Retrospective analysis of extra-gastrointestinal stromal tumors.

Abstract:

AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors (EGISTs) in South Korea. METHODS:A total of 51 patients with an EGIST were identified. The clinicopathologic features, including sex, age, location, tumor size, histology, mitotic rate, immunohistochemical features, genetic status and survival data, were analyzed. RESULTS:The median age was 55 years (range: 29-80 years), and male:female ratio was 1:1.04. The most common site was in the mesentery (n = 15) followed by the retroperitoneum (n = 13) and omentum (n = 8). The median tumor size was 9.0 cm (range: 2.6-30.0 cm) and the median mitotic rate was 5.0/50HPF. (1/50 - 185/50). KIT was analyzed in 16, which revealed 10 cases with wild-type KIT and 6 cases with an exon 11 mutation. Among 51 patients, 31 patients had undergone surgery, and 10 had unresectable disease and had taken palliative imatinib, which resulted in 22.7 mo of progression-free survival. Of the patients who had undergone surgery, 18 did not take adjuvant imatinib, and 8 of these were categorized as "high risk" according to the risk criteria. However, the relapse-free survival was not different (P = 0.157) between two groups. CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor, a more stratified strategy is required for managing EGISTs including incorporation of molecular features.

journal_name

World J Gastroenterol

authors

Yi JH,Park BB,Kang JH,Hwang IG,Shin DB,Sym SJ,Ahn HK,Lee SI,Lim DH,Park KW,Won YW,Lim SH,Park SH

doi

10.3748/wjg.v21.i6.1845

subject

Has Abstract

pub_date

2015-02-14 00:00:00

pages

1845-50

issue

6

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

杂志文章
  • When to stop nucleos(t)ide analogues treatment for chronic hepatitis B? Durability of antiviral response.

    abstract::Introduction of nucleos(t)ide analogues (NAs) for oral antiviral therapy has dramatically improved the clinical outcome in patients with chronic hepatitis B (CHB). Although current international guidelines for the management of CHB provide information regarding when to begin the antiviral therapy with NAs, there is no...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i23.7207

    authors: Kang W,Park JY

    更新日期:2014-06-21 00:00:00

  • Gallbladder motor function, plasma cholecystokinin and cholecystokinin receptor of gallbladder in cholesterol stone patients.

    abstract:AIM:To study the interactive relationship of gallbladder motor function, plasma cholecystokinin (CCK) and cholecystokinin A receptor (CCK-R) of gallbladder in patients with cholesterol stone disease. METHODS:Gallbladder motility was studied by ultrasonography in 33 patients with gallbladder stone and 10 health subject...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i11.1685

    authors: Zhu J,Han TQ,Chen S,Jiang Y,Zhang SD

    更新日期:2005-03-21 00:00:00

  • Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro.

    abstract:AIM:To construct pcDNA3.1-Egr.1p-p16 recombinant plasmid and investigate the expression of p16 in pancreatic cancer JF305 cells induced by radiation and the feasibility of gene radiotherapy for pancreatic carcinoma. METHODS:Human p16 cDNA was ligated to the downstream of Egr-1 promotor to construct pcDNA3.1-Egr.1p-p16...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i31.4214

    authors: Ma HB,Wang XJ,Di ZL,Xia H,Li Z,Liu J,Ma J,Kang HF,Wu CM,Bai MH

    更新日期:2007-08-21 00:00:00

  • Ileum perforation due to delayed operation in obturator hernia: a case report and review of literatures.

    abstract::A 83-year-old woman was admitted to our hospital because of intermittent abdominal colicky pain and vomiting for 26 h. The pain localized over the periumbilical area with radiation along the medial side of the thigh. Computed tomography scan with three-dimensional reconstruction revealed a loop of small bowel protrudi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i1.126

    authors: Zhang H,Cong JC,Chen CS

    更新日期:2010-01-07 00:00:00

  • Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer.

