Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis.

Abstract:

AIM:To investigate the expression of cyclooxygenase-2 (COX-2) in gastric cancer and its relation with the liver metastasis and prognosis. METHODS:Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. The relation between COX-2 expression and prognosis was investigated in 195 cases. RESULTS:The expression of COX-2 mRNA in gastric cancer tissue was significantly higher than that in normal tissue in 47 cases (w = 792, P<0.01). The COX-2 mRNA in pT3-4 tissue expressed higher than that in pT1-2 tissue (w = 204, P<0.05). The positive expression rate of COX-2 protein was 57.9% (113/195). The COX-2 expression was significantly related to histological type, lymphnode metastasis, venous invasion and liver metastasis (P<0.05). No relation was found between COX-2 expression and invasion depth, peritoneal metastasis and International Union against Cancer TNM stage. The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). However, there was no significant correlation between COX-2 immunoreactivity and prognosis. CONCLUSION:COX-2 may play an important role in the development of gastric cancer, and the over-expression of COX-2 protein may be a high risk factor for liver metastasis.

journal_name

World J Gastroenterol

authors

Yu JR,Wu YJ,Qin Q,Lu KZ,Yan S,Liu XS,Zheng SS

doi

10.3748/wjg.v11.i31.4911

keywords:

subject

Has Abstract

pub_date

2005-08-21 00:00:00

pages

4908-11

issue

31

eissn

1007-9327

issn

2219-2840

journal_volume

11

pub_type

杂志文章
  • Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis.

    abstract::Colorectal cancer incidence and mortality in patients younger than 50 years are increasing, but screening before the age of 50 is not offered in Europe. Advanced-stage diagnosis and mortality from colorectal cancer before 50 years of age are increasing. This is not a detection-bias effect; it is a real issue affecting...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i21.2565

    authors: Mannucci A,Zuppardo RA,Rosati R,Leo MD,Perea J,Cavestro GM

    更新日期:2019-06-07 00:00:00

  • Inflammatory bowel disease: a proposal to facilitate the achievement of an unequivocal diagnosis.

    abstract::Following the international guidelines criteria an adequate "diagnostic conclusion" of inflammatory bowel disease (IBD) can be achieved only if clinical, endoscopic and laboratory findings, together with sample technical adequacy and unequivocal histomorphological signs of the disease are available. Thus, a conclusive...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v19.i3.426

    authors: Canavese G,Bassotti G,Astegiano M,Castellano I,Cassoni P,Sapino A,Villanacci V

    更新日期:2013-01-21 00:00:00

  • Treatment of malignant biliary obstruction by combined percutaneous transhepatic biliary drainage with local tumor treatment.

    abstract:AIM:To evaluate the utility of local tumor therapy combined with percutaneous transhepatic biliary drainage (PTBD) for malignant obstructive biliary disease. METHODS:A total of 233 patients with malignant biliary obstruction were treated in our hospital with PTBD by placement of metallic stents and/or plastic tubes. A...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i2.331

    authors: Qian XJ,Zhai RY,Dai DK,Yu P,Gao L

    更新日期:2006-01-14 00:00:00

  • Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications.

    abstract::Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative derangement of intestinal microbial community reported in cirrhotic patients seems to be strictly related with the impairment of liver function. A kind of gut microbial "fingerprint", characterized by the reduced ratio of "good" to...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i43.12322

    authors: Ponziani FR,Gerardi V,Pecere S,D'Aversa F,Lopetuso L,Zocco MA,Pompili M,Gasbarrini A

    更新日期:2015-11-21 00:00:00

  • Prevalence and characteristics of dyspepsia among college students in Zhejiang Province.

    abstract:AIM:To investigate the prevalence and characteristics of uninvestigated dyspepsia among college students in Zhejiang Province. METHODS:Young adult students attending undergraduate (within the 4-year program) and graduate (only first-year students) colleges in Zhejiang Province were recruited between November 2010 and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i13.3649

    authors: Li M,Lu B,Chu L,Zhou H,Chen MY

    更新日期:2014-04-07 00:00:00

  • Methane production and small intestinal bacterial overgrowth in children living in a slum.

