Hereditary pancreatitis.

Abstract:

:Hereditary pancreatitis is an autosomal dominant condition, which results in recurrent attacks of acute pancreatitis, progressing to chronic pancreatitis often at a young age. The majority of patients with hereditary pancreatitis express one of two mutations (R122H or N29I) in the cationic trypsinogen gene (PRSS1 gene). It has been hypothesised that one of these mutations, the R122H mutation causes pancreatitis by altering a trypsin recognition site so preventing deactivation of trypsin within the pancreas and prolonging its action, resulting in autodigestion. Families with these two mutations have been identified in many countries and there are also other rarer mutations, which have also been linked to hereditary pancreatitis. Patients with hereditary pancreatitis present in the same way as those with sporadic pancreatitis but at an earlier age. It is common for patients to remain undiagnosed for many years, particularly if they present with non-specific symptoms. Hereditary pancreatitis should always be considered in patients who present with recurrent pancreatitis with a family history of pancreatic disease. If patients with the 2 common mutations are compared, those with the R122H mutation are more likely to present at a younger age and are more likely to require surgical intervention than those with N29I. Hereditary pancreatitis carries a 40 % lifetime risk of pancreatic cancer with those patients aged between 50 to 70 being most at risk in whom screening tests may become important.

journal_name

World J Gastroenterol

authors

Charnley RM

doi

10.3748/wjg.v9.i1.1

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1-4

issue

1

eissn

1007-9327

issn

2219-2840

journal_volume

9

pub_type

杂志文章,评审
  • Bisphosphonate use and gastrointestinal tract cancer risk: meta-analysis of observational studies.

    abstract:AIM:To perform a meta-analysis of observational studies to further elucidate the relationship between oral bisphosphonate use and gastrointestinal cancer risk. METHODS:Systematic literature search was conducted in MEDLINE, EMBASE, and the Cochrane Library to identify studies through January 2011. Search terms were "bi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v18.i40.5779

    authors: Oh YH,Yoon C,Park SM

    更新日期:2012-10-28 00:00:00

  • Pneumatosis cystoides intestinalis after fluorouracil chemotherapy for rectal cancer.

    abstract::Pneumatosis cystoides intestinalis (PCI) is a relatively rare condition characterized by intraluminal gas in the gastrointestinal tract. Several chemotherapeutic agents have been reported to be associated with PCI, although fluorouracil-related PCI is extremely rare. We report a case of a 76-year old man who received ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3273

    authors: Mimatsu K,Oida T,Kawasaki A,Kano H,Kuboi Y,Aramaki O,Amano S

    更新日期:2008-05-28 00:00:00

  • Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients: incidence and risk factors.

    abstract:AIM:To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma (HCC) in Chinese patients with primary biliary cirrhosis (PBC). METHODS:We reviewed the data of 52 PBC-associated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i12.3554

    authors: Zhang XX,Wang LF,Jin L,Li YY,Hao SL,Shi YC,Zeng QL,Li ZW,Zhang Z,Lau GK,Wang FS

    更新日期:2015-03-28 00:00:00

  • First-line eradication of H pylori infection in Europe: a meta-analysis based on congress abstracts, 1997-2004.

    abstract:AIM:To meta-analyse the European abstracts presented between 1997-2004 at the European H pylori Study Group, United European Gastroenterology Week meetings and World Congresses of Gastroenterology. METHODS:The abstracts of randomized/controlled prospective studies were classified into groups based on first-line eradic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v12.i33.5311

    authors: Buzás GM,Józan J

    更新日期:2006-09-07 00:00:00

  • Helicobacter pylori infection: new pathogenetic and clinical aspects.

    abstract::Helicobacter pylori (H. pylori) infects more than half of the world's human population, but only 1% to 3% of infected people consequently develop gastric adenocarcinomas. The clinical outcome of the infection is determined by host genetic predisposition, bacterial virulence factors, and environmental factors. The asso...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i21.6386

    authors: Hagymási K,Tulassay Z

    更新日期:2014-06-07 00:00:00

  • Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux.

