A case of intrahepatic clear cell cholangiocarcinoma.

Abstract:

:Intrahepatic clear cell cholangiocarcinoma is very rare - only 8 cases have been reported. A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging, and hepatic segmentectomy was performed. Histopathologically, the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests. These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma. Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen, not mucin nor lipid. On immunohistochemical staining, cytokeratin (CK) 7 and CK19 were positive, whereas CK20 was negative. Vimentin was detected on the cell membranes, and CD56 was focally positive. The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively. Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown.

journal_name

World J Gastroenterol

authors

Toriyama E,Nanashima A,Hayashi H,Abe K,Kinoshita N,Yuge S,Nagayasu T,Uetani M,Hayashi T

doi

10.3748/wjg.v16.i20.2571

subject

Has Abstract

pub_date

2010-05-28 00:00:00

pages

2571-6

issue

20

eissn

1007-9327

issn

2219-2840

journal_volume

16

pub_type

杂志文章
  • Laparoscopic wedge resection of synchronous gastric intraepithelial neoplasia and stromal tumor: a case report.

    abstract::Synchronous occurrence of epithelial neoplasia and gastrointestinal stromal tumor (GIST) in the stomach is uncommon. Only rare cases have been reported in the literature. We present here a 60-year-old female case of synchronous occurrence of gastric high-level intraepithelial neoplasia and GIST with the features of 22...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i39.5005

    authors: Mou YP,Xu XW,Xie K,Zhou W,Zhou YC,Chen K

    更新日期:2010-10-21 00:00:00

  • Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples.

    abstract:AIM:To compare gene expression profiles of pancreatic adenocarcinoma tissue specimens, human pancreatic and colon adenocarcinoma and leukemia cell lines and normal pancreas samples in order to distinguish differentially expressed genes and to validate the differential expression of a subset of genes by quantitative rea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i21.3344

    authors: Laurell H,Bouisson M,Berthelemy P,Rochaix P,Dejean S,Besse P,Susini C,Pradayrol L,Vaysse N,Buscail L

    更新日期:2006-06-07 00:00:00

  • Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.

    abstract:AIM:To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC). METHODS:Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i34.5266

    authors: Qiu WH,Zhou BS,Chu PG,Chen WG,Chung C,Shih J,Hwu P,Yeh C,Lopez R,Yen Y

    更新日期:2005-09-14 00:00:00

  • Protective effect of taurine on hypochlorous acid toxicity to nuclear nucleoside triphosphatase in isolated nuclei from rat liver.

    abstract:AIM:Taurine has been shown to be an effective scavenger of hypochlorous acid (HOCl). The role of HOCl is well established in tissue damage associated with inflammation and injury. In the present study, the effect of HOCl on nuclear nucleoside triphosphatase of hepatocytes and the ability of taurine to prevent this effe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i5.694

    authors: Li JX,Pang YZ,Tang CS,Li ZQ

    更新日期:2004-03-01 00:00:00

  • Laser ablation of hepatocellular carcinoma--a review.

    abstract::A wide range of local thermal ablative therapies have been developed in the treatment of non resectable hepatocellular carcinoma (HCC) in the last decade. Laser ablation (LA) and radiofrequency ablation (RFA) are the two most widely used of these. This article provides an up to date overview of the role of laser ablat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.7170

    authors: Gough-Palmer AL,Gedroyc WM

    更新日期:2008-12-21 00:00:00

  • Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis.

    abstract:AIM:To clarify whether there is any difference in the symptom relief in patients with reflux esophagitis following the administration of four Proton pump inhibitors (PPIs). METHODS:Two hundred and seventy-four patients with erosive reflux esophagitis were randomized to receive 8 wk of 20 mg omeprazole (n = 68), 30 mg ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.15.990

    authors: Zheng RN

    更新日期:2009-02-28 00:00:00

  • Hemodynamics and vasoactive substance levels during renal congestion that occurs in the anhepatic phase of liver transplantation.