    abstract:AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests. METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school, all aged between 6 and 10 years, in Osasco, Brazil. Fo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i41.5932

    authors: Mello CS,Tahan S,Melli LC,Rodrigues MS,de Mello RM,Scaletsky IC,de Morais MB

    更新日期:2012-11-07 00:00:00

  • Helicobacter pylori: management in 2013.

    abstract::Helicobacter pylori (H. pylori) is a prevalent, worldwide, chronic infection. Choice of treatment can be modified according to antibiotic-resistance rates of H. pylori. The ideal therapeutic regimen for H. pylori infection should achieve an eradication rate of ≥ 80%. In some countries, triple therapy with a proton-pum...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i18.5302

    authors: Alahdab YO,Kalayci C

    更新日期:2014-05-14 00:00:00

  • Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines: a meta-analysis.

    abstract:AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease (IBD) by conducting a meta-analysis. METHODS:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of IBD. The search terms were: ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v19.i34.5738

    authors: Rahimi R,Nikfar S,Abdollahi M

    更新日期:2013-09-14 00:00:00

  • Frequency of HER2/neu overexpression in adenocarcinoma of the gastrointestinal system.

    abstract:AIM:To determine the frequency of HER2/neu protein overexpression in gastric (group A), small intestine (group B), and colorectal (group C) adenocarcinoma. METHODS:A descriptive, cross-sectional study was performed on 50 cases of gastrointestinal adenocarcinoma (stomach, small intestine, and colorectal); 11 from group...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i19.5889

    authors: Farzand S,Siddique T,Saba K,Bukhari MH

    更新日期:2014-05-21 00:00:00

  • Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer.

    abstract:AIM:To investigate the expression of mitogen-activated protein kinases (MAPKs) and its upstream protein kinase in human gastric cancer and to evaluate the relationship between protein levels and clinicopathological parameters. METHODS:Western blot was used to measure the expression of extracellular signal-regulated ki...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i5.623

    authors: Liang B,Wang S,Zhu XG,Yu YX,Cui ZR,Yu YZ

    更新日期:2005-02-07 00:00:00

  • Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is a disease in which excessive fat accumulates in the liver of a patient without a history of alcohol abuse. This disease includes simple steatosis and nonalcoholic steatohepatitis (NASH). NAFLD/NASH is recognized as a hepatic manifestation of metabolic syndrome. In recent yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i42.5280

    authors: Takahashi Y,Fukusato T

    更新日期:2010-11-14 00:00:00

  • Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders.

    abstract:AIM:To evaluate the feasibility and utility of confocal laser endomicroscopy (CLE) in the description of normal gastrointestinal (GI) mucosa and in the diagnosis of GI disorders in children, in comparison to histology. METHODS:Forty-four patients (19 female) median age 10.9 years (range 0.7-16.6 years) with suspected ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2214

    authors: Venkatesh K,Cohen M,Evans C,Delaney P,Thomas S,Taylor C,Abou-Taleb A,Kiesslich R,Thomson M

    更新日期:2009-05-14 00:00:00

  • Upregulated expression of Ezrin and invasive phenotype in malignantly transformed esophageal epithelial cells.

    abstract:AIM:To investigate the correlation between ezrin expression and invasive phenotype formation in malignantly transformed esophageal epithelial cells. METHODS:The experimental cell line employed in the present study was originated form the progressive induction of a human embryonic esophageal epithelial cell line (SHEE)...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i6.1182

    authors: Shen ZY,Xu LY,Chen MH,Li EM,Li JT,Wu XY,Zeng Y

    更新日期:2003-06-01 00:00:00

  • Pneumatosis cystoides intestinalis after fluorouracil chemotherapy for rectal cancer.

