Theoretical basis of a beneficial role for vitamin D in viral hepatitis.

Abstract:

:Abnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis. Some studies suggested a relationship between vitamin D and viral hepatitis. Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the pathology of viral hepatitis (i.e., the major histocompatibility complex class II molecules, the vitamin D receptor, cytochrome P₄₅₀, the renin-angiotensin system, apolipoprotein E, liver X receptor, toll-like receptor, and the proteins regulated by the Sp1 promoter gene). Vitamin D also exerts its effects on viral hepatitis via non-genomic factors, i.e., matrix metalloproteinase, endothelial vascular growth factor, prostaglandins, cyclooxygenase-2, and oxidative stress. In conclusion, vitamin D could have a beneficial role in viral hepatitis. Calcitriol is best used for viral hepatitis because it is the active form of the vitamin D₃ metabolite.

journal_name

World J Gastroenterol

authors

Lương Kv,Nguyễn LT

doi

10.3748/wjg.v18.i38.5338

subject

Has Abstract

pub_date

2012-10-14 00:00:00

pages

5338-50

issue

38

eissn

1007-9327

issn

2219-2840

journal_volume

18

pub_type

杂志文章,评审
  • Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma.

    abstract:AIM:To estimate the incidence of catheter tract implantation metastasis among patients undergoing percutaneous transhepatic biliary drainage (PTBD) for extrahepatic cholangiocarcinoma, and to provide data regarding the management of this unusual complication of PTBD by reviewing cases reported in the literature. METHO...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i44.7024

    authors: Sakata J,Shirai Y,Wakai T,Nomura T,Sakata E,Hatakeyama K

    更新日期:2005-11-28 00:00:00

  • Barrett's metaplasia: clinical implications.

    abstract::The incidence of Barrett's metaplasia (BM) as well as Barrett's adenocarcinoma (BA) has been increasing in western populations. The prognosis of BA is worse because individuals present at a late stage. Attempts have been made to intervene at early stage using surveillance programmes, although proof of efficacy of endo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v7.i4.563

    authors: Ishaq S,Jankowski JA

    更新日期:2001-08-01 00:00:00

  • Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.

    abstract:AIM:To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis. METHODS:Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and he...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i40.6473

    authors: Takahara Y,Takahashi M,Wagatsuma H,Yokoya F,Zhang QW,Yamaguchi M,Aburatani H,Kawada N

    更新日期:2006-10-28 00:00:00

  • Nonalcoholic fatty liver disease as a multi-systemic disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD includes a wide spectrum of liver conditions ranging from simple steatosis to nonalcoholic steatohepatitis and advanced hepatic fibrosis. NAFLD has been recognized as a hepatic manifestation of metabolic syndrome linked w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i16.4079

    authors: Fotbolcu H,Zorlu E

    更新日期:2016-04-28 00:00:00

  • Pathological evolution of hepatitis C virus-"Healthy carriers".

    abstract:AIM:To determine factors associated with fibrosis progression in hepatitis C virus (HCV)-infected patients without significant initial pathological lesions. METHODS:Seventy six untreated HCV-infected patients with initially normal liver as defined by a Knodell score < or = 3, with 2 liver biopsies and detectable HCV-R...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3861

    authors: Sobesky R,Lebray P,Nalpas B,Vallet-Pichard A,Fontaine H,Lagneau JL,Pol S

    更新日期:2008-06-28 00:00:00

  • Assessment of correlation between serum titers of hepatitis C virus and severity of liver disease.

    abstract:AIM:The significance of hepatitis C virus (HCV) serum titers has been examined in several clinical situations. There is much evidence that patients with a lower viral load have better response rates to anti-viral therapy compared to those with higher levels. Moreover, a direct association has been observed between seru...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i16.2409

    authors: Anand BS,Velez M

    更新日期:2004-08-15 00:00:00

  • Primary hepatic neuroendocrine tumor case with a preoperative course of 26 years: A case report and literature review.

    abstract::Primary hepatic neuroendocrine tumor (PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v24.i24.2640

    authors: Meng XF,Pan YW,Wang ZB,Duan WD

    更新日期:2018-06-28 00:00:00

  • Gut perforation after orthotopic liver transplantation in adults.

    abstract:AIM:To describe cases of gut perforation after orthotopic liver transplantation. METHODS:Data were collected from our center database and medical records. Six of 187 patients (3.2%) who underwent orthotopic liver transplantation from January to December 2005 developed gut perforation. All patients were male with an av...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i14.2125

    authors: Xiong J,You S,He XS

    更新日期:2007-04-14 00:00:00

  • Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway.

