Recurrent severe gastrointestinal bleeding and malabsorption due to extensive habitual megacolon.

abstract：AIM:To explore the mechanism of protection against acetaminophen-induced acute liver injury by Liuweiwuling tablets. METHODS:Intraperitoneal injections of acetaminophen (250 mg/kg) were used to induce acute liver injury in male C57BL/6 mice. A total of 24 healthy mice were randomly assigned to two groups: an acute liv...

journal_title：World journal of gastroenterology

authors： Lei YC,Li W,Luo P

更新日期：2015-07-14 00:00:00

abstract：AIM:To establish a multiple detection method based on comparative polymerase chain reaction (cPCR) and ligase detection reaction (LDR)/ligase chain reaction (LCR) to quantify the intestinal bacterial components. METHODS:Comparative quantification of 16S rDNAs from different intestinal bacterial components was used to ...

journal_title：World journal of gastroenterology

authors： Tang ZR,Li K,Zhou YX,Xiao ZX,Xiao JH,Huang R,Gu GH

更新日期：2012-01-21 00:00:00

abstract：AIM:To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. METHODS:The CT26.WT mouse colon carcinoma cell line was grown and expanded in vitro. Following the expansion, BALB/c mice were inoculated s.c. with viable tumor cells. After the tumors had establ...

journal_title：World journal of gastroenterology

authors： Ojo-Amaize EA,Cottam HB,Oyemade OA,Okogun JI,Nchekwube EJ

更新日期：2007-09-14 00:00:00

abstract：AIM:To study the effects of cortactin on the tumor biology of SGC-7901 cells and identify the mechanism involved in the process. METHODS:Cell lines in which cortactin was stably overexpressed or knocked down as well as the respective control cell lines were established by standard molecular methods. The effects of cor...

journal_title：World journal of gastroenterology

authors： Wei J,Zhao ZX,Li Y,Zhou ZQ,You TG

更新日期：2014-03-28 00:00:00

abstract：:High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, AR...

journal_title：World journal of gastroenterology

authors： Gu DL,Chen YH,Shih JH,Lin CH,Jou YS,Chen CF

更新日期：2013-12-21 00:00:00

abstract：:Eosinophilic esophagitis has rapidly become a recognized entity causing dysphagia in young adults. This review summarizes the current knowledge of eosinophilic esophagitis including the epidemiology, clinical presentation, diagnostic criteria, pathophysiology, treatment, and prognosis. An extensive search of PubMed/Me...

journal_title：World journal of gastroenterology

authors： Yan BM,Shaffer EA

更新日期：2006-04-21 00:00:00

abstract：AIM:To investigate whether cold water intake into the stomach affects colonic motility and the involvement of the oxytocin-oxytocin receptor pathway in rats. METHODS:Female Sprague Dawley rats were used and some of them were ovariectomized. The rats were subjected to gastric instillation with cold (0-4 °C, cold group)...

journal_title：World journal of gastroenterology

authors： Yang X,Xi TF,Li YX,Wang HH,Qin Y,Zhang JP,Cai WT,Huang MT,Shen JQ,Fan XM,Shi XZ,Xie DP

更新日期：2014-08-21 00:00:00

abstract：AIM:To study the effect of IGF-1/IGF-1R and gastrin/CCK-BR on carcinogenesis and development of human gastric carcinoma and to explore its mechanism and provide a credible theoretical foundation for early diagnosis and molecular therapy of gastric carcinoma. METHODS:mRNA expression levels of IGF-1/IGF-1R and gastrin/C...

journal_title：World journal of gastroenterology

authors： Zhao MD,Hu XM,Sun DJ,Zhang Q,Zhang YH,Meng W

更新日期：2005-06-07 00:00:00

abstract：AIM:To detect high risk patients with a progressive disease course of ulcerative colitis (UC) requiring immunosuppressive therapy (IT). METHODS:A retrospective, multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed. Patients were divided into two groups dep...

