Immunotherapy for colorectal cancer.

abstract：BACKGROUND:The human microRNA 375 (MIR375) is significantly downregulated in human colorectal cancer (CRC) and we have previously shown that MIR375 is a CRC-associated miRNA. The metadherin (MTDH) is a candidate target gene of MIR375. AIM:To investigate the interaction and function between MIR375 and MTDH in human CRC...

journal_title：World journal of gastroenterology

authors： Han SH,Mo JS,Park WC,Chae SC

更新日期：2019-11-28 00:00:00

abstract：AIM:To study the effects of IkappaBalpha and its mutants (IkappaBalphaM, IkappaBalpha243N, IkappaBalphaM244C) on NF-kappaB, p53 and their downstream target genes. The relationship of NF-kappaB, p53, and IkappaBalpha was further discussed. METHODS:pECFP-IkappaBalpha, pECFP-IkappaBalphaM (amino acides 1-317, Ser32, 36A)...

journal_title：World journal of gastroenterology

authors： Li X,Xing D,Wang J,Zhu DB,Zhang L,Chen XJ,Sun FY,Hong A

更新日期：2006-11-07 00:00:00

abstract：AIM:To investigate whether regional geography influences ethnic and gender trends for the development of gastric cancer (GC). METHODS:This retrospective analysis of the INVISION patient database at Louisiana State University Health Sciences Center-Shreveport (LSUHSC-S), a southern United States regional hospital, was ...

journal_title：World journal of gastroenterology

authors： Suryawala K,Soliman D,Mutyala M,Nageeb S,Boktor M,Seth A,Aravantagi A,Sheth A,Morris J,Jordan P,Manas K,Cvek U,Trutschl M,Becker F,Alexander J

更新日期：2015-07-07 00:00:00

abstract：AIM:To evaluate the clinical usefulness of (18)F-fluorodeoxyglucose positron emission and computed tomography ((18)F-FDG PET/CT) in restaging of esophageal cancer after surgical resection and radiotherapy. METHODS:Between January 2007 and Aug 2008, twenty histopathologically diagnosed esophageal cancer patients underw...

journal_title：World journal of gastroenterology

authors： Sun L,Su XH,Guan YS,Pan WM,Luo ZM,Wei JH,Zhao L,Wu H

更新日期：2009-04-21 00:00:00

abstract：AIM:To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHODS:The stress-induced gastric mucosal injury in rat model was established by water-immersion and restra...

journal_title：World journal of gastroenterology

authors： Yang ZB,Yan J,Zou XP,Yi SX,Chang XR,Lin YP,Li XP

更新日期：2006-09-14 00:00:00

abstract：AIM:To investigate long-term outcome in obscure gastrointestinal bleeding (OGIB) after negative capsule endoscopy (CE) and identify risk factors for rebleeding. METHODS:A total of 113 consecutive patients underwent CE for OGIB from May 2003 to June 2010 at Seoul National University Hospital. Ninety-five patients (84.1...

journal_title：World journal of gastroenterology

authors： Koh SJ,Im JP,Kim JW,Kim BG,Lee KL,Kim SG,Kim JS,Jung HC

更新日期：2013-03-14 00:00:00

abstract：:A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer (T3N2M0 Stage III) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation, including redness, erosion, edema, bleeding, friability, and exudate wit...

journal_title：World journal of gastroenterology

authors： Takeshita N,Kanda N,Fukunaga T,Kimura M,Sugamoto Y,Tasaki K,Uesato M,Sazuka T,Maruyama T,Aida N,Tamachi T,Hosokawa T,Asai Y,Matsubara H

更新日期：2015-08-14 00:00:00

abstract：:Splenic rupture (SR) after colonoscopy is a very rare but potentially serious complication. Delayed diagnosis is common, and may increase morbidity and mortality associated. There is no clear relation between SR and difficult diagnostic or therapeutic procedures, but it has been suggested that loop formation and exces...

journal_title：World journal of gastroenterology

authors： Herreros de Tejada A,Giménez-Alvira L,Van den Brule E,Sánchez-Yuste R,Matallanos P,Blázquez E,Calleja JL,Abreu LE

