Stable expression of human cytochrome P450 2D6*10 in HepG2 cells.

abstract：:The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients, but the specificity of these antibodies is generally low, and the frequencies vary largely betwee...

journal_title：World journal of gastroenterology

authors： Hov JR,Boberg KM,Karlsen TH

更新日期：2008-06-28 00:00:00

abstract：AIM:To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer. METHODS:Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorect...

journal_title：World journal of gastroenterology

authors： Mainenti PP,Iodice D,Segreto S,Storto G,Magliulo M,De Palma GD,Salvatore M,Pace L

更新日期：2011-03-21 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is the most common cause of hepatic fibrosis and hepatocellular carcinoma (HCC), mainly as a result of chronic necroinflammatory liver disease. A characteristic feature of chronic hepatitis B infection, alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD) is he...

journal_title：World journal of gastroenterology

authors： Shimizu I,Kohno N,Tamaki K,Shono M,Huang HW,He JH,Yao DF

更新日期：2007-08-28 00:00:00

abstract：:Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma (HCC). Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to hepatocarcinogenesis showed a deregulation of G1 and S phases in HCC of genetically susceptible F344 rats...

journal_title：World journal of gastroenterology

authors： Feo F,Frau M,Pascale RM

更新日期：2008-11-21 00:00:00

abstract：:Although the lung is the major site for Mycobacterium tuberculosis infection, gastrointestinal involvement can be present as part of multiorgan disease process or, less commonly, can be seen as primary gastrointestinal tuberculosis. In the cases where the culture is negative, it can be difficult to differentiate tuber...

journal_title：World journal of gastroenterology

authors： Settbas Y,Alper M,Akcan Y,Gurbuz Y,Oksuz S

更新日期：2003-10-01 00:00:00

abstract：AIM:To summarize progress in the study of K-ras gene studies in pancreatic cancer and its potential clinical significance in screening test for early detection of pancreatic cancer, and to differentiate pancreatic cancer from chronic pancreatitis in recent decade. METHODS:Literature search (MEDLINE 1986-2003) was perf...

journal_title：World journal of gastroenterology

authors： Mu DQ,Peng YS,Xu QJ

更新日期：2004-02-15 00:00:00

abstract：AIM:To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS:This study was conducted in 90 patients undergoing autologous HSCT....

journal_title：World journal of gastroenterology

authors： Ceneli O,Ozkurt ZN,Acar K,Rota S,Aki SZ,Yeğin ZA,Yağci M,Ozenirler S,Sucak GT

更新日期：2010-04-14 00:00:00

abstract：AIM:To explore the mechanism of protection against acetaminophen-induced acute liver injury by Liuweiwuling tablets. METHODS:Intraperitoneal injections of acetaminophen (250 mg/kg) were used to induce acute liver injury in male C57BL/6 mice. A total of 24 healthy mice were randomly assigned to two groups: an acute liv...

journal_title：World journal of gastroenterology

authors： Lei YC,Li W,Luo P

更新日期：2015-07-14 00:00:00

abstract：:The liver is the commonest site of distant metastasis of colorectal cancer and nearly half of the patients with colorectal cancer ultimately develop liver involved during the course of their diseases. Surgery is the only therapy that offers the possibility of cure for patients with hepatic metastatic diseases. Five-ye...

journal_title：World journal of gastroenterology

authors： Liu LX,Zhang WH,Jiang HC

更新日期：2003-02-01 00:00:00

abstract：AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis. METHODS:We performed a prospective study of 127 patients who underwent endoscopic retrograde cholangiopancreatography, for various biliary disorders, at 3 tertiary referral centers in Germany from July 2011 through...

journal_title：World journal of gastroenterology

authors： Lenz P,Eckelskemper F,Erichsen T,Lankisch T,Dechêne A,Lubritz G,Lenze F,Beyna T,Ullerich H,Schmedt A,Domagk D

更新日期：2014-09-14 00:00:00

abstract：:Although thousands of DNA damaging events occur in each cell every day, efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the chromosomes to corr...

journal_title：World journal of gastroenterology

authors： Santos JC,Ribeiro ML

更新日期：2015-08-14 00:00:00

abstract：AIM:To investigate the antioxidant effect of caffeic acid phenethyl ester (CAPE) in hepatic stellate cell-T6 (HSC-T6) cells cultured in vitro and the potential mechanisms. METHODS:HSC-T6 cells were cultured in vitro and treated with various concentrations of CAPE for 24, 48 and 72 h, respectively. Cell proliferation w...

