Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.

Abstract:

AIM:To clarify the benefit of surgical excision for patients with extrahepatic metastases of hepatocellular carcinoma (HCC). METHODS:We retrospectively reviewed the medical records of 140 patients with pathologically proven extrahepatic metastases of HCC and evaluated the outcomes of those who had undergone surgical resection (SR) for extrahepatic metastatic lesions. Prognoses made on the basis of extrahepatic metastatic sites were also examined. RESULTS:The survival rates of patients who underwent SR of extrahepatic metastases were significantly better than those of patients who did not receive SR. For the SR group, 1- and 3-year survival rates were 24% and 7%, respectively, while for the non-resection group, the survival rates were 8% and 0%, respectively (P < 0.0001). Survival rates related to metastatic sites were also significantly superior after SR of extrahepatic metastases: median survivals were 32 mo with lung metastasis, 10 mo with bone metastasis, 6.1 mo with brain metastasis. CONCLUSION:SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC.

journal_name

World J Gastroenterol

authors

Chan KM,Yu MC,Wu TJ,Lee CF,Chen TC,Lee WC,Chen MF

doi

10.3748/wjg.15.5481

subject

Has Abstract

pub_date

2009-11-21 00:00:00

pages

5481-8

issue

43

eissn

1007-9327

issn

2219-2840

journal_volume

15

pub_type

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