更新日期：2014-07-28 00:00:00

abstract：AIM:To examine the effect of hepatitis C virus (HCV) structural mimics of regulatory regions of the genome on HCV replication. METHODS:HCV RNA structural mimics were constructed and tested in a HCV genotype 1b aBB7 replicon, and a Japanese fulminant hepatitis-1 (JFH-1) HCV genotype 2a infection model. All sequences we...

journal_title：World journal of gastroenterology

authors： Smolic R,Smolic M,Andorfer JH,Wu CH,Smith RM,Wu GY

更新日期：2010-05-07 00:00:00

abstract：AIM:To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma (SCRC) and their relationship to metastasis and prognosis. METHODS:The lymphatic vessel density (LVD) and microvessel density (MVD) in tumor tissue obtained from 132 patients with primary SCRC, including ...

journal_title：World journal of gastroenterology

authors： Yan G,Zhou XY,Cai SJ,Zhang GH,Peng JJ,Du X

更新日期：2008-01-07 00:00:00

abstract：AIM:To investigate the apoptotic effect of photoexcited titanium dioxide (TiO(2)) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS:Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human...

journal_title：World journal of gastroenterology

authors： Wang L,Mao J,Zhang GH,Tu MJ

更新日期：2007-08-07 00:00:00

abstract：:Gut microbiota plays a key role in the pathogenesis of alcoholic liver disease (ALD). Consumption of alcohol leads to increased gut permeability, small intestinal bacterial overgrowth, and enteric dysbiosis. These factors contribute to the increased translocation of microbial products to the liver via the portal tract...

journal_title：World journal of gastroenterology

authors： Sung H,Kim SW,Hong M,Suk KT

更新日期：2016-08-07 00:00:00

abstract：AIM:To evaluate of scoring system in predicting choledocholithiasis in selective intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC). METHODS:The scoring system of predicting choledocholithiasis was developed during the retrospective study in 264 cases, and was tested in 184 to evaluate its p...

journal_title：World journal of gastroenterology

authors： Sun XD,Cai XY,Li JD,Cai XJ,Mu YP,Wu JM

更新日期：2003-04-01 00:00:00

abstract：:Desmoid tumor is a locally invasive, myofibroblastic, nonmetastatic tumor. Its pathogenesis remains unclear and it may involve genetic abnormalities, sex hormones and traumatic injury, including surgery. Postoperative intra-abdominal desmoid tumor is rare, especially in the retroperitoneum. We report a case of postope...

journal_title：World journal of gastroenterology

authors： Shih LY,Wei CK,Lin CW,Tseng CE

更新日期：2012-11-14 00:00:00

abstract：AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy. METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre, were rev...

journal_title：World journal of gastroenterology

authors： Pang TC,Fung T,Samra J,Hugh TJ,Smith RC

更新日期：2011-03-28 00:00:00

abstract：AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for <2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to study its enzymatic activity...

journal_title：World journal of gastroenterology

authors： Zhuge J,Yu YN,Wu XD

更新日期：2004-01-15 00:00:00

abstract：:Based on reviews of the literature and experts' consensus, the Chinese Society of Hepatology developed guidelines for the diagnosis and treatment of liver cirrhosis, in order to improve clinical practice. In addition to what has been covered in previously published guidelines on the management of cirrhosis complicatio...

journal_title：World journal of gastroenterology

authors： Xu XY,Ding HG,Li WG,Xu JH,Han Y,Jia JD,Wei L,Duan ZP,Ling-Hu EQ,Zhuang H

更新日期：2020-12-07 00:00:00

abstract：:Corticosteroids and immunomodulators have been the mainstay therapies for Crohn's disease. Corticosteroids are highly effective to control symptoms in the short-term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an...

journal_title：World journal of gastroenterology

authors： Ricart E,García-Bosch O,Ordás I,Panés J

更新日期：2008-09-28 00:00:00

abstract：AIM:To study the beneficial effects of triterpene alpha,beta-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS:Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 x 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of alph...

journal_title：World journal of gastroenterology

authors： Melo CM,Carvalho KM,Neves JC,Morais TC,Rao VS,Santos FA,Brito GA,Chaves MH