    abstract:AIM:To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation. METHODS:New Zealand rabbits received ligation of the hepatic pedicle, supra-hepatic vena cava and infra-hepatic vena cava [anhepatic phase group (APH); n = 8], the renal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i18.5482

    authors: Li ZX,Wang MC,Zhang YC,Mao J,Chen M,Ni R,Wei FX,Wang GN,Zhang LY

    更新日期:2015-05-14 00:00:00

  • Changes of ECM and CAM gene expression profile in the cirrhotic liver after HCV infection: analysis by cDNA expression array.

    abstract:AIM:We aimed to observe the expression of extracellular matrix (ECM) and cellular adhesion molecules (CAM) in cirrhotic liver tissues after hepatitis C virus (HCV) infection. METHODS:Twelve patients with post HCV inflammatory liver cirrhosis were selected to evaluate their liver function and other virological, patholo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i14.2184

    authors: Xu X,Li YM,Ji H,Hou CZ,Cheng YB,Ma FP

    更新日期:2005-04-14 00:00:00

  • Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?

    abstract:AIM:To evaluate the importance of endoscopic ultrasonography (EUS) for small (≤ 10 mm) rectal neuroendocrine tumor (NET) treatment. METHODS:Patients in whom rectal NETs were diagnosed by endoscopic resection (ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A tot...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i11.2037

    authors: Park SB,Kim DJ,Kim HW,Choi CW,Kang DH,Kim SJ,Nam HS

    更新日期:2017-03-21 00:00:00

  • Crohn's disease complicated by multiple stenoses and internal fistulas clinically mimicking small bowel endometriosis.

    abstract::We report a 31-year-old woman with Crohn's disease complicated by multiple stenoses and internal fistulas clinically misdiagnosed as small bowel endometriosis, due to the patient's perimenstrual symptoms of mechanical subileus for 3 years; at first monthly, but later continuous, and gradually increasing in severity. W...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.146

    authors: Teke Z,Aytekin FO,Atalay AO,Demirkan NC

    更新日期:2008-01-07 00:00:00

  • Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway.

    abstract:BACKGROUND:Enterotoxigenic Bacteroides fragilis (ETBF) causes colitis and diarrhea, and is considered a candidate pathogen in inflammatory bowel diseases as well as colorectal cancers. These diseases are dependent on ETBF-secreted toxin (BFT). Dendritic cells (DCs) play an important role in directing the nature of adap...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i3.291

    authors: Ko SH,Jeon JI,Woo HA,Kim JM

    更新日期:2020-01-21 00:00:00

  • Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells.

    abstract:AIM:To investigate the anti-hepatofibrotic effects of Gardenia jasminoides in liver fibrosis. METHODS:Male Sprague-Dawley rats underwent common bile duct ligation (BDL) for 14 d and were treated with Gardenia jasminoides by gavage. The effects of Gardenia jasminoides on liver fibrosis and the detailed molecular mechan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i48.7158

    authors: Chen YH,Lan T,Li J,Qiu CH,Wu T,Gou HJ,Lu MQ

    更新日期:2012-12-28 00:00:00

  • Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy.

    abstract:AIM:To evaluate the impact of glycemic control and nutritional status after total pancreatectomy (TP) on complications, tumor recurrence and overall survival. METHODS:Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i2.265

    authors: Shi HJ,Jin C,Fu DL

    更新日期:2017-01-14 00:00:00

  • Lower body weight and female gender: hyperphosphatemia risk factors after sodium phosphate preparations.

    abstract::Casais et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g. Our group has already described the relationship between body weight and hyperphosphatemia with these preparations, although our study was not quoted by Casais. We perfo...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v17.i21.2681

    authors: Deepak P,Ehrenpreis ED

    更新日期:2011-06-07 00:00:00

  • Is alcoholic pancreatitis associated with enteroviral infection?

    abstract:AIM:To investigate whether enteroviral infection might trigger acute pancreatitis in patients made susceptible due to high alcohol consumption. METHODS:Patients with alcohol-induced acute pancreatitis were analyzed for signs of simultaneous or preceding enteroviral infection. We studied the serum samples of 40 patient...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i24.3819

    authors: Khan J,Nordback I,Seppänen H,Lappalainen-Lehto R,Järvinen S,Oikarinen S,Tauriainen S,Räty S,Hyöty H,Sand J

