Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer.

Abstract:

AIM:To observe the expression of cyclooxygenase-2 (COX-2) and to investigate the association between COX-2 expression and infection with cytotoxic-associated gene A (cagA) positive strain Helicobacter pylori (Hp) in human gastric cancer, and subsequently to provide fresh ideas for the early prevention of gastric cancer. METHODS:32 Specimens of gastric cancer and corresponding adjacent normal gastric mucosa were obtained from patients who had undergone surgical operations of gastric cancer. All the samples including 1 case of stomach malignant lymphoma and 31 cases of gastric adenocarcinoma were confirmed by pathology diagnosis. The expression of COX-2 in 32 specimens of gastric cancer and corresponding adjacent normal gastric mucosa was quantitatively determined and analyzed with Flow Cytometry, and the levels of COX-2 protein were compared between specimens with cagA(+) Hp infection and those without cagA(+) Hp infection. The cagA gene in 32 specimens of gastric cancer was detected by polymerase chain reaction (PCR) method. RESULTS:Twenty-seven of 32 (84 %) specimens of gastric cancer showed over-expression of COX-2, compared with the adjacent normal gastric mucosa. cagA(+) gene were detected from 19 specimens of gastric cancer, but not from the other 13 specimens. The levels of COX-2 protein in 19 specimens of gastric cancer with cagA(+) Hp infection (the number of positive cells was 73.82+/-18.2) were significantly higher than those in the 13 specimens without cagA(+) Hp infection (the number of positive cells was 35.92+/-22.1). CONCLUSION:COX-2 is overexpressed in gastric cancer and cagA(+) Hp infection could up-regulate the expression of COX-2 in gastric cancer in human. There may also exist another way or channel to regulate the expression of COX-2 in gastric cancer in addition to cagA(+) Hp infection. Therefore, applying COX-2 selective inhibitors could be an effective and promising way to prevent gastric cancer.

journal_name

World J Gastroenterol

authors

Guo XL,Wang LE,Du SY,Fan CL,Li L,Wang P,Yuan Y

doi

10.3748/wjg.v9.i2.246

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

246-9

issue

2

eissn

1007-9327

issn

2219-2840

journal_volume

9

pub_type

杂志文章
  • Two cases of neuroendocrine carcinoma of the gallbladder.

    abstract::Neuroendocrine carcinoma (NEC) of the gallbladder is a rare subtype of gallbladder tumor. Here, we report two cases of NEC in two patients initially suspected to have gallbladder carcinoma. No specific symptoms or abnormal blood test results were observed preoperatively. Abdominal computed tomography scans indicated i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i33.11916

    authors: Chen H,Shen YY,Ni XZ

    更新日期:2014-09-07 00:00:00

  • Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect.

    abstract:AIM:To assess numbers and case fatality of patients with upper gastrointestinal bleeding (UGIB), effects of deprivation and whether weekend presentation affected outcomes. METHODS:Data was obtained from Information Services Division (ISD) Scotland and National Records of Scotland (NRS) death records for a ten year per...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i38.10890

    authors: Ahmed A,Armstrong M,Robertson I,Morris AJ,Blatchford O,Stanley AJ

    更新日期:2015-10-14 00:00:00

  • New technologies in gastrointestinal research.

    abstract::This issue presents different new techniques aiming to increase our understanding of the gastrointestinal system and to improve treatment. The technologies cover selected methods to evoke and assess gut pain, new methods for imaging and physiological measurements, histochemistry, pharmacological modelling etc. There i...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.15.129

    authors: Drewes AM,Gregersen H

    更新日期:2009-01-14 00:00:00

  • Letter to the editor: Diagnosis of erythropoietic protoporphyria with severe liver injury - a case report.

    abstract::Erythropoietic protoporphyria (EPP) is an extremely rare disease which is often unrecognized as diagnosis. In the recent article Lui et al describe a patient with a new diagnosis of EPP with severe liver injury. Approximately 5%-20% of patients with EPP develop liver manifestations. The most severe complication of EPP...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v25.i30.4292

    authors: Wensink D,Wagenmakers MA,Wilson JP,Langendonk JG

    更新日期:2019-08-14 00:00:00

  • Effects of iron manipulation on trace elements level in a model of colitis in rats.

