Pathogenesis and clinical spectrum of primary sclerosing cholangitis.


:Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory bowel disease, more commonly with ulcerative colitis, and is also part of the clinical spectrum of IgG4-related diseases. Small-duct PSC, a variant of PSC, also has an association with inflammatory bowel disease. The exact pathogenesis of PSC is not well understood at present, however, is likely a combination of a genetic predisposition with alteration of the molecular structure of the gut. Abnormal serum liver chemistry and presence of certain autoimmune markers are usually the first indicators leading to a diagnosis of PCS, however, these may often be normal in early stages of this disease. The diagnosis is made by cholangiography, which is now considered the gold standard. PSC is a known pre-malignant condition. Such patients have an increased risk of developing cholangiocarcinoma, gallbladder neoplasia, and colon cancer. Many new treatment modalities have emerged in the recent past, including anti-tumor necrosis factor- α and anti-integrins; however, liver transplantation is the only known cure for PSC. Despite past and present research, PSC remains an enigmatic biliary disease with few viable treatment options.


World J Gastroenterol


Gidwaney NG,Pawa S,Das KM




Has Abstract


2017-04-14 00:00:00












  • Identification of effective siRNA against K-ras in human pancreatic cancer cell line MiaPaCa-2 by siRNA expression cassette.

    abstract:AIM:We shall construct the small interfering RNA (siRNA) expression cassette (SEC) targeting activated K-ras gene sequence, identify more effective siRNA sequence against K-ras gene in human pancreatic cancer cell line MiaPaCa-2 by SEC and reveal the anti-cancer effects of RNA interference (RNAi) and its therapeutic po...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang W,Wang CY,Dong JH,Chen X,Zhang M,Zhao G

    更新日期:2005-04-07 00:00:00

  • Effects of selenium on peripheral blood mononuclear cell membrane fluidity, interleukin-2 production and interleukin-2 receptor expression in patients with chronic hepatitis.

    abstract:AIM:To study the effect of selenium on peripheral blood mononuclear cell (PBMC) membrane fluidity and immune function in patients with chronic hepatitis. METHODS:PBMCs were pretreated with selenium (1.156x10(-7) mol/L) for 6 h in vitro or extracted directly from patients after administration of selenium-yeast continuo...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: He SX,Wu B,Chang XM,Li HX,Qiao W

    更新日期:2004-12-01 00:00:00

  • p53-expressing conditionally replicative adenovirus CNHK500-p53 against hepatocellular carcinoma in vitro.

    abstract:AIM:To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepatocellular carcinoma (HCC). METHODS:CNHK500-p53 was constructed by using human telomerase reverse transcr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhao HC,Zhang Q,Yang Y,Lu MQ,Li H,Xu C,Chen GH

    更新日期:2007-02-07 00:00:00

  • Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran).

    abstract:AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by us...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Jafarzadeh A,Rezayati MT,Nemati M

    更新日期:2007-06-14 00:00:00

  • Stool DNA methylation assays in colorectal cancer screening.

    abstract::Colorectal cancer (CRC) is fourth most common cancer in men and third in women worldwide. Developing a diagnostic panel of sensitive and specific biomarkers for the early detection of CRC is recognised as to be crucial for early initial diagnosis, which in turn leads to better long term survival. Most of the research ...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审


    authors: Kadiyska T,Nossikoff A

    更新日期:2015-09-21 00:00:00

  • Preoperative gamma-glutamyltransferase to lymphocyte ratio predicts long-term outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection.

    abstract:BACKGROUND:Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous hepatobiliary cancer with limited treatment options. A number of studies have illuminated the relationship between inflammation-based prognostic scores and outcomes in patients with ICC. However, the use of reliable and personalized prognostic algorith...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang JJ,Li H,Li JX,Xu L,Wu H,Zeng Y

    更新日期:2020-04-07 00:00:00

  • Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon.

    abstract::Hepatitis C virus (HCV) infection is estimated to affect 130-150 million people globally which corresponds to 2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Belga S,Doucette KE

    更新日期:2016-01-28 00:00:00

  • Multimodality magnetic resonance imaging in hepatic encephalopathy: an update.

    abstract::Hepatic encephalopathy (HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying factors which contribute to the neurol...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zhang XD,Zhang LJ,Wu SY,Lu GM

    更新日期:2014-08-28 00:00:00

  • Patients without hepatocellular carcinoma progression after transarterial chemoembolization benefit from liver transplantation.

    abstract:AIM:To assess the outcome of patients, who underwent transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and subsequently liver transplantation (OLT) irrespective of tumor size when no tumor progression was observed. METHODS:Records, imaging studies and pathology of 84 patients with HCC were revi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Obed A,Beham A,Püllmann K,Becker H,Schlitt HJ,Lorf T

    更新日期:2007-02-07 00:00:00

  • Prevalence of diverticulosis in recurrent Clostridium difficile infection.

