Chemotherapy beyond second-line in advanced gastric cancer.

abstract：AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer (ESCC) and the survival of the patients. METHODS:Sixty-four patients (median age of 63 years) with histological or cytological confirmation of ESCC receiv...

journal_title：World journal of gastroenterology

authors： Qin TJ,An GL,Zhao XH,Tian F,Li XH,Lian JW,Pan BR,Gu SZ

更新日期：2009-02-21 00:00:00

abstract：AIM:To study the protein C activation system in human liver myofibroblasts, and the effects of activated protein C (APC) on these cells. METHODS:Human liver myofibroblasts were obtained by outgrowth. Expression of protease activated receptor 1 (PAR-1), endothelial protein C receptor (EPCR) and thrombomodulin (TM) was ...

journal_title：World journal of gastroenterology

authors： Gillibert-Duplantier J,Rullier A,Neaud V,Kisiel W,Rosenbaum J

更新日期：2010-01-14 00:00:00

abstract：AIM:To find potential mutable sites by detecting mutations of the candidate gene in a kindred with polycystic liver disease (PCLD). METHODS:First, we chose a kindred with PCLD and obtained five venous blood samples of this kindred after the family members signed the informed consent form. In the kindred two cases were...

journal_title：World journal of gastroenterology

authors： Jin S,Cui K,Sun ZQ,Shen YY,Li P,Wang ZD,Li FF,Gong KN,Li S

更新日期：2015-02-28 00:00:00

abstract：AIM:To investigate the effect of Boschniakia rossica (BR), oxymatrine (OM) and interferon-alpha (IFN-alpha) 1b on the therapy of rat liver fibrosis and its mechanism. METHODS:By establishing a rat model of pig serum-induced liver fibrosis, liver/weight index and serum alanine transaminase (ALT) were observed to invest...

journal_title：World journal of gastroenterology

authors： Wu CS,Piao XX,Piao DM,Jin YR,Li CH

更新日期：2005-01-07 00:00:00

abstract：:Lymph node dissection is always a hot issue in radical resection of hilar cholangiocarcinoma (HCCA). There are still controversies regarding whether some lymph nodes should be dissected, of which the para-aortic lymph nodes are the most controversial. This review synthesized findings in the literature using the PubMed...

journal_title：World journal of gastroenterology

authors： Li J,Zhou MH,Ma WJ,Li FY,Deng YL

更新日期：2020-06-28 00:00:00

abstract：AIM:To identify the actual clinical management and associated factors of delayed perforation after gastric endoscopic submucosal dissection (ESD). METHODS:A total of 4943 early gastric cancer (EGC) patients underwent ESD at our hospital between January 1999 and June 2012. We retrospectively assessed the actual managem...

journal_title：World journal of gastroenterology

authors： Suzuki H,Oda I,Sekiguchi M,Abe S,Nonaka S,Yoshinaga S,Nakajima T,Saito Y

更新日期：2015-11-28 00:00:00

abstract：:Corticosteroids and immunomodulators have been the mainstay therapies for Crohn's disease. Corticosteroids are highly effective to control symptoms in the short-term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an...

journal_title：World journal of gastroenterology

authors： Ricart E,García-Bosch O,Ordás I,Panés J

更新日期：2008-09-28 00:00:00

abstract：AIM:To study the relationship between the expression of the c-erbB-2 proto-oncogene product with gastric mucosal carcinogenesis and the behavior of gastric carcinoma. METHODS:Specimens from nine normal gastric mucosa, 23 gastric mucosal dysplasia (10 slight, six moderate, seven severe), 18 early gastric carcinoma, and...

journal_title：World journal of gastroenterology

authors： Mi JQ,Yang SQ,Shen MC

更新日期：1997-06-15 00:00:00

abstract：AIM:Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this study was to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or ...

journal_title：World journal of gastroenterology

authors： Molnár T,Tiszlavicz L,Gyulai C,Nagy F,Lonovics J

更新日期：2005-05-28 00:00:00

abstract：AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients. METHODS:Sixty-four patients with chronic hepatitis, 65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this ...