    abstract:AIM:To evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS:From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i1.123

    authors: You YT,Chang Chien CR,Wang JY,Ng KK,Chen JS,Tang R,Chiang JM,Yeh CY,Hsieh PS

    更新日期:2006-01-07 00:00:00

  • Endoscopic ultrasound-guided choledochoduodenostomies with fully covered self-expandable metallic stents.

    abstract:AIM:To investigate the long-term outcomes of endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) with a fully covered self-expandable metallic stent (FCSEMS). METHODS:From April 2009 to August 2010, 15 patients with distal malignant biliary obstructions who were candidates for alternative techniques for bili...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i32.4435

    authors: Song TJ,Hyun YS,Lee SS,Park DH,Seo DW,Lee SK,Kim MH

    更新日期:2012-08-28 00:00:00

  • Chemotherapy beyond second-line in advanced gastric cancer.

    abstract::Patients with advanced gastric cancer (AGC) can be treated with multiple lines of chemotherapy. Although several randomized trials have demonstrated the benefit of second-line chemotherapy compared with best supportive care, there is no evidence that further lines of chemotherapy will result in substantial prolongatio...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i29.8811

    authors: Kim SM,Park SH

    更新日期:2015-08-07 00:00:00

  • Management of patients with stercoral perforation of the sigmoid colon: report of five cases.

    abstract::To our knowledge, stercoral perforation of the colon is rarely seen with fewer than 90 cases reported in the literature till date. We explored the principles of management to prevent impending mortality in five patients with this condition. Five patients, two males and three females, whose median age was 64 years, had...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i3.500

    authors: Huang WS,Wang CS,Hsieh CC,Lin PY,Chin CC,Wang JY

    更新日期:2006-01-21 00:00:00

  • Serum sIL-2R, TNF-alpha and IFN-gamma in alveolar echinococcosis.

    abstract:AIM:to approach the relationship between alveolar echinococcosis (AE) pathology and level of sIL-2R,TNF-alpha and IFN-gamma in sera and the significance of cytokines in development of AE. METHODS:After 23 patients with AE were confirmed by ELISA and ultrasound, their sera were collected and the concentrations of sIL-2...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i24.3674

    authors: Shi DZ,Li FR,Bartholomot B,Vuitton DA,Craig PS

    更新日期:2004-12-15 00:00:00

  • Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, QBC(939).

    abstract:AIM:To investigate the effects of exogenously mutated p27(kipl) (p27) on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC(939)in vivo. METHODS:Adenviral vectors were used to transfect mutated p27 cDNA into human QBC(939)cell line. Expression of p27 was detected by RT-PCR. Western blot. Cell growt...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5344

    authors: Luo J,Chen YJ,Wang WY,Zou SQ

    更新日期:2008-09-14 00:00:00

  • Role of discs large homolog 5.

    abstract::In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectivel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i23.3651

    authors: Friedrichs F,Stoll M

    更新日期:2006-06-21 00:00:00

  • Exercise-provoked esophageal motility disorder in patients with recurrent chest pain.

    abstract:AIM:To investigate the relationship between exercise-provoked esophageal motility disorders and the prognosis for patients with chest pain. METHODS:The study involved 63 subjects with recurrent angina-like chest pain non-responsive to empirical therapy with proton pump inhibitor (PPI). In all, a coronary artery angiog...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i35.4428

    authors: Budzyński J

    更新日期:2010-09-21 00:00:00

  • Comparison of concomitant and subsequent cholangiocarcinomas associated with hepatolithiasis: Clinical implications.

    abstract:AIM:To compare the outcomes of concomitant cholangiocarcinoma (C-CCA) and subsequent cholangiocarcinoma (S-CCA) associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic resection for hepatolithiasis in Changhua Christian Hospital. Sixty-five patients were excluded du...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i3.375

    authors: Lin CC,Lin PY,Chen YL

    更新日期:2013-01-21 00:00:00

  • Role of bacteria in the etiopathogenesis of inflammatory bowel disease.

