Abstract:
AIM:To summarise the literature data on hepatitis C virus (HCV)-infected patients concerning the prevalence of glucose abnormalities and associated risk. METHODS:We conducted a PubMed search and selected all studies found with the key words "HCV" or "hepatitis C virus" and "diabetes" or "insulin resistance". We included only comparative studies written in English or in French, published from January 2000 to April 2015. We collected the literature data on HCV-infected patients concerning the prevalence of glucose abnormalities [diabetes mellitus (DM) and insulin resistance (IR)] and associated risk [i.e., severe liver fibrosis, response to antivirals, and the occurrence of hepatocellular carcinoma (HCC)]. RESULTS:HCV infection is significantly associated with DM/IR compared with healthy volunteers and patients with hepatitis B virus infection. Glucose abnormalities were associated with advanced liver fibrosis, lack of sustained virologic response to interferon alfa-based treatment and with a higher risk of HCC development. As new antiviral therapies may offer a cure for HCV infection, such data should be taken into account, from a therapeutic and preventive point of view, for liver and non-liver consequences of HCV disease. The efficacy of antidiabetic treatment in improving the response to antiviral treatment and in decreasing the risk of HCC has been reported by some studies but not by others. Thus, the effects of glucose abnormalities correction in reducing liver events need further studies. CONCLUSION:Glucose abnormalities are strongly associated with HCV infection and show a negative impact on the main liver related outcomes.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Desbois AC,Cacoub Pdoi
10.3748/wjg.v23.i9.1697subject
Has Abstractpub_date
2017-03-07 00:00:00pages
1697-1711issue
9eissn
1007-9327issn
2219-2840journal_volume
23pub_type
杂志文章,评审abstract:AIM:To determine the prevalence, characteristics and clinical course of pancreatic cystic neoplasms (PCNs) in liver transplantation (LT) recipients. METHODS:We retrospectively studied consecutive patients who underwent LT between January 1998 to April 2016. Clinical and laboratory data were obtained from patient medic...
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journal_title:World journal of gastroenterology
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更新日期:1998-12-01 00:00:00
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更新日期:2011-04-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v9.i5.1028
更新日期:2003-05-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
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更新日期:2013-06-14 00:00:00
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pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
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更新日期:2006-09-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2004-06-15 00:00:00
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journal_title:World journal of gastroenterology
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更新日期:2006-10-21 00:00:00
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更新日期:2008-04-14 00:00:00