Prediction of the indication criteria for endoscopic resection of early gastric cancer.


AIM:To find risk factors of lymph node metastasis (LNM) in early gastric cancer (EGC) and to find proper endoscopic therapy indication in EGC. METHODS:We retrospectively reviewed the 2270 patients who underwent curative operation for EGC from January 2001 to December 2008. EGC was defined as malignant lesions that do not invade beyond the submucosal layer of the stomach wall irrespective of presence of lymph node metastasis. RESULTS:Among 2270 enrolled patients, LNM was observed in 217 (9%) patients. LNM in intramucosal (M) cancer and submucosal (SM) cancer was detected in 38 (2.8%, 38/1340) patients and 179 (19%, 179/930) patients, respectively. In univariate analysis, the risk factors for LNM in EGC were size of tumor, Lauren classification, ulcer, lymphatic invasion, vascular invasion, and depth of invasion. However, in multivariate analysis, size of tumor, lymphatic invasion, vascular invasion, and depth of invasion were risk factors for LNM in EGC. Size of tumor, lymphatic invasion, vascular invasion, and depth of invasion were risk factors for LNM in cases of intramucosal cancer and submucosal cancer. In particular, there was no lymph node metastasis in cases of well differentiated early gastric cancer below 1 cm in size without ulcer regardless of lymphovascular invasion. CONCLUSION:Tumor size, perilymphatic-vascular invasion, and depth of invasion were risk factors for LNM in EGC. There was no LNM in EGC below 1 cm regardless risk factors.


World J Gastroenterol


Park JH,Lee SH,Park JM,Park CS,Park KS,Kim ES,Cho KB




Has Abstract


2015-10-21 00:00:00












  • Proton pump inhibitors therapy vs H2 receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis.

    abstract:AIM:To compare the therapeutic effects of proton pump inhibitors vs H₂ receptor antagonists for upper gastrointestinal bleeding in patients after successful endoscopy. METHODS:We searched the Cochrane library, MEDLINE, EMBASE and PubMed for randomized controlled trials until July 2014 for this study. The risk of bias ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Zhang YS,Li Q,He BS,Liu R,Li ZJ

    更新日期:2015-05-28 00:00:00

  • Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters.

    abstract:AIM:To explore the grade and stage of pathology and the relationship between grading and staging of hepatic fibrosis and noninvasive diagnostic parameters. METHODS:Inflammatory activity and fibrosis of consecutive liver biopsies from 200 patients with chronic liver disease were determined according to the Diagnostic C...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lu LG,Zeng MD,Wan MB,Li CZ,Mao YM,Li JQ,Qiu DK,Cao AP,Ye J,Cai X,Chen CW,Wang JY,Wu SM,Zhu JS,Zhou XQ

    更新日期:2003-11-01 00:00:00

  • Efficacy, effectiveness, immunogenicity--are not the same in vaccinology.

    abstract::Manuscript of Carrera et al is devoted to immunization in inflammatory bowel disease (IBD) that is very important issue in gastroenterology. However, some specific definitions used in the article need clarification. Efficacy of vaccine is measured in a randomised, placebo-controlled studies, that are expensive and dif...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Banaszkiewicz A,Radzikowski A

    更新日期:2013-11-07 00:00:00

  • Role of three-dimensional endoanal ultrasound in assessing the anal sphincter morphology of female patients with chronic proctalgia.

    abstract:AIM:To assess the role of three-dimensional endoanal ultrasound (3D-EAUS) for morphological assessment of the anal sphincter of female patients with chronic proctalgia (CP). METHODS:In this unmatched case control study, 30 consecutive female patients with CP and 25 normal women (control group) were enrolled. 3D-EAUS w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xue YH,Ding SQ,Ding YJ,Pan LQ

    更新日期:2017-06-07 00:00:00

  • Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.

    abstract::High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, AR...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Gu DL,Chen YH,Shih JH,Lin CH,Jou YS,Chen CF

