HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding.

abstract：:Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years ...

journal_title：World journal of gastroenterology

authors： Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A

更新日期：2018-09-28 00:00:00

abstract：:Hepatobiliary cystadenomas are rare tumors that are difficult to diagnose preoperatively. They can reach large sizes that make them real intraoperative "surprises". A 63-year-old woman, presented with a symptomatic huge abdominal cystic mass, underwent complete resection of the mass with safety margins. Histopathologi...

journal_title：World journal of gastroenterology

authors： Beuran M,Venter MD,Dumitru L

更新日期：2006-06-21 00:00:00

abstract：AIM:To determine the efficacy and safety benefits of performing intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC) to treat symptomatic cholelithiasis. METHODS:Patients admitted to the Minimally Invasive Surgery Center of Tianjin Nankai Hospital between January 2012 and January 2014 for mana...

journal_title：World journal of gastroenterology

authors： Ding GQ,Cai W,Qin MF

更新日期：2015-02-21 00:00:00

abstract：AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis. METHODS:We performed a prospective study of 127 patients who underwent endoscopic retrograde cholangiopancreatography, for various biliary disorders, at 3 tertiary referral centers in Germany from July 2011 through...

journal_title：World journal of gastroenterology

authors： Lenz P,Eckelskemper F,Erichsen T,Lankisch T,Dechêne A,Lubritz G,Lenze F,Beyna T,Ullerich H,Schmedt A,Domagk D

更新日期：2014-09-14 00:00:00

abstract：:Colorectal cancer is one of the most common causes of cancer morbidity both in men and in women. However, females over 65 years old show higher mortality and lower 5-year survival rate of colorectal cancer compared to their age-matched male counterparts. The objective of this review is to suggest gender-based innovati...

journal_title：World journal of gastroenterology

authors： Kim SE,Paik HY,Yoon H,Lee JE,Kim N,Sung MK

更新日期：2015-05-07 00:00:00

abstract：:Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical inter...

journal_title：World journal of gastroenterology

authors： Weiner JP,Wong AT,Schwartz D,Martinez M,Aytaman A,Schreiber D

更新日期：2016-08-21 00:00:00

abstract：AIM:To investigate the effect of activation of canonical Wnt signaling pathway on the proliferation and differentiation of hepatic oval cells in vitro. METHODS:WB-F344 cells were treated with recombinant Wnt3a (20, 40, 80, 160, 200 ng/mL) in serum-free medium for 24 h. Cell proliferation was measured by Brdu incorpora...

journal_title：World journal of gastroenterology

authors： Zhang Y,Li XM,Zhang FK,Wang BE

更新日期：2008-11-21 00:00:00

abstract：AIM:To determine whether efflux systems contribute to multidrug resistance of H pylori. METHODS:A chloramphenicol-induced multidrug resistance model of six susceptible H pylori strains (5 isolates and H pylori NCTC11637) was developed. Multidrug-resistant (MDR) strains were selected and the minimal inhibitory concentr...

journal_title：World journal of gastroenterology

authors： Liu ZQ,Zheng PY,Yang PC

更新日期：2008-09-07 00:00:00

abstract：AIM:To compare the number of regulatory T-cells (Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR (qPCR) method in patients suffering from inflammatory bowel disease (IBD). METHODS:Tregs percentages obtained by both flow cytometry and qPCR methods in 35 adult IBD patients, 18 ou...

journal_title：World journal of gastroenterology

authors： Brandhorst G,Petrova DT,Weigand S,Eberle C,von Ahsen N,Schmitz J,Schultze FC,Raddatz D,Karaus M,Oellerich M,Walson PD

更新日期：2015-03-21 00:00:00

abstract：:Celiac disease is an immune-mediated disorder that causes severe architectural disturbance in the small intestinal mucosa of genetically-predisposed individuals. Impaired absorption of multiple nutrients results and diarrhea and weight loss develop. Evidence has accumulated that a strict gluten-free diet can result in...

journal_title：World journal of gastroenterology

authors： Freeman HJ

更新日期：2017-04-21 00:00:00

abstract：AIM:To investigate the differences in injury patterns caused by arterial, venous or arteriovenous mesenteric occlusion. METHODS:Male Wistar rats were separated equally into four groups. Occlusion was performed by clamping the superior mesenteric artery (A), the mesenteric vein (V) or both (AV) for 30 min, followed by ...

