Abstract:
AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors (EGISTs) in South Korea. METHODS:A total of 51 patients with an EGIST were identified. The clinicopathologic features, including sex, age, location, tumor size, histology, mitotic rate, immunohistochemical features, genetic status and survival data, were analyzed. RESULTS:The median age was 55 years (range: 29-80 years), and male:female ratio was 1:1.04. The most common site was in the mesentery (n = 15) followed by the retroperitoneum (n = 13) and omentum (n = 8). The median tumor size was 9.0 cm (range: 2.6-30.0 cm) and the median mitotic rate was 5.0/50HPF. (1/50 - 185/50). KIT was analyzed in 16, which revealed 10 cases with wild-type KIT and 6 cases with an exon 11 mutation. Among 51 patients, 31 patients had undergone surgery, and 10 had unresectable disease and had taken palliative imatinib, which resulted in 22.7 mo of progression-free survival. Of the patients who had undergone surgery, 18 did not take adjuvant imatinib, and 8 of these were categorized as "high risk" according to the risk criteria. However, the relapse-free survival was not different (P = 0.157) between two groups. CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor, a more stratified strategy is required for managing EGISTs including incorporation of molecular features.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Yi JH,Park BB,Kang JH,Hwang IG,Shin DB,Sym SJ,Ahn HK,Lee SI,Lim DH,Park KW,Won YW,Lim SH,Park SHdoi
10.3748/wjg.v21.i6.1845subject
Has Abstractpub_date
2015-02-14 00:00:00pages
1845-50issue
6eissn
1007-9327issn
2219-2840journal_volume
21pub_type
杂志文章abstract::Introduction of nucleos(t)ide analogues (NAs) for oral antiviral therapy has dramatically improved the clinical outcome in patients with chronic hepatitis B (CHB). Although current international guidelines for the management of CHB provide information regarding when to begin the antiviral therapy with NAs, there is no...
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journal_title:World journal of gastroenterology
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doi:10.3748/wjg.v11.i11.1685
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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