Prognostic and predictive significance of MSI in stages II/III colon cancer.

abstract：AIM:CMU-1 is a new preservation solution with a low potassium concentration as well as low viscosity that is highly effective in reducing preservation injury. The purpose of this experiment is to compare the protective effect of CMU-1 solution with that of UW during cold preservation and normothermic reperfusion. METH...

journal_title：World journal of gastroenterology

authors： Cheng Y,Liu YF,Cheng DH,Li BF,Zhao N

更新日期：2005-04-28 00:00:00

abstract：:Colorectal adenocarcinoma (CRC) is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, ...

journal_title：World journal of gastroenterology

authors： de Noo ME,Tollenaar RA,Deelder AM,Bouwman LH

更新日期：2006-11-07 00:00:00

abstract：AIM:Heat shock protein (HSP)70 is over-expressed in human gastric cancer and plays an important role in the progression of this cancer. We investigated the effects of antisense HSP70 oligomer on human gastric cancer cell line SGC-7901, and its potential role in gene therapy for this cancer. METHODS:Human gastric cance...

journal_title：World journal of gastroenterology

authors： Zhao ZG,Shen WL

更新日期：2005-01-07 00:00:00

abstract：:AIM:To study the anticarcinogenic effect and acute toxicity of liver targeting mitoxantrone nanospheres.METHODS:The anticarcinogenic effect of mitoxan-trone polybutylcyanoacrylate nanoparticles (DHAQ-PBCA-NP) was investigated by using heterotopic and orthotopic transplantation models of human hepatocellular carcinoma ...

journal_title：World journal of gastroenterology

authors： Zhang ZR,He Q,Liao GT,Bai SH

更新日期：1999-12-01 00:00:00

abstract：AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for <2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to study its enzymatic activity...

journal_title：World journal of gastroenterology

authors： Zhuge J,Yu YN,Wu XD

更新日期：2004-01-15 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease in high-income countries and is associated with increased morbidity and mortality. Macrophages appear to play an important role in the development and progression of hepatic fibrosis in patients with NAFLD. Accordingly, modulation of macro...

journal_title：World journal of gastroenterology

authors： Neokosmidis G,Tziomalos K

更新日期：2018-12-28 00:00:00

abstract：AIM:To explore the mechanism for interactions of leptin with ghrelin and orexin in the arcuate nucleus (ARC) activating neuropeptide Y (NPY) neurons during physiological regulation of feeding. METHODS:Single neurons from ARC of adult rats with matured feeding function were isolated. [Ca2+]i was measured to monitor the...

journal_title：World journal of gastroenterology

authors： Kohno D,Suyama S,Yada T

更新日期：2008-11-07 00:00:00

abstract：AIM:To evaluate the effects of diazoxide on ischemia/reperfusion (I/R)-injured hepatocytes and further elucidate its underlying mechanisms. METHODS:Male Sprague-Dawley rats were randomized (8 for donor and recipient per group) into five groups: I/R group (4 h of liver cold ischemia followed by 6 h of reperfusion); hem...

journal_title：World journal of gastroenterology

authors： Zeng Z,Huang HF,He F,Wu LX,Lin J,Chen MQ

更新日期：2012-04-21 00:00:00

abstract：:To review the inhibitory effect of preventive approaches on recurrence after operation in patients with hepatocellular carcinoma (HCC), we summarized all available publications reporting randomized control trial indexed in PubMed. The treatment approaches presented above included pre-operative transcatheter arterial c...

journal_title：World journal of gastroenterology

authors： Sun HC,Tang ZY

更新日期：2003-04-01 00:00:00

abstract：AIM:To establish a quantitative method to measure the amount of lipids. METHODS:The livers of 53 male Wistar rats (225 g) with different degrees of hepatic steatosis were studied. This model of hepatic steatosis was based on a high carbohydrate, fat-free modified diet. Biopsies were classified into four grades dependi...

journal_title：World journal of gastroenterology

authors： Hijona E,Hijona L,Larzabal M,Sarasqueta C,Aldazabal P,Arenas J,Bujanda L

更新日期：2010-03-28 00:00:00

abstract：AIM:To investigate the effect of fermented soy milk on human ecosystem in the intestinal tract by way of examining the population of different microorganisms isolated from fecal samples. METHODS:A crossover experimental design was applied. Twenty-eight healthy adults completed this experiment. Each subject consumed 25...

