Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis.

Abstract:

AIM:To investigate the association between thrombocytopenia and relapse after treatment for hepatocellular carcinoma (HCC). METHODS:We searched the PubMed, EMBASE, and Web of Science databases to obtain eligible studies. The hazard ratios (HRs) values and 95% confidence intervals (CIs) were pooled by random effects model. Subsequently, we estimated the heterogeneity, performed a sensitivity analysis, determined the publication bias, and performed subgroup and meta-regression analyses. Study quality was assessed by using the Oxford Center for Evidence Based Medicine tool. RESULTS:We identified 18 eligible studies by retrieval (published during 2000-2014). Out of the 4163 patients with HCC who were recruited, 2746 (66.0%) experienced recurrence. In general, our meta-analysis suggested that low platelet count (PLT) before therapy significantly increased the probability of postoperative recurrence (HR = 1.53, 95%CI: 1.29-1.81). PLT was also valuable in the prediction of intrahepatic distant recurrence (HR = 1.49, 95%CI: 1.25-1.77). Subgroup and meta-regression analyses identified various therapeutic modalities as the source of a high degree of heterogeneity. The pooled HR values showed no obvious change when a single study was removed, but otherwise, an opposite-effects model was used. In addition, no significant publication bias was detected. CONCLUSION:Thrombocytopenia before treatment might be an inexpensive and useful predictor of postoperative recurrence in patients with HCC.

journal_name

World J Gastroenterol

authors

Pang Q,Qu K,Bi JB,Liu SS,Zhang JY,Song SD,Lin T,Xu XS,Wan Y,Tai MH,Liu HC,Dong YF,Liu C

doi

10.3748/wjg.v21.i25.7895

subject

Has Abstract

pub_date

2015-07-07 00:00:00

pages

7895-906

issue

25

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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