journal_title：World journal of gastroenterology

authors： Stallmach A,Nickel L,Lehmann T,Bokemeyer B,Bürger M,Hüppe D,Kruis W,Nikolaus S,Preiss JC,Sturm A,Teich N,Schmidt C

更新日期：2014-09-21 00:00:00

abstract：:Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis (LNM), including isolated tumor cells, in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer, the clinical sig...

journal_title：World journal of gastroenterology

authors： Sonoda H,Tani T

更新日期：2014-10-14 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma (HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments...

journal_title：World journal of gastroenterology

authors： Zhang YQ,Guo JS

更新日期：2015-04-07 00:00:00

abstract：:As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When con...

journal_title：World journal of gastroenterology

authors： Tenner S

更新日期：2014-11-28 00:00:00

abstract：AIM:To investigate the prevalence and characteristics of uninvestigated dyspepsia among college students in Zhejiang Province. METHODS:Young adult students attending undergraduate (within the 4-year program) and graduate (only first-year students) colleges in Zhejiang Province were recruited between November 2010 and ...

journal_title：World journal of gastroenterology

authors： Li M,Lu B,Chu L,Zhou H,Chen MY

更新日期：2014-04-07 00:00:00

abstract：BACKGROUND:End-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is the second leading indication for liver transplantation. To date, only moderately effective pharmacotherapies exist to treat NASH. Understanding the pathogenesis of NASH is therefore crucial for the development of new therapies. The in...

journal_title：World journal of gastroenterology

authors： Bluemel S,Wang Y,Lee S,Schnabl B

更新日期：2020-09-07 00:00:00

abstract：AIM:To observe the expression of cyclooxygenase-2 (COX-2) and to investigate the association between COX-2 expression and infection with cytotoxic-associated gene A (cagA) positive strain Helicobacter pylori (Hp) in human gastric cancer, and subsequently to provide fresh ideas for the early prevention of gastric cancer...

journal_title：World journal of gastroenterology

authors： Guo XL,Wang LE,Du SY,Fan CL,Li L,Wang P,Yuan Y

更新日期：2003-02-01 00:00:00

abstract：AIM:To review the usefulness of endoscopic biliary stenting for obstructive jaundice caused by hepatocellular carcinoma and identify problems that may need to be addressed. METHODS:The study population consisted of 36 patients with obstructive jaundice caused by hepatocellular carcinoma (HCC) who underwent endoscopic ...

journal_title：World journal of gastroenterology

authors： Sugiyama G,Okabe Y,Ishida Y,Saitou F,Kawahara R,Ishikawa H,Horiuchi H,Kinoshita H,Tsuruta O,Sata M

更新日期：2014-06-14 00:00:00

abstract：:Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most ...

journal_title：World journal of gastroenterology

authors： Losurdo G,Principi M,Iannone A,Amoruso A,Ierardi E,Di Leo A,Barone M

更新日期：2018-04-14 00:00:00

abstract：AIM:To investigate the effect of activation of canonical Wnt signaling pathway on the proliferation and differentiation of hepatic oval cells in vitro. METHODS:WB-F344 cells were treated with recombinant Wnt3a (20, 40, 80, 160, 200 ng/mL) in serum-free medium for 24 h. Cell proliferation was measured by Brdu incorpora...

journal_title：World journal of gastroenterology

authors： Zhang Y,Li XM,Zhang FK,Wang BE

更新日期：2008-11-21 00:00:00

abstract：:Xanthogranulomatous inflammation (XGI) is a disease of unknown origin, most frequently described in the kidney and gallbladder; its localization in the colorectal tract is extremely rare. The extension of the typical inflammatory process to the surrounding tissues may lead to misdiagnosis as cancer. We report the case...

journal_title：World journal of gastroenterology

authors： Addario Chieco P,Antolino L,Giaccaglia V,Centanini F,Cunsolo GV,Sparagna A,Uccini S,Ziparo V

更新日期：2014-07-14 00:00:00

abstract：AIM:To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS:A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospective...