journal_title：World journal of gastroenterology

authors： Utama A,Siburian MD,Purwantomo S,Intan MD,Kurniasih TS,Gani RA,Achwan WA,Arnelis,Lelosutan SA,Lukito B,Harmono T,Zubir N,Julius,Soemohardjo S,Lesmana LA,Sulaiman A,Tai S

更新日期：2011-02-14 00:00:00

abstract：:Inflammatory bowel disease (IBD) results from the interaction between an individual's immune response and precipitant environmental factors, which generate an anomalous chronic inflammatory response in those who are genetically predisposed. Various feeding practices have been implicated in the origin of IBD based on e...

journal_title：World journal of gastroenterology

authors： Lucendo AJ,De Rezende LC

更新日期：2009-05-07 00:00:00

abstract：AIM:To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells (PBMCs) from Crohn's disease (CD) patients in clinical remission. METHODS:Patients with CD in clinical remission or with very low disease activity according to the Crohn's disease activity index were genotyped regarding ...

journal_title：World journal of gastroenterology

authors： Schäffler H,Rohde M,Rohde S,Huth A,Gittel N,Hollborn H,Koczan D,Glass Ä,Lamprecht G,Jaster R

更新日期：2018-03-21 00:00:00

abstract：AIM:To establish an animal model with human hepatocyte-repopulated liver for the study of liver cancer metastasis. METHODS:Cell transplantation into mouse livers was conducted using alpha-fetoprotein (AFP)-producing human gastric cancer cells (h-GCCs) and h-hepatocytes as donor cells in a transgenic mouse line express...

journal_title：World journal of gastroenterology

authors： Fujiwara S,Fujioka H,Tateno C,Taniguchi K,Ito M,Ohishi H,Utoh R,Ishibashi H,Kanematsu T,Yoshizato K

更新日期：2012-08-07 00:00:00

abstract：:Duodenal polyps or lesions are uncommonly found on upper endoscopy. Duodenal lesions can be categorized as subepithelial or mucosally-based, and the type of lesion often dictates the work-up and possible therapeutic options. Subepithelial lesions that can arise in the duodenum include lipomas, gastrointestinal stromal...

journal_title：World journal of gastroenterology

authors： Gaspar JP,Stelow EB,Wang AY

更新日期：2016-01-14 00:00:00

abstract：AIM:To evaluate ATP-binding cassette (ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer (CRC) development. METHODS:Literature search was conducted on PubMed using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflamma...

journal_title：World journal of gastroenterology

authors： Andersen V,Svenningsen K,Knudsen LA,Hansen AK,Holmskov U,Stensballe A,Vogel U

更新日期：2015-11-07 00:00:00

abstract：BACKGROUND:The management strategies for recurrent ampullary adenoma after endoscopic papillectomy are still controversial. Patients with the recurrent papillary lesions need to receive repetitive endoscopic interventions due to the limitations of conventional endoscopic techniques. AIM:To assess the feasibility, effi...

journal_title：World journal of gastroenterology

authors： Wang ZK,Liu F,Wang Y,Wang XD,Tang P,Li W

更新日期：2020-10-07 00:00:00

abstract：:Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepati...

journal_title：World journal of gastroenterology

authors： Paschos KA,Majeed AW,Bird NC

更新日期：2014-04-14 00:00:00

abstract：:Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological spec...

journal_title：World journal of gastroenterology

authors： Wu LJ,Chen ZY,Wang Y,Zhao JG,Xie XZ,Chen G

更新日期：2019-04-28 00:00:00

abstract：AIM:To compare outcome of stapled hemorrhoidopexy (SH) vs LigaSure hemorrhoidectomy (LH) by a meta-analysis of available randomized controlled trials (RCTs). METHODS:Databases, including PubMed, EMBASE, the Cochrane Library, and the Science Citation Index updated to December 2012, were searched. The main outcomes meas...

journal_title：World journal of gastroenterology

authors： Yang J,Cui PJ,Han HZ,Tong DN

更新日期：2013-08-07 00:00:00

abstract：:Perfusion of individual tissues is a basic physiological process that is necessary to sustain oxygenation and nutrition at a cellular level. Ischemia, or the insufficiency of perfusion, is a common mechanism for tissue death or degeneration, and at a lower threshold, a mechanism for the generation of sensory signallin...

