Correlation between expression and differentiation of endocan in colorectal cancer.

Abstract:

AIM:To investigate the expression frequency of endocan in colorectal cancer and analyze the relationship between endocan expression and clinical parameters and to study the role of endocan in colorectal carcinogenesis. METHODS:Expression of endocan in 72 tumor tissue samples of colorectal cancer as well as in 27 normal mucous membrane tissue samples was analyzed using in situ hybridization, immunohistochemistry on tissue microarray, Western blot and reverse-transcript polymerase chain reaction (RT-PCR). RESULTS:The expression of endocan was higher in normal colon and rectum tissue samples than in cancerous tissue samples (mRNA = 92.6%, protein = 36%), and was lower in colorectal cancer tissue samples (mRNA = 70.4%, protein = 36.1%). No correlation was found between staining intensity and clinical parameters such as sex, age, tumor size and TNM stage. However, the expression of endocan was positively correlated with the tissue differentiation in colorectal cancer. CONCLUSION:The expression of endocan is down-regulated in colorectal cancer and is positively correlated with the tissue differentiation in colorectal cancer, suggesting that the expression of endocan is associated with development and differentiation of colorectal cancer.

journal_name

World J Gastroenterol

authors

Zuo L,Zhang SM,Hu RL,Zhu HQ,Zhou Q,Gui SY,Wu Q,Wang Y

doi

10.3748/wjg.14.4562

subject

Has Abstract

pub_date

2008-07-28 00:00:00

pages

4562-8

issue

28

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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