Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice.

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids in the form of triglycerides in hepatocytes. It is most prevalent in western countries and includes a wide range of clinical and histopathological findings, namely from simple steatosis to steatohepatitis and fibrosis, which...

journal_title：World journal of gastroenterology

authors： Katsarou A,Moustakas II,Pyrina I,Lembessis P,Koutsilieris M,Chatzigeorgiou A

更新日期：2020-05-07 00:00:00

abstract：AIM:To explore the preliminary identification of serum protein pattern models that may be novel potential biomarkers in the detection of gastric cancer. METHODS:A total of 130 serum samples, including 70 from patients with gastric cancer and 60 from healthy adults, were detected by surface-enhanced laser desorption an...

journal_title：World journal of gastroenterology

authors： Qian HG,Shen J,Ma H,Ma HC,Su YH,Hao CY,Xing BC,Huang XF,Shou CC

更新日期：2005-10-28 00:00:00

abstract：:AIM:To explore the risk factors of gallbladder stone recurrence.METHODS:A multifactorial analysis was made for 1058 patients in Shanghai area whose gallbladder stones disappeared after different kinds of nonsurgical therapy,including oral litholytic therapy, extracorporeal shock wave lithotripsy and percutaneous chole...

journal_title：World journal of gastroenterology

authors： Chen P,Wang BS,He LQ

更新日期：1999-02-01 00:00:00

abstract：:INTRODUCTION:To intrestigate the relationship between tumor necrosis factor-alphaand liver fibrosis in patients with chronic liver disease.METHODS:Radioimmunoassay was made in 20 patients with mild chronic hepatitis(CMH),20 patients with severe chronic hepatitis(CSH),51 patients with liver cirrhosis(LC)and 32-normal p...

journal_title：World journal of gastroenterology

authors： Wang X,Chen YX,Xu CF,Zhao GN,Huang YX,Wang QL

更新日期：1998-02-01 00:00:00

abstract：:The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn's disease and ulcerative colitis. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine, 6-mercaptopurine and thioguanine. We wi...

journal_title：World journal of gastroenterology

authors： Frei P,Biedermann L,Nielsen OH,Rogler G

更新日期：2013-02-21 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major health burden. The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity, unhealthy dietary pattern, and sedentary lifestyle. The efficacy and safety profile of pharmacotherapy in the treatment of NAFLD remains uncertai...

journal_title：World journal of gastroenterology

authors： Zelber-Sagi S,Ratziu V,Oren R

更新日期：2011-08-07 00:00:00

abstract：AIM:To investigate the changes in apoptosis in gastrointestinal cancer cells from patients with gastrointestinal cancers treated with arsenic trioxide (As₂O₃); and to study the possible molecular mechanisms of such changes by detecting the expression levels of p53 and Bcl-2. METHODS:Twenty patients with gastrointestin...

journal_title：World journal of gastroenterology

authors： Ma ZB,Xu HY,Jiang M,Yang YL,Liu LX,Li YH

更新日期：2014-05-14 00:00:00

abstract：AIM:To assess the efficiency and safety of radiofrequency-assisted hepatectomy in patients with hepatocellular carcinoma (HCC) and cirrhosis. METHODS:From January 2010 to December 2013, 179 patients with HCC and cirrhosis were recruited for this retrospective study. Of these, 100 patients who received radiofrequency-a...

journal_title：World journal of gastroenterology

authors： Zhang F,Yan J,Feng XB,Xia F,Li XW,Ma KS,Bie P

更新日期：2015-09-21 00:00:00

abstract：:Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host's metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have ...

journal_title：World journal of gastroenterology

authors： Kawaguchi Y,Mizuta T

更新日期：2014-03-21 00:00:00

abstract：AIM:To determine the utility of endoscopic ultrasound-guided biliary drainage (EUS-BD) with a fully covered self-expandable metal stent for managing malignant biliary stricture. METHODS:We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered...

journal_title：World journal of gastroenterology

authors： Kim TH,Kim SH,Oh HJ,Sohn YW,Lee SO

更新日期：2012-05-28 00:00:00

abstract：AIM:To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer. METHODS:E-cadherin expression was detected by immunohistochemistry and two indices of expression were calculated which reflected the level of expression and the locations (membrane and cytoplasm). ...

