Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps.

Abstract:

AIM:To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.

journal_name

World J Gastroenterol

authors

Karaman A,Binici DN,Kabalar ME,Calikuşu Z

doi

10.3748/wjg.14.6835

subject

Has Abstract

pub_date

2008-11-28 00:00:00

pages

6835-9

issue

44

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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