Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism.


AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pink-color sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range: 2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI: 5.5-632). Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pink-color positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining.


World J Gastroenterol


Ishihara R,Kanzaki H,Iishi H,Nagai K,Matsui F,Yamashina T,Matsuura N,Ito T,Fujii M,Yamamoto S,Hanaoka N,Takeuchi Y,Higashino K,Uedo N,Tatsuta M,Tomita Y,Ishiguro S




Has Abstract


2013-07-21 00:00:00












  • Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review.

    abstract::Vanishing bile duct syndrome (VBDS) has been described in different pathologic conditions including infection, ischemia, adverse drug reactions, autoimmune diseases, allograft rejection, and humoral factors associated with malignancy. It is an acquired condition characterized by progressive destruction and loss of the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Bakhit M,McCarty TR,Park S,Njei B,Cho M,Karagozian R,Liapakis A

    更新日期:2017-01-14 00:00:00

  • Pancreatitis in hand-foot-and-mouth disease caused by enterovirus 71.

    abstract::Some viruses, including certain members of the enterovirus genus, have been reported to cause pancreatitis, especially Coxsackie virus. However, no case of human enterovirus 71 (EV71) associated with pancreatitis has been reported so far. We here report a case of EV71-induced hand-foot-and-mouth disease (HFMD) present...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhang YF,Deng HL,Fu J,Zhang Y,Wei JQ

    更新日期:2016-02-14 00:00:00

  • Combination of allopurinol and hyperbaric oxygen therapy: a new treatment in experimental acute necrotizing pancreatitis?

    abstract:AIM:To investigate the individual and combined effects of allopurinol and hyperbaric oxygen (HBO) therapy on biochemical and histopathological changes, oxidative stress, and bacterial translocation (BT) in the experimental rat acute pancreatitis (AP). METHODS:Eighty-five Sprague-Dawley rats were included in the study....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Comert B,Isik AT,Aydin S,Bozoglu E,Unal B,Deveci S,Mas N,Cinar E,Mas MR

    更新日期:2007-12-14 00:00:00

  • In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy.

    abstract::Recently, the use of confocal laser endomicroscopy (CLE) in the diagnosis of chronic ulcerative colitis (CUC) was reported. In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC. The study involved a patient presenting long-standing CUC. Confocal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: De Palma GD,Staibano S,Siciliano S,Maione F,Siano M,Esposito D,Persico G

    更新日期:2011-02-07 00:00:00

  • Hepatic failure caused by plasma cell infiltration in multiple myeloma.

    abstract::Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma (MM), it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with ka...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Rahhal FE,Schade RR,Nayak A,Coleman TA

    更新日期:2009-04-28 00:00:00

  • Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation.

    abstract:AIM:Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS:A reporter gene system in HT-29 cells was used to measure levels of NF-kappaB activation after challenge with bifid...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Riedel CU,Foata F,Philippe D,Adolfsson O,Eikmanns BJ,Blum S

    更新日期:2006-06-21 00:00:00

  • Helicobacter pylori infection: new pathogenetic and clinical aspects.

    abstract::Helicobacter pylori (H. pylori) infects more than half of the world's human population, but only 1% to 3% of infected people consequently develop gastric adenocarcinomas. The clinical outcome of the infection is determined by host genetic predisposition, bacterial virulence factors, and environmental factors. The asso...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Hagymási K,Tulassay Z

    更新日期:2014-06-07 00:00:00

  • Stroke and dilated cardiomyopathy associated with celiac disease.

    abstract::Celiac disease (CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life. Neurological symptoms without signs of malabsorption have been observed for a long time in CD. In this report, an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Doğan M,Peker E,Cagan E,Akbayram S,Acikgoz M,Caksen H,Uner A,Cesur Y

    更新日期:2010-05-14 00:00:00

  • Transforming growth factor-beta and fibrosis.

    abstract::Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Verrecchia F,Mauviel A

    更新日期:2007-06-14 00:00:00

  • Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide.

    abstract:AIM:To investigate the effects and mechanisms of melatonin on immunological liver injury in mice. METHODS:A model of liver injury was induced by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice. Kupffer cells and hepatocytes were isolated and cultured according to a modified t...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang H,Wei W,Shen YX,Dong C,Zhang LL,Wang NP,Yue L,Xu SY

