Seropharmalogical effects of Fuzheng Huayu decoction on rat Ito cell morphology and function in culture.

Abstract:

AIM:To investigate the mechanisms of anti-liver fibrosis actions of Fuzheng Huayu (FZHY) decoction, which acts to strengthen the body's resistance and promote blood circulation. METHODS:Ito cells were isolated from rats and cultured. Serum samples were collected from healthy (normal) rats after administration of FZHY decoction and added to the subcultured cells. The effects of FZHY decoction on the Ito cells were investigated by contrast microscopy (to observe cell morphology), [(3)H]Pro incorporation assay (cell viability), [(3)H]TdR incorporation and MTT colorimetric assay (cell proliferation), and [(3)H]Pro incorporation and collagenase digestion (collagen synthesis rate). RESULTS:The rat sera samples from rats treated with FZHY decoction had no influence on Ito cell morphology, but improved cell viability and markedly inhibited cell proliferation and collagen synthesis. The magnitude of these effects showed dependence on treatment dosage and drug concentration in serum. CONCLUSION:The seropharmalogical method can be efficiently used to investigate the pharmacological mechanism of anti-fibrotic traditional Chinese herbs and formulae. Inhibition of Ito cell proliferation and collagen synthesis may be two of the major mechanisms underlying the anti-fibrosis actions of the FZHY decoction.

journal_name

World J Gastroenterol

authors

Liu CH,Liu C,Liu P,Xu LM

doi

10.3748/wjg.v3.i4.263

subject

Has Abstract

pub_date

1997-12-15 00:00:00

pages

263-5

issue

4

eissn

1007-9327

issn

2219-2840

journal_volume

3

pub_type

杂志文章
  • Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma.

    abstract:AIM:To investigate the role of neoadjuvant chemoradiotherapy in prognosis and surgery for esophageal carcinoma by a meta-analysis. METHODS:PubMed and manual searches were done to identify all published randomized controlled trials (RCTs) that compared neoadjuvant chemoradiotherapy plus surgery (CRTS) with surgery alon...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.15.4962

    authors: Lv J,Cao XF,Zhu B,Ji L,Tao L,Wang DD

    更新日期:2009-10-21 00:00:00

  • Combined en bloc liver/pancreas transplantation in two different patients.

    abstract::Combined en bloc liver/pancreas transplantation (CLPT) was used primarily in the treatment of otherwise non-resectable upper abdominal malignancy. In fact, a more appropriate indication is in patients with liver disease and insulin-dependent diabetes mellitus (IDDM). Here, we report on two successful cases of CLPT at ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2552

    authors: Chen ZS,Meng FY,Chen XP,Liu DG,Wei L,Jiang JP,Du DF,Zhang WJ,Ming CS,Gong NQ

    更新日期:2009-05-28 00:00:00

  • A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints.

    abstract:AIM:To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal complaints. METHODS:For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT sca...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i13.1981

    authors: Mizrahi M,Mintz Y,Rivkind A,Kisselgoff D,Libson E,Brezis M,Goldin E,Shibolet O

    更新日期:2005-04-07 00:00:00

  • Infections with Helicobacter pylori and challenges encountered in Africa.

    abstract::Helicobacter pylori (H. pylori) is the causative agent of gastritis, peptic ulcer disease, mucosa associated lymphoid tissue lymphoma and gastric cancer (GC). While this bacterium infects 50% of the world's population, in Africa its prevalence reach as high as 80% as the infection is acquired during childhood. Risk fa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i25.3183

    authors: Smith S,Fowora M,Pellicano R

    更新日期:2019-07-07 00:00:00

  • Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: a prospective serial study.

    abstract:AIM:To determine the resistance patterns of Helicobacter pylori (H. pylori) strains isolated from patients in Beijing and monitor the change of antibiotic resistance over time. METHODS:In this prospective, serial and cross-sectional study, H. pylori cultures were successfully obtained from 371 and 950 patients (never ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i9.2786

    authors: Zhang YX,Zhou LY,Song ZQ,Zhang JZ,He LH,Ding Y

    更新日期:2015-03-07 00:00:00

  • Paraneoplastic hyperinsulinism and secondary hypoglycaemia in a patient with advanced colon cancer: a rare association.