    abstract::Pneumatosis cystoides intestinalis (PCI) is a relatively rare condition characterized by intraluminal gas in the gastrointestinal tract. Several chemotherapeutic agents have been reported to be associated with PCI, although fluorouracil-related PCI is extremely rare. We report a case of a 76-year old man who received ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3273

    authors: Mimatsu K,Oida T,Kawasaki A,Kano H,Kuboi Y,Aramaki O,Amano S

    更新日期:2008-05-28 00:00:00

  • Superior mesenteric artery syndrome following scoliosis surgery: its risk indicators and treatment strategy.

    abstract:AIM:To investigate the risk indicators, pattern of clinical presentation and treatment strategy of superior mesenteric artery syndrome (SMAS) after scoliosis surgery. METHODS:From July 1997 to October 2003, 640 patients with adolescent scoliosis who had undergone surgical treatment were evaluated prospectively, and am...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i21.3307

    authors: Zhu ZZ,Qiu Y

    更新日期:2005-06-07 00:00:00

  • Translational pancreatic cancer research: A comparative study on patient-derived xenograft models.

    abstract:AIM:To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS:This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i7.794

    authors: Rubio-Manzanares Dorado M,Marín Gómez LM,Aparicio Sánchez D,Pereira Arenas S,Praena-Fernández JM,Borrero Martín JJ,Farfán López F,Gómez Bravo MÁ,Muntané Relat J,Padillo Ruiz J

    更新日期:2018-02-21 00:00:00

  • Shunting branch of portal vein and stent position predict survival after transjugular intrahepatic portosystemic shunt.

    abstract:AIM:To evaluate the effect of the shunting branch of the portal vein (PV) (left or right) and the initial stent position (optimal or suboptimal) of a transjugular intrahepatic portosystemic shunt (TIPS). METHODS:We retrospectively reviewed 307 consecutive cirrhotic patients who underwent TIPS placement for variceal bl...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i3.774

    authors: Bai M,He CY,Qi XS,Yin ZX,Wang JH,Guo WG,Niu J,Xia JL,Zhang ZL,Larson AC,Wu KC,Fan DM,Han GH

    更新日期:2014-01-21 00:00:00

  • Interaction between hepatitis C virus and metabolic factors.

    abstract::Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host's metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i11.2888

    authors: Kawaguchi Y,Mizuta T

    更新日期:2014-03-21 00:00:00

  • Emerging use of artificial intelligence in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a complex, immune-mediated gastrointestinal disorder with ill-defined etiology, multifaceted diagnostic criteria, and unpredictable treatment response. Innovations in IBD diagnostics, including developments in genomic sequencing and molecular analytics, have generated tremendous int...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i44.6923

    authors: Kohli A,Holzwanger EA,Levy AN

    更新日期:2020-11-28 00:00:00

  • Advances in the management of acute liver failure.

    abstract::Acute liver failure (ALF) is an uncommon but dramatic clinical syndrome characterized by hepatic encephalopathy and a bleeding tendency due to abrupt loss of liver function caused by massive or submassive liver necrosis in a patient with a previously healthy liver. The causes of ALF encompass a wide variety of toxic, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i41.7069

    authors: Wang DW,Yin YM,Yao YM

    更新日期:2013-11-07 00:00:00

  • Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model.

    abstract:AIM:To investigate the diagnosis of nonalcoholic steatohepatitis (NASH) using contrast ultrasonography in the NASH rat model. METHODS:The liver in methionine choline-deficient diet (MCDD) rats, a NASH model constructed by feeding an MCDD, was examined by contrast ultrasonography at weeks 2, 4, 8, 12 and 16, with late ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i37.4191

    authors: Miyata Y,Miyahara T,Moriyasu F

    更新日期:2011-10-07 00:00:00

  • Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior.

    abstract:AIM:To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior. METHODS:Twenty pathologically and clinically confirmed CMUSE patients (males:females = 8:12; mean ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i25.4615

    authors: Hwang J,Kim JS,Kim AY,Lim JS,Kim SH,Kim MJ,Kim MS,Song KD,Woo JY

    更新日期:2017-07-07 00:00:00

  • Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon.