    更新日期:2004-09-15 00:00:00

  • Liver bioengineering: current status and future perspectives.

    abstract::The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes. There are two general pathways to liver bioengineering and regeneration. The first consists of creating a supporting scaffold, either synthetically or by decellularization of human...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Booth C,Soker T,Baptista P,Ross CL,Soker S,Farooq U,Stratta RJ,Orlando G

    更新日期:2012-12-21 00:00:00

  • Achieving the best bowel preparation for colonoscopy.

    abstract::Bowel preparation is a core issue in colonoscopy, as it is closely related to the quality of the procedure. Patients often find that bowel preparation is the most unpleasant part of the examination. It is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic lesions. In spi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Parra-Blanco A,Ruiz A,Alvarez-Lobos M,Amorós A,Gana JC,Ibáñez P,Ono A,Fujii T

    更新日期:2014-12-21 00:00:00

  • Acute appendicitis following endoscopic mucosal resection of cecal adenoma.

    abstract::Endoscopic mucosal resection (EMR) allows the removal of flat or sessile lesions, laterally spreading tumors, and carcinoma of the colon or the rectum limited to the mucosa or the superficial submucosa. Acute appendicitis is the most common abdominal emergency requiring emergency surgery, and it is also a rare complic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Nemoto Y,Tokuhisa J,Shimada N,Gomi T,Maetani I

    更新日期:2015-07-21 00:00:00

  • Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats.

    abstract:AIM:To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS:Rats were randomly assigned to three groups: group I: control, group II: experimental colitis, group III: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necro...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Akcan A,Kucuk C,Sozuer E,Esel D,Akyildiz H,Akgun H,Muhtaroglu S,Aritas Y

    更新日期:2008-02-14 00:00:00

  • Rupture of abdominal aortic aneurysm into sigmoid colon: a case report.

    abstract::Primary aorto-colic fistula is rarely reported in the literature. Although infrequently encountered, it is an important complication since it is usually fatal unless detected. Primary aorto-colic fistula is a spontaneous rupture of abdominal aortic aneurysm into the lumen of the adjacent colon loop. Here we report a c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Aksoy M,Yanar H,Taviloglu K,Ertekin C,Ayalp K,Yanar F,Guloglu R,Kurtoglu M

    更新日期:2006-12-14 00:00:00

  • Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound.

    abstract:AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

    更新日期:2012-02-14 00:00:00

  • Multimodality magnetic resonance imaging in hepatic encephalopathy: an update.

    abstract::Hepatic encephalopathy (HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying factors which contribute to the neurol...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zhang XD,Zhang LJ,Wu SY,Lu GM

    更新日期:2014-08-28 00:00:00

  • Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease.

    abstract:AIM:To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease (IBD) risk among Moroccan patients. METHODS:The distribution of (TAAA)n_rs12720460 and (CCTTT)n _rs3833912 NOS2A microsatellite repeats, HIF-1A_rs11549467 and NFKB1-94ins/delATTG_rs28362491 was analyzed in 50...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Senhaji N,Nadifi S,Zaid Y,Serrano A,Rodriguez DAL,Serbati N,Karkouri M,Badre W,Martín J

    更新日期:2017-12-21 00:00:00

  • Effect of liver regeneration on malignant hepatic tumors.

    abstract::Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Shi JH,Line PD

    更新日期:2014-11-21 00:00:00

  • Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

    abstract:BACKGROUND:It is unclear whether immune escape-associated mutations in the major hydrophilic region of hepatitis B virus surface antigen (HBsAg) are associated with nucleoside/nucleotide analog resistance. AIM:To evaluate the association between immune escape-associated mutations and nucleoside/nucleotide analog resis...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Huang BX,Liu Y,Fan ZP,Si LL,Chen RJ,Wang J,Luo D,Wang FS,Xu DP,Liu XG

    更新日期:2020-09-21 00:00:00

  • DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese.

    abstract:AIM:To investigate the relationship between 579 G>T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of esophagus cancer (EC) in Chinese. METHODS:DNMT3B 579 G>T genotypes were determined by PCR-RFLP in 194 EC patients and 210 healthy controls matched for age and s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Fan H,Liu DS,Zhang SH,Hu JB,Zhang F,Zhao ZJ

