Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma.

Abstract:

:Chronic hepatitis B virus (HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma (HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments inhibit the replication of HBV, reduce serum viral load and accelerate hepatitis B e antigen serum conversion. Timely initiation of antiviral treatment is not only essential for preventing the incidence of HCC in chronic hepatitis B patients, but also important for reducing HBV reactivation, improving liver function, reducing or delaying HCC recurrence, and prolonging overall survival of HBV-related HCC patients after curative and palliative therapies. The selection of antiviral drugs, monitoring of indicators such as HBV DNA and hepatitis B surface antigen, and timely rescue treatment when necessary, are essential in antiviral therapies for HBV-related HCC.

journal_name

World J Gastroenterol

authors

Zhang YQ,Guo JS

doi

10.3748/wjg.v21.i13.3860

subject

Has Abstract

pub_date

2015-04-07 00:00:00

pages

3860-6

issue

13

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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