Intratumoral functional heterogeneity and chemotherapy.


:Intratumoral heterogeneity including genetic and nongenetic mechanisms refers to biological differences amongst malignant cells originated within the same tumor. Both, cell differentiation hierarchy and stochasticity in gene expression and signaling pathways may result in phenotypic differences of cancer cells. Since a tumor consists of cancer cell clones that display distinct behaviours, changes in clonal proliferative behavior may also contribute to the phenotypic variability of tumor cells. There is a need to reveal molecular actions driving chemotherapeutic resistance in colon cancer cells. In general, it is widely hypothesized that therapeutic resistance in colorectal cancer is a consequence of the preferential survival of cancer stem cells. However, recent data regarding colorectal cancer suggest that resistance to anticancer therapy and post-therapeutic tumor reappearence could be related to variations of clonal dynamics. Understanding the interaction of genetic and nongenetic determinants influencing the functional diversity and therapy response of tumors should be a future direction for cancer research.


World J Gastroenterol


Sipos F,Constantinovits M,Műzes G




Has Abstract


2014-03-14 00:00:00












  • Effect of psychological stress on gastric motility assessed by electrical bio-impedance.

    abstract:AIM:To evaluate gastric motility using electrical bio-impedance (EBI) and gastric changes as a result of stress induced by psychological tests. METHODS:A group of 57 healthy women, aged 40-60 years, was recruited, and a clinical history and physical examination were performed. The women were free from severe anxiety, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Huerta-Franco MR,Vargas-Luna M,Montes-Frausto JB,Morales-Mata I,Ramirez-Padilla L

    更新日期:2012-09-28 00:00:00

  • Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance.

    abstract:AIM:To investigate the expression of p28/gankyrin gene and its role in the carcinogenetic process of human hepatocellular carcinoma (HCC). METHODS:64 specimens of HCC and para-carcinoma tissues, 22 specimens of non-tumor liver tissues (7 normal, 15 cirrhosis), 10 specimens of normal human tissues and 5 hepatoma cell l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Fu XY,Wang HY,Tan L,Liu SQ,Cao HF,Wu MC

    更新日期:2002-08-01 00:00:00

  • Construction and characterization of chimeric BHIV (BIV/HIV-1) viruses carrying the bovine immunodeficiency virus gag gene.

    abstract:AIM:To explore the possibility of the replacement of the gag gene between human immunodeficiency virus and bovine immunodeficiency virus, to achieve chimeric virions, and thereby gain a new kind of AIDS vaccine based on BHIV chimeric viruses. METHODS:A series of chimeric BHIV proviral DNAs differing in the replacement...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhu YX,Liu C,Liu XL,Qiao WT,Chen QM,Zeng Y,Geng YQ

    更新日期:2005-05-07 00:00:00

  • Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms.

    abstract::A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical examination. Endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Urata T,Naito Y,Izumi Y,Takekuma Y,Yokomizo H,Nagamine M,Fukuda S,Notohara K,Hifumi M

    更新日期:2013-12-21 00:00:00

  • Contrast enhanced computed tomography and reconstruction of hepatic vascular system for transjugular intrahepatic portal systemic shunt puncture path planning.

    abstract:AIM:To describe a method for the transjugular intrahepatic portal systemic shunt (TIPS) placement performed with the aid of contrast-enhanced computed tomography (CECT) and three-dimensional reconstructed vascular images (3D RVIs), and to assess its safety and effectiveness. METHODS:Four hundred and ninety patients we...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Qin JP,Tang SH,Jiang MD,He QW,Chen HB,Yao X,Zeng WZ,Gu M

    更新日期:2015-08-28 00:00:00

  • A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints.

    abstract:AIM:To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal complaints. METHODS:For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT sca...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Mizrahi M,Mintz Y,Rivkind A,Kisselgoff D,Libson E,Brezis M,Goldin E,Shibolet O

    更新日期:2005-04-07 00:00:00

  • Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran).

    abstract:AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by us...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Jafarzadeh A,Rezayati MT,Nemati M

    更新日期:2007-06-14 00:00:00

  • Correction to "Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [World J Gastroenterol 2018 March 14; 24(10): 1107-1119]".

    abstract::[This corrects the article on p. 1107 in vol. 21, PMID: 26640344.]. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,已发布勘误


    authors: Tong YF,Cai XJ

    更新日期:2018-10-21 00:00:00

  • Relationship between tumor necrosis factor-alphaand liver fibrosis.

