Nonalcoholic fatty liver disease as a multi-systemic disease.

Abstract:

:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD includes a wide spectrum of liver conditions ranging from simple steatosis to nonalcoholic steatohepatitis and advanced hepatic fibrosis. NAFLD has been recognized as a hepatic manifestation of metabolic syndrome linked with insulin resistance. NAFLD should be considered not only a liver specific disease but also an early mediator of systemic diseases. Therefore, NAFLD is usually associated with cardiovascular disease, chronic kidney disease, type 2 diabetes, obesity, and dyslipidemia. NAFLD is highly prevalent in the general population and is associated with increased cardiovascular morbidity and mortality. The underlying mechanisms and pathogenesis of NAFLD with regard to other medical disorders are not yet fully understood. This review focuses on pathogenesis of NAFLD and its relation with other systemic diseases.

journal_name

World J Gastroenterol

authors

Fotbolcu H,Zorlu E

doi

10.3748/wjg.v22.i16.4079

subject

Has Abstract

pub_date

2016-04-28 00:00:00

pages

4079-90

issue

16

eissn

1007-9327

issn

2219-2840

journal_volume

22

pub_type

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