Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells.

abstract：:The bacterium Helicobacter pylori (H. pylori) infects the stomachs of approximately 50% of all humans. With its universal occurrence, high infectivity and virulence properties it is considered as one of the most severe global burdens of modern humankind. It has accompanied humans for many thousands of years, and due t...

journal_title：World journal of gastroenterology

authors： Maixner F,Thorell K,Granehäll L,Linz B,Moodley Y,Rattei T,Engstrand L,Zink A

更新日期：2019-11-14 00:00:00

abstract：AIM:To investigate the existence and clinical significance of hepatitis C virus (HCV) RNA in the serum and peripheral blood mononuclear cells (PBMC) of patients with hepatitis C. METHODS:HCV RNA was detected by nested polymerase chain reaction (Nested PCR) in serum and in PBMC of 46 patients with acute hepatitis C (AH...

journal_title：World journal of gastroenterology

authors： Zhou P,Cai Q,Chen YC,Zhang MS,Guan J,Li XJ

更新日期：1997-06-15 00:00:00

abstract：:Complete response to chemoradiotherapy for rectal cancer is becoming a common clinical entity. Techniques to diagnose complete response and how to survey these patients without operative intervention are still unclear. We review the most recent evidence. Barriers to firm conclusions regarding this are heterogeneity of...

journal_title：World journal of gastroenterology

authors： Couch DG,Hemingway DM

更新日期：2016-01-14 00:00:00

abstract：AIM:To investigate the effects of guggulsterone on the proliferation and apoptosis of human hepatoma HepG2 cells in vitro and relevant mechanisms. METHODS:Human hepatocellular carcinoma HepG2 cells and normal human liver L-02 cells were treated with different concentrations of guggulsterone (5-100 μmol/L) for 24-72 h....

journal_title：World journal of gastroenterology

authors： Shi JJ,Jia XL,Li M,Yang N,Li YP,Zhang X,Gao N,Dang SS

更新日期：2015-12-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. Multiple treatment options are available for HCC including curative resection, liver transplantation, radiofrequency ablation, trans-arterial chemoembolization, radioembolization and systemic targeted agent like sorafenib. The treatment of HCC de...

journal_title：World journal of gastroenterology

authors： Raza A,Sood GK

更新日期：2014-04-21 00:00:00

abstract：AIM:To study the protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury and its mechanism after hemorrhagic shock in rats. METHODS:A total of 32 SD rats were randomly divided into four groups (n = 8, each group): normal group, model group, low dosage group (treated with 10 g/kg Astragalus...

journal_title：World journal of gastroenterology

authors： Hei ZQ,Huang HQ,Zhang JJ,Chen BX,Li XY

更新日期：2005-08-28 00:00:00

abstract：AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori (H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated in...

journal_title：World journal of gastroenterology

authors： Kim KK,Kim HB

更新日期：2009-09-28 00:00:00

abstract：:We report a case of severe thrombocytopenia following pegylated interferon-alpha 2a (Peg-IFN-alpha 2a) treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-alpha induced severe thrombocytopenia and its immune-mediated mechanism. Discontinuation of IFN-alpha and early a...

journal_title：World journal of gastroenterology

authors： Li L,Han DK,Lu J

更新日期：2010-03-21 00:00:00

abstract：AIM:To assess the clinical outcomes of pre-, pro- and synbiotics therapy in patients with acute pancreatitis. METHODS:The databases including Medline, Embase, the Cochrane Library, Web of Science and Chinese Biomedicine Database were searched for all relevant randomized controlled trials that studied the effects of pr...

journal_title：World journal of gastroenterology

authors： Zhang MM,Cheng JQ,Lu YR,Yi ZH,Yang P,Wu XT

更新日期：2010-08-21 00:00:00

abstract：:The nasogastric tube (NGT) has become a frequently used device to alleviate gastrointestinal symptoms. Nasogastric tube syndrome (NTS) is an uncommon but potentially life-threatening complication of an indwelling NGT. NTS is characterized by acute upper airway obstruction due to bilateral vocal cord paralysis. We repo...

journal_title：World journal of gastroenterology

authors： Sano N,Yamamoto M,Nagai K,Yamada K,Ohkohchi N

更新日期：2016-04-21 00:00:00

abstract：AIM:To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats. METHODS:Giving a fructose-enriched diet (FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats (150-200 ...