journal_title：World journal of gastroenterology

authors： Jin YJ,Lee JW,Park SW,Lee JI,Lee DH,Kim YS,Cho SG,Jeon YS,Lee KY,Ahn SI

更新日期：2013-07-28 00:00:00

abstract：:We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients. A 37-year-old Japanese man with an 8-year history of CD and a medication history of azathioprine underwent...

journal_title：World journal of gastroenterology

authors： Ishida M,Naka S,Shiomi H,Tsujikawa T,Andoh A,Nakahara T,Saito Y,Kurumi Y,Takikita-Suzuki M,Kojima F,Hotta M,Tani T,Fujiyama Y,Okabe H

更新日期：2010-07-07 00:00:00

abstract：AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among ...

journal_title：World journal of gastroenterology

authors： Roman F,Hawotte K,Struck D,Ternes AM,Servais JY,Arendt V,Hoffman P,Hemmer R,Staub T,Seguin-Devaux C,Schmit JC

更新日期：2008-02-28 00:00:00

abstract：AIM:To investigate the location alteration of Smad2 and Smad4 mRNAs in the liver during and after fibrogenesis in rats. METHODS:Eighty male Wistar rats weighing approximately 200 g each were used. The rat models of experimental hepatic fibrosis were established by injection with carbon tetrachloride (CCl4), normal rat...

journal_title：World journal of gastroenterology

authors： Liu Y,Wang LF,Zou HF,Song XY,Xu HF,Lin P,Zheng HH,Yu XG

更新日期：2006-03-14 00:00:00

abstract：:Rescue antiviral treatment for patients with resistance to preexisting nucleos(t)ide analogues remains a clinical challenge. The correct choice of a first-line treatment of high potency and with a high genetic barrier to achieve sustained long-term suppression of viral replication provides the best chance of preventin...

journal_title：World journal of gastroenterology

authors： Bang KB,Kim HJ

更新日期：2014-09-07 00:00:00

abstract：AIM:To investigate the therapeutic efficacy and complications of splenectomy with endoscopic variceal ligation (EVL) and splenectomy with pericardial devascularization (i.e. Hassab's operation) in patients with portal hypertension. METHODS:A total of 103 patients with liver cirrhosis and portal hypertension were rando...

journal_title：World journal of gastroenterology

authors： Lin N,Liu B,Xu RY,Fang HP,Deng MH

更新日期：2006-12-07 00:00:00

abstract：:To review the underlying pathophysiology and currently available treatments for pruritis associated with jaundice. English language literature was reviewed using MEDLINE, PubMed, EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jau...

journal_title：World journal of gastroenterology

authors： Bassari R,Koea JB

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recycling of related cellular components. Recent studies have shown that autophagy plays an important role in the pathogenesis of Crohn's disease (CD). Herbal cake-partitioned moxi...

journal_title：World journal of gastroenterology

authors： Wang SY,Zhao JM,Zhou CL,Zheng HD,Huang Y,Zhao M,Zhang ZY,Wu LY,Wu HG,Liu HR

更新日期：2020-10-21 00:00:00

abstract：AIM:To observe the effect of protocatechuic aldchyde on the proliferation of hepatic stellate cells (HSCs). METHODS:Liver fibrosis was induced in rats by carbon tetrachloride (CCl4). Then normal and fibrotic drug sera were extracted from rats. The effects of protocatechuic aldchyde, raw Radix Salvia miltiorrhiza and d...

journal_title：World journal of gastroenterology

authors： Lv T,Yao XX

更新日期：2006-04-14 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic infla...

journal_title：World journal of gastroenterology

authors： Mohammed N,Subramanian V

更新日期：2016-11-14 00:00:00

abstract：AIM:To explore the effects of the nucleoside analogues beta-L-D4A and beta-LPA on hepatitis B virus (HBV) promoters. METHODS:Four HBV promoters were amplified by polymerase chain reaction (PCR) and subcloned into the expression vector pEGFP-1. The four recombinants controlled by HBV promoters were confirmed by restric...

journal_title：World journal of gastroenterology

authors： He XX,Lin JS,Chang Y,Zhang YH,Li Y,Wang XY,Xu D,Cheng XM

更新日期：2008-03-28 00:00:00