Abstract:
AIM:To investigate the effects of butyrate on interleukin (IL)-32alpha expression in epithelial cell lines. METHODS:The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL-32alpha was determined by Western blotting analyses. IL-32alpha mRNA expression was analyzed by real-time polymerase chain reaction. RESULTS:Acetate and propionate had no effects on IL-32alpha mRNA expression. Butyrate significantly enhanced IL-32alpha expression in all cell lines. Butyrate also up-regulated IL-1beta-induced IL-32alpha mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL-32alpha expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1beta-induced IL-32alpha mRNA expression. CONCLUSION:Butyrate stimulated IL-32alpha expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32alpha expression.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Kobori A,Bamba S,Imaeda H,Ban H,Tsujikawa T,Saito Y,Fujiyama Y,Andoh Adoi
10.3748/wjg.v16.i19.2355subject
Has Abstractpub_date
2010-05-21 00:00:00pages
2355-61issue
19eissn
1007-9327issn
2219-2840journal_volume
16pub_type
杂志文章abstract:AIM:To investigate the antioxidative status of patients with alcoholic liver disease (ALD) in southeastern Taiwan. METHODS:Our study comprised 27 patients with ALD recruited from Taitung Mackay Memorial Hospital, located in southeastern Taiwan. Patients with ALD included 12 non-aborigines (12 men) and 15 aborigines (1...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v17.i8.1063
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i28.4492
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
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doi:10.3748/wjg.v12.i32.5234
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journal_title:World journal of gastroenterology
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doi:10.3748/wjg.v21.i6.1915
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doi:10.3748/wjg.15.4392
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 社论
doi:10.3748/wjg.v23.i42.7495
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pub_type: 杂志文章
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更新日期:2008-08-21 00:00:00
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pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 社论,评审
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i10.1567
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pub_type: 杂志文章
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更新日期:2014-08-14 00:00:00