Relationship between serum calcium and CA 19-9 levels in colorectal cancer.

Abstract:

AIM:To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. METHODS:Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above. RESULTS:A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. CONCLUSION:Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.

journal_name

World J Gastroenterol

authors

Fuszek P,Lakatos P,Tabak A,Papp J,Nagy Z,Takacs I,Horvath HC,Lakatos PL,Speer G

doi

10.3748/wjg.v10.i13.1890

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

1890-2

issue

13

eissn

1007-9327

issn

2219-2840

journal_volume

10

pub_type

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