    更新日期:2013-12-21 00:00:00

  • Is interferon-beta an alternative treatment for chronic hepatitis C?

    abstract::The treatment of chronic hepatitis C (CHC) is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-alpha (IFNalpha) plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approac...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Moreno-Otero R,Trapero-Marugán M,Gómez-Domínguez E,García-Buey L,Moreno-Monteagudo JA

    更新日期:2006-05-07 00:00:00

  • Prevalence and factors associated with irritable bowel syndrome among university students in Lebanon: findings from a cross-sectional study.

    abstract:AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Costanian C,Tamim H,Assaad S

    更新日期:2015-03-28 00:00:00

  • Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography.

    abstract:AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Jang SY,Park HG,Jung MK,Cho CM,Park SY,Jeon SW,Tak WY,Kweon YO,Kim SK,Jeon YH

    更新日期:2012-11-21 00:00:00

  • Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival.

    abstract:AIM:To identify whether chitinase 3-like 1 (CHI3L1) serves as a suitable biomarker for the prognosis of esophageal squamous cell carcinoma (ESCC) and to analyze this protein's cellular source. METHODS:An ELISA was conducted to detect the concentration of CHI3L1 in the serum of 150 ESCC patients diagnosed between Janua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xing S,Zheng X,Zeng T,Zeng MS,Zhong Q,Cao YS,Pan KL,Wei C,Hou F,Liu WL

    更新日期:2017-11-21 00:00:00

  • Seek protein which can interact with hepatitis B virus X protein from human liver cDNA library by yeast two-hybrid system.

    abstract:AIM:To seek the X associated protein (XAP) with the constructed bait vector pAS2-1X from normal human liver cDNA library. METHODS:The X region of the HBV gene was amplied by PCR and cloned into the eukaryotic expression vector pAS2-1. The reconstituted plasmid pAS2-1X was transformed into the yeast cells and the expre...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang XZ,Jiang XR,Chen XC,Chen ZX,Li D,Lin JY,Tao QM

    更新日期:2002-02-01 00:00:00

  • Anal metastasis from recurrent breast lobular carcinoma: a case report.

    abstract::We report a case of isolated gastrointestinal metastasis from breast lobular carcinoma, which mimicked primary anal cancer. In July 2000, an 88-year-old woman presented with infiltrating lobular cancer (pT1/G2/N2). The patient received postoperative radiotherapy and hormonal therapy. Four years later, she presented wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Puglisi M,Varaldo E,Assalino M,Ansaldo G,Torre G,Borgonovo G

    更新日期:2009-03-21 00:00:00

  • New treatments for chronic hepatitis C: an overview for paediatricians.

    abstract::Pegylated interferon (IFN) α-2a or 2b in combination with ribavirin for children aged 3 years and older is the standard treatment for paediatric chronic hepatitis C. This treatment regimen was developed firstly in adults. In recent years, a number of direct-acting antiviral agents (DAAs) are under development for trea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Serranti D,Indolfi G,Resti M

    更新日期:2014-11-21 00:00:00

  • Stevens-Johnson syndrome complicating adalimumab therapy in Crohn's disease.

    abstract::The anti-tumor necrosis factor (TNF)alpha medications demonstrate efficacy in the induction of remission and its maintenance in numerous chronic inflammatory conditions. With the increasing number of patients receiving anti-TNFalpha agents, however, less common adverse reactions will occur. Cutaneous eruptions complic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Salama M,Lawrance IC

    更新日期:2009-09-21 00:00:00

  • Case of pediatric traditional serrated adenoma resected via endoscopic submucosal dissection.

    abstract::Traditional serrated adenoma (TSA) is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion. There are three types of serrated polyps, namely, hyperplastic polyps, sessile serrated adenomas/polyps, and TSAs. TSA is the least common of the three types and accounts for about 5% of serrate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kondo S,Mori H,Nishiyama N,Kondo T,Shimono R,Okada H,Kusaka T

    更新日期:2017-06-28 00:00:00

  • Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients.