    abstract:AIM:To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions. METHODS:Fluorescent probes were used to detect reactive oxygen species (ROS) in LOVO cells. Wound healing assay and transwell assay were performed to examine the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i8.2071

    authors: Wang P,Zeng Y,Liu T,Zhang C,Yu PW,Hao YX,Luo HX,Liu G

    更新日期:2014-02-28 00:00:00

  • A case of hypereosinophilic syndrome presenting with intractable gastric ulcers.

    abstract::We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.15.6129

    authors: Park TY,Choi CH,Yang SY,Oh IS,Song ID,Lee HW,Kim HJ,Do JH,Chang SK,Cho AR,Cha YJ

    更新日期:2009-12-28 00:00:00

  • Autoimmune hepatitis in childhood: the role of genetic and immune factors.

    abstract::Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Altho...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i28.4455

    authors: Ferri Liu PM,de Miranda DM,Fagundes ED,Ferreira AR,Simões e Silva AC

    更新日期:2013-07-28 00:00:00

  • Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway.

    abstract:BACKGROUND:Gastric cancer (GC) is one of the most common and deadliest types of cancer worldwide due to its delayed diagnosis and high metastatic frequency, but its exact pathogenesis has not been fully elucidated. ETS homologous factor (EHF) is an important member of the ETS family and contributes to the pathogenesis ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i47.7497

    authors: Gu ML,Zhou XX,Ren MT,Shi KD,Yu MS,Jiao WR,Wang YM,Zhong WX,Ji F

    更新日期:2020-12-21 00:00:00

  • Altered profiles of nuclear matrix proteins during the differentiation of human gastric mucous adenocarcinoma MGc80-3 cells.

    abstract:AIM:To find and identify specific nuclear matrix proteins associated with proliferation and differentiation of carcinoma cells, which will be potential markers for cancer diagnosis and targets in cancer therapy. METHODS:Nuclear matrix proteins were selectively extracted from MGc80-3 cells treated with or without hexam...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i30.4628

    authors: Zhao CH,Li QF

    更新日期:2005-08-14 00:00:00

  • Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver.

    abstract:AIM:To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS:Fifty-four adult male Wistar rats were randomly divided i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i47.7621

    authors: Xu CP,Ji WM,van den Brink GR,Peppelenbosch MP

    更新日期:2006-12-21 00:00:00

  • Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study.

    abstract:AIM:To determine the incidence of hepatocellular carcinoma (HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS:In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i46.10219

    authors: Appel-da-Silva MC,Miozzo SA,Dossin IA,Tovo CV,Branco F,de Mattos AA

    更新日期:2016-12-14 00:00:00

  • Acid suppressive drugs and gastric cancer: a meta-analysis of observational studies.

    abstract:AIM:To evaluate the association between acid suppressive drug use and the development of gastric cancer. METHODS:A systematic search of relevant studies that were published through June 2012 was conducted using the MEDLINE (PubMed), EMBASE, and Cochrane Library databases. The search included observational studies on t...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v19.i16.2560

    authors: Ahn JS,Eom CS,Jeon CY,Park SM

    更新日期:2013-04-28 00:00:00

  • Protective effect of YHI and HHI-I against experimental acute pancreatitis in rabbits.

    abstract::AIM:To observe the protective effect of combined i.v. administraction of Yuanhu injection (YHI) and Huoxuehuayu injection-I (HHI-I) against acute pancreatitis (AP) in rabbits.METHODS:Sever acute pancreatitis (SAP) was induced by retrograde infusion of artificial bile juice into biliary-pancreatic duct, and treated wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i3.256

    authors: Zhao LG,Wu XX,Han EK,Chen YL,Chen C,Xu DQ

    更新日期:1998-06-01 00:00:00

  • Lactase non-persistence and milk consumption in Estonia.

    abstract:AIM:To define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia. METHODS:We genotyped 355 Estonians by polymerase chain reaction and direct sequencing. Milk consumption was analyzed by a que...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i45.7329

    authors: Lember M,Torniainen S,Kull M,Kallikorm R,Saadla P,Rajasalu T,Komu H,Järvelä I

    更新日期:2006-12-07 00:00:00

  • Immunosuppressive therapies for inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is comprised of Crohn's disease and ulcerative colitis, both chronic inflammatory intestinal disorders of unknown etiology characterized by a waxing and waning clinical course. For many years, the drug therapy was limited to sulfasalazine and related aminosalicylates, corticosteroids a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i12.3146

    authors: Zenlea T,Peppercorn MA

    更新日期:2014-03-28 00:00:00

  • Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

    abstract:AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma (PDAC) and to determine whether RASSF6 has an independent prognostic value in PDAC. METHODS:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quanti...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i21.6621

    authors: Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

    更新日期:2015-06-07 00:00:00

  • Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial.