    abstract:AIM:Trace elements (TE) metabolism is altered in inflammatory bowel diseases. TE (zinc and copper) are constituents of antioxidant enzymes. Iron is involved in the pathogenesis of chronic inflammation. The aim was to evaluate zinc and copper status and the effects of iron manipulation in experimental colitis. METHODS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i28.4396

    authors: Barollo M,D'Inca R,Scarpa M,Medici V,Cardin R,Bortolami M,Ruffolo C,Angriman I,Sturniolo GC

    更新日期:2005-07-28 00:00:00

  • Chronic hepatitis B in children with or without malignancies: a 13-year follow-up.

    abstract:AIM:To evaluate the outcome of chronic hepatitis B (CHB) in children with or without malignancies. METHODS:Twenty four children (15 boys and 9 girls) with malignancies, followed up by the pediatric gastroenterology outpatient clinic for CHB between January 2000 and December 2013, were enrolled in the study (Group 1). ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i7.2073

    authors: Usta M,Urgancı N,Yıldırmak ZY,Dogan Vural S

    更新日期:2015-02-21 00:00:00

  • First-line eradication of H pylori infection in Europe: a meta-analysis based on congress abstracts, 1997-2004.

    abstract:AIM:To meta-analyse the European abstracts presented between 1997-2004 at the European H pylori Study Group, United European Gastroenterology Week meetings and World Congresses of Gastroenterology. METHODS:The abstracts of randomized/controlled prospective studies were classified into groups based on first-line eradic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v12.i33.5311

    authors: Buzás GM,Józan J

    更新日期:2006-09-07 00:00:00

  • Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis.

    abstract:AIM:Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP). Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation. METHODS:AP was indu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i15.2340

    authors: Andican G,Gelisgen R,Unal E,Tortum OB,Dervisoglu S,Karahasanoglu T,Burçak G

    更新日期:2005-04-21 00:00:00

  • A newly designed big cup nitinol stent for gastric outlet obstruction.

    abstract:AIM:To find out whether a newly designed big cup nitinol stent is suitable for treatment of patients with gastric outlet obstruction resulting from gastric cancer. METHODS:The new stent is composed of a proximal big cup segment (20 mm in length and 48-55 mm in diameter), a middle part (60 mm in length and 20 mm in dia...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i33.4206

    authors: Shi D,Liao SH,Geng JP

    更新日期:2010-09-07 00:00:00

  • Pneumocystis jiroveci pneumonia and pneumomediastinum in an anti-TNFalpha naive patient with ulcerative colitis.

    abstract::We report the case of a 21-year-old man who was noted to have pneumomediastinum during an admission for an acute flare of ulcerative colitis. At that time, he was on maintenance treatment with azathioprine at a dose of 1.25 mg/kg per day, and had not received supplementary steroids for 9 mo. He had never received anti...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.1897

    authors: Lee JC,Bell DC,Guinness RM,Ahmad T

    更新日期:2009-04-21 00:00:00

  • A case of intrahepatic clear cell cholangiocarcinoma.

    abstract::Intrahepatic clear cell cholangiocarcinoma is very rare - only 8 cases have been reported. A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging, and hepatic segmentectomy was performed. Histopathologically, the tumor cells had copious clear cytop...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i20.2571

    authors: Toriyama E,Nanashima A,Hayashi H,Abe K,Kinoshita N,Yuge S,Nagayasu T,Uetani M,Hayashi T

    更新日期:2010-05-28 00:00:00

  • Comparison of two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma.

    abstract:AIM:To compare two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma. METHODS:Thirty New Zealand rabbits were randomly divided into two groups: A and B. Group A was assigned a traditional laparotomy method (embedding tumor fragments directly into the liver with tweezers). Group B was subjected to an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i16.4875

    authors: Chen Z,Kang Z,Xiao EH,Tong M,Xiao YD,Li HB

    更新日期:2015-04-28 00:00:00

  • Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice.