    abstract:AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients. METHODS:Sixty-four patients with chronic hepatitis, 65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Utama A,Siburian MD,Purwantomo S,Intan MD,Kurniasih TS,Gani RA,Achwan WA,Arnelis,Lelosutan SA,Lukito B,Harmono T,Zubir N,Julius,Soemohardjo S,Lesmana LA,Sulaiman A,Tai S

    更新日期:2011-02-14 00:00:00

  • Effect of caffeic acid phenethyl ester on proliferation and apoptosis of hepatic stellate cells in vitro.

    abstract:AIM:To investigate the role of nuclear factor-kappaB (NF-kappaB) inhibitor caffeic acid phenethy1 ester (CAPE) in the proliferation, collagen synthesis and apoptosis of hepatic stellate cells (HSCs) of rats. METHODS:The HSCs from rats were isolated and cultured in Dulbecco's Modified Eagle's Medium (DMEM) and treated ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhao WX,Zhao J,Liang CL,Zhao B,Pang RQ,Pan XH

    更新日期:2003-06-01 00:00:00

  • Retinal vein thrombosis associated with pegylated-interferon and ribavirin combination therapy for chronic hepatitis C.

    abstract::An estimated 300 million people worldwide suffer from chronic hepatitis C with a prevalence of 0.8%-1.0% of the general population in Canada. An increasing pool of evidence exists supporting the use of pegylated- interferon (pegIFN) and ribavirin combination therapy for hepatitis C. We report a 49-year old male of Nor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zandieh I,Adenwalla M,Cheong-Lee C,Ma PE,Yoshida EM

    更新日期:2006-08-14 00:00:00

  • Correlation of fibrinogen-like protein 2 with progression of acute pancreatitis in rats.

    abstract:AIM:To examine fibrinogen-like protein 2 (fgl2) expression during taurocholate-induced acute pancreatitis progression in rats and its correlation with pancreatic injury severity. METHODS:Forty-eight male Sprague-Dawley rats were randomly divided into the severe acute pancreatitis (SAP) group (n = 24) and the sham oper...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ye XH,Chen TZ,Huai JP,Lu GR,Zhuge XJ,Chen RP,Chen WJ,Wang C,Huang ZM

    更新日期:2013-04-28 00:00:00

  • Improvement of clinical parameters in patients with gastroesophageal reflux disease after radiofrequency energy delivery.

    abstract:AIM:To evaluate the efficacy of Stretta procedure with gastroesophageal reflux disease (GERD) based on symptom control, medication changes and oesophagitis grade. METHODS:Ninety patients with a history of GERD underwent Stretta procedure from June 2007 to March 2010. All patients with GERD diagnosed by the presence of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Liu HF,Zhang JG,Li J,Chen XG,Wang WA

    更新日期:2011-10-21 00:00:00

  • A focus on parietal cells as a renewing cell population.

    abstract::The fact that the acid-secreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using (3)H-thymidine radioautography in combination with electron microscopy, it was possible to demonstrate...

    journal_title:World journal of gastroenterology

    pub_type: 社论


    authors: Karam SM

    更新日期:2010-02-07 00:00:00

  • Sclerosing encapsulating peritonitis in a liver transplant patient: a case report.

    abstract::We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

    更新日期:2005-09-14 00:00:00

  • Is the required therapeutic effect always achieved by racemic switch of proton-pump inhibitors?

    abstract::Many of the drugs currently used in medical practice are racemates. The enantiomers of a racemic drug differ in pharmacodynamics and/or pharmacokinetics, thus in some cases it is preferable to develop pure enantiomers by racemic switch. In a recent study by Pai et al, dexrabeprazole [R(+)-rabeprazole] (10 mg) was foun...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Zhou Q,Yan XF,Pan WS,Zeng S

    更新日期:2008-04-28 00:00:00

  • Study on hepatoprotective effect of peptide S-8300 from shark liver.