journal_title：World journal of gastroenterology

authors： Cheng IC,Shang HF,Lin TF,Wang TH,Lin HS,Lin SH

更新日期：2005-02-28 00:00:00

abstract：AIM:To investigate the acute toxicity, phytochemical profile, antidiarrheal activity and mechanisms of action of Maytenus erythroxylon (M. erythroxylon) ethanol extract. METHODS:A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity. Intestinal transit and gastric emptying protocols were used ...

journal_title：World journal of gastroenterology

authors： Formiga RO,Quirino ZGM,Diniz MFFM,Marinho AF,Tavares JF,Batista LM

更新日期：2017-06-28 00:00:00

abstract：AIM:To evaluate the association between acid suppressive drug use and the development of gastric cancer. METHODS:A systematic search of relevant studies that were published through June 2012 was conducted using the MEDLINE (PubMed), EMBASE, and Cochrane Library databases. The search included observational studies on t...

journal_title：World journal of gastroenterology

authors： Ahn JS,Eom CS,Jeon CY,Park SM

更新日期：2013-04-28 00:00:00

abstract：:Patients with ulcerative colitis (UC) and Crohn's disease (CD) are at increased risk for developing colorectal cancer (CRC), and this is believed to be a result of chronic inflammation. Although conclusive evidence is still missing, both epidemiological and experimental observations suggest that certain drugs used to ...

journal_title：World journal of gastroenterology

authors： Stolfi C,Pellegrini R,Franze E,Pallone F,Monteleone G

更新日期：2008-07-28 00:00:00

abstract：AIM:To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS:The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed us...

journal_title：World journal of gastroenterology

authors： Frokjaer JB,Andersen SD,Ejskjaer N,Funch-Jensen P,Drewes AM,Gregersen H

更新日期：2007-09-28 00:00:00

abstract：AIM:To evaluate the usefulness of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) in differentiating between pancreatic adenocarcinomas and other pancreatic disease. METHODS:This retrospective cohort study evaluated 90 patients who were seen between November 2010 and May 2013. All these patients had solid pa...

journal_title：World journal of gastroenterology

authors： Park JS,Kim HK,Bang BW,Kim SG,Jeong S,Lee DH

更新日期：2014-01-14 00:00:00

abstract：AIM:To determine the immune-modulatory and the hepatoprotective effects of oral administration of two soy extracts in immune mediated liver injury and non-alcoholic steatohepatitis (NASH). METHODS:Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to hig...

journal_title：World journal of gastroenterology

authors： Khoury T,Ben Ya'acov A,Shabat Y,Zolotarovya L,Snir R,Ilan Y

更新日期：2015-06-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual occurrence of one million new cases. An etiologic association between HBV infection and the development of HCC has been established with a relative risk 200-fold greater than in non-infected individuals. Hepatitis C virus is...

journal_title：World journal of gastroenterology

authors： Delis SG,Dervenis C

更新日期：2008-06-14 00:00:00

abstract：AIM:To investigate the effect of Danzhijiangtang capsule (DJC) on monocyte chemoattractant protein-1 (MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus (T2DM) subclinical vascular lesions. METHODS:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a co...

journal_title：World journal of gastroenterology

authors： Fang ZH,Liu Y,Bao TT,Ni YQ,Liu J,Shi GB,Wu JP,Yang JP,Zhang H

更新日期：2013-05-21 00:00:00

abstract：:Bone metastases from gastric cancer (GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells (MCs) positive to tryptase...

journal_title：World journal of gastroenterology

authors： Leporini C,Ammendola M,Marech I,Sammarco G,Sacco R,Gadaleta CD,Oakley C,Russo E,De Sarro G,Ranieri G

更新日期：2015-10-07 00:00:00

abstract：:The role of whole-body FDG [((18)F) 2-fluoro-2-deoxyglucose] positron emission tomography (PET) scanning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two decades. FDG-PET has demonstrated significant efficacy in the staging, prognostication and detection of ...

journal_title：World journal of gastroenterology

authors： Smyth EC,Shah MA

更新日期：2011-12-14 00:00:00

abstract：:The KRAS oncogene is mutated in approximately 35%-45% of colorectal cancers, and KRAS mutational status testing has been highlighted in recent years. The most frequent mutations in this gene, point substitutions in codons 12 and 13, were validated as negative predictors of response to anti-epidermal growth factor rece...

