Measurement of biological age may help to assess the risk of colorectal adenoma in screening colonoscopy.

Abstract:

AIM:To investigate the clinical utility of biological age (BA) measurement in screening colonoscopy for the detection of colorectal adenomas in the average-risk population. METHODS:A consecutive series of asymptomatic subjects aged ≥ 30 years who underwent colonoscopy in routine check-ups were enrolled. Colorectal adenoma was classified according to size, number, and location. BAs were calculated using the MEDIAGETM Biological Age Measurement System. RESULTS:A total of 2696 subjects were investigated (1876 men and 820 women). The mean chronological age (CA) was 46.0 years and the mean BA was 44.7 years. Metabolic syndrome (MS) was diagnosed in 218 subjects (8.1%). The prevalence of overall colorectal adenoma was 23.1% (622/2,696). When the subjects were divided into four groups based on BA (≤ 39 years; 40-49 years; 50-59 years; ≥ 60 years), the prevalence of colorectal adenoma was increased as BA increased (P < 0.001). Colorectal adenoma located in the proximal colon was more prevalent in the BA-dominant group (BA-CA ≥ 5 years) than the CA-dominant group (CA-BA ≥ 5 years) (P = 0.034). When the subjects were categorized into four groups according to MS and age gap between BA and CA, the incidence of colorectal adenoma increased with MS and BA-dominance (P < 0.05). CONCLUSION:Measurement of BA may help to assess the risk of colorectal adenoma in screening colonoscopy.

journal_name

World J Gastroenterol

authors

Kim SJ,Kim BJ,Kang H

doi

10.3748/wjg.v23.i37.6877

subject

Has Abstract

pub_date

2017-10-07 00:00:00

pages

6877-6883

issue

37

eissn

1007-9327

issn

2219-2840

journal_volume

23

pub_type

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