Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond.

abstract：AIM:To investigate whether Dihydromyricetin (DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 expression. METHODS:The correlation between Notch1 and Hes1 (a Notch1 target molecule) expression in hepatoma samples was confirmed by qRT-PCR. In addition, MTT assays, flow cytometry and TUNEL...

journal_title：World journal of gastroenterology

authors： Lu CJ,He YF,Yuan WZ,Xiang LJ,Zhang J,Liang YR,Duan J,He YH,Li MY

更新日期：2017-09-14 00:00:00

abstract：AIM:To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection. METHODS:Gastric biopsies from normal mucosa (NM, n=10), chronic gastritis (CG, n=38),...

journal_title：World journal of gastroenterology

authors： Gobbo César AC,de Freitas Calmon M,Cury PM,Caetano A,Borim AA,Silva AE

更新日期：2006-01-28 00:00:00

abstract：:Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn's disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome...

journal_title：World journal of gastroenterology

authors： Tawfik A,Flanagan PK,Campbell BJ

更新日期：2014-07-21 00:00:00

abstract：AIM:To evaluate the impact of glycemic control and nutritional status after total pancreatectomy (TP) on complications, tumor recurrence and overall survival. METHODS:Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected...

journal_title：World journal of gastroenterology

authors： Shi HJ,Jin C,Fu DL

更新日期：2017-01-14 00:00:00

abstract：:Acute acalculous cholecystitis (AAC) is defined as an acute inflammation of the gallbladder in the absence of stones. We herein report a case of a young man who developed AAC after a Salmonella enteritidis gastrointestinal infection. ...

journal_title：World journal of gastroenterology

authors： Ruiz-Rebollo ML,Sánchez-Antolín G,García-Pajares F,Vallecillo-Sande MA,Fernández-Orcajo P,Velicia-Llames R,Caro-Patón A

更新日期：2008-11-07 00:00:00

abstract：AIM:To investigate the effects of butyrate on interleukin (IL)-32alpha expression in epithelial cell lines. METHODS:The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL-32alpha was determined by Western blotting analyses. IL-32alpha mRNA expression was analyzed by real-time poly...

journal_title：World journal of gastroenterology

authors： Kobori A,Bamba S,Imaeda H,Ban H,Tsujikawa T,Saito Y,Fujiyama Y,Andoh A

更新日期：2010-05-21 00:00:00

abstract：AIM:To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and naive chronic hepatitis B, we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS:Eighty patients who had received lamivudine treatment for various periods ...

journal_title：World journal of gastroenterology

authors： Nam SW,Bae SH,Lee SW,Kim YS,Kang SB,Choi JY,Cho SH,Yoon SK,Han JY,Yang JM,Lee YS

更新日期：2008-03-21 00:00:00

abstract：:The incidence of colonic diverticulosis with or without diverticulitis has increased in the Japanese population due to the modernization of food and aging. The rate of diverticulitis in colon diverticulosis ranges from 8.1% to 9.6%. However, few cases of stenosis due to diverticulitis have been reported. These reports...

journal_title：World journal of gastroenterology

authors： Nishiyama N,Mori H,Kobara H,Rafiq K,Fujihara S,Kobayashi M,Masaki T

更新日期：2012-07-21 00:00:00

abstract：AIM:To investigate the effect of APOBEC3G mediated antiviral activity against hepatitis B virus (HBV) in cell cultures and replication competent HBV vector-based mouse model. METHODS:The mammalian hepatoma cells Huh7 and HepG2 were cotransfected with various amounts of CMV-driven expression vector encoding APOBEC3G an...

journal_title：World journal of gastroenterology

authors： Lei YC,Hao YH,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Zhao XP,Lu MJ,Gong FL,Yang DL

更新日期：2006-07-28 00:00:00

abstract：AIM:To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum. METHODS:Data was collected from 350 consecutive ...

journal_title：World journal of gastroenterology

authors： Lahner E,Grossi E,Intraligi M,Buscema M,Corleto VD,Delle Fave G,Annibale B

更新日期：2005-10-07 00:00:00

abstract：AIM:To investigate the efficacy and potential mechanism of Xiaotan Tongfu granules (XTTF) in stress ulcers. METHODS:One hundred sixty rats were randomly divided into 4 groups (n = 10) as follows: the model group (MP group), the control group (CP group), the ranitidine group (RP group) and the XTTF granule group (XP gr...

journal_title：World journal of gastroenterology

authors： Yan B,Shi J,Xiu LJ,Liu X,Zhou YQ,Feng SH,Lv C,Yuan XX,Zhang YC,Li YJ,Wei PK,Qin ZF

更新日期：2013-09-07 00:00:00

abstract：:Bone metastases from gastric cancer (GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells (MCs) positive to tryptase...

journal_title：World journal of gastroenterology

authors： Leporini C,Ammendola M,Marech I,Sammarco G,Sacco R,Gadaleta CD,Oakley C,Russo E,De Sarro G,Ranieri G

更新日期：2015-10-07 00:00:00

abstract：:Acute pancreatitis constitutes 3% of all admissions with abdominal pain. There are reports of osteal fat necrosis leading to periosteal reactions and osteolytic lesions following severe pancreatitis, particularly in long bones. A 54-year-old man was admitted to our hospital with acute pancreatitis, who later developed...

journal_title：World journal of gastroenterology

authors： Muthukumarasamy G,Shanmugam V,Yule SR,Ravindran R

更新日期：2007-07-21 00:00:00

abstract：:An insufficient future liver remnant (FLR) is associated with post-hepatectomy liver failure. Associating liver partition and portal vein ligation for stage hepatectomy (ALPPS) has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR...

