Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma.

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids in the form of triglycerides in hepatocytes. It is most prevalent in western countries and includes a wide range of clinical and histopathological findings, namely from simple steatosis to steatohepatitis and fibrosis, which...

journal_title：World journal of gastroenterology

authors： Katsarou A,Moustakas II,Pyrina I,Lembessis P,Koutsilieris M,Chatzigeorgiou A

更新日期：2020-05-07 00:00:00

abstract：:Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. Splenic hemolymphangioma is extremely rare. Herein, we present a case of 62-year-old woman with ambiguous upper quadrant abdominal pain for two months who was found to have an occupying lesion in the spleen on computed tomography. She was ...

journal_title：World journal of gastroenterology

authors： Mei Y,Peng CJ,Chen L,Li XX,Li WN,Shu DJ,Xie WT

更新日期：2015-05-07 00:00:00

abstract：:The origin of inflammatory bowel disease is unknown. Attempts have been made to isolate a microorganism that could explain the onset of inflammation, but no pathological agent has ever been identified. Johne's disease is a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies par...

journal_title：World journal of gastroenterology

authors： Liverani E,Scaioli E,Cardamone C,Dal Monte P,Belluzzi A

更新日期：2014-09-28 00:00:00

abstract：AIM:To provide hepatic protection through administration of doxorubicin before stop-flow chemotherapy (SFC) and to investigate the expression of heat shock protein 72 (HSP72) and role of nuclear factor kappa B (NF-kappaB) in this effect. METHODS:The hepatic preconditioning of doxorubicin was established in a porcine m...

journal_title：World journal of gastroenterology

authors： Lu H,Zhu ZG,Yao XX,Zhao R,Yan C,Zhang Y,Liu BY,Yin HR,Lin YZ

更新日期：2005-04-14 00:00:00

abstract：:Interferon (IFN) therapy is the only treatment strategy for hepatitis C virus (HCV) infection after liver transplantation (LT), but prophylactic and treatable IFN therapy after LT has been shown to be insufficient due to the adverse effects of IFN and rivabirin. In this paper, we describe the disappearance of HCV afte...

journal_title：World journal of gastroenterology

authors： Ichikawa T,Nakao K,Hamasaki K,Honda T,Shibata H,Akahoshi M,Eguchi S,Takatsuki M,Kanematsu T,Eguchi K

更新日期：2007-08-14 00:00:00

abstract：AIM:To study the nuclear microsatellite instability (nMSI) at BAT26 and mitochondrial microsatellite instability (mtMSI) in the occurrence and development of hepatocellular carcinoma and the relationship between nMSI and mtMSI. METHODS:nMSI was observed with PCR and mtMSI with PCR-SSCP in 52 cases of hepatocellular ca...

journal_title：World journal of gastroenterology

authors： Fang DC,Fang L,Wang RQ,Yang SM

更新日期：2004-02-01 00:00:00

abstract：AIM:To investigate the effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing radical distal gastrectomy. METHODS:Within 24 h of intensive care unit management, patients with gastric cancer were enrolled after written informed consent and randomize...

journal_title：World journal of gastroenterology

authors： Liu HC,Zhou YB,Chen D,Niu ZJ,Yu Y

更新日期：2012-06-07 00:00:00

abstract：AIM:To investigate the expression profiles of hsa-miR-29c and hsa-miR-135b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS:The expression levels of hsa-miR-29c and hsa-miR-135b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type ...

journal_title：World journal of gastroenterology

authors： Vidal AF,Cruz AM,Magalhães L,Pereira AL,Anaissi AK,Alves NC,Albuquerque PJ,Burbano RM,Demachki S,Ribeiro-dos-Santos Â

更新日期：2016-02-14 00:00:00

abstract：AIM:To determine the changes of CD8+ T subsets especially CD8+CD28- T regulatory cells in rat model of experimental colitis induced by 2,4-dinitrofluorobenzene (DNFB). METHODS:The rat model of experimental colitis was induced by enema with DNFB. Ten days later, colonic intraepithelial and splenic lymphocytes were isol...

journal_title：World journal of gastroenterology

authors： Xiao WB,Liu YL

更新日期：2003-11-01 00:00:00

abstract：:Exocrine pancreatic insufficiency caused by chronic pancreatitis results from various factors which regulate digestion and absorption of nutrients. Pancreatic function has been extensively studied over the last 40 years, even if some aspects of secretion and gastrointestinal adaptation are not completely understood. T...