journal_title：World journal of gastroenterology

authors： Yang N,Shi JJ,Wu FP,Li M,Zhang X,Li YP,Zhai S,Jia XL,Dang SS

更新日期：2017-02-21 00:00:00

abstract：AIM:To evaluate the diagnostic value of gadobenate dimeglumine (Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging (MRI) in evaluating hepatic fibrosis and hepatitis. METHODS:Hepatocyte-phase images of Gd-BOPTA-enhanced MRI were retrospectively evaluated in 76 patients with chronic liver disease. These pat...

journal_title：World journal of gastroenterology

authors： Li XM,Chen Z,Xiao EH,Shang QL,Ma C

更新日期：2017-05-07 00:00:00

abstract：AIM:To evaluate the effects of DA-9701 on the gastric emptying of a solid meal using the ¹³C-octanoic acid breath test in a mouse model. METHODS:Male C57BL/6 mice aged > 8 wk and with body weights of 20-25 g were used in this study. The solid test meal consisted of 200 mg of egg yolk labeled with 1.5 L/g ¹³C-octanoic ...

journal_title：World journal of gastroenterology

authors： Lim CH,Choi MG,Park H,Baeg MK,Park JM

更新日期：2013-07-21 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids in the form of triglycerides in hepatocytes. It is most prevalent in western countries and includes a wide range of clinical and histopathological findings, namely from simple steatosis to steatohepatitis and fibrosis, which...

journal_title：World journal of gastroenterology

authors： Katsarou A,Moustakas II,Pyrina I,Lembessis P,Koutsilieris M,Chatzigeorgiou A

更新日期：2020-05-07 00:00:00

abstract：:For an electron microscopic study of the liver, expertise and complicated, time-consuming processing of hepatic tissues and cells is needed. The interpretation of electron microscopy (EM) images requires knowledge of the liver fine structure and experience with the numerous artifacts in fixation, embedding, sectioning...

journal_title：World journal of gastroenterology

authors： Wisse E,Braet F,Duimel H,Vreuls C,Koek G,Olde Damink SW,van den Broek MA,De Geest B,Dejong CH,Tateno C,Frederik P

更新日期：2010-06-21 00:00:00

abstract：AIM:To evaluate the therapeutic effectiveness of oxaliplatin on human gastric carcinoma and to explore its mechanisms. METHODS:Twenty-two cases of stage IV gastric carcinoma received 4-6 (mean 4.6) cycles of first line combined chemotherapy with oxaliplatin (oxaliplatin 85 mg/m(2), iv, gtt, 1 h, d 1; leukovorin 200 mg...

journal_title：World journal of gastroenterology

authors： Lin WL,Li DG,Chen Q,Lu HM

更新日期：2004-10-01 00:00:00

abstract：AIM:To compare the hemostatic efficacy and safety of two mechanical endoscopic methods: endoscopic band ligation (EBL) and endoscopic hemoclip placement (EHP) in patients with actively bleeding Mallory-Weiss syndrome (MWS). METHODS:A prospective randomized study to compare the efficacy and safety of EHP with EBL was p...

journal_title：World journal of gastroenterology

authors： Cho YS,Chae HS,Kim HK,Kim JS,Kim BW,Kim SS,Han SW,Choi KY

更新日期：2008-04-07 00:00:00

abstract：AIM:To investigate the allelic and haplotypic association of reg1alpha gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1alpha polymorphisms. METHODS:We analyzed th...

journal_title：World journal of gastroenterology

authors： Mahurkar S,Bhaskar S,Reddy DN,Rao GV,Chandak GR

更新日期：2007-11-28 00:00:00

abstract：AIM:Hepatitis B virus (HBV) re-activation often occurs spontaneously or after withdrawal of immunosuppressive therapy in patients with chronic hepatitis B. Severe exacerbation, sometimes developing into fulminant hepatic failure, is at high risk of mortality. The efficacy of corticosteroid therapy in "clinically severe...

