Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study.

Abstract:

AIM:To determine the incidence of hepatocellular carcinoma (HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS:In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS:Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients (16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients (P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less (P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54 (0.15-1.89), P = 0.33]. CONCLUSION:HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis.

journal_name

World J Gastroenterol

authors

Appel-da-Silva MC,Miozzo SA,Dossin IA,Tovo CV,Branco F,de Mattos AA

doi

10.3748/wjg.v22.i46.10219

subject

Has Abstract

pub_date

2016-12-14 00:00:00

pages

10219-10225

issue

46

eissn

1007-9327

issn

2219-2840

journal_volume

22

pub_type

杂志文章
  • Stretta: a valuable endoscopic treatment modality for gastroesophageal reflux disease.

    abstract::One potential option for the management of refractory gastro-esophageal reflux disease (GERD) is the delivery of radiofrequency energy to the gastro-esophageal junction (Stretta). This endoscopic therapy is safe, effective, durable, and repeatable if necessary and serves an unmet need for many GERD sufferers. Stretta ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i24.7730

    authors: Triadafilopoulos G

    更新日期:2014-06-28 00:00:00

  • Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.

    abstract:AIM:To identify the susceptible gene (s) for type 2 diabetes in the previously mapped region, 1p36.33-p36.23, in Han population of North China using single nucleotide polymorphisms (SNPs) and to analyze the haplotypes of the gene (s) related to type 2 diabetes. METHODS:Twenty three SNPs located in 10 candidate genes i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.2078

    authors: Li YF,Sun HX,Wu GD,Du WN,Zuo J,Shen Y,Qiang BQ,Yao ZJ,Wang H,Huang W,Chen Z,Xiong MM,Meng Y,Fang FD

    更新日期:2003-09-01 00:00:00

  • Therapeutic procedures for submucosal tumors in the gastrointestinal tract.

    abstract::This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs). The aim of this paper is to investigate the treatments of GI SMTs and to present a case of a gastrointestinal stromal tumor (GIST). Literature searches were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i24.3316

    authors: Ponsaing LG,Hansen MB

    更新日期:2007-06-28 00:00:00

  • Incidence of brain metastasis in patients with esophageal carcinoma.

    abstract:AIM:To determine the incidence of brain metastasis in a contemporary group of patients with carcinoma of the esophagus. METHODS:Retrospective analysis of 53 patients with esophageal carcinoma who received radiotherapy as a component of treatment between 1998 and 2007, including patient and tumor characteristics, and s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i19.2407

    authors: Smith RS,Miller RC

    更新日期:2011-05-21 00:00:00

  • Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis.

    abstract:AIM:To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis. METHODS:The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i43.4906

    authors: Zhang J,Wu Y,Jin HY,Guo S,Dong Z,Zheng ZC,Wang Y,Zhao Y

    更新日期:2018-11-21 00:00:00

  • Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors.

    abstract::During the last decades, further knowledge of hepatocellular carcinoma (HCC) molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors (TKIs) and immunotherapy. In this review, we describe first and second line systemic treatment options for advanced HCC. Several...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i16.1888

    authors: Piñero F,Silva M,Iavarone M

    更新日期:2020-04-28 00:00:00

  • Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis.

    abstract:AIM:To investigate the intestinal anti-inflammatory effect and mechanism of a probiotic Lactobacillus salivarius ssp. salivarius CECT5713 in the TNBS model of rat colitis. METHODS:Female Wistar rats (180-200 g) were used in this study. A group of rats were administered orally the probiotic L. salivarius ssp. salivariu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i33.5185

    authors: Peran L,Camuesco D,Comalada M,Nieto A,Concha A,Diaz-Ropero MP,Olivares M,Xaus J,Zarzuelo A,Galvez J

    更新日期:2005-09-07 00:00:00

  • Molecular evolution of hepatitis A virus in a human diploid cell line.

    abstract:AIM:To investigate the hotspots, direction, and the time course of evolution of hepatitis A virus in the process of consecutive cell culture passage in human KMB17 diploid cells. METHODS:Wild type hepatitis A virus H2w was serially propagated in KMB17 cells until passage 30, and the full-length genomes of H2w and its ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i34.4630

    authors: Tang CH,Mao JS,Chai SA,Chen Y,Zhuang FC

    更新日期:2007-09-14 00:00:00

  • Comparison of four models for end-stage liver disease in evaluating the prognosis of cirrhosis.

    abstract:AIM:To investigate the prognostic value of the model for end-stage liver disease (MELD) and three new MELD-based models combination with serum sodium in decompensated cirrhosis patients-the MELD with the incorporation of serum sodium (MELD-Na), the integrated MELD (iMELD), and the MELD to sodium (MESO) index. METHODS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.6546

    authors: Jiang M,Liu F,Xiong WJ,Zhong L,Chen XM

    更新日期:2008-11-14 00:00:00

  • Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.