    abstract:AIM:To explore the effects of peptide S-8300 from shark liver (S-8300) on liver function as well as in regulating immune functions in experimental injury models. METHODS:Mice were administered with different doses of S-8300 for four consecutive days, followed by mice injected with tetrachloromethane (CCl(4)) on d 3. T...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Huang FJ,Lv ZB,Li Q,Wei LJ,Zhang L,Wu WT

    更新日期:2005-03-28 00:00:00

  • Living-related liver transplantation for multiple liver metastases from rectal carcinoid tumor: a case report.

    abstract::A 42-year-old woman was admitted to our hospital because of multiple liver tumors detected by ultrasonography. Colonoscopy revealed submucosal tumor in the rectum, which was considered the primary lesion. Endoscopic mucosal resection followed by histopathological examination revealed that the tumor was carcinoid. The ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Nakajima Y,Takagi H,Sohara N,Sato K,Kakizaki S,Nomoto K,Suzuki H,Suehiro T,Shimura T,Asao T,Kuwano H,Mori M,Nishikura K

    更新日期:2006-03-21 00:00:00

  • Association of hepatitis C virus infection and diabetes.

    abstract::Epidemiologic studies have suggested a relation between hepatitis C virus (HCV) infection and diabetes mellitus. HCV infection is emerging as a metabolic disease, and diabetes mellitus as a risk factor for HCV infection. However, some data on the prevalence of antibodies to HCV in patients with diabetes are conflictin...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Rouabhia S,Malek R,Bounecer H

    更新日期:2009-10-28 00:00:00

  • Hepatitis C virus lymphotropism and peculiar immunological phenotype: effects on natural history and antiviral therapy.

    abstract::Hepatitis C virus (HCV) has been recognized to be both a hepato- and lymphotropic virus. HCV lymphotropism represents an essential lap in the pathogenesis of virus-related autoimmune and lymphoproliferative disorders, ranging from clonal expansion of B-cells with organ- and non-organ-specific autoantibody production u...

    journal_title:World journal of gastroenterology

    pub_type: 社论


    authors: Conca P,Tarantino G

    更新日期:2009-05-21 00:00:00

  • Campylobacter concisus and inflammatory bowel disease.

    abstract::Investigation of the possible role of Campylobacter concisus (C. concisus) in inflammatory bowel disease (IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zhang L,Lee H,Grimm MC,Riordan SM,Day AS,Lemberg DA

    更新日期:2014-02-07 00:00:00

  • Heterogeneity across the murine small and large intestine.

    abstract::The small and large intestine of the gastrointestinal tract (GIT) have evolved to have discrete functions with distinct anatomies and immune cell composition. The importance of these differences is underlined when considering that different pathogens have uniquely adapted to live in each region of the gut. Furthermore...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Bowcutt R,Forman R,Glymenaki M,Carding SR,Else KJ,Cruickshank SM

    更新日期:2014-11-07 00:00:00

  • Inhibition of hepatitis B virus replication by APOBEC3G in vitro and in vivo.

    abstract:AIM:To investigate the effect of APOBEC3G mediated antiviral activity against hepatitis B virus (HBV) in cell cultures and replication competent HBV vector-based mouse model. METHODS:The mammalian hepatoma cells Huh7 and HepG2 were cotransfected with various amounts of CMV-driven expression vector encoding APOBEC3G an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lei YC,Hao YH,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Zhao XP,Lu MJ,Gong FL,Yang DL

    更新日期:2006-07-28 00:00:00

  • Replication and gene expression of mutant hepatitis B virus in a transgenic mouse containing the complete viral genome with mutant s gene.

    abstract:AIM:To establish the transgenic mouse line harbouring complete hepatitis B virus (HBV) genome with mutant s gene (adr subtype). METHODS:Transgenic mice were generated by microinjecting HBV genome into fertilized eggs. Integration, expression, replication of HBV gene and histological changes in transgenic mice were est...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ge JH,Zhang LZ,Li JX,Liu H,Liu HM,He J,Yao YC,Yang YJ,Yu HY,Hu YP

    更新日期:2004-11-01 00:00:00