KRAS mutation testing in metastatic colorectal cancer.

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer. Despite advances in diagnostic techniques during the past decade, cholangiocarcinoma is usually encountered at an advanced stage. In this review, we describe the classification, diagnosis, and initial management of cholangiocarcinoma with obstructive...

journal_title：World journal of gastroenterology

authors： Tajiri T,Yoshida H,Mamada Y,Taniai N,Yokomuro S,Mizuguchi Y

更新日期：2008-05-21 00:00:00

abstract：AIM:To investigate the effect of pituitary homeobox 1 (PITX1) expression in cases of human gastric cancer on cancer differentiation and progression, and carcinogenesis. METHODS:Using polyclonal PITX1 antibodies, we studied the expression of PITX1 in normal gastric mucosa, atypical hyperplasia, intestinal metaplasia, a...

journal_title：World journal of gastroenterology

authors： Chen YN,Chen H,Xu Y,Zhang X,Luo Y

更新日期：2008-01-14 00:00:00

abstract：AIM:Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this study was to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or ...

journal_title：World journal of gastroenterology

authors： Molnár T,Tiszlavicz L,Gyulai C,Nagy F,Lonovics J

更新日期：2005-05-28 00:00:00

abstract：:Alcohol-induced fatty liver (steatosis) was believed to result from excessive generation of reducing equivalents from ethanol metabolism, thereby enhancing fat accumulation. Recent findings have revealed a more complex picture in which ethanol oxidation is still required, but specific transcription as well as humoral ...

journal_title：World journal of gastroenterology

authors： Donohue TM Jr

更新日期：2007-10-07 00:00:00

abstract：BACKGROUND:People with achalasia typically have a thick lower esophageal muscularis propria (LEMP), and peroral endoscopic myotomy (POEM) has been effective in treating most patients. LEMP thickness may be associated with the outcomes and prognosis after POEM. However, more evidence is needed regarding the relationship...

journal_title：World journal of gastroenterology

authors： Liao Y,Xiao TY,Wu YF,Zhang JJ,Zhang BZ,Wang YD,Wang S,Liu X,Sun SY,Guo JT

更新日期：2020-10-14 00:00:00

abstract：AIM:To compare natural orifice transluminal endoscopic surgery (NOTES) vs standard laparoscopic ovariectomy in mini pigs with respect to technical aspects, complications and parameters of systemic inflammatory response. METHODS:This was a randomized, experimental, survival study. Ten female mini pigs underwent NOTES t...

journal_title：World journal of gastroenterology

authors： Martínek J,Ryska O,Filípková T,Doležel R,Juhas S,Motlík J,Holubová M,Nosek V,Rotnáglová B,Zavoral M,Ryska M

更新日期：2012-07-21 00:00:00

abstract：:Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of the liver by initiating complex pathological events characterized by steatosis, steatohepatitis, hepatic fibrosis and cirrhosis. Subsequently, these initial pathological events are sustained and ushered into a more complex and p...

journal_title：World journal of gastroenterology

authors： Boye A,Zou YH,Yang Y

更新日期：2016-01-07 00:00:00

abstract：AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by en...

journal_title：World journal of gastroenterology

authors： Ishihara R,Kanzaki H,Iishi H,Nagai K,Matsui F,Yamashina T,Matsuura N,Ito T,Fujii M,Yamamoto S,Hanaoka N,Takeuchi Y,Higashino K,Uedo N,Tatsuta M,Tomita Y,Ishiguro S

更新日期：2013-07-21 00:00:00

abstract：AIM:To prepare and characterize polyclonal antibodies against aldose reductase-like (ARL-1) protein. METHODS:ARL-1 gene was inserted into the E. coli expression vector pGEX-4T-1(His)(6)C and vector pQE-30. Recombinant ARL-1 proteins named ARL-(His)(6) and ARL-GST were expressed. They were purified by affinity chromato...

journal_title：World journal of gastroenterology

authors： Jin JF,Yuan LD,Liu L,Zhao ZJ,Xie W

更新日期：2003-07-01 00:00:00

abstract：AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease (GERD) and dyspepsia in South America. METHODS:A telephone survey was conducted among adult owners of land-based telephones in São Paulo, Brazil, using previously validated computer-assisted sampling and survey protocols. The ...

journal_title：World journal of gastroenterology

authors： do Rosário Dias de Oliveira Latorre M,Medeiros da Silva A,Chinzon D,Eisig JN,Dias-Bastos TR