    abstract::We review the case of a 74-year-old patient with advanced colon cancer who suffered recurrent bouts of hypoglycemia. A state of inappropriate, non-suppressed hyperinsulinism in the presence of severe hypoglycemia was diagnosed. We finally discuss the known mechanisms behind fasting hypoglycemia in patients with advanc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.1952

    authors: Díaz R,Aparicio J,Mendizábal A,Faus M,Fleitas T,Aparisi F,Martín M

    更新日期:2008-03-28 00:00:00

  • Endoscopic trans-esophageal submucosal tunneling surgery: A new therapeutic approach for diseases located around the aorta ventralis.

    abstract:AIM:To assess the efficiency of endoscopic trans-esophageal submucosal tunneling surgery (EESTS) technique for diseases located around the aorta ventralis. METHODS:Nine pigs were assigned to EESTs. The procedures were as follows: First, a long esophageal submucosal tunnel was established. Second, full-thickness myotom...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i1.85

    authors: Xiong Y,Chen QQ,Chai NL,Jiao SC,Ling Hu EQ

    更新日期:2019-01-07 00:00:00

  • Ultrastructure of oval cells in children with chronic hepatitis B, with special emphasis on the stage of liver fibrosis: the first pediatric study.

    abstract:AIM:To investigate the ultrastructure of oval cells in children with chronic hepatitis B, with special emphasis on their location in areas of collagen fibroplasia. METHODS:Morphological investigations were conducted on biopsy material obtained from 40 children, aged 3-16 years with chronic hepatitis B. The stage of fi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i21.2918

    authors: Sobaniec-Lotowska ME,Lotowska JM,Lebensztejn DM

    更新日期:2007-06-07 00:00:00

  • Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles.

    abstract:AIM:To prepare the chitosan-pmEpo nanoparticles and to study their ability for transcellular and paracellular transport across intestinal epithelia by oral administration. METHODS:ICR mice were fed with recombinant plasmid AAV-tetO-CMV-mEpo (containing mEpo gene) or pCMVbeta(containing LacZ gene), whether it was wrapp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i1.112

    authors: Chen J,Yang WL,Li G,Qian J,Xue JL,Fu SK,Lu DR

    更新日期:2004-01-01 00:00:00

  • Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vitro and in vivo.

    abstract:AIM:To investigate the effects of adeno-associated virus (AAV) mediated expression of human interferon-gamma for gene therapy in experimental hepatic fibrosis in vitro and in vivo. METHODS:We constructed the recombinant AAV encoding human INF-gamma (rAAV- INF-gamma) and took the primary rat hepatic stellate cells and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i26.4045

    authors: Chen M,Wang GJ,Diao Y,Xu RA,Xie HT,Li XY,Sun JG

    更新日期:2005-07-14 00:00:00

  • Study on the anticarcinogenic effect and acute toxicity of liver-targeting mitoxantrone nanoparticles.

    abstract::AIM:To study the anticarcinogenic effect and acute toxicity of liver targeting mitoxantrone nanospheres.METHODS:The anticarcinogenic effect of mitoxan-trone polybutylcyanoacrylate nanoparticles (DHAQ-PBCA-NP) was investigated by using heterotopic and orthotopic transplantation models of human hepatocellular carcinoma ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v5.i6.511

    authors: Zhang ZR,He Q,Liao GT,Bai SH

    更新日期:1999-12-01 00:00:00

  • Laparoscopic cholecystectomy in situs inversus totalis with "inferior" cystic artery: a case report.

    abstract::A 76-year-old man with known situs inversus totalis presented with left-sided discomfort. Abdominal ultrasonography and CT scan confirmed the diagnosis of a gallstone, as well as, situs inversus; the liver and gallbladder on the left side and the spleen on the right. The biliary system was thought to be left-right rev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i33.5232

    authors: Kamitani S,Tsutamoto Y,Hanasawa K,Tani T

    更新日期:2005-09-07 00:00:00

  • Role of stress-activated MAP kinase P38 in cisplatin- and DTT-induced apoptosis of the esophageal carcinoma cell line Eca109.