    abstract::INTRODUCTION:To intrestigate the relationship between tumor necrosis factor-alphaand liver fibrosis in patients with chronic liver disease.METHODS:Radioimmunoassay was made in 20 patients with mild chronic hepatitis(CMH),20 patients with severe chronic hepatitis(CSH),51 patients with liver cirrhosis(LC)and 32-normal p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang X,Chen YX,Xu CF,Zhao GN,Huang YX,Wang QL

    更新日期:1998-02-01 00:00:00

  • Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology: A meta-analysis.

    abstract:AIM:To evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) with undifferentiated-type histology. METHODS:A systematic literature review was conducted using the core databases. Complete resection, curative resection, en bloc resection, recurrence and adverse event r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Bang CS,Baik GH,Shin IS,Kim JB,Suk KT,Yoon JH,Kim YS,Kim DJ,Shin WG,Kim KH,Kim HY,Lim H,Kang HS,Kim JH,Kim JB,Jung SW,Kae SH,Jang HJ,Choi MH

    更新日期:2015-05-21 00:00:00

  • Common bile duct obstruction due to fibrous pseudotumor of pancreas associated with retroperitoneal fibrosis: a case report.

    abstract::One 63-year-old woman, who presented with cholestatic jaundice due to common bile duct compression produced by primary retroperitoneal fibrosis, is studied. The patient was operated six years ago because of hydronephrosis, when the disease was first diagnosed. Magnetic resonance cholangiopancreatography (MRCP) reveale...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhao MF,Tian Y,Guo KJ,Ma ZG,Liao HH

    更新日期:2004-10-15 00:00:00

  • Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers.

    abstract:AIM:To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS:The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli U...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Hulagu S,Senturk O,Aygun C,Kocaman O,Celebi A,Konduk T,Koc D,Sirin G,Korkmaz U,Duman AE,Bozkurt N,Dindar G,Attila T,Gurbuz Y,Tarcin O,Kalayci C

    更新日期:2011-04-07 00:00:00

  • Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway.

    abstract:AIM:To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions. METHODS:Fluorescent probes were used to detect reactive oxygen species (ROS) in LOVO cells. Wound healing assay and transwell assay were performed to examine the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang P,Zeng Y,Liu T,Zhang C,Yu PW,Hao YX,Luo HX,Liu G

    更新日期:2014-02-28 00:00:00

  • Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells.

    abstract:AIM:To investigate the anti-hepatofibrotic effects of Gardenia jasminoides in liver fibrosis. METHODS:Male Sprague-Dawley rats underwent common bile duct ligation (BDL) for 14 d and were treated with Gardenia jasminoides by gavage. The effects of Gardenia jasminoides on liver fibrosis and the detailed molecular mechan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Chen YH,Lan T,Li J,Qiu CH,Wu T,Gou HJ,Lu MQ

    更新日期:2012-12-28 00:00:00

  • Effect of preoperative transcatheter arterial chemoembolization on proliferation of hepatocellular carcinoma cells.

    abstract:AIM:To evaluate the effect of preoperative transcatheter arterial chemoembolization (TACE) on proliferation of hepatocellular carcinoma (HCC) cells. METHODS:A total of 136 patients with HCC underwent liver resection. Of 136 patients, 79 patients received 1 to 5 courses of TACE prior to liver resection (TACE group), wh...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xiao EH,Li JQ,Huang JF

    更新日期:2007-09-07 00:00:00

  • Hepatocellular carcinoma review: current treatment, and evidence-based medicine.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. Multiple treatment options are available for HCC including curative resection, liver transplantation, radiofrequency ablation, trans-arterial chemoembolization, radioembolization and systemic targeted agent like sorafenib. The treatment of HCC de...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Raza A,Sood GK

    更新日期:2014-04-21 00:00:00

  • Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.

    abstract:AIM:To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis. METHODS:Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and he...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Takahara Y,Takahashi M,Wagatsuma H,Yokoya F,Zhang QW,Yamaguchi M,Aburatani H,Kawada N

    更新日期:2006-10-28 00:00:00

  • Relationship between entero-hepatic bile acid circulation and interdigestive migrating myoelectrical activity in rats.

