Transforming growth factor-beta and fibrosis.

abstract：AIM:To evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS:From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for ...

journal_title：World journal of gastroenterology

authors： You YT,Chang Chien CR,Wang JY,Ng KK,Chen JS,Tang R,Chiang JM,Yeh CY,Hsieh PS

更新日期：2006-01-07 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Altho...

journal_title：World journal of gastroenterology

authors： Ferri Liu PM,de Miranda DM,Fagundes ED,Ferreira AR,Simões e Silva AC

更新日期：2013-07-28 00:00:00

abstract：:Primary rectal lymphoma is a rare presentation of gastrointestinal lymphomas. Its clinical presentation is indistinguishable from that of rectal carcinoma. Although surgical resection is often technically feasible, optimal therapy for colorectal lymphoma has not yet been identified. We report a case of primary rectal ...

journal_title：World journal of gastroenterology

authors： Bilsel Y,Balik E,Yamaner S,Bugra D

更新日期：2005-01-21 00:00:00

abstract：:Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab...

journal_title：World journal of gastroenterology

authors： Seo GS,Chae SC

更新日期：2014-10-07 00:00:00

abstract：AIM:To further investigate the role of human B7 homolog 1 (B7-H1) in the mechanism of persistent hepatitis B virus (HBV) infection. METHODS:Peripheral and intra-hepatic B7-H1 expression were compared by flow cytometry and immunochemical staining between two 2 distinct groups, one being chronic HBV tolerance patients (C...

journal_title：World journal of gastroenterology

authors： Zhang WJ,Xie HY,Duan X,Wan YL,Peng CH,Shi SH,Su R,Zheng ZH,Pan LL,Zhou L,Zheng SS

更新日期：2012-07-28 00:00:00

abstract：AIM:To examine the effect of Fusobacterium nucleatum (F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs (miRNAs). METHODS:Levels of F. nucleatum DNA, cytokine gene mRNA (TLR2, TLR4, NFKB1, TNF, IL1B, IL6 and IL8), and potentially interacting miRNAs (m...

journal_title：World journal of gastroenterology

authors： Proença MA,Biselli JM,Succi M,Severino FE,Berardinelli GN,Caetano A,Reis RM,Hughes DJ,Silva AE

更新日期：2018-12-21 00:00:00

abstract：:Hepatitis C virus (HCV) has been recognized to be both a hepato- and lymphotropic virus. HCV lymphotropism represents an essential lap in the pathogenesis of virus-related autoimmune and lymphoproliferative disorders, ranging from clonal expansion of B-cells with organ- and non-organ-specific autoantibody production u...

journal_title：World journal of gastroenterology

authors： Conca P,Tarantino G

更新日期：2009-05-21 00:00:00

abstract：:Henry Norman Bethune was a physician and surgeon from Canada. He had a highly impressive medical career in Montreal but did his most important work in China where he cared for soldiers on the battlefield. He died in 1939 and was recognized as a hero, but only much later received recognition in Canada. He was a skilled...

journal_title：World journal of gastroenterology

authors： Freeman HJ

更新日期：2008-01-14 00:00:00

abstract：:Hepatitis C virus (HCV) affects 130-210 million people worldwide and is one of the major risk factors for hepatocellular carcinoma. Globally, at least one third of hepatocellular carcinoma cases are attributed to HCV infection, and 350000 people died from HCV related diseases per year. There is a great geographical va...

journal_title：World journal of gastroenterology

authors： Lee MH,Yang HI,Yuan Y,L'Italien G,Chen CJ

更新日期：2014-07-28 00:00:00

abstract：:The management of intraductal papillary mucinous neoplasms (IPMN) is presently evolving as a result of the improved understanding of the natural history and biological behavior of the different pancreatic cystic neoplasms; and better preoperative diagnosis of these neoplasms due to advancement in preoperative diagnost...

journal_title：World journal of gastroenterology

authors： Goh BK

更新日期：2015-09-14 00:00:00

abstract：AIM:To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS:We examined relationships between MVC and clinicopathological factors in 128 HC...

journal_title：World journal of gastroenterology

authors： Nanashima A,Nakayama T,Sumida Y,Abo T,Takeshita H,Shibata K,Hidaka S,Sawai T,Yasutake T,Nagayasu T

更新日期：2008-08-21 00:00:00

abstract：AIM:To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS:This study was conducted in 90 patients undergoing autologous HSCT....

journal_title：World journal of gastroenterology

authors： Ceneli O,Ozkurt ZN,Acar K,Rota S,Aki SZ,Yeğin ZA,Yağci M,Ozenirler S,Sucak GT

更新日期：2010-04-14 00:00:00

abstract：AIM:To investigate the diagnosis of nonalcoholic steatohepatitis (NASH) using contrast ultrasonography in the NASH rat model. METHODS:The liver in methionine choline-deficient diet (MCDD) rats, a NASH model constructed by feeding an MCDD, was examined by contrast ultrasonography at weeks 2, 4, 8, 12 and 16, with late ...

journal_title：World journal of gastroenterology

authors： Miyata Y,Miyahara T,Moriyasu F

更新日期：2011-10-07 00:00:00

abstract：AIM:To determine the frequency of HER2/neu protein overexpression in gastric (group A), small intestine (group B), and colorectal (group C) adenocarcinoma. METHODS:A descriptive, cross-sectional study was performed on 50 cases of gastrointestinal adenocarcinoma (stomach, small intestine, and colorectal); 11 from group...

journal_title：World journal of gastroenterology

authors： Farzand S,Siddique T,Saba K,Bukhari MH

更新日期：2014-05-21 00:00:00

abstract：AIM:To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma (SCRC) and their relationship to metastasis and prognosis. METHODS:The lymphatic vessel density (LVD) and microvessel density (MVD) in tumor tissue obtained from 132 patients with primary SCRC, including ...