    abstract:AIM:To evaluate the agreement of multichannel intraluminal impedance-pH monitoring (MII-pHM) and gastroesophageal reflux scintigraphy (GES) for the diagnosis of gastroesophageal reflux disease. METHODS:Seventy-five consecutive patients with suspected gastroesophageal reflux disease (GERD) underwent 24-h combined MII-p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i43.9595

    authors: Uslu Kızılkan N,Bozkurt MF,Saltık Temizel IN,Demir H,Yüce A,Caner B,Özen H

    更新日期:2016-11-21 00:00:00

  • Ischemic enterocolitis examined by colonoscopy and selective angiography.

    abstract:AIM:To study the value of colonoscopy and selective angiography in diagnosing ischemic enterocolitis. METHODS:Among the 16 cases under study, 10 cases had hypertension and a history of coronary artery disease (one was hospitalized for sub-ventricular-wall infarction). The blood pressure of 10 of the 16 cases ranged fr...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i24.3788

    authors: He L,Luo HS

    更新日期:2005-06-28 00:00:00

  • Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy.

    abstract:AIM:To explore the role of mammalian target of rapamycin (mTOR) in the pathogenesis of cirrhotic cardiomyopathy and the potential of rapamycin to improve this pathologic condition. METHODS:Male albino Wistar rats weighing 100-120 g were treated with tetrachloride carbon (CCl4) for 8 wk to induce cirrhosis. Subsequentl...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i19.4685

    authors: Saeedi Saravi SS,Ghazi-Khansari M,Ejtemaei Mehr S,Nobakht M,Mousavi SE,Dehpour AR

    更新日期:2016-05-21 00:00:00

  • Molecular markers (PECAM-1, ICAM-3, HLA-DR) determine prognosis in primary non-Hodgkin's gastric lymphoma patients.

    abstract:AIM:To investigate the prognostic significance of PECAM-1, ICAM-3 and HLA-DR antigens in patients with primary non-Hodgkin's gastric lymphoma. METHODS:We immunohistochemically studied PECAM-1, ICAM-3 and HLA-DR antigen expression in 36 B-cell MALT-type primary gastric lymphoma patients. Ten non-malignant and ten healt...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i12.1924

    authors: Darom A,Gomatos IP,Leandros E,Chatzigianni E,Panousopoulos D,Konstadoulakis MM,Androulakis G

    更新日期:2006-03-28 00:00:00

  • Alcoholism and liver disease in Mexico: genetic and environmental factors.

    abstract::Alcoholism and cirrhosis, which are two of the most serious health problems worldwide, have a broad spectrum of clinical outcomes. Both diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each population. In contrast to other regions around the world, Mexican...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i44.7972

    authors: Roman S,Zepeda-Carrillo EA,Moreno-Luna LE,Panduro A

    更新日期:2013-11-28 00:00:00

  • Diagnostic value of gadobenate dimeglumine-enhanced hepatocyte-phase magnetic resonance imaging in evaluating hepatic fibrosis and hepatitis.

    abstract:AIM:To evaluate the diagnostic value of gadobenate dimeglumine (Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging (MRI) in evaluating hepatic fibrosis and hepatitis. METHODS:Hepatocyte-phase images of Gd-BOPTA-enhanced MRI were retrospectively evaluated in 76 patients with chronic liver disease. These pat...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v23.i17.3133

    authors: Li XM,Chen Z,Xiao EH,Shang QL,Ma C

    更新日期:2017-05-07 00:00:00

  • Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats.

    abstract:AIM:To study the inhibitory effect of mononuclear bone marrow cell (BMC) transplantation on carbon tetrachloride (CCl(4)) -induced liver fibrosis in rats. METHODS:Rat liver fibrosis models were induced by CCl(4) and alcohol administration. After 8 wk, twenty rats were randomly allocated into treatment group (n = 10) a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i12.1851

    authors: Cao BQ,Lin JZ,Zhong YS,Huang SB,Lin N,Tang ZF,Chen R,Xiang P,Xu RY

    更新日期:2007-03-28 00:00:00

  • Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis.