journal_title：World journal of gastroenterology

authors： Abd El-Haleim EA,Bahgat AK,Saleh S

更新日期：2016-03-14 00:00:00

abstract：AIM:To investigate the immunogenicity of candidate DNA vaccine against hepatitis C virus (HCV) delivered by two plasmids expressing HCV envelope protein 1 (E1) and envelope protein 2 (E2) antigens respectively and to study the effect of CpG adjuvant on this candidate vaccine. METHODS:Recombinant plasmids expressing HC...

journal_title：World journal of gastroenterology

authors： Zhu LX,Liu J,Ye Y,Xie YH,Kong YY,Li GD,Wang Y

更新日期：2004-09-01 00:00:00

abstract：AIM:To establish cell line and patient-derived xenograft (PDX) models for neuroendocrine carcinomas (NEC) which is highly desirable for gaining insight into tumor development as well as preclinical research including biomarker testing and drug response prediction. METHODS:Cell line establishment was conducted from dir...

journal_title：World journal of gastroenterology

authors： Gock M,Mullins CS,Harnack C,Prall F,Ramer R,Göder A,Krämer OH,Klar E,Linnebacher M

更新日期：2018-09-07 00:00:00

abstract：AIM:To study the effect of probiotics on interleukin-8 secretion in intestinal epithelia when stimulated by proinflammatory cytokines. METHODS:Colonic adenocarcinoma HT29 cells were cultured and divided into four groups: control, TNF-alpha (group T in short), bifidobacterium (group B), lactobacillus (group L). B. Long...

journal_title：World journal of gastroenterology

authors： Bai AP,Ouyang Q,Zhang W,Wang CH,Li SF

更新日期：2004-02-01 00:00:00

abstract：AIM:To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis. METHODS:Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S...

journal_title：World journal of gastroenterology

authors： Hernández R,Martínez-Lara E,Cañuelo A,del Moral ML,Blanco S,Siles E,Jiménez A,Pedrosa JA,Peinado MA

更新日期：2005-12-21 00:00:00

abstract：AIM:To evaluate the effect of gastrectomy on diabetes mellitus (DM) and hypertension (HTN) in non-obese gastric cancer patients. METHODS:A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and ...

journal_title：World journal of gastroenterology

authors： Lee EK,Kim SY,Lee YJ,Kwak MH,Kim HJ,Choi IJ,Cho SJ,Kim YW,Lee JY,Kim CG,Yoon HM,Eom BW,Kong SY,Yoo MK,Park JH,Ryu KW

更新日期：2015-01-28 00:00:00

abstract：AIM:To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS:After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type I),...

journal_title：World journal of gastroenterology

authors： Ewald N,Marzeion AM,Bretzel RG,Kloer HU,Hardt PD

更新日期：2007-02-14 00:00:00

abstract：AIM:To explore the regulator of G-protein signaling 5 (RGS5) expression in gastric carcinoma and its association with differentiation and microvascular density (MVD). METHODS:Expression of RGS5 and CD34 were examined in 76 cases of gastric carcinoma, including 22 cases with lymph node metastasis and 54 cases without l...

journal_title：World journal of gastroenterology

authors： Wang JH,Huang WS,Hu CR,Guan XX,Zhou HB,Chen LB

更新日期：2010-11-28 00:00:00

abstract：AIM:To explore the influence of polymorphisms in genes encoding for the chemokines Stromal cell-Derived Factor-1 (SDF-1)/CXCL12 and Monocyte Chemotactic Protein-1 (MCP-1)/CCL2, or for the chemokine receptor CCR5 on the risks of liver-related death and hepatocellular carcinoma (HCC) occurrence in hepatitis C virus (HCV)...

journal_title：World journal of gastroenterology

authors： Nahon P,Sutton A,Rufat P,Simon C,Trinchet JC,Gattegno L,Beaugrand M,Charnaux N

更新日期：2008-02-07 00:00:00

abstract：:Hereditary pancreatitis is an autosomal dominant condition, which results in recurrent attacks of acute pancreatitis, progressing to chronic pancreatitis often at a young age. The majority of patients with hereditary pancreatitis express one of two mutations (R122H or N29I) in the cationic trypsinogen gene (PRSS1 gene...