    abstract:AIM:To study the role of P38 kinase in esophageal cancer cell apoptosis induced by genotoxin, cisplatin and the unfolded protein response (UPR) inducer, dithiothreitol (DTT). METHODS:Esophageal carcinoma cell line Eca109 was cultured in RPMI 1640 medium to 70% confluency and treated with either cisplatin, DTT, or cisp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i29.4451

    authors: Zhang QX,Feng R,Zhang W,Ding Y,Yang JY,Liu GH

    更新日期:2005-08-07 00:00:00

  • Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors.

    abstract::Hepatocellular carcinoma (HCC) is the fourth cause of cancer related mortality, and its incidence is rapidly increasing. Viral hepatitis, alcohol abuse, and exposure to hepatotoxins are major risk factors, but nonalcoholic fatty liver disease (NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i36.12945

    authors: Dongiovanni P,Romeo S,Valenti L

    更新日期:2014-09-28 00:00:00

  • Diagnosis and treatment of benign multicystic peritoneal mesothelioma.

    abstract::Benign multicystic peritoneal mesothelioma (BMPM) is a rare cystic mesothelial lesion that occurs predominantly in reproductive aged women. A 56-year-old Caucasian male was admitted to our surgical department with a chief complaint of a painful mass in his right lower abdomen for almost 2 years. The physical examinati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i39.6689

    authors: Wang TB,Dai WG,Liu DW,Shi HP,Dong WG

    更新日期:2013-10-21 00:00:00

  • Changes in the esophageal mucosa of patients with non erosive reflux disease: How far have we gone?

    abstract::The normal esophageal mucosa creates a protective epithelial barrier that constrains the acidic reflux in the esophageal lumen. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease (NERD) but not in patients with functional heartburn (FH)....

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v21.i19.5762

    authors: Triantos C,Koukias N,Karamanolis G,Thomopoulos K

    更新日期:2015-05-21 00:00:00

  • Pernicious anemia: new insights from a gastroenterological point of view.

    abstract::Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B(12) deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damag...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.15.5121

    authors: Lahner E,Annibale B

    更新日期:2009-11-07 00:00:00

  • Ambiguous roles of innate lymphoid cells in chronic development of liver diseases.

    abstract::Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v24.i18.1962

    authors: Shen Y,Li J,Wang SQ,Jiang W

    更新日期:2018-05-14 00:00:00

  • Construction and characterization of chimeric BHIV (BIV/HIV-1) viruses carrying the bovine immunodeficiency virus gag gene.

    abstract:AIM:To explore the possibility of the replacement of the gag gene between human immunodeficiency virus and bovine immunodeficiency virus, to achieve chimeric virions, and thereby gain a new kind of AIDS vaccine based on BHIV chimeric viruses. METHODS:A series of chimeric BHIV proviral DNAs differing in the replacement...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i17.2609

    authors: Zhu YX,Liu C,Liu XL,Qiao WT,Chen QM,Zeng Y,Geng YQ

    更新日期:2005-05-07 00:00:00

  • Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis.

    abstract::Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and a potential tendency to progress to ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i25.7683

    authors: Reshetnyak VI

    更新日期:2015-07-07 00:00:00

  • Protection of gastric mucosa from ethanol induced injury by recombinant epidermal growth factor in rats.

    abstract::AIM:To determine whether recombinant human epidermal growth factor (rhEGF) can protect gastric mucosa against ethanol induced injury in rats.METHOD: Fifty-four SD rats weighing 200g-500g each were divided into six groups after fasting for 24 hours.Three groups received different doses of oral rhEGF (30, 60 and 120&mgr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i5.437

    authors: Xu CD,Gan RB,Chen SN,Jiang SH,Xu JY

    更新日期:1998-10-01 00:00:00

  • Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes.