journal_title：World journal of gastroenterology

authors： Elzagheid A,Algars A,Bendardaf R,Lamlum H,Ristamaki R,Collan Y,Syrjanen K,Pyrhonen S

更新日期：2006-07-21 00:00:00

abstract：AIM:To compare two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma. METHODS:Thirty New Zealand rabbits were randomly divided into two groups: A and B. Group A was assigned a traditional laparotomy method (embedding tumor fragments directly into the liver with tweezers). Group B was subjected to an...

journal_title：World journal of gastroenterology

authors： Chen Z,Kang Z,Xiao EH,Tong M,Xiao YD,Li HB

更新日期：2015-04-28 00:00:00

abstract：AIM:To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. METHODS:Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or...

journal_title：World journal of gastroenterology

authors： Chen YY,Chen CM,Chao PY,Chang TJ,Liu JF

更新日期：2005-01-21 00:00:00

abstract：AIM:To investigate the effect of moxibustion on intestinal flora and release of interleukin-12 (IL-12) and tumor necrosis factor-α (TNF-α) from the colon in rat with ulcerative colitis (UC). METHODS:A rat model of UC was established by local stimulation of the intestine with supernatant from colonic contents harvested...

journal_title：World journal of gastroenterology

authors： Wang XM,Lu Y,Wu LY,Yu SG,Zhao BX,Hu HY,Wu HG,Bao CH,Liu HR,Wang JH,Yao Y,Hua XG,Guo HY,Shen LR

更新日期：2012-12-14 00:00:00

abstract：:A clinical trial of radiotherapy with modified simultaneous integrated boost (SIB) technique against huge tumors was conducted. A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this trial. The total dose of 77 Gy (equivale...

journal_title：World journal of gastroenterology

authors： Nomiya T,Akamatsu H,Harada M,Ota I,Hagiwara Y,Ichikawa M,Miwa M,Kawashiro S,Hagiwara M,Chin M,Hashizume E,Nemoto K

更新日期：2014-12-28 00:00:00

abstract：BACKGROUND:Acute severe ulcerative colitis unresponsive to systemic steroid treatment is a life-threatening medical condition requiring hospitalization and often colectomy. Despite the increasing choice of medical therapy options for ulcerative colitis, the condition remains a great challenge in the field of inflammato...

journal_title：World journal of gastroenterology

authors： Hoffmann P,Wehling C,Krisam J,Pfeiffenberger J,Belling N,Gauss A

更新日期：2019-04-07 00:00:00

abstract：AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

journal_title：World journal of gastroenterology

authors： Costanian C,Tamim H,Assaad S

更新日期：2015-03-28 00:00:00

abstract：AIM:To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats. METHODS:Ninety male Wistar rats were randomly divided into five groups: I (n=0): controls, II (n= 20): sham operated, III (n=20): partial hepatectomy 70% (PHx), IV (...

journal_title：World journal of gastroenterology

authors： Assimakopoulos SF,Alexandris IH,Scopa CD,Mylonas PG,Thomopoulos KC,Georgiou CD,Nikolopoulou VN,Vagianos CE

更新日期：2005-11-21 00:00:00

abstract：:The bacterium Helicobacter pylori (H. pylori) infects the stomachs of approximately 50% of all humans. With its universal occurrence, high infectivity and virulence properties it is considered as one of the most severe global burdens of modern humankind. It has accompanied humans for many thousands of years, and due t...

journal_title：World journal of gastroenterology

authors： Maixner F,Thorell K,Granehäll L,Linz B,Moodley Y,Rattei T,Engstrand L,Zink A

更新日期：2019-11-14 00:00:00

abstract：AIM:To explore the efficacy and safety of herbal medicines (HM) in the treatment of irritable bowel syndrome (IBS). METHODS:A computer-based as well as manual literature search was performed. We reviewed randomized controlled trials on the treatment of IBS with and without HM. RESULTS:A total of 22 studies with 25 HM...