journal_title：World journal of gastroenterology

authors： Charnley RM

更新日期：2003-01-01 00:00:00

abstract：AIM:To retrospectively collect inpatient and outpatient data and to assess the use of endoscopic procedures during the years 1991, 1997 and 2003 to analyse for trends. METHODS:This retrospective survey was conducted in a University-associated Gastroenterology Unit offering secondary and tertiary health care services f...

journal_title：World journal of gastroenterology

authors： Schultz M,Davidson A,Donald S,Targonska B,Turnbull A,Weggery S,Livingstone V,Dockerty JD

更新日期：2009-02-07 00:00:00

abstract：AIM:To evaluate the association between liver stiffness (LS) prior to the initiation of dual/triple therapy and viral response. METHODS:LS was measured in all patients before treatment was administered. The therapeutic approach was based on hepatic, virological, and immunological evaluations and considered the fact th...

journal_title：World journal of gastroenterology

authors： Stasi C,Piluso A,Arena U,Salomoni E,Montalto P,Monti M,Boldrini B,Corti G,Marra F,Laffi G,Milani S,Zignego AL

更新日期：2015-03-14 00:00:00

abstract：:The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world's population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Trip...

journal_title：World journal of gastroenterology

authors： Takeuchi H,Trang VT,Morimoto N,Nishida Y,Matsumura Y,Sugiura T

更新日期：2014-07-21 00:00:00

abstract：AIM:To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. METHODS:The CT26.WT mouse colon carcinoma cell line was grown and expanded in vitro. Following the expansion, BALB/c mice were inoculated s.c. with viable tumor cells. After the tumors had establ...

journal_title：World journal of gastroenterology

authors： Ojo-Amaize EA,Cottam HB,Oyemade OA,Okogun JI,Nchekwube EJ

更新日期：2007-09-14 00:00:00

abstract：AIM:To investigate the intestinal segment-specific effects of diabetes and insulin replacement on the density of different subpopulations of submucous neurons. METHODS:Ten weeks after the onset of type 1 diabetes samples were taken from the duodenum, ileum and colon of streptozotocin-induce diabetic, insulin-treated d...

journal_title：World journal of gastroenterology

authors： Bódi N,Szalai Z,Chandrakumar L,Bagyánszki M

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:End-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is the second leading indication for liver transplantation. To date, only moderately effective pharmacotherapies exist to treat NASH. Understanding the pathogenesis of NASH is therefore crucial for the development of new therapies. The in...

journal_title：World journal of gastroenterology

authors： Bluemel S,Wang Y,Lee S,Schnabl B

更新日期：2020-09-07 00:00:00

abstract：AIM:To evaluate the serum concentration of antimitochondrial antibodies (AMAs) as a prognostic indicator of progressive primary biliary cirrhosis (pPBC). METHODS:Serum concentrations of AMA subtypes (anti-M2, anti-M4, and anti-M9), biochemical indices of liver function and Mayo risk factor (MRF) were determined in 30 ...

journal_title：World journal of gastroenterology

authors： Flisiak R,Pelszynska M,Prokopowicz D,Rogalska M,Grygoruk U

更新日期：2005-09-28 00:00:00

abstract：BACKGROUND:Increasing levels of antibiotic resistance have reduced the Helicobacter pylori (H. pylori) eradication rates afforded by the standard triple therapy. Thus, 2-wk first-line four-drug regimens must be considered. AIM:To analyze the eradication rates of modified bismuth-containing quadruple therapy (mBCQT) an...

journal_title：World journal of gastroenterology

authors： Kim SJ,Chung JW,Woo HS,Kim SY,Kim JH,Kim YJ,Kim KO,Kwon KA,Park DK

更新日期：2019-12-14 00:00:00

abstract：AIM:To prospectively investigate the detection rate of laterally spreading tumors (LSTs) of the colorectum by computed tomography (CT) colonography (CTC). METHODS:Patients with LSTs measuring ≥ 20 mm detected during colonoscopy were prospectively enrolled in the study. All patients underwent colonoscopy and subsequent...

journal_title：World journal of gastroenterology

authors： Togashi K,Utano K,Kijima S,Sato Y,Horie H,Sunada K,Lefor AT,Sugimoto H,Yasuda Y

更新日期：2014-12-14 00:00:00

abstract：:We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed...

journal_title：World journal of gastroenterology

authors： Park TY,Choi CH,Yang SY,Oh IS,Song ID,Lee HW,Kim HJ,Do JH,Chang SK,Cho AR,Cha YJ

更新日期：2009-12-28 00:00:00