    abstract:AIM:To re-evaluate the theory that colonic diverticulosis is associated with relapse of Clostridium difficile associated disease (CDAD) in light of data suggesting increasing rates of CDAD infection and relapse. METHODS:Charts were reviewed for patients with recurrent CDAD who had also had a prior colonoscopy or flexi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lipp MJ,Pagovich OE,Rabin D,Min AD,Bernstein BB

    更新日期:2010-01-21 00:00:00

  • Therapeutic proteasome inhibition in experimental acute pancreatitis.

    abstract:AIM:To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis. METHODS:Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Letoha T,Fehér LZ,Pecze L,Somlai C,Varga I,Kaszaki J,Tóth G,Vizler C,Tiszlavicz L,Takács T

    更新日期:2007-09-07 00:00:00

  • Clinical characteristics of remote Zeus robot-assisted laparoscopic cholecystectomy: a report of 40 cases.

    abstract:AIM:To summarize the performing essentials and analyze the characteristics of remote Zeus robot-assisted laparoscopic cholecystectomy. METHODS:Robot-assisted laparoscopic cholecystectomy was performed in 40 patients between May 2004 and July 2005. The operating procedures and a variety of clinical parameters were reco...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhou HX,Guo YH,Yu XF,Bao SY,Liu JL,Zhang Y,Ren YG,Zheng Q

    更新日期:2006-04-28 00:00:00

  • Sclerosing encapsulating peritonitis in a liver transplant patient: a case report.

    abstract::We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

    更新日期:2005-09-14 00:00:00

  • Comparison of four models for end-stage liver disease in evaluating the prognosis of cirrhosis.

    abstract:AIM:To investigate the prognostic value of the model for end-stage liver disease (MELD) and three new MELD-based models combination with serum sodium in decompensated cirrhosis patients-the MELD with the incorporation of serum sodium (MELD-Na), the integrated MELD (iMELD), and the MELD to sodium (MESO) index. METHODS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Jiang M,Liu F,Xiong WJ,Zhong L,Chen XM

    更新日期:2008-11-14 00:00:00

  • Helicobacter pylori isolates from ethnic minority patients in Guangxi: resistance rates, mechanisms, and genotype.

    abstract:AIM:To investigate the rate of Helicobacter pylori (H. pylori) resistance to clarithromycin among ethnic minority patients in Guangxi, explore the underlying mechanisms, and analyze factors influencing genotype distribution of H. pylori isolates. METHODS:H. pylori strains were isolated, cultured and subjected to drug ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhao LJ,Huang YQ,Chen BP,Mo XQ,Huang ZS,Huang XF,Wei LD,Wei HY,Chen YH,Tang HY,Huang GR,Qin YC,Li XH,Wang LY

    更新日期:2014-04-28 00:00:00

  • Massive upper gastrointestinal hemorrhage due to invasive hepatocellular carcinoma and hepato-gastric fistula.

    abstract::A 36-year-old male Asian immigrant with a history of hepatitis B and hepatitis C related unresectable hepatocellular carcinoma in the left lobe of the liver presented with hematemesis and severe anemia. He was diagnosed with a liver mass that was resected 8 years ago described as a benign tumor in his home country. He...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Sayana H,Yousef O,Clarkston WK

    更新日期:2013-11-14 00:00:00

  • Gastric intramural hematoma accompanied by severe epigastric pain and hematemesis after endoscopic mucosal resection.

    abstract::Gastric intramural hematoma is a rare injury of the stomach, and is most often seen in patients with underlying disease. Such injury following endoscopic therapy is even rarer, and there are no universally accepted guidelines for its treatment. In this case report, we describe a gastric intramural hematoma which occur...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Sun P,Tan SY,Liao GH

    更新日期:2012-12-21 00:00:00

  • Indomethacin suppresses growth of colon cancer via inhibition of angiogenesis in vivo.

    abstract:AIM:It has been reported that regular consumption of nonsteroidal anti-inflammatory drugs like indomethacin decreases the incidence and mortality rate of a number of gastrointestinal cancers. We aimed to explore the efficacy and possible mechanisms of indomethacin on tumor growth and tumor angiogenesis of human colon c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang HM,Zhang GY

    更新日期:2005-01-21 00:00:00

  • KAI1 gene is differently expressed in papillary and pancreatic cancer: influence on metastasis.

    abstract::AIM:To compare KAI1 in cancer of papilla of Vater and pancreas to evaluate whether there are differences in biologic behavior which might account for prognosis.METHODS:We compared the expression in 24 papillay and 29 pancreatic cancers using Northern blot analysis, immunochemical assay and in situ hybridization, and i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Guo XZ,Friess H,Shao XD,Liu MP,Xia YT,Xu JH,Buchler MW

    更新日期:2000-12-01 00:00:00

  • Left-sided gallbladder: its clinical significance and imaging presentations.