    abstract:AIM:To investigate the effect of Clostridium difficile (C. difficile) infection in an interleukin 10-deficient (IL-10(-/-)) mouse model of inflammatory bowel disease. METHODS:Bone marrow-derived dendritic cells isolated from wild type (WT) and IL-10(-/-)mice were stimulated for 4 h with C. difficile toxin A (200 μg/mL...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i45.17084

    authors: Kim MN,Koh SJ,Kim JM,Im JP,Jung HC,Kim JS

    更新日期:2014-12-07 00:00:00

  • Preparation of monoclonal antibody against apoptosis-associated antigens of hepatoma cells by subtractive immunization.

    abstract:AIM:To elucidate the expression of the apoptosis-associated molecules in human primary hepatocellular carcinoma (HCC) cells, and prepare the monoclonal antibodies (mAb) against the apoptosis-associated antigens of HCC cells. METHODS:Human HCC cell line HCC-9204 cells were induced apoptosis with 60 mL x L(-1) ethanol f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i5.808

    authors: Yang LJ,Wang WL

    更新日期:2002-10-01 00:00:00

  • Stable expression of human cytochrome P450 2D6*10 in HepG2 cells.

    abstract:AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for <2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to study its enzymatic activity...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i2.234

    authors: Zhuge J,Yu YN,Wu XD

    更新日期:2004-01-15 00:00:00

  • Effect of probiotics on pro-inflammatory cytokines and NF-kappaB activation in ulcerative colitis.

    abstract:AIM:To demonstrate the therapeutic effect of probiotics in patients with ulcerative colitis (UC), and their effect on inflammatory mediators and nuclear factor (NF)-kappaB activation in these patients. METHODS:Thirty patients with mild to moderate UC were randomly classified into two groups: sulfasalazine group, who r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v16.i33.4145

    authors: Hegazy SK,El-Bedewy MM

    更新日期:2010-09-07 00:00:00

  • Acute upper gastrointestinal bleeding in operated stomach: outcome of 105 cases.

    abstract:AIM:To compare the causes and clinical outcome of patients with acute upper gastrointestinal bleeding (AUGB) and a history of gastric surgery to those with AUGB but without a history of gastric surgery in the past. METHODS:The causes and clinical outcome were compared between 105 patients with AUGB and a history of ga...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i29.4570

    authors: Nikolopoulou VN,Thomopoulos KC,Theocharis GI,Arvaniti VA,Vagianos CE

    更新日期:2005-08-07 00:00:00

  • Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review.

    abstract:BACKGROUND:Anemia is considered a public health issue and is often caused by iron deficiency. Iron-deficiency anemia (IDA) often originates from blood loss from lesions in the gastrointestinal tract in men and postmenopausal women, and its prevalence among patients with gastrointestinal bleeding has been estimated to b...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i45.7242

    authors: Cotter J,Baldaia C,Ferreira M,Macedo G,Pedroto I

    更新日期:2020-12-07 00:00:00

  • Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure.

    abstract::Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i7.2214

    authors: Bockmann JH,Dandri M,Lüth S,Pannicke N,Lohse AW

    更新日期:2015-02-21 00:00:00

  • Prognostic value of KIT mutation in gastrointestinal stromal tumors.

    abstract:AIM:To examine the prevalence and prognostic significance of C-kit gene mutation and analysis the correlation of C-kit gene mutation and the clinicalpathologic parameters of GISTs. METHODS:Eighty-two GISTs were studied for the mutation of C-kit gene by PCR-SSCP, DNA sequence. Statistical comparison were used to analys...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i25.3948

    authors: Liu XH,Bai CG,Xie Q,Feng F,Xu ZY,Ma DL

    更新日期:2005-07-07 00:00:00

  • Improvements of postburn renal function by early enteral feeding and their possible mechanisms in rats.

    abstract:AIM:To investigate the protective effects of early enteral feeding (EEF) on postburn impairments of renal function and their possible mechanisms. METHODS:Wistar rats with 30 % of total body surface area (TBSA) full-thickness burn were adopted as the experimental model. The effects of EEF on the postburn changes of gas...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i7.1545

    authors: Zhu L,Yang ZC,Chen DC

    更新日期:2003-07-01 00:00:00

  • NAFLD prevalence differs among hispanic subgroups: the Multi-Ethnic Study of Atherosclerosis.