    abstract::Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases, Crohn d' disease (CD) and ulcerative colitis (UC). A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i42.5571

    authors: Barnich N,Darfeuille-Michaud A

    更新日期:2007-11-14 00:00:00

  • Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma.

    abstract:AIM:To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA). METHODS:We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients receiv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i18.3301

    authors: Jung JH,Lee HJ,Lee HS,Jo JH,Cho IR,Chung MJ,Park JY,Park SW,Song SY,Bang S

    更新日期:2017-05-14 00:00:00

  • Primary hepatic carcinoid: a case report and literature review.

    abstract::Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide hormones. Approximately 54.5% arise in the gastrointestinal tract and frequently metastasize to the liver. Primary hepatic carcinoid tumors (PHCT) are extremely rare; only 95 cases have been reported. A 65-year-old man came to...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.15.2418

    authors: Fenoglio LM,Severini S,Ferrigno D,Gollè G,Serraino C,Bracco C,Castagna E,Brignone C,Pomero F,Migliore E,David E,Salizzoni M

    更新日期:2009-05-21 00:00:00

  • Extended lymphadenectomy in hilar cholangiocarcinoma: What it will bring?

    abstract::Lymph node dissection is always a hot issue in radical resection of hilar cholangiocarcinoma (HCCA). There are still controversies regarding whether some lymph nodes should be dissected, of which the para-aortic lymph nodes are the most controversial. This review synthesized findings in the literature using the PubMed...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i24.3318

    authors: Li J,Zhou MH,Ma WJ,Li FY,Deng YL

    更新日期:2020-06-28 00:00:00

  • Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion.

    abstract:AIM:To determine whether increased blood flow of the liver can cause oxidative stress and hepatocyte damage, and to elaborate methods suitable for measuring the antioxidant defence during hepatic surgery on rat model. METHODS:In nembutal narcosis, the left lateral and the medial lobes of the liver were clipped for 45 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i7.1086

    authors: Váli L,Taba G,Szentmihályi K,Fébel H,Kurucz T,Pallai Z,Kupcsulik P,Blázovics A

    更新日期:2006-02-21 00:00:00

  • Serum proteins in chronic hepatitis B patients treated with peginterferon alfa-2b.

    abstract:AIM:To study the differential protein profile in serum of hepatitis B patients. METHODS:Serum samples were obtained from patients with chronic hepatitis B who were receiving peginterferon alfa-2b. The serum samples were subjected to albumin depletion and analyzed by two-dimensional gel electrophoresis (2-DE). Differen...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i31.5067

    authors: Kuakarn S,SomParn P,Tangkijvanich P,Mahachai V,Thongboonkerd V,Hirankarn N

    更新日期:2013-08-21 00:00:00

  • Incidence and clinical features of endoscopic ulcers developing after gastrectomy.

    abstract:AIM:To determine the precise incidence and clinical features of endoscopic ulcers following gastrectomy. METHODS:A consecutive series of patients who underwent endoscopic examination following gastrectomy between 2005 and 2010 was retrospectively analyzed. A total of 78 patients with endoscopic ulcers and 759 without ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i25.3260

    authors: Chung WC,Jeon EJ,Lee KM,Paik CN,Jung SH,Oh JH,Kim JH,Jun KH,Chin HM

    更新日期:2012-07-07 00:00:00

  • Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.

    abstract::Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v24.i17.1839

    authors: Mukaida N,Nakamoto Y

    更新日期:2018-05-07 00:00:00

  • Fourth-generation quinolones in the treatment of Helicobacter pylori infection: A meta-analysis.

    abstract:AIM:To assess the efficacy and safety of fourth-generation quinolones for Helicobacter pylori (H. pylori) eradication, we conducted this systematic review and meta-analysis of randomized clinical trials. METHODS:Major literature databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials) were sea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v24.i29.3302

    authors: An Y,Wang Y,Wu S,Wang YH,Qian X,Li Z,Fu YJ,Xie Y

    更新日期:2018-08-07 00:00:00

  • Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics.