journal_title：World journal of gastroenterology

authors： Pezzilli R

更新日期：2009-04-14 00:00:00

abstract：AIM:To report the outcome of Chinese patents with non-cystic adenocarcinoma in pancreatic body and tail (NCAPBT) after resection and to discuss its surgical strategy. METHODS:Resection of NCAPBT was performed in eight Chinese patients with complete clinical-pathological data in our hospital from January 2000 to May 20...

journal_title：World journal of gastroenterology

authors： Yan HC,Wu YL,Chen LR,Gao SL

更新日期：2006-09-21 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is known for its poor prognosis. Most of the patients are diagnosed with advanced stages, when no curative treatment is available. Currently, despite extensive clinical research on PDA, the median overall survival remains short. Diagnosis delay and primary chemo-resistance due to...

journal_title：World journal of gastroenterology

authors： Lamarca A,Feliu J

更新日期：2014-06-28 00:00:00

abstract：AIM:To find risk factors of lymph node metastasis (LNM) in early gastric cancer (EGC) and to find proper endoscopic therapy indication in EGC. METHODS:We retrospectively reviewed the 2270 patients who underwent curative operation for EGC from January 2001 to December 2008. EGC was defined as malignant lesions that do ...

journal_title：World journal of gastroenterology

authors： Park JH,Lee SH,Park JM,Park CS,Park KS,Kim ES,Cho KB

更新日期：2015-10-21 00:00:00

abstract：:Functional gastrointestinal disorders (FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions i...

journal_title：World journal of gastroenterology

authors： Koutouratsas T,Kalli T,Karamanolis G,Gazouli M

更新日期：2019-02-07 00:00:00

abstract：:Common gastrointestinal diseases such as radiation enteritis (RE), acute pancreatitis, inflammatory bowel diseases (IBD) and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level, mostly involving the activation of many pathways of the immune response, ultimately leading to tissue inju...

journal_title：World journal of gastroenterology

authors： Camara-Lemarroy CR

更新日期：2014-04-07 00:00:00

abstract：:The severity of fecal incontinence widely varies and can have dramatic devastating impacts on a person's life. Fecal incontinence is common, though it is often under-reported by patients. In addition to standard treatment options, new treatments have been developed during the past decade to attempt to effectively trea...

journal_title：World journal of gastroenterology

authors： Van Koughnett JA,Wexner SD

更新日期：2013-12-28 00:00:00

abstract：AIM:To provide long-term survival results of operable duodenal gastrointestinal stromal tumors (DGISTs) in a tertiary center in China. METHODS:In this retrospective study, the pathological data of 28 patients with DGISTs who had been treated surgically at the Second Department of General Surgery, Sir Run Run Shaw Hosp...

journal_title：World journal of gastroenterology

authors： Liang X,Yu H,Zhu LH,Wang XF,Cai XJ

更新日期：2013-09-28 00:00:00

abstract：BACKGROUND:The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease, ulcerative colitis (UC), with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole. In Germany, there are n...

journal_title：World journal of gastroenterology

authors： Teich N,Grümmer H,Jörgensen E,Liceni T,Holtkamp-Endemann F,Fischer T,Hohenberger S

更新日期：2020-06-07 00:00:00

abstract：:Several drugs are used in the treatment of irritable bowel syndrome (IBS) but all have side effects and variable efficacy. Considering the role of the gut-brain axis, immune, neural, and endocrine pathways in the pathogenesis of IBS and possible beneficial effects of benzodiazepines (BZD) in this axis, the present sys...

journal_title：World journal of gastroenterology

authors： Salari P,Abdollahi M

更新日期：2011-10-14 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common renal tumor, accounting for 2%-3% of all malignancies. Though RCC is known to spread hematogenously, isolated RCC metastasis to the stomach is a rare event. In this article, we describe the clinical course of a patient who developed a pancreatic recurrence of RCC and 1 yea...

journal_title：World journal of gastroenterology

authors： Riviello C,Tanini I,Cipriani G,Pantaleo P,Nozzoli C,Poma A,Riccardo V,Valeri A