    更新日期:2008-04-14 00:00:00

  • Overexpression of HBxAg in hepatocellular carcinoma and its relationship with Fas/FasL system.

    abstract:AIM:To study the expression and serum level of HBxAg, Fas and FasL in tissues of HCC patients, and to assess the relationship between HBxAg and Fas/FasL system. METHODS:Tissues from 50 patients with HCC were tested for the expression of HBxAg, Fas and FasL by S-P immunohistochemistry. Serum levels of sFas/sFasL and HB...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang XZ,Chen XC,Chen YX,Zhang LJ,Li D,Chen FL,Chen ZX,Chen HY,Tao QM

    更新日期:2003-12-01 00:00:00

  • Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance.

    abstract::The efficacy of triple therapy for Helicobacter pylori infection has dramatically declined over the last decade, largely related to increasing clarithromycin resistance rates. From a microbiological standpoint, bismuth quadruple therapy is the ideal replacement since it combines drugs for which resistance does not imp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Molina-Infante J,Gisbert JP

    更新日期:2014-08-14 00:00:00

  • Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis: a report of 46 cases.

    abstract:AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics of colonic schistosomiasis in order to further improve our understanding of the disease and decrease its misdiagnosis. METHODS:Endoscopy findings and clinicopathologic characteristics of 46 intestinal schistosomiasis patie...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Cao J,Liu WJ,Xu XY,Zou XP

    更新日期:2010-02-14 00:00:00

  • Current hurdles in the management of eosinophilic oesophagitis: the next steps.

    abstract::Eosinophilic oesophagitis (EoE) is a chronic, antigen mediated disease of the disease of the oesophagus that may present in both adults and children. It is characterised by intermittent dysphagia, food bolus obstruction and weight loss. The pathogenesis is incompletely understood but is thought to culminate in poor co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Attwood SE,Wilson MS

    更新日期:2013-02-14 00:00:00

  • H pylori and host interactions that influence pathogenesis.

    abstract::H. pylori is probably the most prevalent human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H. pylori has also been implicated in gastric carcinoma and was classified as a class I carcinogen. In the last two decades, a notew...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审


    authors: Beswick EJ,Suarez G,Reyes VE

    更新日期:2006-09-21 00:00:00

  • Tumor necrosis factor-α inhibitors and chronic hepatitis C: a comprehensive literature review.

    abstract::Tumor necrosis factor-α (TNF-α) inhibitors are known to increase reactivation of concurrent chronic hepatitis B, but their impact on the hepatitis C virus (HCV) is controversial. Some conditions of immunosuppression, such as liver transplantation, typically cause an increase in the rate of HCV evolution. Inhibition of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Pompili M,Biolato M,Miele L,Grieco A

    更新日期:2013-11-28 00:00:00

  • Clinicopathological and biological significance of cripto overexpression in human colon cancer.

    abstract:AIM:To assess the clinicopathological and biological significance of cripto in human colorectal cancer. METHODS:Real-time reverse-transcription polymerase chain reaction (PCR) was used to examine cripto mRNA levels in primary colon cancer and normal colon tissues as well as normal and metastatic lymph nodes from colon...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Jiang PC,Zhu L,Fan Y,Zhao HL

    更新日期:2013-12-14 00:00:00

  • Hepatoid adenocarcinoma of the stomach: a report of three cases.

    abstract::Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ye MF,Tao F,Liu F,Sun AJ

    更新日期:2013-07-21 00:00:00

  • Analysis of ABC (D) stratification for screening patients with gastric cancer.

    abstract:AIM:To evaluate the value of ABC (D) stratification [combination of serum pepsinogen and Helicobacter pylori (H. pylori) antibody] of patients with gastric cancer. METHODS:Ninety-five consecutive patients with gastric cancer were enrolled into the study. The serum pepsinogen I (PG I)/pepsinogen II (PG II) and H. pylor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kudo T,Kakizaki S,Sohara N,Onozato Y,Okamura S,Inui Y,Mori M

    更新日期:2011-11-21 00:00:00