journal_title：World journal of gastroenterology

authors： Tan C,Du X

更新日期：2012-10-07 00:00:00

abstract：:Many epidemiological reports indicate that Helicobacter pylori (H pylori) infection plays an important role in gastric carcinogenesis. Several genetic and epigenetic alterations contribute to the initiation, promotion, and progression of the cancer cells in a multi-step manner. H pylori is known to induce chronic infl...

journal_title：World journal of gastroenterology

authors： Ito M,Tanaka S,Kamada T,Haruma K,Chayama K

更新日期：2006-01-07 00:00:00

abstract：AIM:To study the effect of nicotine on the migration and invasion of human esophageal squamous carcinoma cells and to investigate whether nimesulide can inhibit the effect of nicotine. METHODS:The esophageal squamous carcinoma cell line (TE-13) was treated with different concentrations of nicotine (100 microg/mL and 2...

journal_title：World journal of gastroenterology

authors： Zong Y,Zhang ST,Zhu ST

更新日期：2009-05-28 00:00:00

abstract：AIM:To investigate the clinical value of ultrasonographic diagnosis of biliary atresia (BA), a retrospective analysis of the sonogram of 20 children with BA was undertaken. METHODS:Ultrasonography (US) was performed in 20 neonates and infants with BA, which was confirmed with cholangiography by operation or abdominosc...

journal_title：World journal of gastroenterology

authors： Li SX,Zhang Y,Sun M,Shi B,Xu ZY,Huang Y,Mao ZQ

更新日期：2008-06-14 00:00:00

abstract：AIM:To establish the rapid, specific, and sensitive method for detecting O157:H7 with DNA microchips. METHODS:Specific oligonucleotide probes (26-28 nt) of bacterial antigenic and virulent genes of E. coli O157:H7 and other related pathogen genes were pre-synthesized and immobilized on a solid support to make microchi...

journal_title：World journal of gastroenterology

authors： Jin HY,Tao KH,Li YX,Li FQ,Li SQ

更新日期：2005-10-07 00:00:00

abstract：AIM:To study the epidemiology of gastric malignancies in Jordan as a model for Middle East countries where such data is scarce. METHODS:Pertinent epidemiological and clinicopathological data for 201 patients with gastric malignancy in north of Jordan between 1991 and 2001 were analyzed. RESULTS:Male: female ratio was...

journal_title：World journal of gastroenterology

authors： Bani-Hani KE,Yaghan RJ,Heis HA,Shatnawi NJ,Matalka II,Bani-Hani AM,Gharaibeh KA

更新日期：2004-08-01 00:00:00

abstract：AIM:To explore the effects of peptide S-8300 from shark liver (S-8300) on liver function as well as in regulating immune functions in experimental injury models. METHODS:Mice were administered with different doses of S-8300 for four consecutive days, followed by mice injected with tetrachloromethane (CCl(4)) on d 3. T...

journal_title：World journal of gastroenterology

authors： Huang FJ,Lv ZB,Li Q,Wei LJ,Zhang L,Wu WT

更新日期：2005-03-28 00:00:00

abstract：AIM:To classify gallstone disease as a basis for assessment of post-cholecystectomy symptoms. METHODS:One hundred and fifty three patients with a clinical and ultrasonographic diagnosis of gallstones filled out a structured questionnaire on abdominal pain symptoms and functional gastrointestinal disorder (FGID) before...

journal_title：World journal of gastroenterology

authors： Schmidt M,Søndenaa K,Dumot JA,Rosenblatt S,Hausken T,Ramnefjell M,Njølstad G,Eide GE

更新日期：2012-03-28 00:00:00

abstract：AIM:To investigate the feasibility of a single-use endoscopy as an alternative procedure to nasogastric lavage in patients with acute gastrointestinal (GI) bleeding. METHODS:Patients who presented with hematemesis, melena or hematochezia were enrolled in this study. EG scan™ and conventional esophagogastroduodenoscopy...

journal_title：World journal of gastroenterology

authors： Cho JH,Kim HM,Lee S,Kim YJ,Han KJ,Cho HG,Song SY

更新日期：2013-01-07 00:00:00