Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis.

Abstract:

AIM:To investigate the allelic and haplotypic association of reg1alpha gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1alpha polymorphisms. METHODS:We analyzed the polymorphisms in the reg1alpha gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes. RESULTS:We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1alpha. None of the 5'UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with any reg1alpha variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status. CONCLUSION:Polymorphisms in reg1alpha gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis.

journal_name

World J Gastroenterol

authors

Mahurkar S,Bhaskar S,Reddy DN,Rao GV,Chandak GR

doi

10.3748/wjg.v13.i44.5938

subject

Has Abstract

pub_date

2007-11-28 00:00:00

pages

5938-43

issue

44

eissn

1007-9327

issn

2219-2840

journal_volume

13

pub_type

杂志文章
  • A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats.

    abstract:AIM:To study the role of gastric mucosal ascorbic acid (AA) in the progression of acute gastric mucosal lesions induced by compound 48/80 (C48/80), a mast cell degranulator, in rats. METHODS:C48/80 (0.75 mg/kg) was intraperitoneally injected to fasted Wistar rats. Oral administration of AA (10, 50 or 100 mg/kg) was pe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i9.1324

    authors: Kamiya Y,Ohta Y,Imai Y,Arisawa T,Nakano H

    更新日期:2005-03-07 00:00:00

  • Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy.

    abstract::Liver penetration is a rare but serious complication of peptic ulcer disease. Usually the diagnosis is made by operation or autopsy. Clinical and laboratory data were no specific. A 64-year-old man was admitted with upper gastrointestinal bleeding. Hepatic penetration was diagnosed as the cause of bleeding. Endoscopy ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i12.1838

    authors: Kayacetin E,Kayacetin S

    更新日期:2004-06-15 00:00:00

  • Maytenus erythroxylon Reissek (Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms.

    abstract:AIM:To investigate the acute toxicity, phytochemical profile, antidiarrheal activity and mechanisms of action of Maytenus erythroxylon (M. erythroxylon) ethanol extract. METHODS:A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity. Intestinal transit and gastric emptying protocols were used ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i24.4381

    authors: Formiga RO,Quirino ZGM,Diniz MFFM,Marinho AF,Tavares JF,Batista LM

    更新日期:2017-06-28 00:00:00

  • Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond.

    abstract::Systemic therapy for hepatocellular carcinoma (HCC) has markedly advanced since the survival benefit of a molecular targeted agent, sorafenib, were demonstrated in the SHARP and Asia Pacific trials in 2007. Treatment options for patients with advanced HCC increased by sorafenib, and long-term survival for patients wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i7.789

    authors: Kudo M

    更新日期:2019-02-21 00:00:00

  • JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease.

    abstract::The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem. Therefore, the contribution of adipose tissue to metabolic homeostasis has become a focus of interest. In this review, we discuss th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i33.3785

    authors: Tarantino G,Caputi A

    更新日期:2011-09-07 00:00:00

  • Hemolymphangioma of the spleen: A report of a rare case.

    abstract::Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. Splenic hemolymphangioma is extremely rare. Herein, we present a case of 62-year-old woman with ambiguous upper quadrant abdominal pain for two months who was found to have an occupying lesion in the spleen on computed tomography. She was ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i17.5442

    authors: Mei Y,Peng CJ,Chen L,Li XX,Li WN,Shu DJ,Xie WT

    更新日期:2015-05-07 00:00:00

  • Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.

    abstract:AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers. METHODS:DNA was extracted from undiluted pancreatic and biliary fluids. As a surrogate for a genome-wide hypomethylation assay, levels of long interspersed nuc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i11.1718

    authors: Kato N,Yamamoto H,Adachi Y,Ohashi H,Taniguchi H,Suzuki H,Nakazawa M,Kaneto H,Sasaki S,Imai K,Shinomura Y

    更新日期:2013-03-21 00:00:00

  • Trocar-related abdominal wall bleeding in 200 patients after laparoscopic cholecistectomy: Personal experience.

    abstract:AIM:To determine the complications and incidence of the first and second access-related vascular injuries induced by videolaparoscopic cholecistectomy. METHODS:We retrospectively reviewed vascular injuries in 200 consecutive patients who underwent videolaparoscopic cholecistectomy from 2003 to 2005. One hundred and on...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i44.7165

    authors: Geraci G,Sciume C,Pisello F,Li Volsi F,Facella T,Modica G

    更新日期:2006-11-28 00:00:00

  • Laparoscopic resection of synchronous intraductal papillary mucinous neoplasms: a case report.