journal_title：World journal of gastroenterology

authors： Guzmán-de la Garza FJ,Cámara-Lemarroy CR,Alarcón-Galván G,Cordero-Pérez P,Muñoz-Espinosa LE,Fernández-Garza NE

更新日期：2009-08-21 00:00:00

abstract：:Inflammatory bowel disease (IBD) is comprised of Crohn's disease and ulcerative colitis, both chronic inflammatory intestinal disorders of unknown etiology characterized by a waxing and waning clinical course. For many years, the drug therapy was limited to sulfasalazine and related aminosalicylates, corticosteroids a...

journal_title：World journal of gastroenterology

authors： Zenlea T,Peppercorn MA

更新日期：2014-03-28 00:00:00

abstract：:AIM:To evaluate a culture system for bile acid formation in primary human hepatocytes in comparison with HepG2 cells.METHODS:Hepatocytes were isolated from normal human liver tissue and we re cultured in serum-free William's E medium.The medium was collected and re newed every 24 h. Bile acids and their precursors in ...

journal_title：World journal of gastroenterology

authors： Einarsson C,Ellis E,Abrahamsson A,Ericzon BG,Bjorkhem I,Axelson M

更新日期：2000-08-01 00:00:00

abstract：:A 65-year-old man with cT1bN0M0 stage I middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred, but it spontaneously improved...

journal_title：World journal of gastroenterology

authors： Uesato M,Kono T,Akutsu Y,Murakami K,Kagaya A,Muto Y,Nakano A,Aikawa M,Tamachi T,Amagai H,Arasawa T,Muto Y,Matsubara H

更新日期：2017-07-28 00:00:00

abstract：AIM:To study the origin of calcium necessary for agonist-induced contraction of the distal colon in rats. METHODS:The change in intracellular calcium concentration ([Ca2+]i) evoked by elevating external Ca2+ was detected by fura 2/AM fluorescence. Contractile activity was measured with a force displacement transducer....

journal_title：World journal of gastroenterology

authors： Zhou H,Kong DH,Pan QW,Wang HH

更新日期：2008-02-21 00:00:00

abstract：AIM:To evaluate the risk factors for ampullary adenoma and ampullary cancer. METHODS:This case-control study included ampullary tumor patients referred to Peking Union Medical College Hospital. Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center of the same h...

journal_title：World journal of gastroenterology

authors： He XD,Wu Q,Liu W,Hong T,Li JJ,Miao RY,Zhao HT

更新日期：2014-07-28 00:00:00

abstract：AIM:To determine the pattern and distribution of colonic diverticulosis in Thai adults. METHODS:A review of the computerized radiology database for double contrast barium enema (DCBE) in Thai adults was performed at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Incomplete studies and...

journal_title：World journal of gastroenterology

authors： Lohsiriwat V,Suthikeeree W

更新日期：2013-12-14 00:00:00

abstract：AIM:To determine the upper cut-off values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a Northern Chinese population. METHODS:A total of 3769 subjects in Jilin Province Northeast China were stratified to determine the potential factors affecting serum ALT and AST levels. The upper cu...

journal_title：World journal of gastroenterology

authors： Zhang P,Wang CY,Li YX,Pan Y,Niu JQ,He SM

更新日期：2015-02-28 00:00:00

abstract：AIM:To evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease (CD) with a single non-invasive examination, by using PillCam COLON 2 (PCC2). METHODS:Patients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis...

journal_title：World journal of gastroenterology

authors： Boal Carvalho P,Rosa B,Dias de Castro F,Moreira MJ,Cotter J

更新日期：2015-06-21 00:00:00

abstract：AIM:To evaluate the effects of ethanol on the insulin-like growth factor-I (IGF-I) system involved in c-Jun N-terminal kinase (JNK1/2) and alcoholdehydrogenase (ADH) activity in primary cultured rat hepatocytes. METHODS:Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of et...

journal_title：World journal of gastroenterology

authors： Oh YI,Kim JH,Kang CW

更新日期：2008-07-21 00:00:00

abstract：AIM:To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. METHODS:Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium o...

journal_title：World journal of gastroenterology

authors： Fuszek P,Lakatos P,Tabak A,Papp J,Nagy Z,Takacs I,Horvath HC,Lakatos PL,Speer G

