of gastroenterology

authors： Akiyama T,Sekino Y,Iida H,Koyama S,Gotoh E,Maeda S,Nakajima A,Inamori M

更新日期：2012-07-14 00:00:00

abstract：AIM:To investigate the anti-tumor effects of combined cytotoxic drug (gemcitabine) and photodynamic therapy (PDT) on human pancreatic cancer xenograft in nude mice. METHODS:Human pancreatic cancer cell line SW1990 was used in the investigation of the in vivo effect of combined gemcitabine and PDT on human pancreatic c...

journal_title：World journal of gastroenterology

authors： Xie Q,Jia L,Liu YH,Wei CG

更新日期：2009-02-14 00:00:00

abstract：:The motor function of the gastrointestinal tract has primarily been studied using manometry and radiography, though more indirect tests have also been applied. Manometry and radiography do not provide detailed information about the muscle properties as can be assessed from studies of muscle properties in muscle strips...

journal_title：World journal of gastroenterology

authors： Gregersen H,Liao D

更新日期：2006-05-14 00:00:00

abstract：AIM:To explore risk factors for lymph node metastases in early gastric cancer (EGC) and to confirm the appropriate range of lymph node dissection. METHODS:A total of 202 patients with EGC who underwent curative gastrectomy with lymphadenectomy in the Department of Surgery, Xinhua Hospital and Ruijin Hospital of Shangh...

journal_title：World journal of gastroenterology

authors： Ren G,Cai R,Zhang WJ,Ou JM,Jin YN,Li WH

更新日期：2013-05-28 00:00:00

abstract：:Primary liver cancer is amongst the commonest tumors worldwide, particularly in parts of the developing world, and is increasing in incidence. Over the past three decades, surgical hepatic resection has evolved from a high risk, resource intensive procedure with limited application, to a safe and commonly performed op...

journal_title：World journal of gastroenterology

authors： Tsim NC,Frampton AE,Habib NA,Jiao LR

更新日期：2010-02-28 00:00:00

abstract：AIM:Both Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are major causative agents of transfusion-associated and community-acquired hepatitis worldwide. Development of a HCV vaccine as well as more effective HBV vaccines is an urgent task. DNA immunization provides a promising approach to elicit protective humoral...

journal_title：World journal of gastroenterology

authors： Jin J,Yang JY,Liu J,Kong YY,Wang Y,Li GD

更新日期：2002-06-01 00:00:00

abstract：AIM:To determine the mechanical properties of anastomotic colonic tissue in experimental settings and therefore give a measure of wound healing. METHODS:Thirty-six male Wistar rats were used as experimental models of anastomotic tissue integrity. On the 5th post-operative day, the tensile strength was measured by appl...

journal_title：World journal of gastroenterology

authors： Ekmektzoglou KA,Zografos GC,Kourkoulis SK,Dontas IA,Giannopoulos PK,Marinou KA,Poulakou MV,Perrea DN

更新日期：2006-09-21 00:00:00

abstract：:Dysphagia lusoria is a term used to describe dysphagia secondary to vascular compression of the oesophagus. The various embryologic anomalies of the arterial brachial arch system often remain unrecognised and asymptomatic, but in 30%-40% of cases can result in tracheo-oesophageal symptoms, which in the majority of cas...

journal_title：World journal of gastroenterology

authors： Bennett AL,Cock C,Heddle R,Morcom RK

更新日期：2013-04-21 00:00:00

abstract：:Gastric intramural hematoma is a rare injury of the stomach, and is most often seen in patients with underlying disease. Such injury following endoscopic therapy is even rarer, and there are no universally accepted guidelines for its treatment. In this case report, we describe a gastric intramural hematoma which occur...

journal_title：World journal of gastroenterology

authors： Sun P,Tan SY,Liao GH

更新日期：2012-12-21 00:00:00

abstract：AIM:To transfer hepatitis E virus (HEV) ORF2 partial gene to tomato plants, to investigate its expression in transformants and the immunoactivity of expression products, and to explore the feasibility of developing a new type of plant-derived HEV oral vaccine. METHODS:Plant binary expression vector p1301E2, carrying a...

journal_title：World journal of gastroenterology

authors： Ma Y,Lin SQ,Gao Y,Li M,Luo WX,Zhang J,Xia NS

更新日期：2003-10-01 00:00:00

abstract：:Celiac disease (CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life. Neurological symptoms without signs of malabsorption have been observed for a long time in CD. In this report, an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and...

journal_title：World journal of gastroenterology

authors： Doğan M,Peker E,Cagan E,Akbayram S,Acikgoz M,Caksen H,Uner A,Cesur Y

更新日期：2010-05-14 00:00:00