    abstract::We describe herein a 68-year-old woman who was diagnosed with a quite rare entity of intraductal papillary mucinous neoplasms (IPMNs) occurring simultaneously in the left lateral lobe of liver and the tail of pancreas. Abdominal computed tomography and magnetic resonance cholangiopancreatography showed a cystic dilata...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i44.6510

    authors: Xu XW,Li RH,Zhou W,Wang J,Zhang RC,Chen K,Mou YP

    更新日期:2012-11-28 00:00:00

  • Colorectal cancer screening.

    abstract::Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Most evidence points towards screening with fecal occult blood testing. The immunochemical fecal occult blood te...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v12.i42.6747

    authors: McLoughlin RM,O'Morain CA

    更新日期:2006-11-14 00:00:00

  • Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME.

    abstract:AIM:To counteract/reveal celecoxib-induced toxicity and NO system involvement. METHODS:Celecoxib (1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157 (known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine (100 mg/kg ip), as well as NOS blockade [N(G)-nitro...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i29.5304

    authors: Drmic D,Kolenc D,Ilic S,Bauk L,Sever M,Zenko Sever A,Luetic K,Suran J,Seiwerth S,Sikiric P

    更新日期:2017-08-07 00:00:00

  • Management of patients with sphincter of Oddi dysfunction based on a new classification.

    abstract:AIM:To propose a new classification system for sphincter of Oddi dysfunction (SOD) based on clinical data of patients. METHODS:The clinical data of 305 SOD patients documented over the past decade at our center were analyzed retrospectively, and typical cases were reported. RESULTS:The new classification with two mor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i3.385

    authors: Gong JQ,Ren JD,Tian FZ,Jiang R,Tang LJ,Pang Y

    更新日期:2011-01-21 00:00:00

  • Successful treatment of complex cholangiolithiasis following orthotopic liver transplantation with interventional radiology.

    abstract::Bile duct stones are a serious and the third most common complication of the biliary system that can occur following liver transplantation. The incidence rate of bile duct stones after liver transplantation is 1.8%-18%. The management of biliary stones is usually performed with endoscopic techniques; however, the tech...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i6.2000

    authors: Zhou CG,Wei BJ,Gao K,Dai DK,Zhai RY

    更新日期:2015-02-14 00:00:00

  • Mucosal blood flow measurements using laser Doppler perfusion monitoring.

    abstract::Perfusion of individual tissues is a basic physiological process that is necessary to sustain oxygenation and nutrition at a cellular level. Ischemia, or the insufficiency of perfusion, is a common mechanism for tissue death or degeneration, and at a lower threshold, a mechanism for the generation of sensory signallin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.15.198

    authors: Hoff DA,Gregersen H,Hatlebakk JG

    更新日期:2009-01-14 00:00:00

  • Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial.

    abstract:BACKGROUND:The optimal way to home-monitor patients with inflammatory bowel disease (IBD) for disease progression or relapse remains to be found. AIM:To determine whether an electronic health (eHealth) screening procedure for disease activity in IBD should be implemented in clinical practice, scheduled every third mon...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v25.i40.6158

    authors: Ankersen DV,Weimers P,Marker D,Bennedsen M,Saboori S,Paridaens K,Burisch J,Munkholm P

    更新日期:2019-10-28 00:00:00

  • A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes.

    abstract:AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes. METHODS:Silybin-phospholipid complex containing vitamin E (Realsil(®)) was daily administered by gavage (one pouch diluted in 3 mL of water and containing 15 mg ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i20.3007

    authors: Grattagliano I,Diogo CV,Mastrodonato M,de Bari O,Persichella M,Wang DQ,Liquori A,Ferri D,Carratù MR,Oliveira PJ,Portincasa P

    更新日期:2013-05-28 00:00:00

  • Theoretical basis of a beneficial role for vitamin D in viral hepatitis.

    abstract::Abnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis. Some studies suggested a relationship between vitamin D and viral hepatitis. Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i38.5338

    authors: Lương Kv,Nguyễn LT

    更新日期:2012-10-14 00:00:00

  • XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis.

    abstract:AIM:To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of meta-analysis. METHODS:We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our sel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.14.6733

    authors: Geng J,Zhang YW,Huang GC,Chen LB

    更新日期:2008-11-21 00:00:00

  • Analysis of gene expression profile of pancreatic carcinoma using cDNA microarray.

    abstract:AIM:To identify new diagnostic markers and drug targets, the gene expression profiles of pancreatic cancer were compared with that of adjacent normal tissues utilizing cDNA microarray analysis. METHODS:cDNA probes were prepared by labeling mRNA from samples of six pancreatic carcinoma tissues with Cy5-dUTP and mRNA fr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i4.818

    authors: Tan ZJ,Hu XG,Cao GS,Tang Y

    更新日期:2003-04-01 00:00:00

  • Nonalcoholic fatty liver disease as a multi-systemic disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD includes a wide spectrum of liver conditions ranging from simple steatosis to nonalcoholic steatohepatitis and advanced hepatic fibrosis. NAFLD has been recognized as a hepatic manifestation of metabolic syndrome linked w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i16.4079

    authors: Fotbolcu H,Zorlu E

    更新日期:2016-04-28 00:00:00

  • Extraintestinal manifestations of Helicobacter pylori: a concise review.