journal_title：World journal of gastroenterology

authors： Fujiwara K,Yokosuka O,Kojima H,Kanda T,Saisho H,Hirasawa H,Suzuki H

更新日期：2005-02-28 00:00:00

abstract：AIM:To investigate the protective effect and mechanism of rebamipide on small intestinal permeability induced by diclofenac in mice. METHODS:Diclofenac (2.5 mg/kg) was administered once daily for 3 d orally. A control group received the vehicle by gavage. Rebamipide (100 mg/kg, 200 mg/kg, 400 mg/kg) was administered i...

journal_title：World journal of gastroenterology

authors： Diao L,Mei Q,Xu JM,Liu XC,Hu J,Jin J,Yao Q,Chen ML

更新日期：2012-03-14 00:00:00

abstract：AIM:To investigate the diagnostic significance of transient elastography (TE) in a daily routine clinical setting in comparison to clinical signs, laboratory parameters and ultrasound. METHODS:TE, ultrasound, laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver d...

journal_title：World journal of gastroenterology

authors： Göbel T,Schadewaldt-Tümmers J,Greiner L,Poremba C,Häussinger D,Erhardt A

更新日期：2015-01-21 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the digestive tract with systemic manifestations. Etiology is unknown, even if immunological, genetic and environmental factors are involved. The majority of CD patients require surgery during their lifetime due to progressive bowel damage, but, even when all m...

journal_title：World journal of gastroenterology

authors： Spinelli A,Sacchi M,Fiorino G,Danese S,Montorsi M

更新日期：2011-07-21 00:00:00

abstract：:We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by gian...

journal_title：World journal of gastroenterology

authors： Okazaki H,Higuchi K,Shiba M,Nakamura S,Wada T,Yamamori K,Machida A,Kadouchi K,Tamori A,Tominaga K,Watanabe T,Fujiwara Y,Nakamura K,Arakawa T

更新日期：2006-09-07 00:00:00

abstract：AIM:To investigate the protective effect of stronger neo-minophafen C (SNMC) on fulminant hepatic failure (FHF) and its underlying mechanism. METHODS:A mouse model of FHF was established by intraperitoneal injection of galactosamine (D-Gal N) and lipopolysaccharide (LPS). The survival rate, liver function, inflammator...

journal_title：World journal of gastroenterology

authors： Yang BS,Ma YJ,Wang Y,Chen LY,Bi MR,Yan BZ,Bai L,Zhou H,Wang FX

更新日期：2007-01-21 00:00:00

abstract：AIM:To evaluate the impact of therapeutic education on adherence to antiviral treatment and sustained virological response (SVR) in a real-life setting in genotype 2/3 hepatitis C, as there are few adherence data in genotype 2/3 infection, even from randomized trials. METHODS:This prospective survey included genotype ...

journal_title：World journal of gastroenterology

authors： Cacoub P,Ouzan D,Melin P,Lang JP,Rotily M,Fontanges T,Varastet M,Chousterman M,Marcellin P

更新日期：2008-10-28 00:00:00

abstract：:Many of the drugs currently used in medical practice are racemates. The enantiomers of a racemic drug differ in pharmacodynamics and/or pharmacokinetics, thus in some cases it is preferable to develop pure enantiomers by racemic switch. In a recent study by Pai et al, dexrabeprazole [R(+)-rabeprazole] (10 mg) was foun...

journal_title：World journal of gastroenterology

authors： Zhou Q,Yan XF,Pan WS,Zeng S

更新日期：2008-04-28 00:00:00

abstract：AIM:To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori (H pylori) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type IV secretion system and the two pathways, nuclear f...

journal_title：World journal of gastroenterology

authors： Shibata W,Hirata Y,Yoshida H,Otsuka M,Hoshida Y,Ogura K,Maeda S,Ohmae T,Yanai A,Mitsuno Y,Seki N,Kawabe T,Omata M

更新日期：2005-10-21 00:00:00

abstract：AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats. METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups: control (C), control supplemented with quercetin (200 mg/kg que...

journal_title：World journal of gastroenterology

authors： Ferreira PE,Lopes CR,Alves AM,Alves ÉP,Linden DR,Zanoni JN,Buttow NC

更新日期：2013-10-14 00:00:00

abstract：AIM:To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver. METHODS:The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol...

journal_title：World journal of gastroenterology

authors： Jármay K,Karácsony G,Nagy A,Schaff Z

更新日期：2005-11-07 00:00:00