Translational research in pancreatic ductal adenocarcinoma: current evidence and future concepts.

abstract：AIM:To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC. METHODS:Data were collected from 85 poorly-dif...

journal_title：World journal of gastroenterology

authors： Li H,Lu P,Lu Y,Liu CG,Xu HM,Wang SB,Chen JQ

更新日期：2008-07-14 00:00:00

abstract：:Dilatation of the colon and the rectum, which is not attributable to aganglionosis, is a rare finding and can be the result of intractable chronic constipation. We report a rare case of a 29-year-old male patient with impressive megacolon, in whom Hirschsprung's or Chagas disease was ruled out. In the present case, di...

journal_title：World journal of gastroenterology

authors： Mecklenburg I,Leibig M,Weber C,Schmidbauer S,Folwaczny C

更新日期：2005-12-28 00:00:00

abstract：:AIM:To explore the expression and changes of hepatoma specific alkaline phospatase (ALP) in rats during canceration.METHODS:The ALPs and isoenzymes of rat livers and sera were investigated in SD hepatomas induced with 0.05% 2-fluoenylacetamide (2-FAA).RESULTS: By pathological examination and biochemical analysis. ALPs...

journal_title：World journal of gastroenterology

authors： Xiao MB,Yao DF,Zhang H,Qiang H,Huang JF,Wei Q,Jiang F

更新日期：1998-08-01 00:00:00

abstract：:Wireless capsule endoscopy (CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal (GI) bleeding. Over subsequent years, this technology has bee...

journal_title：World journal of gastroenterology

authors： Redondo-Cerezo E,Sánchez-Capilla AD,De La Torre-Rubio P,De Teresa J

更新日期：2014-11-14 00:00:00

abstract：AIM:To globally compare the gene expression profiles during the capillary morphogenesis of human microvascular endothelial cells (HMVECs) in an in vitro angiogenesis system with affymetrix oligonucleotide array. METHODS:A microcarrier-based in vitro angiogenesis system was developed, in which ECs migrated into the mat...

journal_title：World journal of gastroenterology

authors： Sun XT,Zhang MY,Shu C,Li Q,Yan XG,Cheng N,Qiu YD,Ding YT

更新日期：2005-04-21 00:00:00

abstract：:Mother-to-child transmission of hepatitis B virus (HBV) is among the most important causes of chronic HBV infection and is the commonest mode of transmission worldwide. Currently, the presence of HBsAg, HBeAg and HBV DNA in breast milk is confirmed. Several studies have reported that breastfeeding carries no additiona...

journal_title：World journal of gastroenterology

authors： Petrova M,Kamburov V

更新日期：2010-10-28 00:00:00

abstract：:Colorectal cancer metastasizes predictably, with liver predominance in most cases. Because liver involvement has been shown to be a major determinant of survival in this population, liver-directed therapies are increasingly considered even in cases where there is (limited) extrahepatic disease. Unfortunately, these pa...

journal_title：World journal of gastroenterology

authors： Sag AA,Selcukbiricik F,Mandel NM

更新日期：2016-03-21 00:00:00

abstract：AIM:To investigate the effect of epigallocatechin gallate (EGCG) on structural changes of gut microbiota in colorectal carcinogenesis. METHODS:An azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis mouse model was established. Forty-two female FVB/N mice were randomly divided into the following three group...

journal_title：World journal of gastroenterology

authors： Wang X,Ye T,Chen WJ,Lv Y,Hao Z,Chen J,Zhao JY,Wang HP,Cai YK

更新日期：2017-12-14 00:00:00

abstract：:Colonic motility subserves large bowel functions, including absorption, storage, propulsion and defaecation. Colonic motor dysfunction remains the leading hypothesis to explain symptom generation in chronic constipation, a heterogeneous condition which is extremely prevalent in the general population, and has huge soc...

journal_title：World journal of gastroenterology

authors： Dinning PG,Benninga MA,Southwell BR,Scott SM

更新日期：2010-11-07 00:00:00

abstract：:Liver penetration is a rare but serious complication of peptic ulcer disease. Usually the diagnosis is made by operation or autopsy. Clinical and laboratory data were no specific. A 64-year-old man was admitted with upper gastrointestinal bleeding. Hepatic penetration was diagnosed as the cause of bleeding. Endoscopy ...