journal_title：World journal of gastroenterology

authors： Yan G,Zhou XY,Cai SJ,Zhang GH,Peng JJ,Du X

更新日期：2008-01-07 00:00:00

abstract：AIM:To explore risk factors for lymph node metastases in early gastric cancer (EGC) and to confirm the appropriate range of lymph node dissection. METHODS:A total of 202 patients with EGC who underwent curative gastrectomy with lymphadenectomy in the Department of Surgery, Xinhua Hospital and Ruijin Hospital of Shangh...

journal_title：World journal of gastroenterology

authors： Ren G,Cai R,Zhang WJ,Ou JM,Jin YN,Li WH

更新日期：2013-05-28 00:00:00

abstract：AIM:To explore the relationship of clinicopathological features and the distribution of neutrophils in the tumor microenvironment with the prognosis of cholangiocarcinoma. METHODS:Two hundred and fifty-four formalin-fixed and paraffin embedded tissue blocks were analyzed, including tissues from cholangiocarcinoma (n =...

journal_title：World journal of gastroenterology

authors： Mao ZY,Zhu GQ,Xiong M,Ren L,Bai L

更新日期：2015-04-28 00:00:00

abstract：AIM:To investigate genetic factors that might help define which Crohn's disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODS:This was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who rece...

journal_title：World journal of gastroenterology

authors： Netz U,Carter JV,Eichenberger MR,Dryden GW,Pan J,Rai SN,Galandiuk S

更新日期：2017-07-21 00:00:00

abstract：AIM:To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS:Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehic...

journal_title：World journal of gastroenterology

authors： Nur Azlina MF,Qodriyah HMS,Chua KH,Kamisah Y

更新日期：2017-08-28 00:00:00

abstract：AIM:To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia. METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained...

journal_title：World journal of gastroenterology

authors： Hu ML,Rayner CK,Wu KL,Chuah SK,Tai WC,Chou YP,Chiu YC,Chiu KW,Hu TH

更新日期：2011-01-07 00:00:00

abstract：AIM:To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC). METHODS:Liver biopsies and HCC specimens from patients were collected and histologically examined. The expression of PD-1, PD-L1, and PD-L...

journal_title：World journal of gastroenterology

authors： Wang BJ,Bao JJ,Wang JZ,Wang Y,Jiang M,Xing MY,Zhang WG,Qi JY,Roggendorf M,Lu MJ,Yang DL

更新日期：2011-07-28 00:00:00

abstract：AIM:To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309. METHODS:We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted...

journal_title：World journal of gastroenterology

authors： Leu JD,Lin IF,Sun YF,Chen SM,Liu CC,Lee YJ

更新日期：2009-11-28 00:00:00

abstract：AIM:To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC). METHODS:Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression ...

journal_title：World journal of gastroenterology

authors： Qiu WH,Zhou BS,Chu PG,Chen WG,Chung C,Shih J,Hwu P,Yeh C,Lopez R,Yen Y

更新日期：2005-09-14 00:00:00

abstract：AIM:To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS:The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed us...

journal_title：World journal of gastroenterology

authors： Frokjaer JB,Andersen SD,Ejskjaer N,Funch-Jensen P,Drewes AM,Gregersen H

更新日期：2007-09-28 00:00:00

abstract：AIM:To find and identify specific nuclear matrix proteins associated with proliferation and differentiation of carcinoma cells, which will be potential markers for cancer diagnosis and targets in cancer therapy. METHODS:Nuclear matrix proteins were selectively extracted from MGc80-3 cells treated with or without hexam...

journal_title：World journal of gastroenterology

authors： Zhao CH,Li QF

更新日期：2005-08-14 00:00:00

abstract：AIM:To prepare the human hepatocellular carcinoma-(HCC)-targeted liposome microbubbles and to investigate their immunological properties. METHODS:Human hepatocarcinoma specific monoclonal antibody HAb18 was attached to the surface of home-made liposome microbubbles by static attraction to prepare the targeted liposome...

journal_title：World journal of gastroenterology

authors： Bian AN,Gao YH,Tan KB,Liu P,Zeng GJ,Zhang X,Liu Z

更新日期：2004-12-01 00:00:00

abstract：:Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal (GI) system is an ideal model to analyze the int...

journal_title：World journal of gastroenterology

authors： Panduro A,Rivera-Iñiguez I,Sepulveda-Villegas M,Roman S

更新日期：2017-05-07 00:00:00

abstract：:In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is...

journal_title：World journal of gastroenterology

authors： Peparini N,Chirletti P

更新日期：2013-03-28 00:00:00

abstract：AIM:To observe the frequent complications of stent placement for stricture of the gastrointestinal tract and to find proper treatment. METHODS:A total number of 140 stents were inserted in 138 patients with benign stricture of the gastrointestinal tract. The procedure was completed under fluoroscopy in all of the pati...

journal_title：World journal of gastroenterology

authors： Cheng YS,Li MH,Chen WX,Chen NW,Zhuang QX,Shang KZ

更新日期：2004-01-15 00:00:00

abstract：AIM:To investigate the prevalence of hepatitis G virus (HGV) infection and to analyse the homology of different HGV strains in Southern China. METHODS:A total of 1993 sera from different groups in Guangdong, Hong Kong, and Yunnan were detected by reverse transcription polymerase chain reaction (RT-PCR). The nucleotide...

journal_title：World journal of gastroenterology

authors： Li G,Ma HH,Lau GK,Leung YK,Yao CL,Chong YT,Tang WH,Yao JL

更新日期：2002-12-01 00:00:00