    abstract::Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i1.60

    authors: Gatselis NK,Zachou K,Koukoulis GK,Dalekos GN

    更新日期:2015-01-07 00:00:00

  • Combination of three-gene immunohistochemical panel and magnetic resonance imaging-detected extramural vascular invasion to assess prognosis in non-advanced rectal cancer patients.

    abstract:AIM:To identify a small, clinically applicable immunohistochemistry (IHC) panel that could be combined with magnetic resonance imaging (MRI)-detected extramural vascular invasion (EMVI) for assessment of prognosis concerning the non-advanced rectal cancer patients prior to operation. METHODS:About 329 patients with pa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i38.8576

    authors: Li XF,Jiang Z,Gao Y,Li CX,Shen BZ

    更新日期:2016-10-14 00:00:00

  • Mycobacterium avium subspecies paratuberculosis causes Crohn's disease in some inflammatory bowel disease patients.

    abstract::Crohn's disease (CD) is a chronic inflammatory condition that plagues millions all over the world. This debilitating bowel disease can start in early childhood and continue into late adulthood. Signs and symptoms are usually many and multiple tests are often required for the diagnosis and confirmation of this disease....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i23.7403

    authors: Naser SA,Sagramsingh SR,Naser AS,Thanigachalam S

    更新日期:2014-06-21 00:00:00

  • Positron emission tomography/computer tomography in guidance of extrahepatic hepatocellular carcinoma metastasis management.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common primary cancers in the world. Surgery is the gold standard for treatment of patients with HCC. Recurrence and metastasis are the major obstacles to further improve the prognosis of HCC. Most recurrences are intrahepatic. However, 30% of the recurrences are extra...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i40.5413

    authors: Sun L,Guan YS,Pan WM,Chen GB,Luo ZM,Wu H

    更新日期:2007-10-28 00:00:00

  • MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1.

    abstract:AIM:To investigate the underlying molecular mechanisms of miR-451 to inhibit proliferation of esophageal carcinoma cell line EC9706. METHODS:Assays for cell growth, apoptosis and invasion were used to evaluate the effects of miR-451 expression on EC cells. Luciferase reporter and Western blot assays were used to test ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i19.5867

    authors: Zang WQ,Yang X,Wang T,Wang YY,Du YW,Chen XN,Li M,Zhao GQ

    更新日期:2015-05-21 00:00:00

  • Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis.

    abstract::Colorectal cancer incidence and mortality in patients younger than 50 years are increasing, but screening before the age of 50 is not offered in Europe. Advanced-stage diagnosis and mortality from colorectal cancer before 50 years of age are increasing. This is not a detection-bias effect; it is a real issue affecting...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i21.2565

    authors: Mannucci A,Zuppardo RA,Rosati R,Leo MD,Perea J,Cavestro GM

    更新日期:2019-06-07 00:00:00

  • Learning curve for hand-assisted laparoscopic D2 radical gastrectomy.

    abstract:AIM:To describe the learning curves of hand-assisted laparoscopic D2 radical gastrectomy (HALG) for the treatment of gastric cancer. METHODS:The HALG surgical procedure consists of three stages: surgery under direct vision via the port for hand assistance, hand-assisted laparoscopic surgery, and gastrointestinal tract...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i5.1606

    authors: Gong JQ,Cao YK,Wang YH,Zhang GH,Wang PH,Luo GD

    更新日期:2015-02-07 00:00:00

  • Complications of stent placement for benign stricture of gastrointestinal tract.

    abstract:AIM:To observe the frequent complications of stent placement for stricture of the gastrointestinal tract and to find proper treatment. METHODS:A total number of 140 stents were inserted in 138 patients with benign stricture of the gastrointestinal tract. The procedure was completed under fluoroscopy in all of the pati...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i2.284

    authors: Cheng YS,Li MH,Chen WX,Chen NW,Zhuang QX,Shang KZ

    更新日期:2004-01-15 00:00:00