journal_title：World journal of gastroenterology

authors： Kayacetin E,Kayacetin S

更新日期：2004-06-15 00:00:00

abstract：AIM:To evaluate the impact of therapeutic education on adherence to antiviral treatment and sustained virological response (SVR) in a real-life setting in genotype 2/3 hepatitis C, as there are few adherence data in genotype 2/3 infection, even from randomized trials. METHODS:This prospective survey included genotype ...

journal_title：World journal of gastroenterology

authors： Cacoub P,Ouzan D,Melin P,Lang JP,Rotily M,Fontanges T,Varastet M,Chousterman M,Marcellin P

更新日期：2008-10-28 00:00:00

abstract：AIM:To investigate the anti-tumor mechanism of antisense oligodeoxynucleotide cantide against hTERT. METHODS:Tumor cells were cultured overnight and grown to 50-60 % confluence. HepG2 and SMMC-7721 were treated with cantide mixed with lipofectin, or lipofectin alone. After inducted for 6 h at 37 degrees, 10 % FCS in D...

journal_title：World journal of gastroenterology

authors： Du QY,Wang XB,Chen XJ,Zheng W,Wang SQ

更新日期：2003-09-01 00:00:00

abstract：AIM:To compare the efficacy and safety of single daily amikacin vs. cefotaxime in the 5-d treatment of spontaneous bacterial peritonitis (SBP). METHODS:Thirty-seven cirrhotic patients with SBP, 19 in group A and 18 in group B, were studied. Group A received 1 g of cefotaxime every 6 h, and group B received 500 mg of a...

journal_title：World journal of gastroenterology

authors： Chen TA,Lo GH,Lai KH,Lin WJ

更新日期：2005-11-21 00:00:00

abstract：AIM:To study the condition and potentiality of human umbilical cord blood stem cells (HUCBSC) to differentiate into hepatocytes in vivo or in vitro. METHODS:In a cell culture study of human umbilical cord blood stem cell (HUCBSC) differentiation, human umbilical cord blood mononuclear cells (HUCBMNC) were separated by...

journal_title：World journal of gastroenterology

authors： Tang XP,Zhang M,Yang X,Chen LM,Zeng Y

更新日期：2006-07-07 00:00:00

abstract：:A number of alterations have been found within the gut microbial profile of patients with inflammatory bowel diseases when compared with the healthy population; however, it is unclear whether such dysbiosis is the cause or simply the consequence of the disease state. In ulcerative colitis, the environment seems to pla...

journal_title：World journal of gastroenterology

authors： Sorrentino D

更新日期：2017-10-07 00:00:00

abstract：AIM:To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS). METHODS:55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done ...

journal_title：World journal of gastroenterology

authors： Kohut M,Nowak A,Nowakowska-Dulawa E,Marek T,Kaczor R

更新日期：2003-03-01 00:00:00

abstract：AIM:To analyze the clinicopathologic characteristics and prognostic factors of rectal neuroendocrine tumors. METHODS:The records of 48 patients with rectal neuroendocrine tumors who were treated at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, from March 2004 to September 2009 were r...

journal_title：World journal of gastroenterology

authors： Chi Y,Du F,Zhao H,Wang JW,Cai JQ

更新日期：2014-11-21 00:00:00

abstract：AIM:To investigate the clinical implications of hepatitis B virus (HBV) preS1 deletion. METHODS:We developed a fluorescence resonance energy transfer-based real-time polymerase chain reaction (RT-PCR) that can detect four genotypes (wild type, 15-bp, 18-bp and 21-bp deletion). The PCR method was used in two cohorts of...

journal_title：World journal of gastroenterology

authors： Lee SA,Kim KJ,Kim H,Choi WH,Won YS,Kim BJ

更新日期：2015-04-28 00:00:00

abstract：AIM:To identify preoperative predictive factors associated with malignancy of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. METHODS:Between April 1995 and April 2010, 129 patients underwent surgical resection for IPMNs at our institute and had confirmed pathologic diagnoses. The medical records wer...