    abstract::Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. pylori. Different conditions associated wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i34.11950

    authors: Wong F,Rayner-Hartley E,Byrne MF

    更新日期:2014-09-14 00:00:00

  • Endoscopic management of intragastric penetrated adjustable gastric band for morbid obesity.

    abstract::This report describes a case of successful endoscopic management of intragastric penetrated adjustable gastric band in a patient with morbid obesity. The favorable course of the case described here demonstrates that adjustable gastric bands in the process of migration need not be removed surgically in patients who are...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i25.4098

    authors: De Palma GD,Formato A,Pilone V,Rega M,Giuliano ME,Simeoli I,Forestieri P

    更新日期:2006-07-07 00:00:00

  • Endoscopic submucosal dissection for early gastric cancer: quo vadis?

    abstract::The diagnosis of early gastric cancer (EGC) is of great interest because its endoscopic and surgical treatment presents the best chance for a cure. With technical development, endoscopic submucosal dissection (ESD) has been widely performed for the curative treatment of EGC in Korea. Multinational studies of ESD for E...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i21.2623

    authors: Cho WY,Cho JY,Chung IK,Kim JI,Jang JS,Kim JH

    更新日期:2011-06-07 00:00:00

  • Effect of Helicobacter pylori infection on gastric mucosal pathologic change and level of nitric oxide and nitric oxide synthase.

    abstract:AIM:To investigate the level of nitric oxide (NO) and nitrous oxide synthase (NOS) enzyme and its effect on gastric mucosal pathologic change in patients infected with Helicobacter pylori (H pylori), and to study the pathogenic mechanism of H pylori. METHODS:The mucosal tissues of gastric antrum were taken by endoscop...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i32.5029

    authors: Wang YF,Guo CL,Zhao LZ,Yang GA,Chen P,Wang HK

    更新日期:2005-08-28 00:00:00

  • Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn's disease.

    abstract:AIM:To determine the association of circulating miR-125a/b expression with the risk and disease severity of Crohn's disease (CD), and with inflammatory cytokines. METHODS:Plasma samples were collected from patients with active CD (A-CD), or CD in remission (R-CD) and from healthy controls (HCs). The levels of the infl...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v23.i44.7888

    authors: Sun CM,Wu J,Zhang H,Shi G,Chen ZT

    更新日期:2017-11-28 00:00:00

  • Peeling a giant ileal lipoma with endoscopic unroofing and submucosal dissection.

    abstract::Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i13.1676

    authors: Morimoto T,Fu KI,Konuma H,Izumi Y,Matsuyama S,Ogura K,Miyazaki A,Watanabe S

    更新日期:2010-04-07 00:00:00

  • Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29.

    abstract:AIM:To evaluate the proinflammatory effects and molecular mechanisms of interleukin (IL)-17 in intestinal epithelial cell line HT-29. METHODS:HT-29 cells were cultured with IL-17, tumor necrosis factor (TNF)-α, or the combination of both IL-17 and TNF-α. Real-time PCR and Western blot were used to measure the gene exp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i47.17924

    authors: Wang YL,Fang M,Wang XM,Liu WY,Zheng YJ,Wu XB,Tao R

    更新日期:2014-12-21 00:00:00

  • Alterations of seminal and hormonal parameters: An extrahepatic manifestation of HCV infection?

    abstract:AIM:To evaluate the possible influences of HCV infection and relative antiviral treatment on seminal parameters and reproductive hormonal serum levels. METHODS:Ten male patients with HCV-related chronic hepatitis and 16 healthy male volunteers were studied. In all subjects seminal parameters (nemaspermic concentration...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i19.3073

    authors: Durazzo M,Premoli A,Di Bisceglie C,Bertagna A,Faga E,Biroli G,Manieri C,Bo S,Pagano G

    更新日期:2006-05-21 00:00:00

  • Mechanisms of hepatocellular carcinoma progression.

    abstract::Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i19.2279

    authors: Ogunwobi OO,Harricharran T,Huaman J,Galuza A,Odumuwagun O,Tan Y,Ma GX,Nguyen MT

    更新日期:2019-05-21 00:00:00

  • Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana.

    abstract::Gastroduodenal disease (GDD) was initially thought to be uncommon in Africa. Amongst others, lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world. Following the increasing availa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i26.3344

    authors: Archampong TN,Asmah RH,Richards CJ,Martin VJ,Bayliss CD,Botão E,David L,Beleza S,Carrilho C

    更新日期:2019-07-14 00:00:00