    abstract:AIM:To assess the importance of preoperative diagnosis and presentation of left-sided gallbladder using ultrasound (US), CT and angiography. METHODS:Retrospective review of 1482 patients who underwent enhanced CT scanning was performed. Left-sided gallbladder was diagnosed if a right-sided ligamentum teres was present...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Hsu SL,Chen TY,Huang TL,Sun CK,Concejero AM,Tsang LL,Cheng YF

    更新日期:2007-12-21 00:00:00

  • Experimental study on mechanism and protection of stress ulcer produced by explosive noise.

    abstract::AIM:To establish an experimental model of stress ulcer produced by explosive noise, and to probe into its mechanism and protection.METHODS:The country standard Wistar white rats were randomly divided into control group(n =8), which were neither stimulated nor protected, and stimulating group (divided into subgroups A,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Liu GS,Huang YX,Li SW,Pan BR,Wang X,Sun DY,Wang QL

    更新日期:1998-12-01 00:00:00

  • Analysis of infections in the first 3-month after living donor liver transplantation.

    abstract:AIM:To identify factors related to serious postoperative bacterial and fungal infections in the first 3 mo after living donor liver transplantation (LDLT). METHODS:In the present study, the data of 207 patients from 2004 to 2011 were reviewed. The pre-, intra- and post-operative factors were statistically analyzed. Al...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li C,Wen TF,Mi K,Wang C,Yan LN,Li B

    更新日期:2012-04-28 00:00:00

  • Carcinosarcoma of the liver with mesenchymal differentiation.

    abstract::We report an extremely rare case where a mesenchymal differentiation, especially embryonal sarcoma, was demonstrated in cholangiocarcinoma. At autopsy, a yellowish-white tumor (15 cm x 12 cm) was found in the right hepatic lobe, and there were several daughter nodules in both hepatic lobes. Histologically, most of the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Sumiyoshi S,Kikuyama M,Matsubayashi Y,Kageyama F,Ide Y,Kobayashi Y,Nakamura H

    更新日期:2007-02-07 00:00:00

  • Idiopathic neonatal pneumoperitoneum with favorable outcome: A case report and review.

    abstract::Neonatal pneumoperitoneum is a surgical emergency indicative of gastrointestinal perforation that requires immediate treatment to prevent death. There have been non-surgical conditions secondary to neonatal pneumoperitoneum (e.g., mechanical ventilation, pulmonary diseases and pneumatosis cystoides intestinalis) that ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: He TZ,Xu C,Ji Y,Sun XY,Liu M

    更新日期:2015-05-28 00:00:00

  • Nano-cerium-element-doped titanium dioxide induces apoptosis of Bel 7402 human hepatoma cells in the presence of visible light.

    abstract:AIM:To investigate the apoptotic effect of photoexcited titanium dioxide (TiO(2)) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS:Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang L,Mao J,Zhang GH,Tu MJ

    更新日期:2007-08-07 00:00:00

  • Comparison of Abbott and Da-an real-time PCR for quantitating serum HBV DNA.

    abstract:AIM:To compare the performance of the Da-an real-time hepatitis B virus (HBV) DNA assay and Abbott RealTime HBV assay. METHODS:HBV DNA standards as well as a total of 180 clinical serum samples from patients with chronic hepatitis B were measured using the Abbott and Da-an real-time polymerase chain reaction (PCR) ass...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Qiu N,Li R,Yu JG,Yang W,Zhang W,An Y,Li T,Liu XE,Zhuang H

    更新日期:2014-09-07 00:00:00

  • Long term outcome of antiviral therapy in patients with hepatitis B associated decompensated cirrhosis.

    abstract:AIM:To investigate survival rate and incidence of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis in the antiviral era. METHODS:We used the Korean Health Insurance Review and Assessment. Korea's health insurance system is a public single-payer system. The study population consisted of 286871 pa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ju YC,Jun DW,Choi J,Saeed WK,Lee HY,Oh HW

    更新日期:2018-10-28 00:00:00

  • Biological therapy for ulcerative colitis: an update.

    abstract::Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Seo GS,Chae SC

    更新日期:2014-10-07 00:00:00

  • Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.

    abstract:AIM:To identify the susceptible gene (s) for type 2 diabetes in the previously mapped region, 1p36.33-p36.23, in Han population of North China using single nucleotide polymorphisms (SNPs) and to analyze the haplotypes of the gene (s) related to type 2 diabetes. METHODS:Twenty three SNPs located in 10 candidate genes i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li YF,Sun HX,Wu GD,Du WN,Zuo J,Shen Y,Qiang BQ,Yao ZJ,Wang H,Huang W,Chen Z,Xiong MM,Meng Y,Fang FD

    更新日期:2003-09-01 00:00:00

  • Primary epithelial tumours of the appendix in a black population: a review of cases.

    abstract:AIM:To determine the prevalence, histologic types and clinical features of primary epithelial tumours of the vermiform appendix in a predominantly black population. METHODS:All cases of primary tumours of the appendix identified by review of the histopathology records at the University of the West Indies between Janua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Graham RP,Williams NP,West KA

    更新日期:2009-03-28 00:00:00