    abstract:AIM:To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC). METHODS:Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i34.5266

    authors: Qiu WH,Zhou BS,Chu PG,Chen WG,Chung C,Shih J,Hwu P,Yeh C,Lopez R,Yen Y

    更新日期:2005-09-14 00:00:00

  • Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients.

    abstract:AIM:To investigate the association of tumor necrosis factor alpha (TNFα) -G308A polymorphism with different liver pathological changes in treatment-naïve Egyptian patients infected with hepatitis C virus (HCV) genotype 4. METHODS:This study included 180 subjects, composed of 120 treatment-naïve chronic HCV patients wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i34.7767

    authors: Bader El Din NG,Farouk S,El-Shenawy R,Ibrahim MK,Dawood RM,Elhady MM,Salem AM,Zayed N,Khairy A,El Awady MK

    更新日期:2016-09-14 00:00:00

  • Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection.

    abstract:AIM:Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159) polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i38.6031

    authors: Meiler C,Muhlbauer M,Johann M,Hartmann A,Schnabl B,Wodarz N,Schmitz G,Scholmerich J,Hellerbrand C

    更新日期:2005-10-14 00:00:00

  • Determination of optical properties of normal and adenomatous human colon tissues in vitro using integrating sphere techniques.

    abstract:AIM:The purpose of the present study is to compare the optical properties of normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion in vitro at 476.5, 488, 496.5, 514.5 and 532 nm. We believe these differences in optical properties should help...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i16.2413

    authors: Wei HJ,Xing D,Lu JJ,Gu HM,Wu GY,Jin Y

    更新日期:2005-04-28 00:00:00

  • Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats.

    abstract:AIM:To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS:Rats were randomly assigned to three groups: group I: control, group II: experimental colitis, group III: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necro...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.918

    authors: Akcan A,Kucuk C,Sozuer E,Esel D,Akyildiz H,Akgun H,Muhtaroglu S,Aritas Y

    更新日期:2008-02-14 00:00:00

  • Current status of function-preserving surgery for gastric cancer.

    abstract::Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer (GC) at an early stage. Due to the low incidence of lymph node metastasis and favorable prognosis in early GC, function-preserving surgery which improves postoperative quality of life may be possible. Pylorus-preserving gastrectomy (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i46.17297

    authors: Saito T,Kurokawa Y,Takiguchi S,Mori M,Doki Y

    更新日期:2014-12-14 00:00:00

  • Effect of Danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions.

    abstract:AIM:To investigate the effect of Danzhijiangtang capsule (DJC) on monocyte chemoattractant protein-1 (MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus (T2DM) subclinical vascular lesions. METHODS:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v19.i19.2963

    authors: Fang ZH,Liu Y,Bao TT,Ni YQ,Liu J,Shi GB,Wu JP,Yang JP,Zhang H

    更新日期:2013-05-21 00:00:00

  • Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells.

    abstract:AIM:To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis. METHODS:Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i47.7480

    authors: Hernández R,Martínez-Lara E,Cañuelo A,del Moral ML,Blanco S,Siles E,Jiménez A,Pedrosa JA,Peinado MA

    更新日期:2005-12-21 00:00:00

  • Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound.

    abstract:AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i6.541

    authors: Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

    更新日期:2012-02-14 00:00:00

  • Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: a prospective serial study.

    abstract:AIM:To determine the resistance patterns of Helicobacter pylori (H. pylori) strains isolated from patients in Beijing and monitor the change of antibiotic resistance over time. METHODS:In this prospective, serial and cross-sectional study, H. pylori cultures were successfully obtained from 371 and 950 patients (never ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i9.2786

    authors: Zhang YX,Zhou LY,Song ZQ,Zhang JZ,He LH,Ding Y

    更新日期:2015-03-07 00:00:00

  • Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer.

    abstract:AIM:To investigate the relationship between the expression of p16 gene and the gastric carcinogenesis, depth of invasion and lymph node metastases, and to evaluate the deletion and mutation of exon 2 in p16 gene in gastric carcinoma. METHODS:The expression of p16 protein was examined by streptavidin-peroxidase conjuga...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i4.515

    authors: He XS,Su Q,Chen ZC,He XT,Long ZF,Ling H,Zhang LR

    更新日期:2001-08-01 00:00:00

  • Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai.

    abstract:AIM:To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS:A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levof...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i40.5118

    authors: Sun QJ,Liang X,Zheng Q,Gu WQ,Liu WZ,Xiao SD,Lu H

    更新日期:2010-10-28 00:00:00

  • Fedora-type magnetic compression anastomosis device for intestinal anastomosis.