    abstract::Hepatitis C virus (HCV) infection is estimated to affect 130-150 million people globally which corresponds to 2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i4.1650

    authors: Belga S,Doucette KE

    更新日期:2016-01-28 00:00:00

  • Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review.

    abstract:AIM:To summarise the literature data on hepatitis C virus (HCV)-infected patients concerning the prevalence of glucose abnormalities and associated risk. METHODS:We conducted a PubMed search and selected all studies found with the key words "HCV" or "hepatitis C virus" and "diabetes" or "insulin resistance". We includ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i9.1697

    authors: Desbois AC,Cacoub P

    更新日期:2017-03-07 00:00:00

  • Tuberculous esophagomediastinal fistula with concomitant mediastinal bronchial artery aneurysm-acute upper gastrointestinal bleeding: A case report.

    abstract:BACKGROUND:Esophagomediastinal fistula is a very rare complication of tuberculosis in otherwise healthy adults, and mediastinal bronchial artery aneurysm is even rarer. In this case report, we describe a rare case of tuberculosis complication that presented with acute upper gastrointestinal (GI) bleeding. It also highl...

    journal_title:World journal of gastroenterology

    pub_type:

    doi:10.3748/wjg.v25.i17.2144

    authors: Alharbi SR

    更新日期:2019-05-07 00:00:00

  • Psychological controversies in gastroparesis: A systematic review.

    abstract:AIM:To systematically review literature addressing three key psychologically-oriented controversies associated with gastroparesis. METHODS:A comprehensive search of PubMed, CINAHL, and PsycINFO databases was performed to identify literature addressing the relationship between gastroparesis and psychological factors. T...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i7.1298

    authors: Woodhouse S,Hebbard G,Knowles SR

    更新日期:2017-02-21 00:00:00

  • Hepatic resection for hepatocellular carcinoma in end-stage renal disease patients: two decades of experience at Chang Gung Memorial Hospital.

    abstract:AIM:Hepatocellular carcinoma (HCC) is a common disease in Taiwan. The prevalence of viral hepatitis infection and the subsequent development of HCC are well known to be higher in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) or peritoneal dialysis (PD) than among the general population. Howev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i14.20

    authors: Yeh CN,Lee WC,Chen MF

    更新日期:2005-04-14 00:00:00

  • Construction and analysis of tree models for chromosomal classification of diffuse large B-cell lymphomas.

    abstract:AIM:To construct tree models for classification of diffuse large B-cell lymphomas (DLBCL) by chromosome copy numbers, to compare them with cDNA microarray classification, and to explore models of multi-gene, multi-step and multi-pathway processes of DLBCL tumorigenesis. METHODS:Maximum-weight branching and distance-ba...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i11.1737

    authors: Jiang HY,Huang ZX,Zhang XF,Desper R,Zhao T

    更新日期:2007-03-21 00:00:00

  • Effects of p53 on apoptosis and proliferation of hepatocellular carcinoma cells treated with transcatheter arterial chemoembolization.

    abstract:AIM:To evaluate the effects of p53 on apoptosis and proliferation of hepatocellular carcinoma (HCC) cells treated with transcatheter arterial chemoembolization (TACE). METHODS:A total of 136 patients with HCC received TACE and other management before surgery were divided into TACE group and non-TACE group. TACE group ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i2.190

    authors: Xiao EH,Li JQ,Huang JF

    更新日期:2004-01-15 00:00:00

  • Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice.

    abstract:AIM:To investigate the effects of restraint stress on chronic colitis in interleukin (IL)-10 deficient (IL-10(-/-)) mice. METHODS:The first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10(-/-) mice. Both wild-type and IL-10(-/-) mice were physical...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i28.8580

    authors: Koh SJ,Kim JW,Kim BG,Lee KL,Kim JS

    更新日期:2015-07-28 00:00:00