    abstract:AIM:To investigate the effects of entero-hepatic bile acid circulation on the inter-digestive migrating myoelectrical complex (MMC) in rats. METHODS:Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Fang P,Dong L,Zhang WJ,Luo JY

    更新日期:2005-09-14 00:00:00

  • Benign retroperitoneal schwannoma presenting as colitis: a case report.

    abstract::We report a case of a patient presenting with clinical, radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed, which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Fass G,Hossey D,Nyst M,Smets D,Saligheh EN,Duttmann R,Claes K,da Costa PM

    更新日期:2007-11-07 00:00:00

  • Gut perforation after orthotopic liver transplantation in adults.

    abstract:AIM:To describe cases of gut perforation after orthotopic liver transplantation. METHODS:Data were collected from our center database and medical records. Six of 187 patients (3.2%) who underwent orthotopic liver transplantation from January to December 2005 developed gut perforation. All patients were male with an av...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xiong J,You S,He XS

    更新日期:2007-04-14 00:00:00

  • Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?

    abstract::Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A

    更新日期:2018-09-28 00:00:00

  • Biological therapy for ulcerative colitis: an update.

    abstract::Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Seo GS,Chae SC

    更新日期:2014-10-07 00:00:00

  • Impact of alcohol on hepatitis C virus replication and interferon signaling.

    abstract::Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which ove...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: McCartney EM,Beard MR

    更新日期:2010-03-21 00:00:00

  • Prognosis and feasibility of en-bloc vascular resection in stage II pancreatic adenocarcinoma.

    abstract:AIM:To establish the prognosis and feasibility of en-bloc vascular resection of stage II pancreatic adenocarcinoma of the head and uncinate process. METHODS:We retrospectively analyzed 87 patients with stage II pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPP...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Chakravarty KD,Hsu JT,Liu KH,Yeh CN,Yeh TS,Hwang TL,Jan YY,Chen MF

    更新日期:2010-02-28 00:00:00

  • Immunosuppressive therapies for inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is comprised of Crohn's disease and ulcerative colitis, both chronic inflammatory intestinal disorders of unknown etiology characterized by a waxing and waning clinical course. For many years, the drug therapy was limited to sulfasalazine and related aminosalicylates, corticosteroids a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zenlea T,Peppercorn MA

    更新日期:2014-03-28 00:00:00

  • Factors associated with patient absenteeism for scheduled endoscopy.

    abstract:AIM:To identify risk factors to help predict which patients are likely to fail to appear for an endoscopic procedure. METHODS:This was a retrospective, chart review, cohort study in a Canadian, tertiary care, academic, hospital-based endoscopy clinic. Patients included were: those undergoing esophagogastroduodenoscopy...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wong VK,Zhang HB,Enns R

    更新日期:2009-06-21 00:00:00

  • Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation.

    abstract:AIM:To investigate the dynamic features of insulin-like growth factor-I receptor (IGF-IR) expression in rat hepatocarcinogenesis, and the relationship between IGF-IR and hepatocytes malignant transformation at mRNA or protein level. METHODS:Hepatoma models were made by inducing with 2-fluorenylacetamide (2-FAA) on mal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yan XD,Yao M,Wang L,Zhang HJ,Yan MJ,Gu X,Shi Y,Chen J,Dong ZZ,Yao DF

    更新日期:2013-09-28 00:00:00

  • Androgens and esophageal cancer: What do we know?

    abstract::Significant disparities exist between genders for the development and progression of several gastro-intestinal (GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvem...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Sukocheva OA,Li B,Due SL,Hussey DJ,Watson DI

    更新日期:2015-05-28 00:00:00

  • The prognostic significance of clinical and pathological features in hepatocellular carcinoma.

    abstract::The prognosis of patients with HCC still remains dismal. The life expectancy of HCC patients is hard to predict because of the high possibility of postoperative recurrence. Many factors, such as patient's general conditions, macroscopic tumor morphology, as well as tumor histopathology features, have been proven of pr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Qin LX,Tang ZY

    更新日期:2002-04-01 00:00:00

  • Choroidal and cutaneous metastasis from gastric adenocarcinoma.

    abstract::Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of me...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kawai S,Nishida T,Hayashi Y,Ezaki H,Yamada T,Shinzaki S,Miyazaki M,Nakai K,Yakushijin T,Watabe K,Iijima H,Tsujii M,Nishida K,Takehara T

    更新日期:2013-03-07 00:00:00