journal_title：World journal of gastroenterology

authors： Shi J,Tong Y,Shen JG,Li HX

更新日期：2008-01-21 00:00:00

abstract：:Systemic therapy for hepatocellular carcinoma (HCC) has markedly advanced since the survival benefit of a molecular targeted agent, sorafenib, were demonstrated in the SHARP and Asia Pacific trials in 2007. Treatment options for patients with advanced HCC increased by sorafenib, and long-term survival for patients wit...

journal_title：World journal of gastroenterology

authors： Kudo M

更新日期：2019-02-21 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is one of the major causes for cancer death worldwide. Treatment of metastatic disease remains challenging as only certain patients benefit from advances made with the intensified chemotherapy regimen folinic acid, irinotecan and oxaliplatin, the epidermal growth factor receptor ...

journal_title：World journal of gastroenterology

authors： Kruger S,Haas M,Ormanns S,Bächmann S,Siveke JT,Kirchner T,Heinemann V,Boeck S

更新日期：2014-08-21 00:00:00

abstract：AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

journal_title：World journal of gastroenterology

authors： Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

更新日期：2012-02-14 00:00:00

abstract：AIM:To evaluate the efficacy of stents in treating patients with anastomotic site obstructions due to cancer recurrence following colorectal surgery. METHODS:The medical records of patients who underwent endoscopic self-expanding metal stents (SEMS) insertion for colorectal obstructions between February 2004 and Janua...

journal_title：World journal of gastroenterology

authors： Kim JH,Lee JJ,Cho JH,Kim KO,Chung JW,Kim YJ,Kwon KA,Park DK,Kim JH

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:The prognosis of gastric cancer continues to remain poor, and epigenetic drugs like histone deacetylase inhibitors (HDACi) have been envisaged as potential therapeutic agents. Nevertheless, clinical trials are facing issues with toxicity and efficacy against solid tumors, which may be partly due to the lack ...

journal_title：World journal of gastroenterology

authors： Amnekar RV,Khan SA,Rashid M,Khade B,Thorat R,Gera P,Shrikhande SV,Smoot DT,Ashktorab H,Gupta S

更新日期：2020-02-14 00:00:00

abstract：AIM:To explore the relationship among interferon-gamma (IFN-gamma) activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity. METHODS:Peripheral blood samples from a total of 43 hepatitis B cirrhotic patients (LC) and 19 healthy controls (NC) were collected to measure their serum levels of IFN-...

journal_title：World journal of gastroenterology

authors： Tang JT,Fang JY,Gu WQ,Li EL

更新日期：2006-05-21 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a group of diseases with excess fat in liver in the absence of a poorly defined limit of alcohol consumption. Most common variety, a universal public health problem, is associated with insulin resistance caused by a host of genetic and epigenetic defects modulated by life st...

journal_title：World journal of gastroenterology

authors： Sanal MG

更新日期：2008-02-14 00:00:00

abstract：AIM:To evaluate the effect of preoperative transcatheter arterial chemoembolization (TACE) on proliferation of hepatocellular carcinoma (HCC) cells. METHODS:A total of 136 patients with HCC underwent liver resection. Of 136 patients, 79 patients received 1 to 5 courses of TACE prior to liver resection (TACE group), wh...

journal_title：World journal of gastroenterology

authors： Xiao EH,Li JQ,Huang JF

更新日期：2007-09-07 00:00:00

abstract：:Transplantation is the optimal treatment for end-stage organ failure, and modern immunosuppression has allowed important progress in short-term outcomes. However, immunosuppression poorly influences chronic rejection and elicits chronic toxicity in current clinical practice. Thus, a major goal in transplantation is to...

journal_title：World journal of gastroenterology

authors： Baroja-Mazo A,Revilla-Nuin B,Parrilla P,Martínez-Alarcón L,Ramírez P,Pons JA

更新日期：2016-09-14 00:00:00

abstract：:The incidence of colorectal cancer (CRC) is on the rise, and the prognosis for patients with recurrent or metastatic disease is extremely poor. Although chemotherapy and radiation therapy can improve survival rates, it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for pati...

journal_title：World journal of gastroenterology

authors： Koido S,Ohkusa T,Homma S,Namiki Y,Takakura K,Saito K,Ito Z,Kobayashi H,Kajihara M,Uchiyama K,Arihiro S,Arakawa H,Okamoto M,Gong J,Tajiri H

更新日期：2013-12-14 00:00:00