    更新日期:2013-06-28 00:00:00

  • Post-gastrectomy patients need to be followed up for 20-30 years.

    abstract::AIM:To investigate the incidence and management of nutritional deficiencies following a gastrectomy.METHODS:A gastrectomy population of 227 patients in London was followed up for 30 years after operation to detect and treat nutritional deficiencies.RESULTS:By the end of the first decade iron deficiency was the commone...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i1.45

    authors: Tovey FI,Hobsley M

    更新日期:2000-02-01 00:00:00

  • Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment.

    abstract::Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly underst...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i18.2126

    authors: Qiu LW,Liu YF,Cao XQ,Wang Y,Cui XH,Ye X,Huang SW,Xie HJ,Zhang HJ

    更新日期:2020-05-14 00:00:00

  • Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm.

    abstract:AIM:To investigate the rate of spontaneous passage of single and symptomatic common bile duct (CBD) stones ≤ 10 mm in diameter in 4 wk with or without a 2-wk course of anisodamine. METHODS:A multicenter, randomized, placebo-controlled trial was undertaken. A total of 197 patients who met the inclusion criteria were en...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3748/wjg.v19.i39.6618

    authors: Gao J,Ding XM,Ke S,Zhou YM,Qian XJ,Ma RL,Ning CM,Xin ZH,Sun WB

    更新日期:2013-10-21 00:00:00

  • Expression changes of activin A in the development of hepatic fibrosis.

    abstract:AIM:To examine the expression of activin A, a member of the transforming growth factor (TGFbeta) superfamily, recently has been reported to be overexpressed in liver cirrhosis, in the course of carbon tetrachloride-induced rat hepatic fibrosis. METHODS:Hepatic fibrosis was induced in rats by subcutaneous injections of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i1.37

    authors: Huang X,Li DG,Wang ZR,Wei HS,Cheng JL,Zhan YT,Zhou X,Xu QF,Li X,Lu HM

    更新日期:2001-02-01 00:00:00

  • Helicobacter pylori in ancient human remains.

    abstract::The bacterium Helicobacter pylori (H. pylori) infects the stomachs of approximately 50% of all humans. With its universal occurrence, high infectivity and virulence properties it is considered as one of the most severe global burdens of modern humankind. It has accompanied humans for many thousands of years, and due t...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i42.6289

    authors: Maixner F,Thorell K,Granehäll L,Linz B,Moodley Y,Rattei T,Engstrand L,Zink A

    更新日期:2019-11-14 00:00:00

  • Neoadjuvant therapy for pancreas cancer: past lessons and future therapies.

    abstract::Pancreatic adenocarcinoma remains a most deadly malignancy, with an overall 5-year survival of 5%. A subset of patients will be diagnosed with potentially resectable disease, and while complete surgical resection provides the only chance at cure, data from trials of postoperative chemoradiation and/or chemotherapy dem...

    journal_title:World journal of gastroenterology

    pub_type: 历史文章,杂志文章,评审

    doi:10.3748/wjg.v20.i42.15564

    authors: Sutton JM,Abbott DE

    更新日期:2014-11-14 00:00:00

  • Analysis of ABC (D) stratification for screening patients with gastric cancer.

    abstract:AIM:To evaluate the value of ABC (D) stratification [combination of serum pepsinogen and Helicobacter pylori (H. pylori) antibody] of patients with gastric cancer. METHODS:Ninety-five consecutive patients with gastric cancer were enrolled into the study. The serum pepsinogen I (PG I)/pepsinogen II (PG II) and H. pylor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i43.4793

    authors: Kudo T,Kakizaki S,Sohara N,Onozato Y,Okamura S,Inui Y,Mori M

    更新日期:2011-11-21 00:00:00

  • Changes of gut flora and endotoxin in rats with D-galactosamine-induced acute liver failure.