更新日期：2006-08-28 00:00:00

abstract：AIM:To study the effect of hepatitis C virus nonstructural protein 3 c-terminal deleted protein (HCV NS3-5') on hepatocyte transformation and tumor development. METHODS:QSG7701 cells were transfected with plasmid pRcHCNS3-5' (expressing HCV NS3 c-terminal deleted protein) by lipofectamine and selected in G418. The exp...

journal_title：World journal of gastroenterology

authors： He QQ,Cheng RX,Sun Y,Feng DY,Chen ZC,Zheng H

更新日期：2003-03-01 00:00:00

abstract：AIM:To examine the expression of pancreatic duodenal homeobox-1 (PDX-1) transcription factor in human colorectal cancer. METHODS:RT-PCR, Western blotting, and immuno-histochemistry were performed to determine the expression pattern of transcription factor PDX-1 in primary colorectal tumor, hepatic metastasis, and beni...

journal_title：World journal of gastroenterology

authors： Ballian N,Liu SH,Brunicardi FC

更新日期：2008-10-14 00:00:00

abstract：AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori (H pylori) infection, bacterial cytotoxicity, topography and gender. METHODS:The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive) with functional dys...

journal_title：World journal of gastroenterology

authors： Stec-Michalska K,Malicki S,Michalski B,Peczek L,Wisniewska-Jarosinska M,Nawrot B

更新日期：2009-11-21 00:00:00

abstract：:Iatrogenic bile duct injuries (IBDI) remain an important problem in gastrointestinal surgery. They are most frequently caused by laparoscopic cholecystectomy which is one of the commonest surgical procedures in the world. The early and proper diagnosis of IBDI is very important for surgeons and gastroenterologists, be...

journal_title：World journal of gastroenterology

authors： Jabłońska B,Lampe P

更新日期：2009-09-07 00:00:00

abstract：AIM:To prepare the human hepatocellular carcinoma-(HCC)-targeted liposome microbubbles and to investigate their immunological properties. METHODS:Human hepatocarcinoma specific monoclonal antibody HAb18 was attached to the surface of home-made liposome microbubbles by static attraction to prepare the targeted liposome...

journal_title：World journal of gastroenterology

authors： Bian AN,Gao YH,Tan KB,Liu P,Zeng GJ,Zhang X,Liu Z

更新日期：2004-12-01 00:00:00

abstract：AIM:To evaluate the role of miniprobe ultrasonography under colonoscope in the diagnosis of submucosal tumor of the large intestine, and to determine its imaging characteristics. METHODS:Thirty-five patients with submucosal tumors of the large intestine underwent miniprobe ultrasonography under colonoscope. The diagno...

journal_title：World journal of gastroenterology

authors： Zhou PH,Yao LQ,Zhong YS,He GJ,Xu MD,Qin XY

更新日期：2004-08-15 00:00:00

abstract：AIM:To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS:A cohort of archival formalin-fixed paraffin-embedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between Apri...

journal_title：World journal of gastroenterology

authors： Kwak JM,Lee HJ,Kim SH,Kim HK,Mok YJ,Park YT,Choi JS,Moon HY

更新日期：2010-08-21 00:00:00

abstract：AIM:To investigate whether hepatitis B virus (HBV) infection activates DNA damage response and DNA repair cofactors inhibit HBV infection and replication. METHODS:Human hepatocyte cell line HL7702 was studied. Immunoblotting was performed to test the expression of ataxia telangiectasia-mutated (ATM)-Rad3-related prote...

journal_title：World journal of gastroenterology

authors： Zhao F,Hou NB,Song T,He X,Zheng ZR,Ma QJ,Li L,Zhang YH,Zhong H

更新日期：2008-08-28 00:00:00

abstract：AIM:To study the viscoelastic properties of human hepatocytes and hepatocellular carcinoma (HCC) cells under cytoskeletal perturbation, and to further to study the viscoelastic properties and the adhesive properties of mouse hepatoma cells (HTC) in different cell cycle. METHODS:Micropipette aspiration technique was ad...

journal_title：World journal of gastroenterology

authors： Zhang G,Long M,Wu ZZ,Yu WQ

更新日期：2002-04-01 00:00:00

abstract：AIM:To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function. METHODS:p53 function of transactivation on p21 promoter was studied with a luciferase reporter system in which the luciferase gene is driven by p21 promoter, and the...

journal_title：World journal of gastroenterology

authors： Gong GZ,Jiang YF,He Y,Lai LY,Zhu YH,Su XS

更新日期：2004-08-01 00:00:00