    abstract:AIM:To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS:A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, acc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v17.i34.3916

    authors: Guerra PV,Lima LN,Souza TC,Mazochi V,Penna FJ,Silva AM,Nicoli JR,Guimarães EV

    更新日期:2011-09-14 00:00:00

  • Combined small bowel and reduced auxiliary liver transplantation: case report.

    abstract:AIM:To present a case of combined small bowel and reduced auxiliary liver transplantation. METHODS:A 55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft. A liver was added to restore the patient's liver funct...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i5.956

    authors: Zhang WJ,Liu DG,Ye QF,Sha B,Zhen FJ,Guo H,Xia SS

    更新日期:2002-10-01 00:00:00

  • Effects of ethanol on insulin-like growth factor-I system in primary cultured rat hepatocytes: implications of JNK1/2 and alcoholdehydrogenase.

    abstract:AIM:To evaluate the effects of ethanol on the insulin-like growth factor-I (IGF-I) system involved in c-Jun N-terminal kinase (JNK1/2) and alcoholdehydrogenase (ADH) activity in primary cultured rat hepatocytes. METHODS:Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of et...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.4324

    authors: Oh YI,Kim JH,Kang CW

    更新日期:2008-07-21 00:00:00

  • Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis.

    abstract:AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis. METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine, butyrate, or saline. Enemas were administered twice a week in the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i32.4278

    authors: Pacheco RG,Esposito CC,Müller LC,Castelo-Branco MT,Quintella LP,Chagas VL,de Souza HS,Schanaider A

    更新日期:2012-08-28 00:00:00

  • Combination of allopurinol and hyperbaric oxygen therapy: a new treatment in experimental acute necrotizing pancreatitis?

    abstract:AIM:To investigate the individual and combined effects of allopurinol and hyperbaric oxygen (HBO) therapy on biochemical and histopathological changes, oxidative stress, and bacterial translocation (BT) in the experimental rat acute pancreatitis (AP). METHODS:Eighty-five Sprague-Dawley rats were included in the study....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i46.6203

    authors: Comert B,Isik AT,Aydin S,Bozoglu E,Unal B,Deveci S,Mas N,Cinar E,Mas MR

    更新日期:2007-12-14 00:00:00

  • Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice.

    abstract:AIM:To investigate the protective effect and mechanism of rebamipide on small intestinal permeability induced by diclofenac in mice. METHODS:Diclofenac (2.5 mg/kg) was administered once daily for 3 d orally. A control group received the vehicle by gavage. Rebamipide (100 mg/kg, 200 mg/kg, 400 mg/kg) was administered i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i10.1059

    authors: Diao L,Mei Q,Xu JM,Liu XC,Hu J,Jin J,Yao Q,Chen ML

    更新日期:2012-03-14 00:00:00

  • Hepatoid adenocarcinoma of the stomach: a report of three cases.

    abstract::Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i27.4437

    authors: Ye MF,Tao F,Liu F,Sun AJ

    更新日期:2013-07-21 00:00:00

  • Prognostic factors in patients with advanced cholangiocarcinoma: role of surgery, chemotherapy and body mass index.

    abstract:AIM:To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS:A retrospective review of the medical records of 55 patients diagnosed with cholangio-carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to de...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3224

    authors: Farhat MH,Shamseddine AI,Tawil AN,Berjawi G,Sidani C,Shamseddeen W,Barada KA

    更新日期:2008-05-28 00:00:00

  • Effectiveness and safety of continuous wound infiltration for postoperative pain management after open gastrectomy.

    abstract:AIM:To prospectively evaluate the effectiveness and safety of continuous wound infiltration (CWI) for pain management after open gastrectomy. METHODS:Seventy-five adult patients with American Society of Anesthesiologists (ASA) Physical Status Classification System (ASA) grade 1-3 undergoing open gastrectomy were rando...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v22.i5.1902

    authors: Zheng X,Feng X,Cai XJ

    更新日期:2016-02-07 00:00:00

  • Clinical presentation and genotype of hepatitis delta in Karachi.

    abstract:AIM:To assess the clinical presentation and genotypes of delta hepatitis in local population. METHODS:In this prospective study, 39 consecutive patients who were positive for HBsAg and hepatitis D virus (HDV) antibody were included. The patients were divided in two groups on the basis of presence or absence of HDV RNA...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i18.2604

    authors: Moatter T,Abbas Z,Shabir S,Jafri W

    更新日期:2007-05-14 00:00:00