更新日期：2014-12-14 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fourth cause of cancer related mortality, and its incidence is rapidly increasing. Viral hepatitis, alcohol abuse, and exposure to hepatotoxins are major risk factors, but nonalcoholic fatty liver disease (NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is...

journal_title：World journal of gastroenterology

authors： Dongiovanni P,Romeo S,Valenti L

更新日期：2014-09-28 00:00:00

abstract：AIM:To examine the potency of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) as a hepatic heme oxygenase-1 (HO-1) inducer and its regulation in HepG2 cells. METHODS:Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immunofluore...

journal_title：World journal of gastroenterology

authors： Pae HO,Oh GS,Jeong SO,Jeong GS,Lee BS,Choi BM,Lee HS,Chung HT

更新日期：2006-01-14 00:00:00

abstract：AIM:To evaluate the potential role of Nimesulide, a selective COX-2 inhibitor, in proliferation and apoptosis of gastric adenocarcinoma cells SGC7901. METHODS:Cell counts and MTT assay were used to quantify the influence of Nimesulide in the proliferation of SGC7901 cells. Transmission electron microscopy and flow cyt...

journal_title：World journal of gastroenterology

authors： Li JY,Wang XZ,Chen FL,Yu JP,Luo HS

更新日期：2003-05-01 00:00:00

abstract：AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

journal_title：World journal of gastroenterology

authors： Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

更新日期：2006-10-21 00:00:00

abstract：AIM:To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS:Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC ...

journal_title：World journal of gastroenterology

authors： Sheen IS,Jeng KS,Wang PC,Shih SC,Chang WH,Wang HY,Chen CC,Shyung LR

更新日期：2004-10-01 00:00:00

abstract：AIM:To determine factors associated with fibrosis progression in hepatitis C virus (HCV)-infected patients without significant initial pathological lesions. METHODS:Seventy six untreated HCV-infected patients with initially normal liver as defined by a Knodell score < or = 3, with 2 liver biopsies and detectable HCV-R...

journal_title：World journal of gastroenterology

authors： Sobesky R,Lebray P,Nalpas B,Vallet-Pichard A,Fontaine H,Lagneau JL,Pol S

更新日期：2008-06-28 00:00:00

abstract：:A 33-year-old woman who presented with epigastric discomfort and diarrhea underwent an abdominal ultrasound (US). This investigation and subsequent contrast-enhanced computed tomography, magnetic resonance imaging and endoscopic US with fine needle aspiration (FNA) revealed a 40 mm well-circumscribed mass in the uncin...

journal_title：World journal of gastroenterology

authors： Poves I,Burdío F,Iglesias M,Martínez-Serrano Mde L,Aguilar G,Grande L

更新日期：2009-09-14 00:00:00

abstract：AIM:To investigate the prevalence of gastroesophageal reflux disease (GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux (LPR). METHODS:Between May 2011 and October 2011, 41 consecutive patients with laryngopharyngeal symptoms (LPS) and laryngoscopic diagnosis of LPR were empirically treated ...

journal_title：World journal of gastroenterology

authors： de Bortoli N,Nacci A,Savarino E,Martinucci I,Bellini M,Fattori B,Ceccarelli L,Costa F,Mumolo MG,Ricchiuti A,Savarino V,Berrettini S,Marchi S

更新日期：2012-08-28 00:00:00

abstract：:A preduodenal portal vein (PDPV) is known to be a rare cause of duodenal stenosis. We treated a 22-year-old male patient with malnutrition as a result of PDPV and a previously performed operation for scoliosis, who showed an improvement in quality of life after being treated with a combination of nutritional support a...

journal_title：World journal of gastroenterology

authors： Masumoto K,Teshiba R,Esumi G,Nagata K,Nakatsuji T,Nishimoto Y,Yamaguchi S,Sumitomo K,Taguchi T

更新日期：2009-08-21 00:00:00

abstract：AIM:To compare the effect of intravenous and oral omeprazole in patients with bleeding peptic ulcers without high-risk stigmata. METHODS:This randomized study included 211 patients [112 receiving iv omeprazole protocol (Group 1), 99 receiving po omeprazole 40 mg every 12 h (Group 2)] with a mean age of 52.7. In 144 pa...

journal_title：World journal of gastroenterology

authors： Yilmaz S,Bayan K,Tüzün Y,Dursun M,Canoruç F

更新日期：2006-12-28 00:00:00

abstract：:Laparoscopic gastrectomy has been widely accepted as a standard alternative for the treatment of early-stage gastric adenocarcinoma because of its favorable short-term outcomes. Although controversies exist, such as establishing clear indications, proper preoperative staging, and oncologic safety, experienced surgeons...