    abstract::Mesenteric venous thrombosis (MVT) is a rare but life threatening form of bowel ischemia. It is implicated in 6%-9% of all cases of acute mesenteric ischemia. The proportion of patients with primary (or idiopathic) MVT varies from 0% to 49%, with a decrease in frequency secondary to more recent availability of newer i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i43.7813

    authors: Karmacharya P,Aryal MR,Donato A

    更新日期:2013-11-21 00:00:00

  • Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions.

    abstract:AIM:To investigate the feasibility of detecting methylated fecal DNA as a screening tool for colorectal carcinoma (CRC) and precancerous lesions. METHODS:Methylated secreted frizzled-related protein gene 2 (SFRP2), hyperplastic polyposis protein gene (HPP1) and O6-methylguanine-DNA methyltransferase gene (MGMT) in sto...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i6.950

    authors: Huang ZH,Li LH,Yang F,Wang JF

    更新日期:2007-02-14 00:00:00

  • Dual specimens increase the diagnostic accuracy and reduce the reaction duration of rapid urease test.

    abstract:AIM:To evaluate the influence of multiple samplings during esophagogastroduodenoscopy (EGD) on the accuracy of the rapid urease test, and the validity of newly developed rapid urease tests, HelicotecUT plus test and HelicotecUT test, CLO test and ProntoDry test. METHODS:A total of 355 patients undergoing EGD for dyspe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i23.2926

    authors: Hsu WH,Wang SS,Kuo CH,Chen CY,Chang CW,Hu HM,Wang JY,Yang YC,Lin YC,Wang WM,Wu DC,Wu MT,Kuo FC

    更新日期:2010-06-21 00:00:00

  • Prognostic and predictive significance of MSI in stages II/III colon cancer.

    abstract::In colon cancer, classic disease staging remains the key prognosis and treatment determinant. Although adjuvant chemotherapy has an established role in stage III colon cancer patients, in stage II it is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i22.6809

    authors: Saridaki Z,Souglakos J,Georgoulias V

    更新日期:2014-06-14 00:00:00

  • Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient.

    abstract::Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract, first described in the pancreas in 1977 and in the duodenum in 1979. They may be functional and cause somatostatinoma or inhibitory syndrome, but more frequently are non-functioning pancreatic endocrine tumors that produce somatos...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5859

    authors: Colović RB,Matić SV,Micev MT,Grubor NM,Atkinson HD,Latincić SM

    更新日期:2009-12-14 00:00:00

  • Little girl who conquered the "ALPPS''.

    abstract::An insufficient future liver remnant (FLR) is associated with post-hepatectomy liver failure. Associating liver partition and portal vein ligation for stage hepatectomy (ALPPS) has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i29.10208

    authors: Chan A,Chung PH,Poon RT

    更新日期:2014-08-07 00:00:00

  • Role of microRNAs in gastric cancer.

    abstract::Although gastric cancer (GC) is one of the leading causes of cancer-related death, major therapeutic advances have not been made, and patients with GC still face poor outcomes. The prognosis of GC also remains poor because the molecular mechanisms of GC progression are incompletely understood. MicroRNAs (miRNAs) are n...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i19.5694

    authors: Ishiguro H,Kimura M,Takeyama H

    更新日期:2014-05-21 00:00:00

  • Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study.

    abstract:BACKGROUND:The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs, including the colon. Accordingly, studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i26.3814

    authors: Gonulcu SC,Unal B,Bassorgun IC,Ozcan M,Coskun HS,Elpek GO

    更新日期:2020-07-14 00:00:00

  • Dynamic changes of HBV DNA in serum and peripheral blood mononuclear cells of chronic hepatitis patients after lamivudine treatment.

    abstract:AIM:To study the dynamic changes of hepatitis B virus (HBV) DNA in serum and peripheral blood mononuclear cells (PBMCs) of patients after lamivudine therapy. METHODS:A total of 72 patients with chronic HBV infection were included in this study. All patients were confirmed to have the following conditions: above 16 yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v12.i25.4061

    authors: Ke CZ,Chen Y,Gong ZJ,Meng ZJ,Liu L,Ren ZJ,Zhou ZH

    更新日期:2006-07-07 00:00:00