    abstract:BACKGROUND:Although previous studies have confirmed the feasibility of magnetic compression anastomosis (MCA), there is still a risk of long-term anastomotic stenosis. For traditional MCA devices, a large device is associated with great pressure, and eventually increased leakage. AIM:To develop a novel MCA device to s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i42.6614

    authors: Chen H,Ma T,Wang Y,Zhu HY,Feng Z,Wu RQ,Lv Y,Dong DH

    更新日期:2020-11-14 00:00:00

  • Role of epithelial-mesenchymal transition in gastric cancer initiation and progression.

    abstract::Gastric cancer is one of the most common malignant tumors worldwide. Due to its intricate initiation and progression mechanisms, early detection and effective treatment of gastric cancer are difficult to achieve. The epithelial-mesenchymal transition (EMT) is characterized as a fundamental process that is critical for...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i18.5403

    authors: Peng Z,Wang CX,Fang EH,Wang GB,Tong Q

    更新日期:2014-05-14 00:00:00

  • Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2.

    abstract:AIM:To investigate the effects of Terminalia arjuna (T. arjuna) extract on human hepatoma cell line (HepG2) and its possible role in induction of apoptosis. METHODS:Human hepatoma cells were treated with different concentrations of ethanolic extract of T. arjuna and its cytotoxicity effect was measured by trypan blue ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i7.1018

    authors: Sivalokanathan S,Vijayababu MR,Balasubramanian MP

    更新日期:2006-02-21 00:00:00

  • Is concomitant radiotherapy necessary with gemcitabine-based chemotherapy in pancreatic cancer?

    abstract:AIM:To evaluate the efficacy and safety of gemcitabine (GEM) plus radiotherapy compared with GEM alone for pancreatic cancer (PC). METHODS:A systematic search for eligible studies comparing gemcitabine plus radiotherapy with gemcitabine alone for PC was performed using MEDLINE, EMBASE, and the Cochrane Library. A qual...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i46.17648

    authors: Zhang X,Huang HJ,Feng D,Yang DJ,Wang CM,Cai QP

    更新日期:2014-12-14 00:00:00

  • Characteristics of nonvariceal upper gastrointestinal hemorrhage in patients with chronic kidney disease.

    abstract:AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage (NGIH) in patients with chronic kidney disease (CKD). METHODS:From 2003 to 2010, a total of 72 CKD patients (male n = 52, 72.2%; female n = 20, 27.8%) who had undergone endoscopic treatments for NGIH were retrospectively iden...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i43.7719

    authors: Bang CS,Lee YS,Lee YH,Sung H,Park HJ,Kim HS,Kim JB,Baik GH,Kim YS,Yoon JH,Kim DJ,Suk KT

    更新日期:2013-11-21 00:00:00

  • CD24 genetic variants contribute to overall survival in patients with gastric cancer.

    abstract:AIM:To investigate the role of single nucleotide polymorphisms (SNPs) in CD24 gene in susceptibility and overall survival of gastric cancer (GC). METHODS:We genotyped 3 tagging SNPs of CD24-P-534 in the promoter region, P170 in the coding region of exon 2 and P1527 in the 3' untranslated region - using polymerase chai...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i7.2373

    authors: Jia ZF,Wang LZ,Cao XY,Wang C,Cao DH,Wu X,You LL,Jin MS,Wang YP,Zhou BS,Jiang J

    更新日期:2016-02-21 00:00:00

  • Novel strategies for the treatment of inflammatory bowel disease: Selective inhibition of cytokines and adhesion molecules.

    abstract::The etiology of inflammatory bowel disease (IBD) has not yet been clarified and immunosuppressive agents which non-specifically reduce inflammation and immunity have been used in the conventional therapies for IBD. Evidence indicates that a dysregulation of mucosal immunity in the gut of IBD causes an overproduction o...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i29.4628

    authors: Nakamura K,Honda K,Mizutani T,Akiho H,Harada N

    更新日期:2006-08-07 00:00:00

  • Stevens-Johnson syndrome complicating adalimumab therapy in Crohn's disease.

    abstract::The anti-tumor necrosis factor (TNF)alpha medications demonstrate efficacy in the induction of remission and its maintenance in numerous chronic inflammatory conditions. With the increasing number of patients receiving anti-TNFalpha agents, however, less common adverse reactions will occur. Cutaneous eruptions complic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.4449

    authors: Salama M,Lawrance IC

    更新日期:2009-09-21 00:00:00

  • N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis.

    abstract:AIM:To evaluate attenuating properties of N-acetylcysteine (NAC) on oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis (NASH). METHODS:Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control, n=8) was free accessed to regular dry rat chow (RC) for 6 wk. Group 2 (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i38.5127

    authors: Thong-Ngam D,Samuhasaneeto S,Kulaputana O,Klaikeaw N

    更新日期:2007-10-14 00:00:00