journal_title：World journal of gastroenterology

authors： Son T,Hyung WJ

更新日期：2016-01-14 00:00:00

abstract：AIM:To develop a potent and safe gene therapy for esophageal cancer. METHODS:An expression vector carrying fusion suicide gene (yCDglyTK) and shRNA against vascular endothelial growth factor (VEGF) was constructed and delivered into EC9706 esophageal cancer cells by calcium phosphate nanoparticles (CPNP). To achieve t...

journal_title：World journal of gastroenterology

authors： Liu T,Wu HJ,Liang Y,Liang XJ,Huang HC,Zhao YZ,Liao QC,Chen YQ,Leng AM,Yuan WJ,Zhang GY,Peng J,Chen YH

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Progressive familial intrahepatic cholestasis (PFIC) encompasses a group of autosomal recessive disorders with high morbidity and mortality. Variants in the gene encoding tight junction protein-2 (TJP2) have been linked to PFIC type 4 (PFIC4), which predominantly presents in childhood. However, there are onl...

journal_title：World journal of gastroenterology

authors： Wei CS,Becher N,Friis JB,Ott P,Vogel I,Grønbæk H

更新日期：2020-02-07 00:00:00

abstract：:Repeated surveys from Europe, the United States, Australia, and New Zealand have shown that adherence to an evidence-based perioperative care protocol, such as Enhanced Recovery After Surgery (ERAS), has been generally low. It is of great importance to support the implementation of the ERAS protocol as it has been sho...

journal_title：World journal of gastroenterology

authors： Segelman J,Nygren J

更新日期：2014-11-28 00:00:00

abstract：AIM:To explore the genetic diversities of UL144 open reading frame (ORF) of cytomegalovirus DNA detected in colon tissue from infants with Hirschsprung's disease (HD) by sequencing UL144 DNA in 23 aganglionic colon tissue and 4 urine samples from 25 HD infants. METHODS:Nest PCR was performed for amplification of the U...

journal_title：World journal of gastroenterology

authors： Mao ZQ,Huang Y,Sun M,Ruan Q,Qi Y,He R,Huang YJ,Ma YP,Ji YH,Sun ZR,Gao H

更新日期：2007-08-28 00:00:00

abstract：:Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases (LM) from neuroendocrine neoplasms (NEN), and minimally invasive, liver-directed therapies are gaining increasing interest. Catheter-based treatments are used in disseminated disease, whereas ablation techniques are usually in...

journal_title：World journal of gastroenterology

authors： Sartori S,Bianchi L,Di Vece F,Tombesi P

更新日期：2020-06-21 00:00:00

abstract：AIM:To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS:A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus, hypertension, hepatolithiasis, primary sclerosing cholangitis, li...

journal_title：World journal of gastroenterology

authors： Zhou YM,Yin ZF,Yang JM,Li B,Shao WY,Xu F,Wang YL,Li DQ

更新日期：2008-01-28 00:00:00

abstract：AIM:To characterize the biochemical and immunological properties of an experimental ISCOMS vaccine prepared from a novel therapeutic polypeptide based on T cell epitopes of HBsAg, and a heptatis B-ISCOMS was prepared and investigated. METHODS:An immunostimulating complexes(ISCOMS)-based vaccine containing a novel ther...

journal_title：World journal of gastroenterology

authors： Guan XJ,Guan XJ,Wu YZ,Jia ZC,Shi TD,Tang Y

更新日期：2002-04-01 00:00:00

abstract：AIM:To investigate the role of neoadjuvant chemoradiotherapy in prognosis and surgery for esophageal carcinoma by a meta-analysis. METHODS:PubMed and manual searches were done to identify all published randomized controlled trials (RCTs) that compared neoadjuvant chemoradiotherapy plus surgery (CRTS) with surgery alon...

journal_title：World journal of gastroenterology

authors： Lv J,Cao XF,Zhu B,Ji L,Tao L,Wang DD

更新日期：2009-10-21 00:00:00

abstract：:Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer (GC) at an early stage. Due to the low incidence of lymph node metastasis and favorable prognosis in early GC, function-preserving surgery which improves postoperative quality of life may be possible. Pylorus-preserving gastrectomy (...

journal_title：World journal of gastroenterology

authors： Saito T,Kurokawa Y,Takiguchi S,Mori M,Doki Y

更新日期：2014-12-14 00:00:00