journal_title：World journal of gastroenterology

authors： Hoff DA,Gregersen H,Hatlebakk JG

更新日期：2009-01-14 00:00:00

abstract：:Over the last 15 years, there have been major advances in the multimodal treatment of gastric cancer, in large part due to several phase III studies showing the treatment benefits of neoadjuvant and adjuvant chemotherapy and chemoradiation protocols. The objective of this editorial is to review the current high-level ...

journal_title：World journal of gastroenterology

authors： Choi AH,Kim J,Chao J

更新日期：2015-06-28 00:00:00

abstract：AIM:To study the beneficial effects of triterpene alpha,beta-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS:Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 x 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of alph...

journal_title：World journal of gastroenterology

authors： Melo CM,Carvalho KM,Neves JC,Morais TC,Rao VS,Santos FA,Brito GA,Chaves MH

更新日期：2010-09-14 00:00:00

abstract：AIM:To investigate the designation, synthesis and biological activity of against vascular endothelial growth factor165 (VEGF165) ribozyme. METHODS:The ribozyme against VEGF165 was designed with computer. The transcriptional vector was constructed which included the anti-VEGF165 ribozyme and 5', 3' self-splicing ribozy...

journal_title：World journal of gastroenterology

authors： Gu ZP,Wang YJ,Wu Y,Li JG,Chen NA

更新日期：2004-05-15 00:00:00

abstract：AIM:To examine the potency of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) as a hepatic heme oxygenase-1 (HO-1) inducer and its regulation in HepG2 cells. METHODS:Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immunofluore...

journal_title：World journal of gastroenterology

authors： Pae HO,Oh GS,Jeong SO,Jeong GS,Lee BS,Choi BM,Lee HS,Chung HT

更新日期：2006-01-14 00:00:00

abstract：BACKGROUND:Computed tomography (CT), liver stiffness measurement (LSM), and magnetic resonance imaging (MRI) are non-invasive diagnostic methods for esophageal varices (EV) and for the prediction of high-bleeding-risk EV (HREV) in cirrhotic patients. However, the clinical use of these methods is controversial. AIM:To ...

journal_title：World journal of gastroenterology

authors： Li Y,Li L,Weng HL,Liebe R,Ding HG

更新日期：2020-05-14 00:00:00

abstract：AIM:To describe the imaging features of solitary fibrous tumors (SFTs) in the abdomen and pelvis, and the clinical and pathologic correlations. METHODS:Fifteen patients with pathologically confirmed SFTs in the abdomen and pelvis were retrospectively studied with imaging techniques by two radiologists in consensus. Pa...

journal_title：World journal of gastroenterology

authors： Li XM,Reng J,Zhou P,Cao Y,Cheng ZZ,Xiao Y,Xu GH

更新日期：2014-05-07 00:00:00

abstract：AIM:To investigate the expression frequency of endocan in colorectal cancer and analyze the relationship between endocan expression and clinical parameters and to study the role of endocan in colorectal carcinogenesis. METHODS:Expression of endocan in 72 tumor tissue samples of colorectal cancer as well as in 27 norma...

journal_title：World journal of gastroenterology

authors： Zuo L,Zhang SM,Hu RL,Zhu HQ,Zhou Q,Gui SY,Wu Q,Wang Y

更新日期：2008-07-28 00:00:00

abstract：:Autoimmune pancreatitis has emerged over the last 40 years from a proposed concept to a well established and recognized entity. As an efficient mimicker of pancreatic carcinoma, its early and appropriate recognition are crucial. With mounting understanding of its pathogenesis and natural history, significant advances ...

journal_title：World journal of gastroenterology

authors： Zandieh I,Byrne MF

更新日期：2007-12-21 00:00:00

abstract：AIM:It has been reported that regular consumption of nonsteroidal anti-inflammatory drugs like indomethacin decreases the incidence and mortality rate of a number of gastrointestinal cancers. We aimed to explore the efficacy and possible mechanisms of indomethacin on tumor growth and tumor angiogenesis of human colon c...

journal_title：World journal of gastroenterology

authors： Wang HM,Zhang GY

更新日期：2005-01-21 00:00:00

abstract：:The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745: (1) An actio...

journal_title：World journal of gastroenterology

authors： Czerucka D,Rampal P

更新日期：2019-05-14 00:00:00