更新日期：2004-07-01 00:00:00

abstract：AIM:To determine whether any changes have occurred on the patterns of colorectal cancer in China. METHODS:Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients' age at diagnosis, sex, the site of the tumor, stage, and the pathology...

journal_title：World journal of gastroenterology

authors： Li M,Gu J

更新日期：2005-08-14 00:00:00

abstract：AIM:To investigate whether the changes of gap junction gene connexin messenger RNA in the noncancerous liver tissue of patients with hepatocellular carcinoma (HCC) could play a significant role in its postresection recurrence. METHODS:Seventy-nine consecutive patients having undergone curative resection for HCC entere...

journal_title：World journal of gastroenterology

authors： Sheen IS,Jeng KS,Shih SC,Kao CR,Wang PC,Chen CZ,Chang WH,Wang HY,Shyung LR

更新日期：2005-01-14 00:00:00

abstract：AIM:To look for the evidence of human papilloma virus (HPV) infection in esophageal squamous cell carcinomas (ESCC) and to investigate the potential role and epidemiology of HPV infection in the pathogenesis of esophageal carcinomas in Henan emigrants. METHODS:Papilloma virus(PV) and HPV were determined by Ultrasensiv...

journal_title：World journal of gastroenterology

authors： Yao PF,Li GC,Li J,Xia HS,Yang XL,Huang HY,Fu YG,Wang RQ,Wang XY,Sha JW

更新日期：2006-03-07 00:00:00

abstract：AIM:To assess the utility of contrast-enhanced ultrasonography (CEUS) with a second-generation contrast medium in the differential diagnosis between mass-forming pancreatitis and pancreatic carcinoma. METHODS:From our radio-pathology database, we retrieved all the patients affected by mass-forming pancreatitis or panc...

journal_title：World journal of gastroenterology

authors： D'Onofrio M,Zamboni G,Tognolini A,Malago R,Faccioli N,Frulloni L,Pozzi Mucelli R

更新日期：2006-07-14 00:00:00

abstract：:We here report a case of a 18-year-old man with a history of recurrent abdominal pain and a previous episode of severe acute pancreatitis. Abdominal ultrasonography, contrast enhanced multislice computer tomography, endoscopic retrograde cholangiopancreatography, endoscopic ultrasonography and magnetic resonance imagi...

journal_title：World journal of gastroenterology

authors： Guarise A,Faccioli N,Ferrari M,Romano L,Parisi A,Falconi M

更新日期：2006-03-14 00:00:00

abstract：AIM:To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS). METHODS:55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done ...

journal_title：World journal of gastroenterology

authors： Kohut M,Nowak A,Nowakowska-Dulawa E,Marek T,Kaczor R

更新日期：2003-03-01 00:00:00

abstract：AIM:To investigate a potential role of S100A4 in esophagus squamous cell carcinoma metastasis (ESCCs). METHODS:Expression of S100A4 and E-cadherin were analyzed in frozen sections from ESCCs (metastasis, n = 28; non-metastasis, n = 20) by reverse transcription-polymerase chain reaction, quantitative polymerase chain r...

journal_title：World journal of gastroenterology

authors： Chen D,Zheng XF,Yang ZY,Liu DX,Zhang GY,Jiao XL,Zhao H

更新日期：2012-03-07 00:00:00

abstract：:Solid-pseudopapillary tumor (SPT) is a rare neoplasm of the pancreas that usually occurs in young females. It is generally considered a low-grade malignant tumor that can remain asymptomatic for several years. The occurrence of infiltrating varieties of SPT is around 10%-15%. Between 1986 and 2006, 282 cystic tumors o...

journal_title：World journal of gastroenterology

authors： Sperti C,Berselli M,Pasquali C,Pastorelli D,Pedrazzoli S

更新日期：2008-02-14 00:00:00

abstract：AIM:To identify the risk factors for postoperative pulmonary complications (PPC) after gastrointestinal surgery. METHODS:A total of 1 002 patients undergoing gastrointestinal surgery in the Second Affiliated Hospital, Sun Yat-Sen University, during December 1999 and December 2003, were retrospectively studied. RESULT...

journal_title：World journal of gastroenterology

authors： Jiang SP,Li ZY,Huang LW,Zhang W,Lu ZQ,Zheng ZY

更新日期：2005-06-28 00:00:00