更新日期：2010-09-14 00:00:00

abstract：AIM:To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS:During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital, a total of 412 patients exposed to oxa...

journal_title：World journal of gastroenterology

authors： Wang JH,King TM,Chang MC,Hsu CW

更新日期：2012-10-14 00:00:00

abstract：:A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors...

journal_title：World journal of gastroenterology

authors： Soga K,Konishi H,Tatsumi N,Konishi C,Nakano K,Wakabayashi N,Mitsufuji S,Kataoka K,Okanoue T,Mukaisho K,Hattori T

更新日期：2008-02-21 00:00:00

abstract：:A wide range of local thermal ablative therapies have been developed in the treatment of non resectable hepatocellular carcinoma (HCC) in the last decade. Laser ablation (LA) and radiofrequency ablation (RFA) are the two most widely used of these. This article provides an up to date overview of the role of laser ablat...

journal_title：World journal of gastroenterology

authors： Gough-Palmer AL,Gedroyc WM

更新日期：2008-12-21 00:00:00

abstract：AIM:To improve the technique of tissue microarray (tissue chip). METHODS:A new tissue microarraying method was invented with a common microscope installed with a special holing needle, a sampling needle, and a special box fixing paraffin blocks on the microscope slide carrier. With the movement of microscope tube and ...

journal_title：World journal of gastroenterology

authors： Dan HL,Zhang YL,Zhang Y,Wang YD,Lai ZS,Yang YJ,Cui HH,Jian YT,Geng J,Ding YQ,Guo CH,Zhou DY

更新日期：2004-02-15 00:00:00

abstract：:Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have b...

journal_title：World journal of gastroenterology

authors： Mariani F,Sena P,Roncucci L

更新日期：2014-08-07 00:00:00

abstract：AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats. METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups: control (C), control supplemented with quercetin (200 mg/kg que...

journal_title：World journal of gastroenterology

authors： Ferreira PE,Lopes CR,Alves AM,Alves ÉP,Linden DR,Zanoni JN,Buttow NC

更新日期：2013-10-14 00:00:00

abstract：AIM:To assess the etiology of chronic liver diseases (CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology. METHODS:A random sample of charts of patients referred to for increased liver enzymes between January 1998 and Decemb...

journal_title：World journal of gastroenterology

authors： Saracco GM,Evangelista A,Fagoonee S,Ciccone G,Bugianesi E,Caviglia GP,Abate ML,Rizzetto M,Pellicano R,Smedile A

更新日期：2016-09-28 00:00:00

abstract：AIM:To compare the results for endoscopic ultrasound (EUS)-guided drainage of clear fluid pancreatic pseudocysts with the results for abscess drainage. METHODS:All patients referred for endoscopic drainage of a fluid collection were prospectively included. The outcome was recorded. RESULTS:Altogether 26 pseudocysts o...

journal_title：World journal of gastroenterology

authors： Sadik R,Kalaitzakis E,Thune A,Hansen J,Jönson C

更新日期：2011-01-28 00:00:00

abstract：:AIM:To study the clinical significance of the diagnosis and catheterized interventional treatment of digital subtraction angiography (DSA) for pancreatic tumors.METHODS: Ninety-two patients with pancreatic tumor, 69 males and 23 females, aged from 41 to 70 years (mean 57.1 years) were diagnosed with DSA. Sixty-one pat...

journal_title：World journal of gastroenterology

authors： Xu HB,Zhang YJ,Wei WJ,Li WM,Tu XQ

更新日期：1998-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the 10 most common cancers worldwide. There is no ideal treatment for HCC yet and many researchers are trying to improve the effects of treatment by changing therapeutic strategies. As the majority of human cancers seem to exhibit either abnormal p53 gene or disrupted p53 gene ...

journal_title：World journal of gastroenterology

authors： Guan YS,La Z,Yang L,He Q,Li P

更新日期：2007-02-21 00:00:00

abstract：:The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn's disease and ulcerative colitis. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine, 6-mercaptopurine and thioguanine. We wi...

journal_title：World journal of gastroenterology

authors： Frei P,Biedermann L,Nielsen OH,Rogler G

更新日期：2013-02-21 00:00:00