journal_title：World journal of gastroenterology

authors： Lee JH,Lee KT,Park J,Bae SY,Lee KH,Lee JK,Jang KT,Heo JS,Choi SH,Choi DW,Rhee JC

更新日期：2010-11-14 00:00:00

abstract：:Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988,000 ne...

journal_title：World journal of gastroenterology

authors： Gao M,Yin H,Fei ZW

更新日期：2013-04-07 00:00:00

abstract：AIM:To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients. METHODS:Four IFR5 SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/...

journal_title：World journal of gastroenterology

authors： Sy BT,Hoan NX,Tong HV,Meyer CG,Toan NL,Song LH,Bock CT,Velavan TP

更新日期：2018-01-14 00:00:00

abstract：:"Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported ...

journal_title：World journal of gastroenterology

authors： Vere CC,Streba CT,Streba LM,Ionescu AG,Sima F

更新日期：2009-06-28 00:00:00

abstract：BACKGROUND:Intestinal inflammation is a common digestive tract disease, which is usually treated with hormone medicines. Hormone medicines are effective to some extent, but long-term use of them may bring about many complications. AIM:To explore the protective effects of panax notoginseng saponin (PNS) against dextran...

journal_title：World journal of gastroenterology

authors： Lu QG,Zeng L,Li XH,Liu Y,Du XF,Bai GM,Yan X

更新日期：2020-03-21 00:00:00

abstract：AIM:To investigate the role of reactive oxygen species (ROS) in ethanol-mediated cell death of polarized hepatic (WIF-B) cells. METHODS:In this work, WIF-B cultures were treated with pyrazole (inducer of cytochrome P4502E1, CYP2E1) and/or L-buthionine sulfoximine (BSO), a known inhibitor of hepatic glutathione (GSH), ...

journal_title：World journal of gastroenterology

authors： McVicker BL,Tuma PL,Kharbanda KK,Lee SM,Tuma DJ

更新日期：2009-06-07 00:00:00

abstract：AIM:To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples. METHODS:A total of 480 blood and tissue specimens were collected in our hospital from January 2011 to October 2012. In the observation group, there were 120...

journal_title：World journal of gastroenterology

authors： Yan ZH,Cui LH,Wang XH,Li C,He X

更新日期：2014-12-28 00:00:00

abstract：:Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of...

journal_title：World journal of gastroenterology

authors： Tamaki K,Shimizu I,Urata M,Kohno N,Fukuno H,Ito S,Sano N

更新日期：2007-05-21 00:00:00

abstract：AIM:To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS:Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as thei...

journal_title：World journal of gastroenterology

authors： Tan Y,Kim J,Cheng J,Ong M,Lao WG,Jin XL,Lin YG,Xiao L,Zhu XQ,Qu XQ

更新日期：2017-06-07 00:00:00

abstract：AIM:To introduce the combination method of radiochemoembolization for the treatment of selected hepatic metastases. METHODS:Twenty patients with biopsy proven hepatic metastases were selected from those who underwent transarterial radiochemoembolization, a novel combination protocol, between January 2009 and July 2010...

journal_title：World journal of gastroenterology

authors： Akhlaghpoor S,Aziz-Ahari A,Amoui M,Tolooee S,Poorbeigi H,Sheybani S

更新日期：2012-10-07 00:00:00

abstract：AIM:To determine the incidence of human epidermal growth factor receptor 2 (HER2) over expression in oesophageal cancers. METHODS:A retrospective study, of one hundred consecutive cases of endoscopic histological samples of oesophageal cancers from a single British cancer network were included. Cancer cases were diagn...

journal_title：World journal of gastroenterology

authors： Al-Momani H,Barnes R,El-Hadi A,Shah R,Lewis WG,Edwards P

更新日期：2012-11-28 00:00:00

abstract：AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by us...

journal_title：World journal of gastroenterology

authors： Jafarzadeh A,Rezayati MT,Nemati M

更新日期：2007-06-14 00:00:00