    abstract:AIM:To investigate the association between interleukin-28B (IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus (HCV) genotype 4. METHODS:Two hundred and one HCV-genotype 4 patients were included. All patients were treated with Peginterferon alph2a/Ribavirin for 48 wk. End...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i47.7003

    authors: Derbala M,Rizk N,Shebl F,Alkaabi S,Eldweik N,John A,Sharma M,Yaqoob R,Almohanadi M,Butt M,Alejji K

    更新日期:2012-12-21 00:00:00

  • Transjugular intrahepatic portosystemic shunt for pyrrolizidine alkaloid-related hepatic sinusoidal obstruction syndrome.

    abstract:BACKGROUND:Treatments for hepatic sinusoidal obstruction syndrome (HSOS) are limited. AIM:To evaluate transjugular intrahepatic portosystemic shunting (TIPS) as a treatment for pyrrolidine alkaloid-related HSOS (PA-HSOS). METHODS:This retrospective analysis included patients with PA-HSOS admitted to the First Affilia...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i24.3472

    authors: Zhou CZ,Wang RF,Lv WF,Fu YQ,Cheng DL,Zhu YJ,Hou CL,Ye XJ

    更新日期:2020-06-28 00:00:00

  • Prospective study of scoring system in selective intraoperative cholangiography during laparoscopic cholecystectomy.

    abstract:AIM:To evaluate of scoring system in predicting choledocholithiasis in selective intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC). METHODS:The scoring system of predicting choledocholithiasis was developed during the retrospective study in 264 cases, and was tested in 184 to evaluate its p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i4.865

    authors: Sun XD,Cai XY,Li JD,Cai XJ,Mu YP,Wu JM

    更新日期:2003-04-01 00:00:00

  • Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis.

    abstract:AIM:To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS:We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for geno...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v16.i34.4348

    authors: Lu WG,Zou YF,Feng XL,Yuan FL,Gu YL,Li X,Li CW,Jin C,Li JP

    更新日期:2010-09-14 00:00:00

  • XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis.

    abstract:AIM:To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of meta-analysis. METHODS:We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our sel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.14.6733

    authors: Geng J,Zhang YW,Huang GC,Chen LB

    更新日期:2008-11-21 00:00:00

  • Primary sclerosing cholangitis--what is the difference between east and west?

    abstract::Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by inflammation and fibrotic obliteration of the hepatic biliary tree. It is commonly associated with inflammatory bowel disease (IBD). A number of complications can occur which require special consideration, the mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.3974

    authors: Shorbagi A,Bayraktar Y

    更新日期:2008-07-07 00:00:00

  • Ileo-ileal intussusception caused by diffuse large B-cell lymphoma of the ileum.

    abstract::The occurrence of adult intussusception from small intestinal lymphoma is quite rare. We present an 82-year-old man with a two-month history of intermittent abdominal pain, nausea and fatigue. Clinical symptoms included moderate abdominal tenderness in the right lower abdomen. Computed tomography scan of the abdomen r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i45.8449

    authors: Xu XQ,Hong T,Li BL,Liu W

    更新日期:2013-12-07 00:00:00

  • Effect of liver regeneration on malignant hepatic tumors.

    abstract::Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i43.16167

    authors: Shi JH,Line PD

    更新日期:2014-11-21 00:00:00

  • Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil.

    abstract:BACKGROUND:The etiology of inflammatory bowel disease (IBD) is unknown, but it is believed to be multifactorial. The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases. AIM:To test the hygiene hypothesi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i25.3611

    authors: Salgado VCL,Luiz RR,Boéchat NLF,Leão IS,Schorr BDC,Parente JML,Lima DC,Silveira Júnior ES,Silva GOS,Almeida NP,Vieira A,de Bueno MLQ,Chebli JM,Bertges ÉR,Brugnara LMDC,Junqueira Neto C,Campbell SBG,Discacciati LL,Céza

