Abstract:
AIM:To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS:After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type I), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clinical signs and symptoms at present and before intervention using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determination of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amylase were measured. RESULTS:Eighty percent of patients reported an improvement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (< 200 microg/g) of fecal elastase prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGT) decreased significantly after ES. CONCLUSION:The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Ewald N,Marzeion AM,Bretzel RG,Kloer HU,Hardt PDdoi
10.3748/wjg.v13.i6.901subject
Has Abstractpub_date
2007-02-14 00:00:00pages
901-5issue
6eissn
1007-9327issn
2219-2840journal_volume
13pub_type
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i48.6575
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journal_title:World journal of gastroenterology
pub_type: 临床试验,杂志文章
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3748/wjg.v17.i15.2007
更新日期:2011-04-21 00:00:00
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更新日期:2005-11-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2011-03-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.5716
更新日期:2009-12-07 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-12-14 00:00:00