Abstract:
AIM:To examine the potency of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) as a hepatic heme oxygenase-1 (HO-1) inducer and its regulation in HepG2 cells. METHODS:Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immunofluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAP/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS:PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, PGG induced Nrf2 nuclear translocation, which was found to be an upstream step of PGG-induced HO-1 expression, and ERK activation, of which pathway was involved in PGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION:PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-dependent manner, and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Pae HO,Oh GS,Jeong SO,Jeong GS,Lee BS,Choi BM,Lee HS,Chung HTdoi
10.3748/wjg.v12.i2.214keywords:
subject
Has Abstractpub_date
2006-01-14 00:00:00pages
214-21issue
2eissn
1007-9327issn
2219-2840journal_volume
12pub_type
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journal_title:World journal of gastroenterology
pub_type: 评论,信件
doi:10.3748/wjg.14.3105
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.3748/wjg.v22.i17.4403
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pub_type: 杂志文章
doi:10.3748/wjg.v26.i6.598
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 信件
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pub_type: 杂志文章,评审
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pub_type: 社论
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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