    abstract:AIM:To investigate the changes of gut microflora and endotoxin levels in rats with acute liver failure (ALF) induced by D-galactosamine (GalN). METHODS:Flora and endotoxin levels in the jejunum, ileum and colon in normal rats (group A) and rats with GalN -induced ALF were determined at 24 h (group B) or 48 h (group C)...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i14.2087

    authors: Li LJ,Wu ZW,Xiao DS,Sheng JF

    更新日期:2004-07-15 00:00:00

  • Effect of interferon alpha2b plus ribavirin treatment on selected growth factors in respect to inflammation and fibrosis in chronic hepatitis C.

    abstract:AIM:Growth factors (GF) that participate in regeneration and apoptosis have an important role in chronic liver diseases. We analyzed serum GF concentration during antiviral treatment and correlated it with morphological liver failure in chronic hepatitis C. METHODS:The levels of GF were determined in sera by ELISA met...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i12.1854

    authors: Anatol P,Robert F,Danuta P

    更新日期:2005-03-28 00:00:00

  • Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.

    abstract:AIM:To investigate the antioxidant effect of caffeic acid phenethyl ester (CAPE) in hepatic stellate cell-T6 (HSC-T6) cells cultured in vitro and the potential mechanisms. METHODS:HSC-T6 cells were cultured in vitro and treated with various concentrations of CAPE for 24, 48 and 72 h, respectively. Cell proliferation w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i7.1203

    authors: Yang N,Shi JJ,Wu FP,Li M,Zhang X,Li YP,Zhai S,Jia XL,Dang SS

    更新日期:2017-02-21 00:00:00

  • Screening analysis of candidate gene mutations in a kindred with polycystic liver disease.

    abstract:AIM:To find potential mutable sites by detecting mutations of the candidate gene in a kindred with polycystic liver disease (PCLD). METHODS:First, we chose a kindred with PCLD and obtained five venous blood samples of this kindred after the family members signed the informed consent form. In the kindred two cases were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i8.2343

    authors: Jin S,Cui K,Sun ZQ,Shen YY,Li P,Wang ZD,Li FF,Gong KN,Li S

    更新日期:2015-02-28 00:00:00

  • Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer.

    abstract::Pseudo-Meigs' syndrome associated with colorectal cancer is extremely rare. We report here a case of pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from colon cancer. A 65-year-old female with a history of surgery for transverse colon cancer and peritoneal dissemination suffered from metachronous ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i18.4604

    authors: Kyo K,Maema A,Shirakawa M,Nakamura T,Koda K,Yokoyama H

    更新日期:2016-05-14 00:00:00

  • Variations of very low-density lipoprotein receptor subtype expression in gastrointestinal adenocarcinoma cells with various differentiations.

    abstract:AIM:This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. METHODS:Thirty-one cases of gastroenteric carcinoma/adjacent normal tissues were enrolled in the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i18.2817

    authors: Chen T,Wu F,Chen FM,Tian J,Qu S

    更新日期:2005-05-14 00:00:00

  • Hepatocellular carcinoma review: current treatment, and evidence-based medicine.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. Multiple treatment options are available for HCC including curative resection, liver transplantation, radiofrequency ablation, trans-arterial chemoembolization, radioembolization and systemic targeted agent like sorafenib. The treatment of HCC de...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i15.4115

    authors: Raza A,Sood GK

    更新日期:2014-04-21 00:00:00

  • Common bile duct obstruction due to fibrous pseudotumor of pancreas associated with retroperitoneal fibrosis: a case report.

    abstract::One 63-year-old woman, who presented with cholestatic jaundice due to common bile duct compression produced by primary retroperitoneal fibrosis, is studied. The patient was operated six years ago because of hydronephrosis, when the disease was first diagnosed. Magnetic resonance cholangiopancreatography (MRCP) reveale...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.3078

    authors: Zhao MF,Tian Y,Guo KJ,Ma ZG,Liao HH

    更新日期:2004-10-15 00:00:00