Clear cell colitis: a form of microscopic colitis in children.

Abstract:

AIM:To describe a new clinical and pathological subtype of microscopic colitis in children. METHODS:A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described. RESULTS:Multiple biopsies of colon showed large mononuclear clear cells in lamina propria of mucous membrane provided that good quality histological sections were performed and observed under a higher magnification. Otherwise, they could be misinterpreted as artefacts. Their presence in routine histology might suggest a systemic storage disease (Whipple's disease), and neuronal intestine dysplasia. Using immunohistochemical staining and electron microscopy we confirmed their origin from CD68 positive mononuclear macrophages. CONCLUSION:The presence of large clear cells is a constant microscopic feature. Failure of transient large bowel stationary macrophages plays a role in the pathogenesis of this benign microscopic clear cell colitis, sometimes coexisting with allergy.

journal_name

World J Gastroenterol

authors

Józefczuk J,Wozniewicz BM

doi

10.3748/wjg.14.231

subject

Has Abstract

pub_date

2008-01-14 00:00:00

pages

231-5

issue

2

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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