    更新日期:2020-07-07 00:00:00

  • Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway.

    abstract:BACKGROUND:Gastric cancer (GC) is one of the most common and deadliest types of cancer worldwide due to its delayed diagnosis and high metastatic frequency, but its exact pathogenesis has not been fully elucidated. ETS homologous factor (EHF) is an important member of the ETS family and contributes to the pathogenesis ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i47.7497

    authors: Gu ML,Zhou XX,Ren MT,Shi KD,Yu MS,Jiao WR,Wang YM,Zhong WX,Ji F

    更新日期:2020-12-21 00:00:00

  • Anti-HBV effect of liposome-encapsulated matrine in vitro and in vivo.

    abstract:AIM:To study the anti-HBV effect of liposome-encapsulated matrine (Lip-M) in vitro and in vivo. METHODS:2.2.15 cell line was cultured in vitro to observe the effect of Lip-M and matrine on the secretion of HBsAg and HBeAg. The toxicity of Lip-M and matrine to 2.2.15 cell line was also studied by MTT method. In in vivo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i3.426

    authors: Li CQ,Zhu YT,Zhang FX,Fu LC,Li XH,Cheng Y,Li XY

    更新日期:2005-01-21 00:00:00

  • Is endoscopic ultrasound examination necessary in the management of esophageal cancer?

    abstract::Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have imp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i5.751

    authors: DaVee T,Ajani JA,Lee JH

    更新日期:2017-02-07 00:00:00

  • Chemotherapy beyond second-line in advanced gastric cancer.

    abstract::Patients with advanced gastric cancer (AGC) can be treated with multiple lines of chemotherapy. Although several randomized trials have demonstrated the benefit of second-line chemotherapy compared with best supportive care, there is no evidence that further lines of chemotherapy will result in substantial prolongatio...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i29.8811

    authors: Kim SM,Park SH

    更新日期:2015-08-07 00:00:00

  • Evaluation and management of patients with refractory ascites.

    abstract::Some patients with ascites due to liver cirrhosis become no longer responsive to diuretics. Once other causes of ascites such as portal vein thrombosis, malignancy or infection and non-compliance with medications and low sodium diet have been excluded, the diagnosis of refractory ascites can be made based on strict cr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.15.67

    authors: Senousy BE,Draganov PV

    更新日期:2009-01-07 00:00:00

  • Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells.

    abstract:AIM:To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS:Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, suc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i40.6312

    authors: Strup-Perrot C,Vozenin-Brotons MC,Vandamme M,Linard C,Mathé D

    更新日期:2005-10-28 00:00:00

  • Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

    abstract:AIM:To investigate the inhibitory effect and possible mechanism of action of schisandrin B in SC-B on gastric cancer cells in vitro. METHODS:SC-B consisted of schisandrin B, aloe-emodin, and Astragalus polysaccharides. Exponentially growing human gastric cancer SGC-7901 cells were divided into six treatment groups: (1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i48.6506

    authors: Liu XN,Zhang CY,Jin XD,Li YZ,Zheng XZ,Li L

    更新日期:2007-12-28 00:00:00

  • A case of a duodenal duplication cyst presenting as melena.

    abstract::Duodenal duplication cysts are benign rare congenital anomalies reported mainly in the pediatric population, but seldom in adults. Symptoms depend on the type and location and can present as abdominal pain, distension, dysphagia or dyspepsia. They have been reported to be responsible for duodenal obstruction, pancreat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i38.6490

    authors: Ko SY,Ko SH,Ha S,Kim MS,Shin HM,Baeg MK

    更新日期:2013-10-14 00:00:00

  • STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.

    abstract:BACKGROUND:Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects. AIM:To explore the mechanisms mediating the clinical effic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i39.5926

    authors: Khayyal MT,Wadie W,Abd El-Haleim EA,Ahmed KA,Kelber O,Ammar RM,Abdel-Aziz H

    更新日期:2019-10-21 00:00:00