journal_title：World journal of gastroenterology

authors： Chan A,Chung PH,Poon RT

更新日期：2014-08-07 00:00:00

abstract：AIM:To investigate the role of reactive oxygen species (ROS) in ethanol-mediated cell death of polarized hepatic (WIF-B) cells. METHODS:In this work, WIF-B cultures were treated with pyrazole (inducer of cytochrome P4502E1, CYP2E1) and/or L-buthionine sulfoximine (BSO), a known inhibitor of hepatic glutathione (GSH), ...

journal_title：World journal of gastroenterology

authors： McVicker BL,Tuma PL,Kharbanda KK,Lee SM,Tuma DJ

更新日期：2009-06-07 00:00:00

abstract：AIM:To investigate the expression of cyclooxygenase-2 (COX-2) in gastric cancer and its relation with the liver metastasis and prognosis. METHODS:Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcription-polymerase chain reac...

journal_title：World journal of gastroenterology

authors： Yu JR,Wu YJ,Qin Q,Lu KZ,Yan S,Liu XS,Zheng SS

更新日期：2005-08-21 00:00:00

abstract：AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

journal_title：World journal of gastroenterology

authors： Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

更新日期：2012-02-14 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory bowel disease, more commonly ...

journal_title：World journal of gastroenterology

authors： Gidwaney NG,Pawa S,Das KM

更新日期：2017-04-14 00:00:00

abstract：AIM:To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis. METHODS:The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at d...

journal_title：World journal of gastroenterology

authors： Shimazu K,Fukuda K,Yoshida T,Inoue M,Shibata H

更新日期：2016-07-14 00:00:00

abstract：AIM:The purpose of the present study is to compare the optical properties of normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion in vitro at 476.5, 488, 496.5, 514.5 and 532 nm. We believe these differences in optical properties should help...

journal_title：World journal of gastroenterology

authors： Wei HJ,Xing D,Lu JJ,Gu HM,Wu GY,Jin Y

更新日期：2005-04-28 00:00:00

abstract：:In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC, it failed in patients with Crohn's disease (CD). This finding strongly hints at a different contribution of JAK signaling in both ...

journal_title：World journal of gastroenterology

authors： Cordes F,Foell D,Ding JN,Varga G,Bettenworth D

更新日期：2020-07-28 00:00:00

abstract：AIM:To evaluate the value of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level for predicting postoperative atrial fibrillation (AF) in patients undergoing surgery for esophageal carcinoma. METHODS:NT-proBNP levels were measured in 142 patients 24 h before and 1 h after surgery for esophageal carcinoma...

journal_title：World journal of gastroenterology

authors： Hou JL,Gao K,Li M,Ma JY,Shi YK,Wang Y,Zhao YF

更新日期：2008-04-28 00:00:00

abstract：:The normal esophageal mucosa creates a protective epithelial barrier that constrains the acidic reflux in the esophageal lumen. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease (NERD) but not in patients with functional heartburn (FH)....

journal_title：World journal of gastroenterology

authors： Triantos C,Koukias N,Karamanolis G,Thomopoulos K

更新日期：2015-05-21 00:00:00

abstract：AIM:To investigate the effects of entero-hepatic bile acid circulation on the inter-digestive migrating myoelectrical complex (MMC) in rats. METHODS:Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of th...

journal_title：World journal of gastroenterology

authors： Fang P,Dong L,Zhang WJ,Luo JY

更新日期：2005-09-14 00:00:00

abstract：AIM:Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this...

journal_title：World journal of gastroenterology

authors： Huang MJ,Yang SS,Lin MS,Huang CS

更新日期：2005-02-14 00:00:00

abstract：:Colorectal cancer is one of the most common causes of cancer morbidity both in men and in women. However, females over 65 years old show higher mortality and lower 5-year survival rate of colorectal cancer compared to their age-matched male counterparts. The objective of this review is to suggest gender-based innovati...

journal_title：World journal of gastroenterology

authors： Kim SE,Paik HY,Yoon H,Lee JE,Kim N,Sung MK

更新日期：2015-05-07 00:00:00

abstract：AIM:To investigate the effect of pituitary homeobox 1 (PITX1) expression in cases of human gastric cancer on cancer differentiation and progression, and carcinogenesis. METHODS:Using polyclonal PITX1 antibodies, we studied the expression of PITX1 in normal gastric mucosa, atypical hyperplasia, intestinal metaplasia, a...

journal_title：World journal of gastroenterology

authors： Chen YN,Chen H,Xu Y,Zhang X,Luo Y

更新日期：2008-01-14 00:00:00

abstract：AIM:To identify the clinicopathological predictors of lymph node (LN) metastasis and evaluate the outcomes of endoscopic submucosal dissection (ESD) in papillary adenocarcinoma-type early gastric cancers (EGCs). METHODS:From January 2005 to May 2013, 49 patients who underwent surgical operation and 24 patients who und...

journal_title：World journal of gastroenterology

authors： Lee HJ,Kim GH,Park DY,Lee BE,Jeon HK,Jhi JH,Song GA

更新日期：2015-04-07 00:00:00

abstract：AIM:To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA). METHODS:We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients receiv...

journal_title：World journal of gastroenterology

authors： Jung JH,Lee HJ,Lee HS,Jo JH,Cho IR,Chung MJ,Park JY,Park SW,Song SY,Bang S

更新日期：2017-05-14 00:00:00

abstract：AIM:To investigate the association of nuclear morphometry and DNA content with resectability of pancreatic cancer. METHODS:A total of 36 patients with pancreatic adenocarcinoma were divided into resectable group and unresectable group. The nuclear morphometry and DNA contents of tumor cells were analyzed by IBAS autoi...

journal_title：World journal of gastroenterology

authors： He YC,Peng W,Qiao JG,Cao J,Chen JW

更新日期：2003-08-01 00:00:00