    abstract:AIM:To compare prevalence rates of non-alcoholic fatty liver disease (NAFLD) between Hispanics of Mexican origin and Hispanics of Dominican and Puerto Rican origin. METHODS:We evaluated prevalence rates of NAFLD between the two largest sub-populations of Hispanics in the United States; Hispanics of Mexican origin and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v20.i17.4987

    authors: Fleischman MW,Budoff M,Zeb I,Li D,Foster T

    更新日期:2014-05-07 00:00:00

  • Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells.

    abstract:AIM:To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS:Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, suc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i40.6312

    authors: Strup-Perrot C,Vozenin-Brotons MC,Vandamme M,Linard C,Mathé D

    更新日期:2005-10-28 00:00:00

  • Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis.

    abstract:AIM:To investigate the role of heme oxygenase-1 (HO-1) in pathogenesis of experimental hepatorenal syndrome (HRS). METHODS:Rats were divided into liver cirrhotic group, zinc protoporphyrin IX (ZnPP) treatment group, cobalt protoporphyrin (CoPP) treatment group and sham group. Biliary cirrhosis was established by bile ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i3.322

    authors: Guo SB,Duan ZJ,Li Q,Sun XY

    更新日期:2011-01-21 00:00:00

  • Ischemic colitis and large bowel infarction: a case report.

    abstract::Ischemic bowel disease results from an acute or chronic drop in the blood supply to the bowel and may have various clinical presentations, such as intestinal angina, ischemic colitis or intestinal infarction. Elderly patients with systemic atherosclerosis who are symptomatic for the disease in two or more vascular bed...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i39.5640

    authors: Georgescu EF,Carstea D,Dumitrescu D,Teodorescu R,Carstea A

    更新日期:2012-10-21 00:00:00

  • Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by E. coli.

    abstract:AIM:To investigate the therapeutic effects of recombinant human growth hormone (rhGH) on rat septic shock with intraabdominal infection by E. coli and its possible mechanism. METHODS:76 SD rats were divided into 3 groups randomly: control group (group C, n=16) without any special treatment, septic shock group (group S...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i6.1134

    authors: Huang Y,Wang SR,Yi C,Ying MY,Lin Y,Zhi MH

    更新日期:2002-12-01 00:00:00

  • Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse.

    abstract:AIM:To assess the risk of relapse in ulcerative colitis (UC) patients in clinical remission using mucosal status and fecal immunochemical test (FIT) results. METHODS:The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores (MESs) an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i21.5079

    authors: Nakarai A,Kato J,Hiraoka S,Takashima S,Takei D,Inokuchi T,Sugihara Y,Takahara M,Harada K,Okada H

    更新日期:2016-06-07 00:00:00

  • Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis.

    abstract:AIM:To investigate the association between thrombocytopenia and relapse after treatment for hepatocellular carcinoma (HCC). METHODS:We searched the PubMed, EMBASE, and Web of Science databases to obtain eligible studies. The hazard ratios (HRs) values and 95% confidence intervals (CIs) were pooled by random effects mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v21.i25.7895

    authors: Pang Q,Qu K,Bi JB,Liu SS,Zhang JY,Song SD,Lin T,Xu XS,Wan Y,Tai MH,Liu HC,Dong YF,Liu C

    更新日期:2015-07-07 00:00:00

  • High expression level of soluble SARS spike protein mediated by adenovirus in HEK293 cells.

    abstract:AIM:To develop a highly efficacious method for preparation of soluble SARS S-protein using adenovirus vector to meet the requirement for S-protein investigation. METHODS:The human adenovirus vector was used to express the soluble S-protein (corresponding to 1 approximately 1190 amino acids) fused with Myc/His tag usin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i9.1452

    authors: Zhong F,Zhong ZY,Liang S,Li XJ

    更新日期:2006-03-07 00:00:00

  • Impact of disease severity on gastric residual volume in critical patients.

    abstract:AIM:To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS:Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i15.2007

    authors: Hsu CW,Sun SF,Lee DL,Lin SL,Wong KF,Huang HH,Li HJ

    更新日期:2011-04-21 00:00:00